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Khóa luận tốt nghiệp dược sĩ: Tổng quan một số ứng dụng của quang phổ raman trong kiểm nghiệm dược phẩm

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1. Tìm hiểu nguyên lý tổng quan về quang phổ Raman, nguyên tắc hoạt động, nguyên tắc cấu tạo và các bộ phận chính của máy quang phổ Raman. 2. Phân tích ưu nhược điểm của phương pháp quang phổ Raman so với các phương pháp phân tích quang phổ khác. 3. Phân tích khả năng ứng dụng thực tế của quang phổ Raman trong ngành Dược và khả năng áp dụng phương pháp quang phổ này trong công tác kiểm tra, giám sát chất lượng thuốc.

g Anh Anil K Deisingh, (2005), “Pharmaceutical counterfeiting”, Analyst, 130, pp.271-279 Al-Zoubi N, Koundourellis JE, Malamataris S, (2002), “FT-IR and Raman spectroscopic methods for identification and quantitation of orthorhombic and monoclinic paracetamol in powder mixes”, Journal of Pharmaceutical and Biomedical Analysis, 29(3), pp.459–467 Auer ME., GriesserUJ.,Sawatzki J (2003), “Qualitative and quantitative study of polymorphic forms in drug formulations by near infrared FT-Raman spectroscopy”, Journal of Molecular Structure, 661–662(16), pp.307–317 R B Bilhorn, P M Epperson, I V Sweedler, and M B Denton (1987), "Spectrochemical Measurements with Multichannel Integrating Detectors", Applied Spectroscopy , 41(7), pp 1125-1136 Derek A Long (2002), The Raman Effect: A Unified Treatment of the Theory of Raman Scattering by Molecules, John Wiley & Sons Ltd, England De Spiegeleer B., Seghers D., Wieme R., Schaubroeck J., Verpoort F., Slegers G., Van Vooren L (2005),“Determination of the relative amounts of three crystal forms of a benzimidazole drug in complex finished formulations by FT-Raman spectroscopy”J Pharm Biomed Anal., 39 (1-2), pp 275–280 Gamberini MC., Baraldi C., Tinti A., Rustichelli C., Ferioli V., Gamberini G (2006), “Solid state characterization of chloramphenicol palmitate Raman spectroscopy applied to pharmaceutical polymorphs”, Journal of Molecular Structure, 785(1–3), pp 216–224 Hwang MS., Cho S., Chung H., Woo YA.(2005), “Nondestructive determination spectroscopy”, of theambroxol Journal content in tablets by Raman of Pharmaceutical and Biomedical Analysis,38(2), Pp 210–215 10 Izolani AO., DeMoraes MT., Tellez CA (2003), “Fourier transform Raman spectroscopy of drugs:Quantitative analysis of 1-phenyl-2,3dimethyl-5-Pyrazolone-4-methylaminomethane sodium sulfonate (dipyrone)”, Journal of Raman Spectroscopy, 34(10), pp 837–843 11 John R Ferraro, Kazuo Nakamoto, Chris W Brown (2003), Introductory Raman Spectroscopy, Elsevier, America 12 Lin W-Q, Jiang J-H, Yang H-F, Ozaki Y, Shen G-L, Yu R-Q (2006), “Characterisation of Chloroamphenicol Palmitate drug polymorphs by Ramanmapping with multi variate image segmentation using a spatial directed agglomeration clustering method”, Analytical Chemistry, 78 (17), pp 6003–6011 13 McCreery RL, (2000), Raman Spectroscopy for Chemical Analysis, John Wiley & Sons Ltd, New York 14 Mazurek S., Szostak R (2006), “Quantitative determination of captopril and prednisolone in tablets by FT-Raman spectroscopy”, Journal of Pharmaceutical and Biomedical Analysis, 40(5), pp 1225– 1230 15 Okumura T., Otsuka M (2005), “Evaluation of the microcrystallinity of a drug substance, indomethacin, in a pharmaceutical model tablet by chemometric FT-Raman spectroscopy”, Pharmaceutical Research, 22(8), pp.1350–1357 16 Pemberton J E., Sobocinski R L., Bryant M A., and Carter D A., (1990), “Raman Spectroscopy Using Charge Coupled Device Detection”, Spectroscopy, 5(2), pp.26 17 Pratiwi D., Fawcett JP., Gordon KC., Rades T (2002),“Quantitative analysis of polymorphic mixtures of ranitidne hydrochloride by Raman spectroscopy and principal component analysis”, European Journal of Pharmaceutics and Biopharmaceutics, 54(3),pp 