... patientofthesideeffectsassociatedwiththis intervention, includingpoor cosmesis, particularly in women with larger breasts Radiotherapy to nodal areas 1.11.9 Do not offer adjuvant radiotherapy ... CBT with other forms ofintervention in breast cancer patients alone Other forms of psychotherapy include psychodynamic counselling, Gestalt therapy or any other psychological interventionThe comparison ... advanced breast cancer 25 Notes on the scope ofthe guidance NICE guidelines are developed in accordance with a scope that defines what the guideline will and will not cover The scope ofthis guideline...
... outcome) Squares denote the odds ratio (OR) for a single study with horizontal lines denoting 95% confidence intervals The centre ofthe diamond denotes the pooled OR and the corners the 95% confidence ... outcome) Squares denote the odds ratio (OR) for a single study with horizontal lines denoting 95% confidence intervals The centre ofthe diamond denotes the pooled OR and the corners the 95% confidence ... outcome) Squares denote the odds ratio (OR) for a single study with horizontal lines denoting 95% confidence intervals The centre ofthe diamond denotes the pooled OR and the corners the 95% confidence...
... group comparisons of these three CSF biomarkers Instead, they were used to employ correlations with other markers within each group and to define ‘individuals within the control group with increased ... limitation ofthe study might be that CSF T-tau, P-tau and Ab42 levels were measured with different methods in the AD patients compared withthe healthy elderly individuals The aim ofthe present ... used The detection limit ofthe assay was 0.008 ng/ml of human recombinant MMP-1, 0.04 ng/ml of human recombinant MMP-3, 0.24 ng/ml of human recombinant MMP-9, and 0.031 ng/ml of human recombinant...
... included model constructs of pRBGP2 and pRBGP4, containing three copies ofthe Maf recognition element (MARE) and three copies ofthe mutated MARE, respectively [39] Co- transfection with siHO-2 ... expression We then performed a time course study to confirm theeffectsof HO-2 siRNA on the expression of HO-1 mRNA in HeLa cells (Fig 6A) HO-2 siRNA efficiently reduced the expression of HO-2 mRNA ... analysis of HO-1 and HO-2 proteins The intensity representing HO-1 or HO-2 protein was normalized with respect to the intensity ofthe b-actin signal The ratio of each normalized value to the control...
... arrowheads) Counterstained with hematoxylin Scale bars represent 50 µm This is the first study to examine the expression of OPN and its receptor, CD44, in the spinal cord of rats with EAN Many studies of ... washes, the sections were incubated withthe appropriate biotinylated second antibody, followed by formation ofthe avidin-biotin peroxidase complexes using the Elite kit (Vector, USA) The peroxidase ... may stimulate the expression of OPN in macrophages and astrocytes, in either an autocrine or paracrine manner Since the expression of OPN paralleled the clinical course of EAN in the present study,...
... both the lung (airways and parenchyma) and the systemic circulation [32-34] The intensity ofthe inflammatory process in the airways and in the systemic circulation is associatedwith severity of ... in lung function in the postmenopausal age group are needed to confirm these observations In view ofthe growing incidence of smoking and the COPD in the female population, there is an urgent ... increased susceptibility of women to cigarette smoke are largely unknown There is now a general consensus that inflammation is at the heart ofthe pathobiology of COPD and that the inflammatory process...
... presented as number of patients (percentage) Data were compared withthe use ofthe chi-square test or the Fisher exact test The effect of serum cortisol level on the occurrence of postoperative ... that high levels of circulating glucocorticoids might have harmful effects on the brain and cause psychiatric symptoms [19-21] This is because there are glucocorticoid receptors in the hippocampus ... these conditions in this study On the other hand, 20 patients (8.2%) in our study had a serum cortisol concentration that was lower than normal in the morning ofthe first postoperative day The...
... excluded from the analysis because of lack of EAA data and patients were excluded because of withdrawal of consent resulting in a sample size of 54 patients Of these 54 participants, the mean age ... endotoxemia at the conclusion of CPB is associatedwith a significant risk ofthe development of postoperative infections Further research is necessary to assess whether a targeted strategy of rapid ... measurement of endotoxin levels coupled with a directed anti-endotoxin therapeutic strategy could improve patient outcomes Key messages • The prevalence of high levels of endotoxemia (as measured by the...
... material The next strategy, which is the basis ofthe present study, is continued surveillance This necessitates the presence of an ongoing surveillance system which is the case withthe Swedish ... lower than that during the first period There are two possible explanations The noticed effect of loratadine during the first period could be the result of a synergism with an unknown factor ... expected number of 16.8, RR = 1.61, 95%CI 1.04-2.34) trimester with an upper confidence limit of 10.5 The authors calculate that in order to rule out a doubling ofthe risk, they would need a...
