mitochondrial biology and oxidative stress in parkinson disease pathogenesis

Ngày tải lên: 11/08/2014, 07:21

... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu- lating arginine and (b) recycling of citrulline ... in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of NO involvement in pathophysiol- ogy of hypobaric hypoxia in brain (42-43). In this...

Ngày tải lên: 26/10/2012, 09:07

... by proteins resi- ding in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca 2+ overloading and other factors including oxidative stress [88,89]. In neurons ... neuron. The turning point upon which the cell looses the ability to buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in [Ca 2+ ] c , probably coincides with ... calcium transients during reversible brain ischemia. Exp Brain Res 104, 462–466. 188 Silver IA & Erecinska M (1992) Ion homeostasis in rat brain in vivo: intra- and extracellular [Ca 2+ ] and [H + ]in the...

Ngày tải lên: 07/03/2014, 12:20

... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis. Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3 Effect of indomethacin plus ... domenico@spirit.gcrc.upenn.edu * Corresponding author Abstract Background: An increasing body of evidence implicates both brain inflammation and oxidative stress in the pathogenesis of Alzheimer's disease (AD). The ... therapeutic interventions suppressed brain inflammatory and oxidative stress responses in the mice. This effect was accompanied by significant reductions of soluble and insoluble Aβ1-40 and Aβ1-42 in...

Ngày tải lên: 19/06/2014, 22:20

... CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi- dative stress also promotes angiogenesis [13]. The link between oxidative stress and angiogenesis is emphasised in SSc by the baseline correlation ... nifedipine can ameliorate endothelium injury in SSc and that VEGF signalling may by impaired in this disease without implication of the sVEGFR-1. Endothelium injury is critical in SSc and is ... VEGF signalling is impaired in SSc. However, more experimental evidence is needed to determine whether the VEGF pathway is intrinsically defective in SSc. Keywords: nifedipine, oxidative stress, ...

Ngày tải lên: 09/08/2014, 01:23

Ngày tải lên: 09/08/2014, 14:21

Ngày tải lên: 14/08/2014, 19:20

... MPK3 and MPK6 in Arabidopsis (group A MAPKs), SIMK and SAMK in alfalfa, and LeMPK1 ⁄ 2(Lycopersicon esculentum SA-induced pro- tein kinase) and LeMPK3 (L. esculentum wound- induced protein kinase) ... protein kinase and wound- induced protein kinase, two MAPKs in group A, were activated by inoculation with the tobacco mosaic virus (TMV) [10]. Their orthologs in other plant species, including ... accumulation in wild-type and transgenic plants in response to abiotic and abiotic stresses. (A) Virus infec- tion-induced H 2 O 2 accumulation detected by DAB staining. (B) Abi- otic stress- induced...

Ngày tải lên: 14/03/2014, 23:20

... indicating the presence of two catalytically independent domains, the N-terminal domain, display- ing ALDH activity, and the C-terminal domain, con- taining an iron-binding domain, which is involved ... against oxidative stress damage, have not been reported. In vivo effects on glucose-fermenting enzymes and fluxes under oxidative stress Recently, we reported that amebas incubated for 30 min in ... solubilized extract were incubated in such buffers for 4 h on ice, and the remaining enzyme activity was determined. Inset: EhPFOR time stability in N 2 -saturated buffer in the absence or presence of...

Ngày tải lên: 15/03/2014, 23:20

... on both hands, mild rigidity and bradykinesia in the upper limbs, gait slowness, and mild postural instability. He cried during the interview, and worried about being unable to continue his work ... pallidotomy Indications Advanced disease with rigidity and bradykinesia, and a poor response to antiparkinsonian medications Disabling dyskinesias Severe motor Xuctuations Painful cramps and severe dystonias Serious ... the cognitive and emotional side-eVects of speciWc antiparkinsonian drugs, such as l-dopa, dopaminergic agonists, amantadine, selegiline, and anticholinergic drugs. In the eighth, and last, chapter...