337–341 18 Pelletier MJ (2003), Quantitative analysis using Raman spectrometry Applied Spectroscopy,57, pp.20A-39A, Society for appied Spectroscop, England and America 19 Pushkar P Kalantri, Rakesh R Somani, Dinesh T Makhija (2010), “Raman spectroscopy: A potential technique in analysis of pharmaceuticals”, Der Chemica Sinica, pp.5-8 20 Pestaner JP., Mullick FG., Centeno JA (1996), “Characterization of acetaminophen: molecular microanalysis with Raman microprobe spectroscopy”, Journal of Forensic Sciences, 41(6) 21 Rantanen J, Wikstrom H, Rhea FE, Taylor LS, (2005), “Improved understanding of factors contributing to quantification of anhydrate/hydrate powder mixtures”, Applied Spectroscopy, 59(7), pp 942–951 22 Roberts SNC., Williams AC., GrimseyIM., Booth SW (2002), “Quantitative analysis of mannitol polymorphs FT-Raman spectroscopy”, Journal of Pharmaceutical and Biomedical Analysis, 28(6), pp 1135–1147 23 Strachan CJ., Pratiwi D., Gordon KC., Rades T (2004), “Quantitative analysis of polymorphic mixtures of carbamazepine by Raman spectroscopy and principal components analysis”,Journal of Raman Spectroscopy, 35(5), pp 347–352 24 Steven E J Bell, D Thorburn Burns, Andrew C Dennisa and James S Speersb, (2000), “Rapid analysis of ecstasy and related phenethylamines in seized tablets by Raman spectroscopy”, Analyst, 125(3), pp 541–544 25 Skoulika SG., Georgiou CA (2003), “Rapid, noninvasive quantitative determination of acyclovir in pharmaceutical solid dosage forms through their poly(vinyl chloride) blister package by solid-state fourier transform Raman spectroscopy”, Applied Spectroscopy, 57(4) 26 Szostak R, Mazurek S, (2002), “Quantitative determination of acetylsalicylic acid and acetaminophen in tablets by FT-Raman spectroscopy”, Analyst, 127, 144–148 27 Szostak R., Mazurek S (2004), “FT-Raman quantitative determination of ambroxol in tablets”, Journal of Molecular Structure, 704(1–3), pp 229-233 28 Slobodan Šašic (2008), Pharmaceutical applications of Raman Spectroscopy, John Wiley & Son, Canada 29 U.S Pharmacopeial Convention 34,(2012), America 30 Vehring R (2005), “Red-excitation dispersive Raman spectroscopy is a suitable technique for solid-state analysis of respirable pharmaceutical powders”, Applied Spectroscopy, 59(3), pp 267-391 31 Vankeirsbilck T., Vercauteren A., Baeyens W., Van derWeken G., Verpoort F., Vergote G., Remon JP (2002), “Applications of Raman spectroscopy in pharmaceutical analysis”, TrAC Trends in Analytical Chemistry, 21(12), pp 869–877 ... content in tablets by Raman of Pharmaceutical and Biomedical Analysis,38(2), Pp 210–215 10 Izolani AO., DeMoraes MT., Tellez CA (2003), “Fourier transform Raman spectroscopy of drugs:Quantitative analysis... D., Gordon KC., Rades T (2004), “Quantitative analysis of polymorphic mixtures of carbamazepine by Raman spectroscopy and principal components analysis”,Journal of Raman Spectroscopy, 35(5), pp... fourier transform Raman spectroscopy”, Applied Spectroscopy, 57(4) 26 Szostak R, Mazurek S, (2002), “Quantitative determination of acetylsalicylic acid and acetaminophen in tablets by FT -Raman spectroscopy”,

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Nguồn tham khảo

Tài liệu tham khảo Loại Chi tiết
1. Trần Quang Hinh, Phát hiện một số thuốc cấm (Heroin-Morphin- Codein Chất gây nghiên) bằng phương pháp quang phổ FT-Raman, (1999), Luận văn thạc sỹ, Đại học khoa học tự nhiên, TP Hồ Chí Minh.Tài liệu tiếng Anh Sách, tạp chí
Tiêu đề: Phát hiện một số thuốc cấm (Heroin-Morphin-Codein Chất gây nghiên) bằng phương pháp quang phổ FT-Raman
Tác giả: Trần Quang Hinh, Phát hiện một số thuốc cấm (Heroin-Morphin- Codein Chất gây nghiên) bằng phương pháp quang phổ FT-Raman
Năm: 1999
