oxidative stress mitochondrial dysfunction and stress signaling in alzheimers disease
Báo cáo khoa học: Liver receptor homolog-1 localization in the nuclear body is regulated by sumoylation and cAMP signaling in rat granulosa cells docx
... forskolin and cholera toxin.Forskolin treatment obviously in uences the expression of membersinvolved in the SUMO pathway. The results obtained in the present studysuggest that cAMP signaling ... regulated by sumoylation and cAMP signaling in ratgranulosa cellsFeng-Ming Yang, Chien-Ting Pan, Huei-Man Tsai, Tai-Wei Chiu, Mei-Ling Wu and Meng-Chun HuGraduate Institute of Physiology, ... factor 1 (Ftz-F1). LRH-1is mainly expressed in tissues derived from the gutendoderm, including the liver, pancreas and intestine, and high levels of LRH-1 are also found in theovary [1,2]. LRH-1...
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báo cáo hóa học: " Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury" potx
... impairment with increased inflammation and apoptosis in the brain. Gelsolin, an actin-binding protein with capping and severing activities, plays a crucial role in the septicresponse. We investigated ... of anti-inflam-matory cytokines, including IL-10 mRNA, induced b ygelsolin infusion (data not shown).Administration of gelsolin suppressed burn-inducedmicroglial activation in the brainMicrogliosis ... for 20 min and were developed by incubating in 0.025% diamino-benzidine (DAB; Sigma-Aldrich) and 0.002% H2O2 in PBS. The DAB reaction was halted usingPBS, followed by three 10-min PBS rinses.Quantification...
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Báo cáo hóa học: " Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?" potx
... against oxidative stress, perhaps byincreasing ATP levels, reducing oxidant-induced ROSproduction, preserving mitochondrial membrane poten-tial, and increasing mitochondrial biogenesis. In ... These include mitochondrial uncoupling pro-teins (UCPs), which reside in the inner mitochondrial membrane and govern mitochondrial membran e poten-tial (ΔΨm) and, therefore, ROS generation and ... (reviewed in [206]). Several classes ofantibiotics function by binding to the bacteri al ribosome and inhibiting bacterial protein synthesis. The mito-chondrial protein synthesis machinery is in many...
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Báo cáo hóa học: " Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain" pptx
... 3A) and a reversible inhibition of both ERK (Figure 3B and C) and mTOR signaling (Figure 3D–H). Hence, resveratrol dose- and time-dependently activates AMPK and inhibits ERK and mTOR signaling ... in all cases upon 1 h washout Abstract Background Despite advances in our understanding of basic mechanisms driving post-surgical pain, treating incision-induced pain remains a major clinical ... activity. Interleukin-6 (IL-6) is thought to play an important role in incision-induced pain and resveratrol potently inhibited IL-6-mediated signaling to ERK in sensory neurons and blocked...
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Báo cáo y học: "Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury" potx
... role in joint specification [30,42] and in the regulation of chondrocyte differentiation inhibitingchondrogenesis in immature mesenchymal cells and enhanc-ing terminal differentiation in mature ... aggrecan mRNA. Since in other organ systemsWNTs are involved in supporting repair processes by main-taining a stem cell pool and specifying cell fates [19,46,47], itis tempting to speculate ... mostimportant signaling pathways involved in embryonic skele-togenesis and joint morphogenesis, suggesting that the artic-ular cartilage is capable of triggering a signaling machinerythat may...
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Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... orunfavorable, depending on the disease. As a case in point, formation of huntingtin-containing inclusionbodies in Huntington’s disease encourages cell survival,whereas monomers and small inclusion bodies ... M & Vierling E (2001) Theexpanding family of Arabidopsis thaliana small heat stress proteins and a new family of proteins containinga-crystallin domains (Acd proteins). Cell Stress Chap-erones ... aA-crystallin requires this domain [66]. Attachment ofR116C aA-crystallin to Hsp27 and aB-crystallinincreases in comparison to wild type, while binding tocC-crystallin and bB2-crystallin decreases....
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Tài liệu Báo cáo khoa học: Osmotic stress sensing and signaling in fishes doc
... mitogen-activated protein kinasekinase kinase 7 interacting protein 2 (TAK 1 bindingprotein 2 ẳ TAB 2), as an IEG during hyperosmotic stress in tilapia gill epithelium [26]. This gene istransiently and very ... to osmotic stress in euryhaline fish is coordinated via hormone- and paracrine factor-mediated extracellular signaling. Overall, currentinsight into osmosensing and osmotic stress- induced signal ... Osmotic stress sensing and signaling in fishesFEBS Journal 274 (2007) 5790–5798 ª 2007 The Authors Journal compilation ª 2007 FEBS 5795 MINIREVIEWOsmotic stress sensing and signaling in fishesDiego...
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Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues ppt
... analyzed.Finally, mitochondrial number was reduced in botheWAT and iBAT in response to PM2.5exposure.Recent studies have implicated PM2.5 in in creased adi-pose inflammation and insulin resistance ... triggers oxidative stress in BAT, and results in key alterations in mitochondrial geneexpression and mitochondrial alterations that are pronounced in BAT. We postulate that exposure to PM2.5mayinduce ... PM2.5exposureinduced a marked increase in macroph age (F4/80+cells)infiltration in eWAT. Next, we analyzed the changes in uncoupling protein 1 (UCP1) in response to PM2.5exposure. As shown in Figure...
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Báo cáo khoa học: Identification and characterization of 1-Cys peroxiredoxin from Sulfolobus solfataricus and its involvement in the response to oxidative stress pdf
... protein instability causedby oxidative stress conditions, are important in deter-mining the level of Bcp2 protein. Similar results areobserved for genes and related proteins involved in oxidative ... Spperoxidatic cysteine;X unidentified electron donor; SRresolvingcysteine; RSH protein or domain with CXXCmotif (e.g. thioredoxin). In typical 2-Cys, Spat the N terminus and SRat the C terminusbelong ... resol-ving cysteine (Cys-SR). In typical 2-Cys, Spat the Nterminus and SRat the C terminus of the proteinbelong to different subunits and condense to form anintersubunit disulfide bond; in...
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Báo cáo khoa học: " Induction of oxidative stress and lipid peroxidation in rats chronically exposed to cypermethrin through dermal application" pps
... Biochem 1983, 52, 711-760.25. Nicholls DG. Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease. Int J Biochem Cell Biol 2002, 34, 1372-1381.26. ... of cypermethrin on oxidative stress after dermal application 259Exacerbated responses to oxidative stress by an Na+ load in isolated nerve terminals: the role of ATP depletion and rise of ... significantly reduced (p ＜ 0.05) in all groups compared to the control group. Similar finding have been reported in other study during oxidative stress [24]. No significant changes in GST activity was...
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Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
... processes.However, after 85 days, the NR activity in the seedlings waslower and decreased with increasing O3. At that time in theseason and with increasing oxidative stress, NH3may havebeen provided ... 10.1051/forest:2006019Original articleResponse to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlingsCatherine Ga,b*,NadineCc,PaulWc, ... material from a single leaf was sam-pled from each ush of each seedling, cut into 2 ì 2 mm pieces and incubated in 5 mL of 100 mM phosphate buffer (pH 7.5) containing40 mM KNO3 and 1.5% 1-propanol....
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