3 finally to understand the relationship between hepatic mitochondria oxidative stress on the mitoproteome and how it may lead to hepatic injury in the het mouse
Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration
... Prolonged troglitazone administration causes oxidative stress in mitochondria and moderate liver injury in HET mice 95 3. 3 HET Mitochondrial Proteome Dynamics induced by prolonged troglitazone ... role in precipitating the toxic effects of troglitazone under compromised mitochondrial ROS defence This further confirms the contribution of glutathione and inheritable mitochondrial dysfunction ... troglitazone caused mitochondrial injury in vitro at high concentrations, troglitazone was allowed to progress to the clinical testing phase stage A hallmark of troglitazone-induced hepatic injury...
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phrasal verbs followed by the -ing form
... went on and on and on and on go on p.v When an event or activity goes on, it continues The party went on until dawn I hate long meetings that go on for hours go on p.v When you go on information, ... to go — one path went off to the left, the other to the right go on go on & goes on going on went on gone on go on p.v When an electrical device or system goes on, it begins to operate A thermostat ... driver to step on it Step on it! We have to be at work in ten minutes take out on take out on & takes out on taking out on took out on taken out on take out on p.v When you take something out on...
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Báo cáo y học: " Enteritis caused by Campylobacter jejuni followed by acute motor axonal neuropathy: a case report" pptx
... of the clinical signs and the history of a preceding gastrointestinal infection, a stool sample was sent to the Republic Institute of Public Health, Belgrade, for microbiological examination ... antibodies On the day of the admission, serum antibodies to C jejuni were positive in a titer of 1:128, while the control sera had titers of up to 1:8 On day 24, the antibody titers were still positive ... GBS In the present case, electrophysiological findings indicated axonal neuropathy which was in accordance with antecedent C jejuni infection and positive anti-GM1 antibodies, and in combination...
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40185 prepositional verbs followed by the gerund
... what you wanted to Writers cannot rely their (share) _ a common context to interpret the other's casual, compact or cryptic speech If you usually keep your windows/doors open, then count ... usually keep your windows/doors open, then count (change) the air filter every month We all agree _ your (open) _ the discussion ...
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Tài liệu Báo cáo khoa học: Perturbation of membranes by the amyloid b-peptide – a molecular dynamics study pptx
... Simulated temperature (K) K28 32 3 K28 30 0 32 3 30 0 32 3 32 3 V24 NA W19 NA 32 3 32 3 32 3 32 3 30 0 32 3 Top leaflet 52.7 49.0 54.4 49.0 46.8 55.9 48.0 52.9 53. 6 49.7 63. 3 60.5 63. 5 59 .3 58.7 58.7 56.0 62.5 57.1 ... headgroup in the bottom leaflet was largely insensitive to proximity to the peptide, even in the simulations wherein the C-terminus of Ab interacted with the lipids of the lower leaflet (A3, C1, and ... pack around the peptide and tilt their acyl chains, as the protein itself tilts Another contribution to the disordering effect is the restriction of motion along the acyl chains once the lipids...
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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
... (not shown) Superposition was calculated using the combinatorial extension method to maximize backbone contacts [42] Labels indicate the positions of the N- and C-termini, the iron ion and residues ... identity between the iron- and manganese-containing superoxide dismutases Protein Eng 1, 39 3 39 7 Meier, B., Sehn, A.P., Schinina, M.E & Barra, D (1994) In vivo incorporation of copper into the iron-exchangeable ... Moreover, these mutants show an increased sensitivity to the inhibitor azide [24] and also, in the case of human MnSOD, to product inhibition [28], processes thought to be analogous Y34 is hydrogen bonded...
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Báo cáo khoa học: Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity pptx
... extension and hydrophobic chaperone binding sites, resulting in the binding sites being less accessible to the target protein, leading to a decrease in target protein binding [26] In summary, the ... the addition of a reducing agent, such as dithiothreitol, which cleaves the disulfide bonds between the A and B chains of insulin, resulting in the aggregation and precipitation of the B chain Reduction ... protein, hsp30 Comp Biochem Physiol B 133 , 95–1 03 26 Carver JA & Lindner RA (1998) NMR spectroscopy of a-crystallin Insights into the structure, interactions and 5896 27 28 29 30 31 32 33 34 35 36 ...
