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A series of 4-methyl carbapenems having structural similarity to ME1036 showed potent activities against MRSA and PRSP, as well as against the gram-negative organism ampicillin-resista[r]
(1)KHAÙNG SINH -LACTAMIN (-LACTAM)
(2)(3)CÁC THUỐC CHÍNH
Penicillin: (PENAM)
penicillin G; penicillin V methicillin; oxacillin
ampicillin; amoxicillin; carbenicillin; ticarcillin
Chất ức chế -lactamase: (OXAPENAM)
acid clavulanic
CARBAPENEM: imipenem
(4)CÁC THUỐC CHÍNH
Cephalosporin (CEPHEM)
Thế hệ I : cephalexin; cephalothin Thế hệ II: cefoxitin; cefaclor
Thế hệ III: cefotaxime; cefoperazone; ceftriaxone Thế hệ IV: cefepime
Thế hệ V: ceftobiprole
MONOBACTAM: aztreonam
N O
S
(5)(6)ME1036 ME1036 (CP5609; developed by Meiji Seika, licensed
by Forest) is a broad-spectrum carbapenem that binds with a high affinity to PBP 2a of MRSA (IC50 0.13 to 0.73 g/ml) and that exhibits potent in vitro inhibitory
activity against MRSA
A series of 4-methyl carbapenems having structural similarity to ME1036 showed potent activities against MRSA and PRSP, as well as against the gram-negative organism ampicillin-resistant, -lactamase-negative Haemophilus influenzae
N HO
O
CO2H S
HN
NH
(7)PZ-601 (Razupenem) PZ-601 (formerly known as SMP-
601; licensed from Dainippon Sumitomo Pharma Co., Ltd.,
Osaka, Japan) is a new carbapenem currently being developed by Protez Pharmaceuticals (now Novartis) that has
demonstrated a high degree of potency against MRSA
N HO
O
CO2H S
HN
NH