3. Al-Zoubi N, Koundourellis JE, Malamataris S, (2002), “FT-IR and Raman spectroscopic methods for identification and quantitation of orthorhombic and monoclinic paracetamol in powder mixes”, Journal of Pharmaceutical and Biomedical Analysis, 29(3), pp.459–467 Sách, tạp chí
Tiêu đề: FT-IR and Raman spectroscopic methods for identification and quantitation of orthorhombic and monoclinic paracetamol in powder mixes”, "Journal of Pharmaceutical and Biomedical Analysis
Tác giả: Al-Zoubi N, Koundourellis JE, Malamataris S
Năm: 2002
4. Auer ME., GriesserUJ.,Sawatzki J. (2003), “Qualitative and quantitative study of polymorphic forms in drug formulations by near infrared FT-Raman spectroscopy”, Journal of Molecular Structure, 661–662(16), pp.307–317 Sách, tạp chí
Tiêu đề: Qualitative and quantitative study of polymorphic forms in drug formulations by near infrared FT-Raman spectroscopy”, "Journal of Molecular Structure
Tác giả: Auer ME., GriesserUJ.,Sawatzki J
Năm: 2003
5. R. B. Bilhorn, P. M. Epperson, I. V. Sweedler, and M. B. Denton (1987), "Spectrochemical Measurements with Multichannel Integrating Detectors", Applied Spectroscopy , 41(7), pp. 1125-1136 Sách, tạp chí
Tiêu đề: Spectrochemical Measurements with Multichannel Integrating Detectors
Tác giả: R. B. Bilhorn, P. M. Epperson, I. V. Sweedler, and M. B. Denton
Năm: 1987
6. Derek A. Long (2002), The Raman Effect: A Unified Treatment of the Theory of Raman Scattering by Molecules, John Wiley & Sons Ltd, England Sách, tạp chí
Tiêu đề: The Raman Effect: A Unified Treatment of the Theory of Raman Scattering by Molecules
Tác giả: Derek A. Long
Năm: 2002
8. Gamberini MC., Baraldi C., Tinti A., Rustichelli C., Ferioli V., Gamberini G. (2006), “Solid state characterization of chloramphenicol palmitate. Raman spectroscopy applied to pharmaceutical polymorphs”, Journal of Molecular Structure, 785(1–3), pp. 216–224 Sách, tạp chí
Tiêu đề: Solid state characterization of chloramphenicol palmitate. Raman spectroscopy applied to pharmaceutical polymorphs”, "Journal of Molecular Structure
Tác giả: Gamberini MC., Baraldi C., Tinti A., Rustichelli C., Ferioli V., Gamberini G
Năm: 2006
9. Hwang MS., Cho S., Chung H., Woo YA.(2005), “Nondestructive determination of theambroxol content in tablets by Raman spectroscopy”, Journal of Pharmaceutical and Biomedical Analysis,38(2), Pp. 210–215 Sách, tạp chí
Tiêu đề: Nondestructive determination of theambroxol content in tablets by Raman spectroscopy”, "Journal of Pharmaceutical and Biomedical Analysis
Tác giả: Hwang MS., Cho S., Chung H., Woo YA
Năm: 2005
10. Izolani AO., DeMoraes MT., Tellez CA. (2003), “Fourier transform Raman spectroscopy of drugs:Quantitative analysis of 1-phenyl-2,3- dimethyl-5-Pyrazolone-4-methylaminomethanesodiumsulfonate(dipyrone)”, Journal of Raman Spectroscopy, 34(10), pp. 837–843 Sách, tạp chí
Tiêu đề: Fourier transform Raman spectroscopy of drugs:Quantitative analysis of 1-phenyl-2,3-dimethyl-5-Pyrazolone-4-methylaminomethane sodium sulfonate (dipyrone)”, "Journal of Raman Spectroscopy
Tác giả: Izolani AO., DeMoraes MT., Tellez CA
Năm: 2003
11. John R. Ferraro, Kazuo Nakamoto, Chris W. Brown (2003), Introductory Raman Spectroscopy, Elsevier, America Sách, tạp chí
Tiêu đề: Introductory Raman Spectroscopy
Tác giả: John R. Ferraro, Kazuo Nakamoto, Chris W. Brown
Năm: 2003
12. Lin W-Q, Jiang J-H, Yang H-F, Ozaki Y, Shen G-L, Yu R-Q (2006), “Characterisation of Chloroamphenicol Palmitate drug polymorphs by Ramanmapping with multi variate image segmentation using a spatial directed agglomeration clustering method”, Analytical Chemistry, 78 (17), pp. 6003–6011 Sách, tạp chí
Tiêu đề: Characterisation of Chloroamphenicol Palmitate drug polymorphs by Ramanmapping with multi variate image segmentation using a spatial directed agglomeration clustering method”, "Analytical Chemistry
Tác giả: Lin W-Q, Jiang J-H, Yang H-F, Ozaki Y, Shen G-L, Yu R-Q
Năm: 2006
