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các dẫn xuất của pyrrolizidine alkaloids có khả năng gây ung thư trong số loài thực vật

Development of new neural stem cell based tumor targeted gene therapy approaches

Development of new neural stem cell based tumor targeted gene therapy approaches

Thạc sĩ - Cao học

... However, the majority of intravenously injected cells become trapped in the lung and liver because of the narrow diameters of lung capillaries and liver sinusoids In a previous study, it was found that ... 2008) or oncolytic viruses (Herrlinger et al., 2000; Tyler et al., 2009) were shown to exert a strong cytotoxicity toward metastatic tumors via bystander effects 1.1.2 Cell source The great potential ... tumor sites, whereas most of the injected cells were trapped in non-target organs including the lung, liver and spleen (Yang et al., 2012; Zhao et al., 2012) One of the safety concerns here is...
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How to translate some of the metaphors in Harry potter Books (book 3 and book 7) into Vietnamese

How to translate some of the metaphors in Harry potter Books (book 3 and book 7) into Vietnamese

Quản trị kinh doanh

... least a way to escape from difficulties Nếu Chúa đóng hết cửa lớn lại, Ngài mở khung cửa sổ Luôn lối thóat, cách thóat khỏi khó khăn The meaning of the metaphor may be translated without keeping ... person In that meaning, the translated version is quite satisfactory: Đây lần tụi đụng đầu với thực tế thực vực đợc đạo: bụng no tinh thần tốt, bụng trống không sinh cãi cọ rầu rĩ 39 39 ( Translated ... chơi tụi lỳ tòa giving were forced to remain inside lâu đài, tìm cách o ép não explanations the castle, trying their to bully tập trung [] brains into ( Translated by Lý Lan,2002, p.435) concentrating...
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Báo cáo khoa học: A steady-state modeling approach to validate an in vivo mechanism of the GAL regulatory network in Saccharomyces cerevisiae ppt

Báo cáo khoa học: A steady-state modeling approach to validate an in vivo mechanism of the GAL regulatory network in Saccharomyces cerevisiae ppt

Báo cáo khoa học

... positive regulatory protein of yeast Cell 40, 767–774 27 Koh, S.S., Ansari, A.Z., Ptashne, M.S & Young, R.A (1998) An activator target in the RNA polymerase II holoenzyme Mol Cell 1, 895–904 28 Kew,...
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An integration of the four english skills in teaching reading texts to beginner learners at asemlink international language centre

An integration of the four english skills in teaching reading texts to beginner learners at asemlink international language centre

Khoa học xã hội

... With closed-item questions, I designed seven questions with likert scales ( strongly agree, agree, disagree and strongly disagree) and true-false items And with open-item questions, I created ... or team of colleagues In the context of second/foreign language education, action research is strongly recommended as an effective intrument of professional development (Burns, 2010) Indeed, ... LANGUAGE CENTRE ( Đường hướng tích hợp bốn kỹ Tiếng Anh trình dạy Đọc hiểu cho cấp độ cấp Trung tâm Anh ngữ quốc tế Asemlink) Field: Theory and Methodology of English Language Teaching Code:...
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How to get out of the friendzone: turn your  friendship into a  relationship

How to get out of the friendzone: turn your friendship into a relationship

Tâm lý - Nghệ thuật sống

... actual relationship, no matter how much you pretend Last but not least, you’re not getting any younger Life is short, and here you are messing around in some vague situation with 32 How to Get ... really hard to see that there’s any damage being done But there is Because when you have such a strong emotional connection with someone else, you should be lovers You treat each other as lovers...
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Tài liệu University Oars Being a Critical Enquiry Into the After Health of the Men Who Rowed in the Oxford and Cambridge Boat-Race, from the Year 1829 to 1869, Based on the Personal Experience of the Rowers Themselves pdf

Tài liệu University Oars Being a Critical Enquiry Into the After Health of the Men Who Rowed in the Oxford and Cambridge Boat-Race, from the Year 1829 to 1869, Based on the Personal Experience of the Rowers Themselves pdf