Ngày tải lên: 28/03/2014, 22:21

... global inhibition of src-family tyrosine kinases or inhibition of phosphati- dylinositol-3 kinase (PI3K) attenuates ROS production. These findings suggest that these kinases are involved in upstream ... leading to protein tyrosine phosphorylation and activation of the src-family kinases Lyn and Fyn as well as the tyrosine kinase Syk [30,32,52]. Activation of these signaling cascades are linked ... demon- strated a ~70% reduction in AD incidence among patient populations receiving statin treatment [117,118]. Despite these promising findings, the use of statins in prospective clinical trials has yielded...

Ngày tải lên: 19/06/2014, 22:20

... Access Health-Related Quality of Life in Parkinson disease: Correlation between Health Utilities Index III and Unified Parkinson s Disease Rating Scale (UPDRS) in U.S. male veterans Galit Kleiner-Fisman 1* , Matthew ... article as: Kleiner-Fisman et al.: Health-Related Quality of Life in Parkinson disease: Correlation between Health Utilities Index III and Unified Parkinson s Disease Rating Scale (UPDRS) in U.S. male ... for inclusion. Review of the diagnosis of parkinsonism was further scrutinized and only individuals fulfilling United King- dom Brain Bank Criteria [18] for idiopathic PD (IPD) were included in...

Ngày tải lên: 20/06/2014, 16:20

... study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells Jin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim 1 , Yoon-Shin Kim 2 , Nam-Hyun Chung 3 and Myung-Haing Cho* Laboratory ... protection standards for PM by adding an indicator for even “fine” particles (PM2.5). In this trend, our government is trying to update on ongoing litigation over PM2.5 standard. However, relative less information ... study, PM2.5 induced more MDA formation than PM10 suggesting that PM2.5 induced more oxidative stress than PM10. In the single strand breakage assay using pBR322 DNA, the ratio of changed form II/total...

Ngày tải lên: 07/08/2014, 17:22

... processes. However, after 85 days, the NR activity in the seedlings was lower and decreased with increasing O 3 . At that time in the season and with increasing oxidative stress, NH 3 may have been provided ... 10.1051/forest:2006019 Original article Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings Catherine G a,b * ,NadineC  c ,PaulW c , ... material from a single leaf was sam- pled from each ush of each seedling, cut into 2 ì 2 mm pieces and incubated in 5 mL of 100 mM phosphate buffer (pH 7.5) containing 40 mM KNO 3 and 1.5% 1-propanol....

Ngày tải lên: 08/08/2014, 00:22

... Access Review Phenomenology and management of cognitive and behavioral disorders in Parkinson& apos;s disease. Rise and logic of dementia in Parkinson& apos;s disease Constantin Potagas* and Sokratis Papageorgiou Address: ... prelim- inary findings from an open trial. Mov Disord 2001, 16:1171-1174. 58. Aarsland D, Hutchinson M, Larsen JP: Cognitive, psychiatric and motor response to galantamine in Parkinson& apos;s disease ... causes of the akinetic-rigid syndrome, or errors in differentiating dementia from con- fusional states, depression and even ageing, or in defining and assessing dementia itself [3]. Indeed, the first...

Ngày tải lên: 08/08/2014, 21:20

... maintain the chondrocyte telomere length and proteoglycan remaining in the cartilage explants, suggesting that oxidative stress induces chondrocyte telomere instability and catabolic changes in cartilage ... Our findings clearly show the presence of oxidative stress in degenerat- ing cartilage, and the resultant telomere erosion and dys- function of chondrocytes in vitro and in vivo, suggesting a role ... and oxidative stress in OA cartilage, as discussed above, we postulated that oxidative stress induces telomere instability and dysfunction in chondrocytes, subsequently resulting in cartilage ageing and...

Ngày tải lên: 09/08/2014, 06:22

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Ngày tải lên: 12/08/2014, 16:20