13. McCreery RL, (2000), Raman Spectroscopy for Chemical Analysis, John Wiley & Sons Ltd, New York Sách, tạp chí
Tiêu đề: Raman Spectroscopy for Chemical Analysis
Tác giả: McCreery RL
Năm: 2000
14. Mazurek S., Szostak R. (2006), “Quantitative determination of captopril and prednisolone in tablets by FT-Raman spectroscopy”, Journal of Pharmaceutical and Biomedical Analysis, 40(5), pp. 1225–1230 Sách, tạp chí
Tiêu đề: Quantitative determination of captopril and prednisolone in tablets by FT-Raman spectroscopy”, "Journal of Pharmaceutical and Biomedical Analysis
Tác giả: Mazurek S., Szostak R
Năm: 2006
15. Okumura T., Otsuka M. (2005), “Evaluation of the microcrystallinity of a drug substance, indomethacin, in a pharmaceutical model tablet by chemometric FT-Raman spectroscopy”, Pharmaceutical Research, 22(8), pp.1350–1357 Sách, tạp chí
Tiêu đề: Evaluation of the microcrystallinity of a drug substance, indomethacin, in a pharmaceutical model tablet by chemometric FT-Raman spectroscopy”, "Pharmaceutical Research
Tác giả: Okumura T., Otsuka M
Năm: 2005
16. Pemberton J. E., Sobocinski R. L., Bryant M. A., and Carter D. A., (1990), “Raman Spectroscopy Using Charge Coupled Device Detection”, Spectroscopy, 5(2), pp.26 Sách, tạp chí
Tiêu đề: Raman "Spectroscopy" Using Charge Coupled Device Detection”, "Spectroscopy
Tác giả: Pemberton J. E., Sobocinski R. L., Bryant M. A., and Carter D. A
Năm: 1990
17. Pratiwi D., Fawcett JP., Gordon KC., Rades T. (2002),“Quantitative analysis of polymorphic mixtures of ranitidne hydrochloride by Raman spectroscopy and principal component analysis”, European Journal of Pharmaceutics and Biopharmaceutics, 54(3),pp. 337–341 Sách, tạp chí
Tiêu đề: Quantitative analysis of polymorphic mixtures of ranitidne hydrochloride by Raman spectroscopy and principal component analysis”, "European Journal of Pharmaceutics and Biopharmaceutics
Tác giả: Pratiwi D., Fawcett JP., Gordon KC., Rades T
Năm: 2002
18. Pelletier MJ (2003), Quantitative analysis using Raman spectrometry. Applied Spectroscopy,57, pp.20A-39A, Society for appied Spectroscop, England and America Sách, tạp chí
Tiêu đề: Quantitative analysis using Raman spectrometry. "Applied Spectroscopy,"57, pp.20A-39A
Tác giả: Pelletier MJ
Năm: 2003
19. Pushkar P. Kalantri, Rakesh R. Somani, Dinesh T. Makhija (2010), “Raman spectroscopy: A potential technique in analysis of pharmaceuticals”, Der Chemica Sinica, pp.5-8 Sách, tạp chí
Tiêu đề: Raman spectroscopy: A potential technique in analysis of pharmaceuticals”, "Der Chemica Sinica
Tác giả: Pushkar P. Kalantri, Rakesh R. Somani, Dinesh T. Makhija
Năm: 2010
20. Pestaner JP., Mullick FG., Centeno JA. (1996), “Characterization of acetaminophen: molecular microanalysis with Raman microprobe spectroscopy”, Journal of Forensic Sciences, 41(6) Sách, tạp chí
Tiêu đề: Characterization of acetaminophen: molecular microanalysis with Raman microprobe spectroscopy”, "Journal of Forensic Sciences
Tác giả: Pestaner JP., Mullick FG., Centeno JA
Năm: 1996
21. Rantanen J, Wikstrom H, Rhea FE, Taylor LS, (2005), “Improved understanding of factors contributing to quantification of anhydrate/hydrate powder mixtures”, Applied Spectroscopy, 59(7), pp.942–951 Sách, tạp chí
Tiêu đề: Improved understanding of factors contributing to quantification of anhydrate/hydrate powder mixtures”, "Applied Spectroscopy
Tác giả: Rantanen J, Wikstrom H, Rhea FE, Taylor LS
Năm: 2005
22. Roberts SNC., Williams AC., GrimseyIM., Booth SW. (2002), “Quantitative analysis of mannitol polymorphs. FT-Raman spectroscopy”, Journal of Pharmaceutical and Biomedical Analysis, 28(6), pp. 1135–1147 Sách, tạp chí
Tiêu đề: Quantitative analysis of mannitol polymorphs. FT-Raman spectroscopy”, "Journal of Pharmaceutical and Biomedical Analysis
Tác giả: Roberts SNC., Williams AC., GrimseyIM., Booth SW
Năm: 2002

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