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Báo cáo khoa học: Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily pot
... enzyme–substrate relationship and to determine whether the activity of Bud32p could be modulated by Sch9p Synthetic genetic interaction between BUD32 and SCH9 In order to find whether a functional relationship ... the double mutation of Ser 133 and Ser 134 (SS-AA) showed the same effect as the single S 134 A mutation, confirming that Ser 134 of Grx4p has a major role in vivo with respect to Ser 133 In addition, ... that these substitutions somehow impaired the activity of the glutaredoxin, rendering it less toxic to the cell Remarkably, the phospho-mimic substitution S 134 D was able to restore the toxicity...
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Báo cáo khoa học: The use of recombinant protein and RNA interference approaches to study the reproductive functions of a gonad-stimulating hormone from the shrimp Metapenaeus ensis ppt
... expression in hepatopancreas and ovary in vitro, the result may provide information on the initial mechanism of hormone action In other words, the in vitro results indicate that MeMIH-B may act ... rMeMIH-B into females to further confirm its gonadstimulatory effect To demonstrate the specificity of rMeMIH-B in gonad maturation, a control group injected with rMeMIH-A was included As compared to the ... CGCTCCACCAGGG -3 ) that contained restriction sites EcoRI and BamHI, respectively The PCR product was first digested with EcoRI and HindIII, and was then ligated into the cloning vector pRSET-B containing...
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Báo cáo khoa học: Variants of b2-microglobulin cleaved at lysine-58 retain the main conformational features of the native protein but are more conformationally heterogeneous and unstable at physiological temperature potx
... unfolding–aggregation process that is monitored at 0, 10 and 41 h from the temperature setting The intensity of the upfield-shifted resonances of Leu 23, Ile35 and Val37 gradually diminishes, while the ... differences in the conformation of the variants are confined to the cleavage site region (the D–E loop) with additional involvement of the adjacent residues of strands D and E and the facing residues ... K showed a generalized resonance doubling at the locations and to the extent reported in Fig The features of the pattern of the second conformer resemble the features of a minor monomeric intermediate...
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Báo cáo khoa học: The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p ppt
... PtdEtn into mitochondria (z) and factors (F) affecting level and activity of Psd1p in mitochondria may contribute to the mitochondrial PtdEtn affect the activity of Psd1p, thereby decreasing or increasing ... activity in mitochondria from mba1D was not decreased, in line with the unchanged mitochondrial level of PtdEtn in this strain (Table 1) Studies on the stability of subunits of the mitochondrial ... membrane proteins into the inner mitochondrial membrane – a guided tour J Mol Biol 32 6, 639 –657 13 Herrmann JM & Neupert W (20 03) Protein insertion into the inner membrane of mitochondria IUBMB...
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Báo cáo hóa học: "Synthesis of SnS nanocrystals by the solvothermal decomposition of a single source precursor" pdf
... obtained due to insolubility of SnS NCs in the short chain ketone and then separated by centrifugation The retrieved flocculate precipitate containing the desired SnS NCs was redissolved in chloroform ... passivation, leading to aggregate formation [28] The dimensions of SnS NCs were in a range of 5–200 nm depending on synthetic conditions Fast nucleation and growth leaded to the formation small (5–10 ... obtained by the extrapolation of the linear region of the plot of (ahv)1/2 against photon energy (hv) as shown in Fig 4(c) Clearly, the absorption corresponds to an indirect allowed transition with an...
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Báo cáo hóa học: " Synthesis of SnS nanocrystals by the solvothermal decomposition of a single source precursor" ppt
... obtained due to insolubility of SnS NCs in the short chain ketone and then separated by centrifugation The retrieved flocculate precipitate containing the desired SnS NCs was redissolved in chloroform ... passivation, leading to aggregate formation [28] The dimensions of SnS NCs were in a range of 5–200 nm depending on synthetic conditions Fast nucleation and growth leaded to the formation small (5–10 ... obtained by the extrapolation of the linear region of the plot of (ahv)1/2 against photon energy (hv) as shown in Fig 4(c) Clearly, the absorption corresponds to an indirect allowed transition with an...
