CÊu tróc cña phospholipidCÊu tróc cña phospholipid H2C-O-C-R1 R2-C-O-CH H2C-O-P-O-X Phospholipase B Phospholipase C Phospholipase D Phospholipid Phospholipase A O O O O Sù thuû ph©n glycerophospholipid Sù thuû ph©n lecithin Tæng hîp lecithinTæng hîp lecithin (CS(CS TK)TK) Cholin PhosphoCholin XDP-Cholin PhosphatidylCholin (Lecithin) ATP ADP XTP PPi XMP Diglycerid (CH 3 ) 3 N + -CH 2 -CH 2 OH ( hoÆc Ethanolamin) (CH 3 ) 3 N + -CH 2 -CH 2 O- ( hoÆc P-ethanolamin) P (CH 3 ) 3 N + -CH 2 -CH 2 O-XDP ( hoÆcXDP-thanolamin) Tõ Base nit¬ (Cholin, Ethanolamin…) “P” H.Ho¸ Acid Phosphatidic XDP-diglycerid Phosphatidyl cholin (Lecithin) Phosphatidyl serin Phosphatidyl ethanolamin XTP PPi XMP Serin CO 2 S-Adenosyl methionin S-Adenosyl homocystein HOCH 2 -CHNH 2 -COOH (Serin) CH 2 O-COR 1 CHO-COR 2 CH 2 O- - OCH 2 – CHNH 2 - COOH P + CH 3 Tõ acid Phosphatidic (Chñ yÕu, quan träng & ?) 1- GPL 2- GPL 3- GPL Néi dung bµI gi¶ngNéi dung bµI gi¶ng §§¹i c¬ng¹i c¬ng I.I. Tiªu ho¸, hÊp thu vµ vËn chuyÓn lipidTiªu ho¸, hÊp thu vµ vËn chuyÓn lipid II.II. ChuyÓn ho¸ ChuyÓn ho¸ acid bÐoacid bÐo 2.1. 2.1. oxyho¸ oxyho¸ acid bÐo acid bÐo nno, C ch½n (o, C ch½n ( O/TKSGK)O/TKSGK) 2.2. Tæng hîp acid bÐo (bµo t2.2. Tæng hîp acid bÐo (bµo tươươngng, ty thÓ), ty thÓ) III.III. ChuyÓn ho¸ ChuyÓn ho¸ triglyceridtriglycerid 3.1. Tho¸i ho¸ TG3.1. Tho¸i ho¸ TG 3.2. Tæng hîp TG3.2. Tæng hîp TG IV.IV. ChuyÓn ho¸ ChuyÓn ho¸ glycerophospholipidglycerophospholipid/ lecithin/ lecithin V.V. ChuyÓn ho¸ cña c¸c thÓ cetonChuyÓn ho¸ cña c¸c thÓ ceton VI.VI. ChuyÓn ho¸ cña ChuyÓn ho¸ cña cholesterolcholesterol . phospholipidCÊu tróc cña phospholipid H2C-O-C-R1 R2-C-O-CH H2C-O-P-O-X Phospholipase B Phospholipase C Phospholipase D Phospholipid Phospholipase A O O O O Sù thuû ph©n glycerophospholipid Sù. ethanolamin XTP PPi XMP Serin CO 2 S-Adenosyl methionin S-Adenosyl homocystein HOCH 2 -CHNH 2 -COOH (Serin) CH 2 O-COR 1 CHO-COR 2 CH 2 O- - OCH 2 – CHNH 2 - COOH P + CH 3 Tõ acid Phosphatidic. TK)TK) Cholin PhosphoCholin XDP-Cholin PhosphatidylCholin (Lecithin) ATP ADP XTP PPi XMP Diglycerid (CH 3 ) 3 N + -CH 2 -CH 2 OH ( hoÆc Ethanolamin) (CH 3 ) 3 N + -CH 2 -CH 2 O- ( hoÆc P-ethanolamin) P (CH 3 ) 3 N + -CH 2 -CH 2 O-XDP