cd8 cells and tenofovir treatment in suppression of viremia of mutant viruses
Báo cáo y học: "Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection" pptx
... mutation in RT Therefore, this animal is described subsequently in more detail The role of both CD8+ cells and tenofovir treatment in suppression of viremia of mutant viruses Before the start of treatment, ... Figure of Kinetics K70E and K65R RT mutants during tenofovir therapy Kinetics of K70E and K65R RT mutants during tenofovir therapy Twelve RT-SHIV infected macaques were started on tenofovir treatment ... reduced in vitro susceptibility to tenofovir [1,2] Many tenofovir- containing regimens induce strong and longlasting suppression of viremia in the majority of persons, with a low occurrence of the...
- 22
- 442
- 0
Báo cáo khoa học: "METONYMY: REASSESSMENT, SURVEY OF ACCEPTABILITY, AND ITS TREATMENT IN A MACHINE TRANSLATION SYSTEM S" ppt
... APPENDIX A Some of the metonymic sentences used in the survey Kamei, Shin-ichiro and Wakao, Takahiro (1992) Metonymy: reassessment, survey of acceptability, and its treatment in a machine translation ... Producer-For-Product (Lakoff and Johnson 1980) or Artist-for-Artform (Fass 1991), or both of them A SURVEY OF METONYMY A comparative survey on acceptability of metonymic expressions in English, Chinese and Japanese ... examples in this pattern are acceptable in English and Chinese, but not in Japanese (3) "The sign said fishing was prohibited here." AN APPROACH TO TRANSLATING METONYMY An important point to realize...
- 3
- 453
- 0
Báo cáo sinh học: " Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneratio" potx
... expression in the serum of AMD patients [15,16], we found significantly increased levels of IL-22 and IL-17 in the sera of AMD patients, suggesting possible roles of IL-22 and IL-17 in the inflammation ... days and compared the percentage of cells undergoing apoptosis for more than 10 individuals Morphological signs of the inhibition of apoptosis, including more cell aggregates and less shrunken cells, ... presenting cells (APC) and T cells are important for IFN and IL-17 Page 10 of 12 production of T cells in a murine EAE (Experimental autoimmune encephalomyelitis) model [32] In another murine sepsis...
- 12
- 389
- 0
báo cáo hóa học: " Formation of multinucleated giant cells and microglial degeneration in rats expressing a mutant Cu/Zn superoxide dismutase gene" ppt
... brainstem (level of cranial nerve VII) in wildtype animals (A) and in late symptomatic/end Lectin staining of microglia in the brainstem (level of cranial nerve VII) in wildtype animals (A) and ... symptomatic of microglia in midbrain with GSA-I-B4 lectin (A-F) and in motor cortex with OX-42 (G) and OX-6 (H) during Visualization disease Visualization of microglia in midbrain with GSA-I-B4 lectin ... determined using chimeric animals consisting of mixtures of normal cells and cell expressing human mutant SOD1 that nonneuronal cells containing mutant SOD1 are indeed required to cause damage to motor...
- 12
- 598
- 0
Báo cáo y học: "The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus" potx
... portion of spleen tissue GC A can be seen in Fig 1, and has two distinct areas of staining for FDC and one large area of B cells encompassing both FDC regions Very few T cells could be seen within ... Structural and immunochemical characterisation of germinal centres within an SLE spleen Clusters of B cells and FDCs, which resembled GCs, were identified in frozen sections of the SLE spleen by staining ... with TA-cloning vector pCRII, and transformed into IFN-αF cells (Invitrogen, Paisley, UK) and cloned Immunohistochemical staining of tissue sections Frozen sections were stained using mouse monoclonal...
- 8
- 378
- 0
báo cáo khoa học: " Efficacy of Mesenchymal Stem Cells in Suppression of Hepatocarcinorigenesis in Rats: Possible Role of Wnt Signaling" doc
... of MSCs to cancer cells, nature of tumour cells and cancer stem cells, integrity of immune system, number of stem cell passages and site of injection; all can affect the outcome of MSCs use in ... regulation of the transcription factor b-catenin, a key component of the Wnt signaling pathway [58] In the normal state, the binding of members of a family of soluble cysteine-rich glycoprotein ligands, ... signaling in tumor tissues by assessing the gene expression profile of some of the Wnt signaling target genes:cyclin D, PCNA, survivin, b-catenin Methods Ninety albino female rats inbred strain (Cux1:...