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Báo cáo y học: "Diabetic ketoacidosis complicated by the use of ecstasy: a case report" ppsx
... amphetamine [6] The drug acts primarily by promoting a massive release of serotonin from the presynaptic cleft and, additionally, inhibits serotonin reuptake and increases its levels in the postsynaptic ... 98 mEq/L Anion gap 30 .9 21.6 peritoneal irritation Her temperature was 37 .3 C and the chest X-ray was normal Urine analysis showed pronounced ketonuria and an absence of pyuria; a urinary bacterioscopy ... replacement and the administration of insulin, although one of the patients developed bronchopneumonia and needed intubation and mechanical ventilation [11] Lee and colleagues conducted a study with...
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Báo cáo y học: "Diabetic ketoacidosis complicated by the use of ecstasy: a case report." docx
... amphetamine [6] The drug acts primarily by promoting a massive release of serotonin from the presynaptic cleft and, additionally, inhibits serotonin reuptake and increases its levels in the postsynaptic ... 98 mEq/L Anion gap 30 .9 21.6 peritoneal irritation Her temperature was 37 .3 C and the chest X-ray was normal Urine analysis showed pronounced ketonuria and an absence of pyuria; a urinary bacterioscopy ... replacement and the administration of insulin, although one of the patients developed bronchopneumonia and needed intubation and mechanical ventilation [11] Lee and colleagues conducted a study with...
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Báo cáo y học: "Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation" pps
... aagctt -3' ) were synthesized with flanking NheI and HindIII sites (underlined), annealed and introduced http://www.journal-inflammation.com/content/6/1/15 into the pGL4.26 (luc2/minP/Hygro) vector ... (Promega, Madison, WI) The construct was linearized with Bsu36I and transfected into HEK2 93 cells using Fugene HD (Roche Diagnostics, Indianapolis, IN) Clonal cell-lines stably expressing the construct ... activity [18,19] Further testing of WFA was conducted in a more relevant in vitro model of CF inflammation In this model, the immortalized CF epithelial cell line KKLEB harboring the most common and...
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A study on the structure of the speech “ I have a dream” by Martin Luther King A systemic functional grammar analysis
... functional grammar as the theoretical framework 1.2 Aims of the study In carrying out the research, the writer aims to: Illustrate the key concepts in FG Analyze the structure and meaning of the ... Text and Discourse London: Continuum Homer, W.B (1998) Rhetoric in the Classical Tradition New York: St Martin’s Press Hoa, Nguyen (2000) An Introduction to Discourse Analysis Hanoi National ... is the reason why I have developed a great attention to Functional Grammar (or FG for short) The further I am absorbed in this linguistic aspect, the stronger my notion of its applications in...
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Tài liệu Protein Data Bank Contents Guide: Atomic Coordinate Entry Format Description Version 3.20 Document Published by the wwPDB ppt
... beginning in October 2008 including DBREF, taxonomy and citation information Version 3. 20: Current version, minor addenda to Version 3. 1, introducing a small number of changes and extensions ... Appears on all continuation records 17 - 18 Continuation continuation Permits long titles 20 - 79 LString title Title of the article EDIT * EDIT appears if editors are associated with a non-journal ... this this one one one one one one one one one Details * It is PDB policy that only the principal investigator and/ or the primary author who submitted an entry has the authority to obsolete it All...
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Tài liệu Báo cáo khoa học: Mitochondrial chaperone tumour necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxic injury by regulating mitochondrial permeability transition pore opening docx
... Purification and N-terminal sequencing of peptidyl-prolyl cis-trans-isomerase from rat liver mitochondrial matrix reveals the 1 938 29 30 31 32 33 34 35 36 37 38 39 existence of a distinct mitochondrial ... chaperone, it has an important role in regulating cell apoptosis and maintaining mitochondrial homeostasis and function Silencing TRAP1 enhances cytochrome c release from the mitochondria and apoptosis ... role in the modulation of the mitochondrial apoptotic cascade [25] Moreover, TRAP1 overexpression improves mitochondrial function after ischaemic injury in primary astrocytes in vitro [16] In the...
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Tài liệu Báo cáo khoa học: Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide pptx
... due to the activation of JNK Other MAP kinase inhibitors as well as G-protein inhibitors should be investigated to find out the participating proteins in RGS1 and RGS2 modulation In conclusion, ... Stimulation of TLR leads to activation of a series of signalling proteins, and to the expression of pro- and in ammatory cytokines There is evidence that the heteromeric guanine nucleotidebinding ... associates with bc subunits to give the inactive heterotrimeric form [15] Regulators of G-protein signalling (RGS) interact directly with the G protein a subunit in order to inhibit G-protein signalling...
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