Sức khỏe giới tính

... the right lung ensued This illness was a very protracted one, and he was assured by one of the physicians who attended him that there was a permanent induration at the top of the right lung which ... well-built fresh and strong man, but with too ruddy and hectic a look about him." I shall now refer to five cases of supposed injury, where although the men appear to have been strong they would still ... fast—was feet 2^in at nineteen, though strong and muscular At the same time, the conclusion I should come to in my own case is that v I over-exerted myself too young, and had I begun when I left off...
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Báo cáo khoa học: The N-terminal region of the bacterial DNA polymerase PolC features a pair of domains, both distantly related to domain V of the DNA polymerase III s subunit ppt

Báo cáo khoa học: The N-terminal region of the bacterial DNA polymerase PolC features a pair of domains, both distantly related to domain V of the DNA polymerase III s subunit ppt

Báo cáo khoa học

... PDB: 2e0g) [20] These structures were detected with high hhsearch probability (97% for both), strongly suggesting a common origin Interestingly, the first half of the PolC N-terminal region ( ... linker region was predicted by three independent approaches (see Materials and methods), with the strongest consensus spanning residues 194–214 These data suggest that the linker connecting the N-terminal ... N-terminal two-domain structure to the OB domain of PolC might be quite flexible Structural models strongly support the sequence-based homology inference Sequence-based searches are a powerful tool...
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JUDGMENTS OF THE COURT OF APPEAL OF NEW ZEALAND ON PROCEEDINGS TO REVIEW ASPECTS OF THE REPORT OF THE ROYAL COMMISSION OF INQUIRY INTO THE MOUNT EREBUS AIRCRAFT DISASTER potx

JUDGMENTS OF THE COURT OF APPEAL OF NEW ZEALAND ON PROCEEDINGS TO REVIEW ASPECTS OF THE REPORT OF THE ROYAL COMMISSION OF INQUIRY INTO THE MOUNT EREBUS AIRCRAFT DISASTER potx

Du lịch

... to fly at such a low level without real visibility That is an aspect which could well have been strongly relied on if, when giving evidence before the Commissioner, they had realised that they ... present the director of flight operations for the airline He appeared in the witness box to be a strong-minded and aggressive official It seemed clear from this further production of First Officer ... about cards in the pack are a reversion to the theme of the 'Stance' section, with its exceedingly strong allegations in paragraph 377 of 'a pre-determined plan of deception' and 'an orchestrated...
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Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf

Báo cáo khoa học: Inhibition of PI3K/Akt partially leads to the inhibition of PrPC-induced drug resistance in gastric cancer cells pdf

Báo cáo khoa học

... be reversed by downregulation of Akt1 by Akt1 small interfering RNA (siRNA) [11] Other studies strongly suggested that the PI3K/Akt pathway is involved in certain functions of PrP [12,13] Some ... (intensity score) was divided into four categories: 0, no IR; 1, weak IR (+); 2, moderate IR (++); 3, strong IR (+++) The proportion of positive cells was classified into five groups: 0, no tumor cells...
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To Cut or Not to Cut? That is the (Central Bank’s) Question In Search of the Neutral Interest Rate in Latin America pdf

To Cut or Not to Cut? That is the (Central Bank’s) Question In Search of the Neutral Interest Rate in Latin America pdf

Ngân hàng - Tín dụng

... Estimations 35 Boxes Why is Brazil’s Neutral Real Interest Rate so High? 16 How strong is the Credit Channel in Latin America? 23 Appendices I Recent Macroprudential Measures ... document a downward trend in the NRIR for all the countries in our sample during recent years Stronger domestic economic fundamentals (lower exchange rate risk and inflation risk premiums, as ... financing conditions in all markets  We observe that the interest rate gap and the output gap are strongly and positively correlated Although we not claim causality, we infer that this correlation...
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Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx

Báo cáo khoa học: A characteristic Glu17 residue of pig carnitine palmitoyltransferase 1 is responsible for the low Km for carnitine and the low sensitivity to malonyl-CoA inhibition of the enzyme docx

Báo cáo khoa học

... positive determinant for malonyl-CoA sensitivity (as in rat CPT1A) Paradoxically, this determinant is stronger than that FEBS Journal 276 (2009) 210–218 ª 2008 The Authors Journal compilation ª 2008 ... malonyl-CoA sensitivity As the degree of identity is high, this specific role, 214 associated with strong sequence similarity, is probably related to a specific interaction with the human or pig C-terminal...
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Báo cáo khoa học: Contributions to catalysis and potential interactions of the three catalytic domains in a contiguous trimeric creatine kinase doc