- 11
- 337
- 0
Báo cáo y học: "The role of mast cells and fibre type in ischaemia reperfusion injury of murine skeletal muscles" pot
... manifestation of the reperfusion injury In order to determine the usefulness of therapies against mast cells, it is important to know the degree to which mast cells are involved in IR injury of other ... obtained by counting a minimum of 100 mast cell profiles in tongue, skin and heart as well as skeletal muscle Using 100 X magnification all mast cell profiles that fell within a grid area of 1.35 ... http://www.journal-inflammation.com/content/1/1/2 Figure Gastrocnemius muscle stained with Haematoxylin and Eosin Gastrocnemius muscle stained with Haematoxylin and Eosin Control (A & C) and IR treated hind...
- 7
- 400
- 0
Báo cáo y học: " Kinetics of hepatitis C virus RNA load during pegylated interferon alpha-2a and ribavirin treatment in naïve genotype 1 patients" potx
... viral kinetics and treatment outcome in combination of high-dose interferon induction vs pegylated interferon plus ribavirin for naive patients infected with hepatitis C virus of genotype 1b and ... reduction of the viral load (in log10) from baseline to week 2, 4, 8, and 12 of treatment, week point time tend to be better than other time points for predicting SVR, with a PPV of 91% and a NPV of ... decline, is also predictive of response to treatment [11] In the present study, viral kinetics during Peg-IFN alpha2a plus ribavirin treatment were determined at week 2, 4, 8, and 12 of treatment...
- 5
- 322
- 0
Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf
... leucine and valine residues N-terminal to the MUC3 and MUC12 specific sequences and a serine residue C-terminal to them Transient expression of epitope-tagged mucin proteins in Cos-7 cells and ... ⁄ SIVV and mutagenesis of the glycine residue to alanine in this sequence reduced the efficiency of cleavage [10], whereas a serine to alanine mutation abolished cleavage in COS cells In addition ... modules of MUC1 and MUC16 and the shortening of the predicted loop in MUC1 (FRPGSV_ _ _VV in MUC1 compared to FRSVSNNNNHT in MUC16) makes detailed structural analysis of specific interactions within...
- 11
- 605
- 0
Child-friendly health care: the views and experiences of children and young people in Council of Europe member States doc
... setting and what could make it more child-friendly, the attitudes and behaviours of health care professionals and issues affecting communication and children’s use of health care services Accordingly, ... experiences of health care in certain parts of the Council of Europe For this reason, a Council of Europe consultation was planned, chiefly by means of a survey, with a view to recording the views of ... children in its legal and policymaking work Children and young people have a right to have their voices heard and taken into account in matters that affect them in accordance with Article 12 of the...
- 22
- 412
- 0
Báo cáo Y học: Group IID heparin-binding secretory phospholipase A2 is expressed in human colon carcinoma cells and human mast cells and up-regulated in mouse inflammatory tissues doc
... respectively (B) Expression of the wild-type (WT) and two mutants of mIID in HEK293 cells, as assessed by RNA blotting (C) Membrane binding of the WT and two mutants of mIID After collecting the culture ... Determination of the heparin-binding site of mouse sPLA2-IID The amino-acid sequences of mouse and human sPLA2-IIDs reveal the presence of multiple cationic amino acid residues in their C-terminal ... (A) Amino acid sequences of the C-terminal part of mouse sPLA2-IID (mIID) and its mutants, KE2 and KE2RS2 Two and four basic amino acids are replaced by glutamic acid or serine in KE2 and KE2RS2,...
- 10
- 334
- 0
Báo cáo khoa học: Mechanism for transcriptional synergy between interferon regulatory factor (IRF)-3 and IRF-7 in activation of the interferon-b gene promoter docx
... The intensity of binding, expressed as percentage of input bound, is indicated by different shades of gray and only interactions resulting in binding to more than 1.5% of input are shown IRF-3 and ... Mapping of domains of hp300/mCBP interacting with transcription factors Summary of interaction studies between domains of the p300 and CBP coactivators and the transcription factors that can bind ... c-Jun for the N- and C-terminal regions and of ATF-2 for the central region of the coactivators Binding of p50 (amino acids 1–503 of p105) to GST– p300/CBP was very weak overall Binding to CBP–N...
