cardiovascular complications in renal failure implications of advanced glycation end products and their receptor receptor rage
Báo cáo y học: "Mechanical ventilation during experimental sepsis increases deposition of advanced glycation end products and myocardial inflammation" pdf
... deposition and the number of macrophages and PMNs is in line with these observations The low number of lymphocytes in the heart of our study may be explained by the observation of increased apoptosis of ... pathophysiologic role of AGE formation in MV-induced myocardial inflammation during sepsis Importantly, the role of AGE in increasing inflammation and subsequent detrimental effects on cardiovascular ... Increased levels of the RAGE has been found in broncho-alveolar lavage fluids and serum of rats with endotoxin-induced lung injury and patients with acute lung injury [29] Treatment with sRAGE significantly...
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Báo cáo khoa học: Advanced glycation end products and lipopolysaccharide synergistically stimulate proinflammatory cytokine⁄chemokine production in endothelial cells via activation of both mitogen-activated protein kinases and nuclear factor-jB pdf
... AGE-HSA and LPS have a synergistic effect on the induction of cytokines ⁄ chemokines To determine whether there is any combined effect of AGE-HSA and LPS on the induction of cytokines ⁄ chemokines, ... NF-jB, indicating a predominant role of the p38 pathway in the AGE-HSA and LPS amplified in ammatory response Furthermore, blockade of both MAP kinases and NF-jB with a combination of inhibitors ... profiles of cytokines ⁄ chemokines in human umbilical vein endothelial cells (HUVECs) upon stimulation with AGE-HSA and LPS, fourteen cytokines ⁄ chemokines, including tumor necrosis factor-a, interleukin...
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Báo cáo khoa học: Analysis and biological relevance of advanced glycation end-products of DNA in eukaryotic cells ppt
... Breyer et al DNA advanced glycation end- products in cells 300 Glycation rate (%) 250 200 150 100 50 0 days of incubation 14 days of incubation Fig Increase in the glycation rate of genomic DNA ... analysis of the CEdG formation rate in genomic DNA of cultured cells Furthermore, the in uence of CEdG DNA advanced glycation end- products in cells formation on cellular protein expression was investigated ... Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanded glycation endproducts Nat Med 4, 1025–1031 Singh R, Barden A, Mori T & Beilin L (2001) Advanced glycation end- products: ...
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Báo cáo y học: "erum levels of soluble receptor for advanced glycation end products and of S100 proteins are associated with inflammatory, autoantibody, and classical risk markers of joint and vascular damage in rheumatoid arthritis" doc
... Binding of receptor for advanced glycation end products (RAGE) ligands is not sufficient to induce inflammatory signals: lack of activity of endotoxin-free albumin-derived advanced glycation end ... splice variants of the receptor for advanced glycation end- products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury Biochem ... PTPN22, protein tyrosine phosphatase, non -receptor type 22; sRAGE, soluble receptor for advanced glycation end products In simple linear regression analysis, serum levels of S100A8 in RA patients...
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Báo cáo y học: "Receptor for advanced glycation end products Glycine 82 Serine polymorphism and risk of cardiovascular events in rheumatoid arthritis" potx
... diabetes and renal failure, and at sites of inflammation (by oxidation) [16] Levels of S100 proteins and HMGB1 are increased in both adult and juvenile RA [17], and inhibition of the RAGE has ... protein (HMGB1)), β-pleated sheet fibrils of amyloid and advanced glycation end products (AGEs) [15] AGEs are the products of nonenzymatic glycation and oxidation of proteins that form with aging, ... commencing a variety of antirheumatic drugs rather than at baseline In RA, proinflammatory ligands of the RAGE, including S100A12 and HMGB1, are reported to be expressed at high levels, levels of...
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Báo cáo y học: "levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control" docx
... for post -RAGE signalling One of the features of the receptor is its recognition of families of ligands, rather than a single protein The RAGE repertoire of ligands includes products of non-enzymatic ... sRAGE? In the case of RA, there is a wide diversity of RAGE ligands present in the inflamed joints, as well as in the circulation, that could lead to the binding and consumption of sRAGE during ... erosions, defined as loss of cortical definition of the joint and recorded in proximal interphalangeal joints, metacarpophalangeal joints, carpal joints, wrist joints and metatarsophalangeal joints Thirty-nine...
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Báo cáo y học: " Blockade of advanced glycation end product formation attenuates bleomycin-induced pulmonary fibrosis in rats" pot
... measurement of hydroxyproline content Hydroxyproline assay was performed according to the instruction of hydroxyproline test kit from Nanjing Jiancheng Bioengineering Institute (Nanjing, China) In brief, ... contribution of AGEs to the lung fibrosis is involved in its receptor, the receptor of AGEs (RAGE) In recent studies, loss of RAGE was observed in the lungs of IPF patients and bleomycin- or asbestos-treated ... Schuppan D: The receptor for advanced glycation end products is highly expressed in the skin and upregulated by advanced glycation end products and tumor necrosis factor-alpha J Invest Dermatol...