Báo cáo khoa học: Contributions to catalysis and potential interactions of the three catalytic domains in a contiguous trimeric creatine kinase doc

Báo cáo khoa học

... though the crystals for both Torpedo and rabbit muscle CK were grown under conditions that would strongly favor TSAC formation, indicating that, at least in multimeric CKs, only one monomer within ... origin of intracellular energy transport systems Biochem Biophys Res Commun 317, 1207–1214 654 34 Strong SJ & Ellington WR (1996) Expression of horseshoe crab arginine kinase in Escherichia coli...
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Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot

Báo cáo khoa học: Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation pot

Báo cáo khoa học

... shock, could also control levels of hDlg protein in the human epithelial cell line HeLa We report a strong decrease in hDlg protein, although this event is independent of its phosphorylation state ... decrease in hDlg protein levels similar to that observed after osmotic sock treatment (Fig 1D) No strong stable accumulation of hDlg cleavage fragments could be detected at these time points (not ... prevents apoptosis (Feijoo & Cuenda, unpublished results) Here we show that caspase and caspase are strongly activated (12- and 20-fold, respectively) in HeLa cells exposed to hyperosmotic shock Caspase...
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Report to the Congress on Practices of the Consumer Credit Industry in Soliciting and Extending Credit and their Effects on Consumer Debt and Insolvency pot

Report to the Congress on Practices of the Consumer Credit Industry in Soliciting and Extending Credit and their Effects on Consumer Debt and Insolvency pot

Ngân hàng - Tín dụng

... of consumer goods These developments began in the nineteenth century and have become especially strong since World War II Today, credit use by consumers is ubiquitous According to the Federal Reserve’s ... bankruptcy decisions of a representative crosssection of U.S households 17 They find that the strongest predictor of whether a household files for bankruptcy in a given year is the financial ... state in which bankruptcy filing rates are generally high Overall, Fay, Hurst, and White adduce strong evidence that households understand bankruptcy laws and that these laws affect their behavior...
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Report and Recommendations Pursuant to Section 133 of the Emergency Economic Stabilization Act of 2008: Study on Mark-To-Market Accounting doc

Report and Recommendations Pursuant to Section 133 of the Emergency Economic Stabilization Act of 2008: Study on Mark-To-Market Accounting doc

Kế toán - Kiểm toán

... “current value” accounting and towards the use of historic cost accounting for long-lived assets was strongly supported by Robert E Healy, the first Chief Accountant of the SEC Healy had participated ... everything except the furnace ashes in the basement.”92 During Healy’s tenure, the newly-formed SEC strongly 88 See IAS 36, Impairment of Assets 89 See Solomon Fabricant, Revaluations of Fixed Assets,...
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Báo cáo khoa học: Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium’s susceptibility to antibiotics that target the cell wall potx

Báo cáo khoa học: Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium’s susceptibility to antibiotics that target the cell wall potx

Báo cáo khoa học

... Antje Schafer for excellent ¨ technical assistance This work was supported by the Deutsche Forschungsgemeinschaft (DFG) and Fonds der chemischen Industrie References Hyyrylainen HL, Vitikainen ... of genes and regulation J Biol Chem 270, 15598–15606 Peschel A, Otto M, Jack RW, Kalbacher H, Jung G & Gotz F (1999) Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity ... Peschel A, Jack RW, Otto M, Collins LV, Staubitz P, Nicholson G, Kalbacher H, Nieuwenhuizen WF, Jung G, Tarkowski A, van Kessel KP & van Strijp JA (2001) Staphylococcus aureus resistance to human...
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Báo cáo sinh học:

Báo cáo sinh học: " Modulation of macrophage functions by sheeppox virus provides clues to understand interaction of the virus with host immune system" docx

Điện - Điện tử

... **P < 0.01 80 SOD activity (unit/ml) The Poxviridae are the largest known viruses [10] that have strong immunogenic properties Poxviruses modulate the immune response in infected hosts by inhibiting ... immunomodulating proteins, as when the respective genes are deleted or the viruses are inactivated, the strong immunogenicity of the viruses may induce host immune reactions which are no longer inhibited ... removed and placed in ice cold sterile PBS, (pH 7.4) Each spleen was squeezed with a ml syringe plunger to extrude cells Cell suspensions were centrifuged at 250 g for 10 Pelleted cells were resuspended...
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