... EPIDEMIOLOGY OF OSTEOPOROSIS A MAGNITUDE OFTHE PROBLEM The number of people considered to have osteoporosis depends entirely on the way the condition is defined in practice A committee ofthe World ... cells ofthe bone marrow, fill in the area of resorption with type collagen [47] Type I collagen ultimately becomes mineralized, probably as a function ofthe osteoblasts, thereby completing the ... strength in the normal population not conform to a monogenetic mode of inheritance The common form of osteoporosis is generally considered to be polygenic arising from the interactions of common polymorphic...
... in Corollary From Lemma 2, Corollary and Proposition 2, we have Theorem Let µ is the 5−fold convolution ofthe standard Cantor measure, then the lower extreme value ofthe local dimension of ... result Main Theorem Let µ be the 5−fold convolution ofthe standard Cantor measure, then the lower extreme value ofthe local dimension of µ is α5 = | log 3.25 √ arccos 145 cos( log 427 √ 59 145 )+5 ... Thanh et al / VNU Journal of Science, Mathematics - Physics 25 (2009) 57-68 65 From (13), (14) and (15), the assertion ofthe corollary follows 2.2 The proof ofthe main theorem Lemma Let x = (x1...
... time task, but withthe provision of c o n t e x t s w h i c h are f e l i c i t o u s w i t h one or other ofthe two versions of their examples thewiththe to NP) In the case ofthe n o n - m ... e v e r s e of w h a t w o u l d be expected on a Minimal Attachment or I,exical Preference account N e i t h e r of these could account for this effect without having to discount the experimental ... a u s e ofthe i n c r e a s e d n u m b e r of t h e s e v i o l a t i o n s It w o u l d appear, then, that much ofthe evidence cited in the literature concerning the resolution of local...
... in which the reducing end ofthe substrate are connected to subsite i and i + 1, respectively Fig shows the structure ofthe program The supposed number of subsites and the position ofthe cleavage ... value; SG, the sum ofthe binding energies ofthe occupied sites; %calculated, the bond cleavage frequency calculated according to the subsite map; Difference, the sum ofthe difference between the measured ... studies ofthe action pattern of PPA on maltooligosaccharides of DP 4–8 Our findings were based on the action pattern of PPA on three different series of b-maltooligosaccharide glycosides and they confirmed...
... withthe catalyst This results in formation of only a few of SiNWs The reaction temperature is usually decided withthe consideration ofthe catalyst type According to the binary phase diagram of ... uration ofthe formed liquid alloy with silicon atoms, which leads to nucleation and growth of a SiNW [19] Therefore, the diameter and location ofthe SiNW are determined by the features ofthe catalyst ... addition, the asformed SiNW is easily oxidized with an oxide shell of 1–3 nm according to the Eq (2) (Fig 3A) 3.2 Sulfide-assisted growth of SiNWs (3) Si is proffered by the decomposition ofthe precursor...
... ambiguity at the lexical level, but their cll~:ctiveness suffers from the rather free word/constituent order Finally, a comment about the computational efficiency ofthe LCA(k) automaton The time complexity ... is the size ofthe grammar) The space complexity of l,CA(k) is proportionM to ]7] k÷~ ; this is why otfly truly short contexts should be used >$ This graph, or more conveniently the table of ... Experiment These two examples not suggest any kind of proof, but they well illustrate the recognition power of even the least powerful automaton in the {LeA(i)} family To get another point of view,...
... In this paper we establish a connection between the Quillen K-theory of certain local fields and the de Rham-Witt complex of their rings of integers with logarithmic poles at the maximal ideal The ... Moreover, the composite ofthe maps in the lower row is equal to the map ofthe statement, and the upper left-hand and upper righthand terms are contractible Hence the theorem is equivalent to the ... the identification ofthe E -term is a consequence ofthe celebrated theorem of Suslin, [43], that ⊗(t/2) ¯ Kt (K, Z/pv ) = µpv e For K a finite extension of Qp , the p-adic homotopy type of the...
... oxidation with MnO2 [34] For the synthesized retinoids, the retinals were the forms of storage Synthesis of 7-cis-retinol, 9-cis-retinol and 11-cisretinol were performed by reduction ofthe corresponding ... Negative immunostaining controls were made by the preadsorption ofthe ADH4 antibody with an excess of purified recombinant ADH4, or by the omission ofthe primary antibody Slides containing adjacent ... protein in the RPE by immunohistochemistry, consistent withthe ADH4 activity previously found in this epithelium [25] Thus, the presence in the RPE, the high activity with 11-cis-retinol, and the specificity...