mitochondrial dna(mtDNA)

... down-regulated both in vitro and in vivo Moreover, Hp induces genomic instability in nuclear CA repeats in mice and in mtDNA of AGS cells and chronic gastritis tissue, and this effect in mtDNA is associated ... Hp infection resulted in increased mutations in the non-coding D-loop as well as the coding genes ND1 and COI of mtDNA of gastric cells [12] The increase...

Ngày tải lên: 25/10/2012, 11:18

... generation of an electrochemical gradient across the IM forms the basis of the IM wm During cell death, MP often increases, allowing for the release of soluble proteins The only mechanism underlying mitochondrial ... the energy producers of the cell, and are essential for the maintenance of cell life However, in the last 10 years, it has also become apparent...

Ngày tải lên: 16/02/2014, 09:20

... 277 (2 010 ) 19 29 19 38 ª 2 010 The Authors Journal compilation ª 2 010 FEBS 19 31 TRAP1 protects cells from hypoxic injury by MPTP F Xiang et al A Ad-TRAP1 Vector Ad-TRAP1 B Vector Control TRAP1 75 ... TRAP1 FEBS Journal 277 (2 010 ) 19 29 19 38 ª 2 010 The Authors Journal compilation ª 2 010 FEBS 19 33 TRAP1 protects cells from hypoxic injury by MPTP F Xiang et al...

Ngày tải lên: 16/02/2014, 14:20

... chaperone proteins is also required The available data indicate that the accessory factor Bcs1p is involved in the binding of ISP to an immature bc1 intermediate Yeast cytochrome bc1 core structure ... the bc1 complex in these two deletion strains, thus leading to the hypothesis that the addition of ISP may play a pivotal role in the structural re...

Ngày tải lên: 18/02/2014, 08:20

... Bhagwat SV, Biswas G, Anandatheerthavarada HK, Addya S, Pandak W & Avadhani NG (199 9) Dual targeting property of the N-terminal signal sequence of P450 1A1 Targeting of heterologous proteins to ... open N-terminal signal domain is critical for protein targeting to the ER (Fig 2D) In contrast to the targeting of CYP 1A1 requiring N-terminal truncation, w...

Ngày tải lên: 18/02/2014, 16:20

... Discussion The main finding of this study is the identification of a metabolic gene switch from fatty acids to glucose in the murine female heart at baseline linked to enhanced mitochondrial respiratory ... al Metabolic gene switching in murine female heart function [8] Likewise, high fatty acid oxidation rates in the diabetic heart results in...

Ngày tải lên: 18/02/2014, 16:20

... in the cytoplasm In conclusion, the NBDs of mitochondrial MDL1 are located in the matrix, whereas the NBDs of the leaderless MDL1 targeted to the ER membrane face the cytosol B MDL1 forms homooligomeric ... 1% of the total mitochondrial protein This correlates with an over-expression compared to native MDL1 of up to 100-fold To determine the loc...

Ngày tải lên: 18/02/2014, 16:20

... ¼ after deducting basal and background values Sepsis resulted in a significant increase in the transcription of the mRNA encoding iNOS in heart of iNOS+ ⁄ + mice The expression of iNOS mRNA was ... cytosolic iNOS Moreover, the absence of any sign of mitochondrial dysfunction and the lack of i-mtNOS expression in iNOS– ⁄ – mice further support the role of i-mtNOS...

Ngày tải lên: 19/02/2014, 00:20

... al Characterization of respiratory complex II Fig Sequencing of porcine heart mitochondrial complex II Total RNA was extracted and purified from the fresh porcine heart, and genes of four complex ... sequencing and crystallization of mitochondrial complex II from porcine heart Characterization of respiratory complex II be the case...

Ngày tải lên: 19/02/2014, 02:20

... Journal compilation ª 20 06 FEBS 528 9 Palmitoyl-CoA and control of mitochondrial function J Ciapaite et al Table Steady-state values of fluxes and intermediates, as affected by palmitoyl CoA Values ... Ciapaite et al Palmitoyl-CoA and control of mitochondrial function Palmitoyl-CoA effects on extramitochondrial AMP concentration We have shown that lm palmitoyl-...

Ngày tải lên: 19/02/2014, 05:20

... the most reliable means of purifying integral membrane proteins from the mitochondrial outer membrane, and of the 11 most abundant integral proteins, 10 had a-helical transmembrane segments Of ... the proteins of the outer membrane, we set out to determine what proportion was integral and to identify the major protein species To determine whether the...

Ngày tải lên: 19/02/2014, 07:20

... number of differences in the N-terminal domain (located on the matrix side) It is likely that the N-terminal domain is involved in protein protein interactions with other hydrophilic domains of neighboring ... chain was established with succinate and glycerol3-phosphate as substrates Complex II activity was determined after addition of succinate, followed by inhibition b...

Ngày tải lên: 19/02/2014, 16:20

... and 3) Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational regulation, ... start sites initiating biosynthesis of the 88, 77, 74 and 63 kDa iPLA2c isoforms Instead, based on current information about iPLA2c and its splici...

Ngày tải lên: 19/02/2014, 16:20

... and the unpairing of four base-pairs in the centre of the junctions [19] Detailed understanding of the functional role of these interactions would require the crystal structure of the Ydc2 junction ... positioning of the SAP motifs in relation to the rest of the protein as well as for the stability of the protein The truncated Ydc2 mutant prote...

Ngày tải lên: 20/02/2014, 11:20

... suppression of respiration during hypoxia In the absence of differential regulation of a speci c nuclear gene coding for the subunits of CytOX, changes in the microenvironment of the cell may induce alterations ... modulates the expression of mRNAs for CytOX subunits and also the catalytic activity of the enzyme complex Our results show tha...

Ngày tải lên: 20/02/2014, 23:20