mitochondrial dysfunction and oxidative stress in parkinsons disease
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu- lating arginine and (b) recycling of citrulline ... in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of NO involvement in pathophysiol- ogy of hypobaric hypoxia in brain (42-43). In this...
Ngày tải lên: 26/10/2012, 09:07
Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... by proteins resi- ding in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca 2+ overloading and other factors including oxidative stress [88,89]. In neurons ... neuron. The turning point upon which the cell looses the ability to buffer the incoming calcium resulting in an abrupt, sustained and irreversible increase in [Ca 2+ ] c , probably coincides with ... calcium transients during reversible brain ischemia. Exp Brain Res 104, 462–466. 188 Silver IA & Erecinska M (1992) Ion homeostasis in rat brain in vivo: intra- and extracellular [Ca 2+ ] and [H + ]in the...
Ngày tải lên: 07/03/2014, 12:20
báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis. Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3 Effect of indomethacin plus ... therapeutic interventions suppressed brain inflammatory and oxidative stress responses in the mice. This effect was accompanied by significant reductions of soluble and insoluble Aβ1-40 and Aβ1-42 in ... flurbiprofen, indomethacin) reduced brain inflammation and Aβ levels in addition to the dep- osition of Aβ in brain [13,14]. Despite this evidence, and the considerable theoretical and therapeutic interest,...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi- dative stress also promotes angiogenesis [13]. The link between oxidative stress and angiogenesis is emphasised in SSc by the baseline correlation ... nifedipine can ameliorate endothelium injury in SSc and that VEGF signalling may by impaired in this disease without implication of the sVEGFR-1. Endothelium injury is critical in SSc and is ... VEGF signalling is impaired in SSc. However, more experimental evidence is needed to determine whether the VEGF pathway is intrinsically defective in SSc. Keywords: nifedipine, oxidative stress, ...
Ngày tải lên: 09/08/2014, 01:23
Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
... MPK3 and MPK6 in Arabidopsis (group A MAPKs), SIMK and SAMK in alfalfa, and LeMPK1 ⁄ 2(Lycopersicon esculentum SA-induced pro- tein kinase) and LeMPK3 (L. esculentum wound- induced protein kinase) ... protein kinase and wound- induced protein kinase, two MAPKs in group A, were activated by inoculation with the tobacco mosaic virus (TMV) [10]. Their orthologs in other plant species, including ... accumulation in wild-type and transgenic plants in response to abiotic and abiotic stresses. (A) Virus infec- tion-induced H 2 O 2 accumulation detected by DAB staining. (B) Abi- otic stress- induced...
Ngày tải lên: 14/03/2014, 23:20
Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
... indicating the presence of two catalytically independent domains, the N-terminal domain, display- ing ALDH activity, and the C-terminal domain, con- taining an iron-binding domain, which is involved ... against oxidative stress damage, have not been reported. In vivo effects on glucose-fermenting enzymes and fluxes under oxidative stress Recently, we reported that amebas incubated for 30 min in ... solubilized extract were incubated in such buffers for 4 h on ice, and the remaining enzyme activity was determined. Inset: EhPFOR time stability in N 2 -saturated buffer in the absence or presence of...
Ngày tải lên: 15/03/2014, 23:20
báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... global inhibition of src-family tyrosine kinases or inhibition of phosphati- dylinositol-3 kinase (PI3K) attenuates ROS production. These findings suggest that these kinases are involved in upstream ... leading to protein tyrosine phosphorylation and activation of the src-family kinases Lyn and Fyn as well as the tyrosine kinase Syk [30,32,52]. Activation of these signaling cascades are linked ... demon- strated a ~70% reduction in AD incidence among patient populations receiving statin treatment [117,118]. Despite these promising findings, the use of statins in prospective clinical trials has yielded...
Ngày tải lên: 19/06/2014, 22:20
Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells Jin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim 1 , Yoon-Shin Kim 2 , Nam-Hyun Chung 3 and Myung-Haing Cho* Laboratory ... protection standards for PM by adding an indicator for even “fine” particles (PM2.5). In this trend, our government is trying to update on ongoing litigation over PM2.5 standard. However, relative less information ... study, PM2.5 induced more MDA formation than PM10 suggesting that PM2.5 induced more oxidative stress than PM10. In the single strand breakage assay using pBR322 DNA, the ratio of changed form II/total...
Ngày tải lên: 07/08/2014, 17:22
Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
... processes. However, after 85 days, the NR activity in the seedlings was lower and decreased with increasing O 3 . At that time in the season and with increasing oxidative stress, NH 3 may have been provided ... 10.1051/forest:2006019 Original article Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings Catherine G a,b * ,NadineC c ,PaulW c , ... material from a single leaf was sam- pled from each ush of each seedling, cut into 2 ì 2 mm pieces and incubated in 5 mL of 100 mM phosphate buffer (pH 7.5) containing 40 mM KNO 3 and 1.5% 1-propanol....
Ngày tải lên: 08/08/2014, 00:22
Báo cáo y học: "Pu-Erh tea and GABA attenuates oxidative stress in kainic acid-induced status epilepticu" docx
Ngày tải lên: 10/08/2014, 10:20
Báo cáo y học: "TNF-α and IL-10 downregulation and marked oxidative stress in Neuromyelitis Optica" pptx
Ngày tải lên: 11/08/2014, 08:22
Báo cáo y học: " Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD" docx
Ngày tải lên: 12/08/2014, 16:20
Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... pilocarpine, on muscarinic and dopaminer- gic receptors and on phosphoinositide metabolism in rat hippocampus and striatum. Neurochem Int 33, 299–306. 21 Viana GSB, Marinho MMF, Sousa FCF, Bruin VMS, Aguiar ... oxidative stress. Our findings show that pilocarpine induces SE, which can produce alterations in superoxide dismutase and catalase activities in different areas, thereby pro- tecting the brain ... sys- tems during SE. An increase in lipid peroxidation, a decrease in GSH content, and excessive free radical formation may occur during SE induced by pilocarpine [4,5]. This model can be used to investigate...
Ngày tải lên: 19/02/2014, 16:20