Khảo sát thành phần hóa học của rễ cây ô dước lindera myrrha (lour ) merr

- - Lindera myrrha (Lour.) Merr  - - Lindera myrrha (Lour.) Merr GVHD: TS SVTH: MSSV: 41.01.201.034 L I C - i M CL C i .ii iv DANH M v v 1 .1 Lindera 1.1 Lindera 1.2 Thành 1.2.1 Lindera strychnifolia 1.2.2 Lindera aggregata 1.2.3 Lindera erythrocarpa Lindera Myrrha (Lour.) Merr 1.3 .8 Ô Lindera myrrha (Lour.) Merr .9 11 2.1 Máy móc, thi t b 11 2.1.1 Hóa ch t .11 .11 11 14 ii L2 .14 L3 .15 18 4.1 18 4.2 .18 19 21 iii Ac Acetone AcOH Acid acetic C Chloroform d Doublet) br q m EA Ethyl acetate H n-hexane HMBC H-13 Heteronuclear Multiple Bond Coherence) HSQC H-13 Heteronuclear Single Quantum Correlation) J -spin) NMR s Nuclear Magnetic Resonance Spectroscopy) Singlet) SKC iv Hình 1.1 Lindera erythrocarpa Hình 1.2 Lindera aggregata Hình 1.3 Lindera Hình 1.4 Lindera Hình 1.5 Lindera Hình 1.6 Lindera Lindera myrrha (Lour.) Merr Hình 1.7 Lindera myrrha (Lour.) Merr Hình 1.8 Hình 3.1 L2 Hình 3.2 L2 Hình 3.3 L3 Hình 3.4 L3 L2 L3 Lindera myrrha (Lour.) Merr L2 L3 -ESI- 13 L2 L2 L2 L2 L2 13 L3 L3 L3 L3 v i PH N M U Lindera myrrha Lindera Lindera myrrha (Lour.) Merr [2] Lindera myrrha (Lour.) Merr Lindera myrrha (Lour.) Merr M c tiêu c Lindera myrrha tài (Lour.) Merr Ô Lindera myrrha (Lour.) Merr Lindera myrrha (Lour.) Merr H-NMR, 13C- Lindera myrrha (Lour.) Merr, Lindera myrrha (Lour.) Merr NG QUAN 1.1 Lindera Lindera Lindera sesquiterpenoid, alkaloid, butanolide, lucidone, flavonoid phenylpropanoid [3] Hình 1.1 Lindera erythrocarpa Hình 1.2 Lindera aggregata Lindera 1.2.1 Lindera strychnifolia Lindera strychnifolia : strychnistenolides A B (1, 2), strychnistenolide 6-o-acetate A (3), strychnistenolide 6-o-acetate B (4), strychnilactone (5) [4] hai -oxo-5 H, H-eudesma-1,4(15),7(11)-trien-8,12-olide (6), 3-oxo-4,5 H,8 H-eudesma1, 7(11)dien-8,12-olide (7) [5] Lindera strychnifolia: linderolide A (8), linderolide B (9), linderolide C (10), linderolide D (1), linderolide E (12), linderolide F (13), linderoline (14) [6] 1.2.2 Lindera aggregata Lindera aggregata, linderagalactone A (15), linderagalactone B (16), linderagalactone C (17), linderagalactone D (18), linderagalactone Ea (19), linderagalactone Eb (20) [7] Lindera aggregata: 8-hydroxylindestenolide (21), neolindenenonelactone (22), linderalactone (23), isolinderalactone (24), linderane (25) [8] Lindera , aggregata: linderanlides A (26), linderanlides B (27), linderanlides C (28), linderanlides D (29), linderanlides E (30), linderanlides F (31), linderanines A (32), linderanines B (33), linderanines C (34), linderalactone (23), linderane (25), ent-4(15)-eudesmene1 ,6 -diol (35), hydroxylindestenolide (36), ( )-linderadine (37), dehydrocostuslactone (38) [9] 1.2.3 Lindera erythrocarpa Lindera erythrocarpa, Lindera erythrocarpa: methyllinederone (39), methyllucidone (40), lucidone (41), linderone (42) [10] 1.2.4 Lindera chunii Lindera chunii: lindenanolide E (43), lindenanolide F (44), lindenanolide G (45), lindenanolide H (46), pseudoneolinderane (47), lindeneol (48), lindeneyl acetate (49), linderalactone (50), strychinstenolide 6-o-acetates A (51), strychinstenolide 6-o-acetates B (52), hernandine (53), hernangerine (54), ocokriptine (55), hernandonine (56), N-methyl hernangerine (57), laurolistine (58), 7-oxohernangerine (59), lindechunine A (60), 7oxohernagine (61), lindechunine B (62) [11] Lindera Hình 1.3 Lindera Hình 1.4 Lindera Hình 1.5 Lindera Hình 1.6 1.3 Lindera Myrrha (lour.) Merr 1.3.1 Gi i thi u chung v c Lindera myrrha Ơ n [1] 1.3.2 Mơ t th c v t 1.4m, càn Thân Lá -4mm Hoa Hình 1.7 Lindera myrrha (Lour.) Merr 1.3.3 Thành ph n hóa h c ho t tính sinh h c c a Ô c Lindera myrrha (Lour.) Merr 1.3.3.1 Thành ph n hóa h c Lindera myrrha (Lour.) Merr Lindera myrrha (Lour.) Merr c: oxoduocine (63), oduocine (64), ovigerine (65), hernovine (66), hernavine (67), hernandine (68), hernangerine (69) [2] Hình 1.8 Lindera myrrha (Lour.) Merr 1.3.3.2 Ho t tính sinh h c c Ô c Lindera myrrha (Lour.) Merr [1] 10 ... Lindera Lindera myrrha (Lour. ) Merr [2] Lindera myrrha (Lour. ) Merr Lindera myrrha (Lour. ) Merr M c tiêu c Lindera myrrha tài (Lour. ) Merr Ô Lindera myrrha (Lour. ) Merr Lindera myrrha (Lour. ) Merr. .. 1.7 Lindera myrrha (Lour. ) Merr 1.3.3 Thành ph n hóa h c ho t tính sinh h c c a Ô c Lindera myrrha (Lour. ) Merr 1.3.3.1 Thành ph n hóa h c Lindera myrrha (Lour. ) Merr Lindera myrrha (Lour. ) Merr. .. isolinderalactone (2 4), linderane (2 5) [8] Lindera , aggregata: linderanlides A (2 6), linderanlides B (2 7), linderanlides C (2 8), linderanlides D (2 9), linderanlides E (3 0), linderanlides F (3 1), linderanines