mitochondrial dysfunction and oxidative stress in parkinsons disease
Báo cáo y học: "NITRIC OXIDE (NO), CITRULLINE – NO CYCLE ENZYMES, GLUTAMINE SYNTHETASE AND OXIDATIVE STRESS IN ANOXIA (HYPOBARIC HYPOXIA) AND REPERFUSION IN RAT BRAIN"
... synthase. The increased activities of argininosuccinate synthetase and argininosuccinate lyase suggest the increased and effective recycling of citrulline to arginine in anoxia, making nitric ... arginine at the site of synthesis. Arginine is a semi essential amino acid and in CNS, its availability depends upon: (a) uptake from the circu-lating arginine and (b) recycling of citrulline ... in brain in anoxia as observed by in- crease in NOx concentration in this study support the earlier findings of NO involvement in pathophysiol-ogy of hypobaric hypoxia in brain (42-43). In this...
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Báo cáo khoa học: Calcium, mitochondria and oxidative stress in neuronal pathology Novel aspects of an enduring theme pdf
... by proteins resi-ding in both the inner and outer mitochondrial membrane, that is activated by mitochondrial Ca2+overloading and other factors including oxidative stress [88,89]. In neurons ... neuron. The turning point upon whichthe cell looses the ability to buffer the incoming calciumresulting in an abrupt, sustained and irreversibleincrease in [Ca2+]c, probably coincides with ... calciumtransients during reversible brain ischemia. Exp BrainRes 104, 462–466.188 Silver IA & Erecinska M (1992) Ion homeostasis in ratbrain in vivo: intra- and extracellular [Ca2+] and [H+ ]in the...
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báo cáo hóa học: " Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis" pptx
... implicating both oxidative stress and inflammatory mechanisms in AD pathogenesis.Effect of indomethacin plus vitamin E supplementation on sol-uble Aβ levelsFigure 3Effect of indomethacin plus ... therapeutic interventions suppressed brain inflammatory and oxidative stress responses in the mice. This effect was accompanied by significant reductionsof soluble and insoluble Aβ1-40 and Aβ1-42 in ... flurbiprofen, indomethacin) reducedbrain inflammation and Aβ levels in addition to the dep-osition of Aβ in brain [13,14]. Despite this evidence, and the considerable theoretical and therapeutic interest,...
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Báo cáo y học: "Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor" potx
... CD40 ligand, interleukin 1, or interleukin 6 [10]. Oxi-dative stress also promotes angiogenesis [13]. The linkbetween oxidative stress and angiogenesis is emphasised in SSc by the baseline correlation ... nifedipine can ameliorate endothelium injury in SSc and that VEGF signalling may by impaired in this disease without implication of the sVEGFR-1.Endothelium injury is critical in SSc and is ... VEGF signalling is impaired in SSc. However, more experimental evidence is needed todetermine whether the VEGF pathway is intrinsically defective in SSc.Keywords: nifedipine, oxidative stress, ...
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Báo cáo khoa học: Cotton GhMPK2 is involved in multiple signaling pathways and mediates defense responses to pathogen infection and oxidative stress doc
... MPK3 and MPK6 in Arabidopsis (group AMAPKs), SIMK and SAMK in alfalfa, and LeMPK1 ⁄ 2(Lycopersicon esculentum SA-induced pro-tein kinase) and LeMPK3 (L. esculentum wound-induced protein kinase) ... protein kinase and wound-induced protein kinase, two MAPKs in group A, wereactivated by inoculation with the tobacco mosaic virus(TMV) [10]. Their orthologs in other plant species,including ... accumulation in wild-type and transgenicplants in response to abiotic and abiotic stresses. (A) Virus infec-tion-induced H2O2accumulation detected by DAB staining. (B) Abi-otic stress- induced...
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Báo cáo khoa học: Pyruvate:ferredoxin oxidoreductase and bifunctional aldehyde–alcohol dehydrogenase are essential for energy metabolism under oxidative stress in Entamoeba histolytica pdf
... indicating the presence of two catalyticallyindependent domains, the N-terminal domain, display-ing ALDH activity, and the C-terminal domain, con-taining an iron-binding domain, which is involved ... against oxidative stress damage, have not been reported. In vivo effects on glucose-fermenting enzymes and fluxes under oxidative stress Recently, we reported that amebas incubated for30 min in ... solubilized extract were incubated in such buffers for 4 hon ice, and the remaining enzyme activity was determined. Inset: EhPFOR time stability in N2-saturated buffer in the absence or presenceof...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... global inhibitionof src-family tyrosine kinases or inhibition of phosphati-dylinositol-3 kinase (PI3K) attenuates ROS production.These findings suggest that these kinases are involved in upstream ... leading to proteintyrosine phosphorylation and activation of the src-familykinases Lyn and Fyn as well as the tyrosine kinase Syk[30,32,52]. Activation of these signaling cascades arelinked ... demon-strated a ~70% reduction in AD incidence among patientpopulations receiving statin treatment [117,118]. Despitethese promising findings, the use of statins in prospectiveclinical trials has yielded...
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Báo cáo khoa học: "Comparative study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cells" pptx
... study of PM2.5 - and PM10 - induced oxidative stress in rat lung epithelial cellsJin-Hyuk Choi, Jun-Sung Kim, Young-Chul Kim1, Yoon-Shin Kim2, Nam-Hyun Chung3 and Myung-Haing Cho*Laboratory ... protectionstandards for PM by adding an indicator for even “fine”particles (PM2.5). In this trend, our government is trying toupdate on ongoing litigation over PM2.5 standard. However,relative less information ... study,PM2.5 induced more MDA formation than PM10suggesting that PM2.5 induced more oxidative stress thanPM10. In the single strand breakage assay using pBR322DNA, the ratio of changed form II/total...
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Báo cáo lâm nghiệp: "Response to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlings" pot
... processes.However, after 85 days, the NR activity in the seedlings waslower and decreased with increasing O3. At that time in theseason and with increasing oxidative stress, NH3may havebeen provided ... 10.1051/forest:2006019Original articleResponse to an ozone gradient of growth and enzymes implicated in tolerance to oxidative stress in Acer saccharum (Marsh.) seedlingsCatherine Ga,b*,NadineCc,PaulWc, ... material from a single leaf was sam-pled from each ush of each seedling, cut into 2 ì 2 mm pieces and incubated in 5 mL of 100 mM phosphate buffer (pH 7.5) containing40 mM KNO3 and 1.5% 1-propanol....
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Tài liệu Báo cáo khoa học: Oxidative stress in the hippocampus after pilocarpineinduced status epilepticus in Wistar rats doc
... pilocarpine, on muscarinic and dopaminer-gic receptors and on phosphoinositide metabolism in rat hippocampus and striatum. Neurochem Int 33,299–306.21 Viana GSB, Marinho MMF, Sousa FCF, Bruin VMS,Aguiar ... oxidative stress. Our findings show that pilocarpine induces SE,which can produce alterations in superoxide dismutase and catalase activities in different areas, thereby pro-tecting the brain ... sys-tems during SE. An increase in lipid peroxidation, adecrease in GSH content, and excessive free radicalformation may occur during SE induced by pilocarpine[4,5].This model can be used to investigate...
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