- 11
- 487
- 0
Báo cáo khoa học: Subcellular localization of yeast Sec14 homologues and their involvement in regulation of phospholipid turnover pptx
... formation, indicating that Sec14p and the two homologues act as inhibitors of Plb1p in vivo This observation explains at least in part the low Plb1p activity in wild-type cells Interestingly, the inhibitory ... integrative versions of C-terminal yEGFP fusions in frame with the ORF of interest Thus, yEGFP fusions were present in single copy in the genome and driven by the native promoter of the ORF of ... level of PtdCho turnover in the strain with intact PLD1 gene and analysis of the turnover products indicate that high PtdCho turnover observed in SFH2 and SFH4 overexpressing cells is linked...
- 13
- 430
- 0
Tế bào gốc và ứng dụng trong y sinh học (Stem cells and the application in biomedicine) potx
... from a human pancreatic cell line in vitro and in vivo Mol Endocrinol 15, 476 - 483 Dzierzak, E et al (1998); Embryonic beginnings of definitive hematopoietic stem cells Ann N Y Acad Sci 872, 256 ... Identification of novel circulating human embryonic blood stem cells Blood 96, 1740 - 1747 IItskovitz - Eldor, J and et al (2000).; Differentiation of human embryonic stem cells into embryoid ... endocrine precursor cell line Mol Endocrinol 14, 814 - 822 Jones, G M., et al (2000); Human embryonic stem cells technology Semin Reprod Med 18, 219 - 223 Orlic D et al (2001); Bone marrow cells...
- 14
- 757
- 2
báo cáo hóa học:" Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma" ppt
... that selected sigma-2 ligands are capable of inducing apoptosis in a multitude of human and murine cancer cells lines and in animal models of cancer including pancreas cancer [12,13,15] The mechanisms ... obtained from Bryan Clary (Duke University) and maintained in supplemented RPMI 1640 containing glutamine (2 mmol/L), pyruvate (1 mmol/L), penicillin (100 IU/ mL), streptomycin (100 IU/mL), and ... pancreatic adenocarcinoma cell lines (Panc-1, AsPC-1, and CFPAC-1) were obtained from ATCC (Bethesda, MD) and maintained in Dulbecco's modified eagle's medium (DMEM) containing glutamine (2 mmol/L),...
- 8
- 726
- 0
báo cáo hóa học: " Proinflammatory and proapoptotic markers in relation to mono and di-cations in plasma of autistic patients from Saudi Arabia" docx
... resulting in increased permeability of the blood-brain barrier [46]; thus the administration of LPS to fetal sheep results in the extravasation of plasma proteins and macrophages into the brain ... entry of Ca2+ into neuron cells can accelerate apoptosis by accelerating the expression of growth arrest and DNA Damage inducible gene 153 (GADD153) and by inducing a prolonged efflux of K+ out of ... responses and cytokine production against common dietary proteins in patients with autism spectrum disorder Neuropsychobiology 2002, 46:76-84 12 Singh VK: Plasma increase of interleukin-12 and interferon-gamma:...
- 9
- 413
- 0
báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx
... FGF-2 and BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in abundance of mineralization-related gene expression Mineralizing ... FGF 5% Mineralizing Media 5% Mineralizing Media + 5ng/ml FGF Page of 5% Normal Media + 50ng/ml BMP 5% Mineralizing Media + 50ng/ml BMP Figure Alizarin Staining of Mineralizing Osteoblast cells ... was rinsed five times in room temperature phosphate buffered saline (PBS) and fixed We then visualized the mineralizing cells with 2% Alizarin Red After rinsing in distilled water and air drying...
- 8
- 547
- 0
báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf
... FGF-2 and BMP-2, the yin and yang of mineralization: Contrast of effect of 24 hours of treatment with FGF-2 or BMP2 on fold increase in abundance of mineralization-related gene expression Mineralizing ... FGF 5% Mineralizing Media 5% Mineralizing Media + 5ng/ml FGF Page of 5% Normal Media + 50ng/ml BMP 5% Mineralizing Media + 50ng/ml BMP Figure Alizarin Staining of Mineralizing Osteoblast cells ... was rinsed five times in room temperature phosphate buffered saline (PBS) and fixed We then visualized the mineralizing cells with 2% Alizarin Red After rinsing in distilled water and air drying...
- 8
- 460
- 0
Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến dòng điện stato i1 fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25