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Báo cáo y học: ":The expression of the receptor for advanced glycation end-products (RAGE) in RA-FLS is induced by IL-17 via Act-1" ppsx
... been attempted Soluble RAGE, a decoy receptor of RAGE, successfully blocks the binding of ligand and RAGE in vitro and in vivo [6,31] Soluble RAGE reduces the complications of diabetes [31], suppresses ... Furthermore, the activation of NF-B results in increased RAGE expression and increases the number of ligand binding sites, which in turn sustains NF-B activation The ability of RAGE to convert acute ... immunohistochemical staining using specific antibodies Coimmunostaining of RAGE and phospho STAT3, phospho IB, phospho c-Jun, and phospho AKT showed the link between in vitro signaling molecules and RAGE Values...
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Báo cáo y học: "Advanced glycation end products induce cell cycle arrest and proinflammatory changes in osteoarthritic fibroblast-like synovial cells" doc
... may play a role in the initiation and perpetuation of inflammation and degradation processes RAGE as well as AGEs are present in the synovial lining, sublining and endothelium of OA synovial tissue ... one, two and seven days of stimulation in 15 and osteoprotegerin in different cell lines In opposite to RAGE, NFκB and the proinflammatory cytokines TNF-α and IL-6, the mRNA levels of RANKL and osteoprotegerin ... degradation into the synovium and the activation of FLS through AGE -RAGE interaction may initiate inflammatory responses In RA, activated NFκB in FLS is involved in the regulation of inflammatory cytokines,...
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Báo cáo y học: "High-risk human papillomavirus in the oral cavity of women with cervical cancer, and their children" pot
... mucosa in 309 women with genital HPV infections, by using dot blot hybridization and found oral HPV infection in only 3.8% women Of these, only had clinical lesions suggestive of HPV infection In ... found in our study In contrast to our findings, a higher percentage (15.4% and 29.4%) of concurrent HPV infection between clinically normal oral mucosa and genital region, by using Southern blot and ... birth and at the end first month of life (6.1%) became HPV-DNA negative by the age of months [34] Similarly, in 1986, Roman and Fife analysed the foreskins of 70 male infants undergoing routine...
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Báo cáo y học: " Soluble receptor for advanced glycation end products in COPD: relationship with emphysema and chronic cor pulmonale: a case-control study" potx
... Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins J Biol Chem 1992, 267:14998-15004 Basta G: Receptor for advanced glycation end products and ... an isoform of RAGE lacking transmembrane and cytosolic domains, acts as a decoy receptor for RAGE ligands in the extracellular compartment, and is believed to afford protection against inflammation ... cross-sectional nature of the study, we obtained a single determination of sRAGE, FEV and DLCO, and a single CT scan study This precluded the possibility of evaluating whether changes in sRAGE over time...
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Tài liệu Cleaner Water in China? The Implications of the Amendments to China’s Law on the Prevention and Control of Water Pollution pptx
... Water in China? 187 improving the environment, maintaining the safety of drinking water, and promoting sustained economic and social development.”33 It “applies to pollution prevention and control ... be imposed a fine equal to 50% of their incomes from their respective employers for the preceding year.”115 Fining the individual is innovative and may decrease the likelihood of premeditated ... Squire, Sanders & Dempsey L.L.P.) Article was amended in the 2008 version The original version was “formulated for the purpose of preventing and controlling water pollution, protecting and improving...
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Báo cáo y học: "Green tea polyphenol epigallocatechin-3-gallate inhibits advanced glycation end product-induced expression of tumor necrosis factor-α and matrix metalloproteinase-13 in human chondrocyte" ppsx
... products and their relation to complications in insulin-dependent diabetes mellitus J Clin Invest 1993, 91:2470-2478 Waine H, Nevinny D, Rosenthal J, Joffe IB: Association of osteoarthritis and ... modulation of the activation and DNA binding activity of NF-κB Inhibition of IKKβ kinase activity by EGCG The effect of EGCG on the phosphorylating activity of IKKβ kinase was determined using an ... Activation of RAGE by multiple ligands including S100 protein, high-mobility group box chromosomal protein and AGEs (complex and specific AGEs) in OA chondrocytes and synoviocytes results in increased...
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Báo cáo y học: "Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection" pptx
... levels in plasma and infectious titers in PBMC, and a similar decline in absolute counts and percentages of CD4+ T lymphocytes and CD4+/CD8+ T cell ratios during the first 20 weeks of infection ... emergence and implications of K70E and K65R viral mutants These data are important and timely, considering (i) the increased use of tenofovir in HAART regimens, and (ii) the ongoing clinical trials ... difficult to unravel, and that are relevant to the clinical use of tenofovir-containing regimens in HIV-1 infected humans In the current study, intravenous inoculation of the first group of macaques with...
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Characteristics of Leachate from Citrus Groves and their Changes in the Collecting Reservoirs in Matsuyama, Japan
... and periphery of the Seto Inland Sea The location of the research area and the distribution of the citrus groves in Matsuyama region are shown in Fig Matsuyama is situated in Shikoku Island in ... parts of the grove from points Sampling points St.1 and St.2 are in the same stream, and sampling point St.3 is in the other stream The two streams flow together to be one stream and the sampling ... also increased through the cultivation and the ratio of the increased amount of SS to the increased amount of Chl.a was higher than that of the algae Increased amount of SS were higher in the...
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Drugs and Poisons in Humans - A Handbook of Practical Analysis (Part 71 and End)
... determination of methemoglobin in blood Clin Chim Acta 30:679–682 5) Katsumata Y, Aoki M, Oya M et al (1980) Simultaneous determination of carboxyhemoglobin and methemoglobin in victims of carbon ... blood samples at the ratio of 1:1 References 1) Evelyn KA, Malloy HAT (1938) Microdetermination of oxyhemoglobin, methemoglobin and sulfhemoglobin in a single sample of blood J Biol Chem 126:655–662 ... medicine 59 EMPC 566 empenthrin 425 emulsion formation 533 endogenous ethanol 136 endogenous GHB 251, 252 endogenous glucuronidase 588 endosulfan 529 endotracheal intubation 22, 359, 386 endrin...
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Tài liệu Báo cáo khoa học: Identification of ATP-NADH kinase isozymes and their contribution to supply of NADP(H) in Saccharomyces cerevisiae docx
... Doubling time of WT (BY4742) and pos5 mutants Means of two independent experiments are provided Arginine concentrations are specified in parentheses in mgÆL)1 In this study, 20 mgÆL)1 arginine ... 4.9 a This strain was grown in media lacking leucine The other strains were grown in media containing leucine Complementing abilities of LEU2, UTR1 and YEF1 for the growth defects of the pos5 mutant ... the poor growth of the pos5 cell on SG solid medium and on and in solid and liquid media lacking arginine (Fig and Table 6), thereby supporting the partial contribution of Utr1p and Yef1p to mitochondrial...
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Báo cáo khoa học: Stage specific expression of poly(malic acid)-affiliated genes in the life cycle of Physarum polycephalum Spherulin 3b and polymalatase potx
... domain The domain fold contains a pair of calcium binding sites While the bc-crystallins of lens (not shown) and lower organisms in Fig contain two domain folds, spherulin 3a and NKA48 contain ... single domain fold The stability of these two proteins is highly dependent on calcium binding [25] The typical domain motives contain a ‘tyrosine corner’ in the domain centre as seen in proteins ... result of loss of induction at the transcriptional level, of loss of activation of the synthetase protein itself, or of derepression of enzyme(s) catalysing PMLA degradation An interesting interplay...
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Báo cáo khoa học: Comprehensive sequence analysis of horseshoe crab cuticular proteins and their involvement in transglutaminase-dependent cross-linking potx
... C-terminal domain of tachycitin (Cys40 to Cys61), a horseshoe crab chitin-binding protein [15], as well as with the chitin-binding domain of hevein (Cys12 to Cys33), a plant chitin-binding protein ... acid, suggesting the presence of disulfide bond-containing proteins in insect cuticles [43,44] Nucleotide sequences of LMM chitin-binding proteins All of the LMM chitin-binding proteins identified, ... chitin-binding proteins in T tridentatus Amino acid compositions of high molecular mass (HMM) chitin-binding proteins HMM chitin-binding proteins resolved by 2D SDS ⁄ PAGE were categorized into...
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facile synthesis of porous a - fe2o3 nanorods and their application in ethanol sensors
... with average diameter of about 10-15 nm and a length of about 200 nm After being calcined at 300 °C for h, the sample still maintains the rodlike 1-D morphology, as is shown in Figure 3c and d ... out, and the resultant products were investigated by TEM (see Figure S1 in the Supporting Information) At a shorter reaction time of only min, there are almost no nanorods formed, and the average ... condition in a chamber with a volume of 15 L at a working temperature of 250 °C and 40% relative humidity (RH) An appropriate amount of ethanol vapor was injected into the closed chamber by a microinjector,...
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Tìm thêm: xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25