Telomere chromosome integrity in breast cancer

... (TPP1, TIN2 and hRap1) include those that bind to the telomeric DNA through interaction with the directly interacting proteins TIN2 binds to TRF1 and TRF2 hRap1 binds to TRF2 (Blasco, 20 07) 1.1 .2: ... through its role in maintaining genome integrity, instead of directly inhibiting cell proliferation (Deng, 20 01b; Deng, 20 01a; Deng and Scott, 20 00b; Venkitaraman, 20 02) The role o...

Ngày tải lên: 12/09/2015, 08:16

... All telomeres (mean + SE) Lþ/2 p 532 /2 cLLp 532 /2 LLp 532 /2 cLLp 532 /2 cLþ/2 p 532 /2 cLLp 532 /2 37 .0 + 0.6 22.4 + 0.5 36 .6 + 0.4 33 .8 + 0.4 38 .1 + 0.5 32 .2 + 0 .3 56 .3 + 0.8 34 .3 + 0.6 45 .3 + 0.5 39 .8 ... 42.9 + 0 .3 33. 8 + 0.2 44.5 + 0.5 39 .1 + 0.5 41.6 + 0.6 33 .2 + 0.4 35 .6 + 0.5 32 .3 + 0.4 56.9 + 0.8 38 .4 + 0.5 51.7 + 0.7 44.4 + 0.7 39 .1 + 0.6 37 ....

Ngày tải lên: 12/09/2015, 08:16

... of telomere dysfunction in breast cancer progression 73 3.2.1: Telomere shortening in breast cancer tissues with greater shortening in the higher grades of tumours 73 3.2.2: Telomere shortening ... observed in breast cancer cell lines compared to normal cell lines 76 3.2.3: Telomere shortening associated with increased chromosomal instability 77 3.2.4: Increased ch...

Ngày tải lên: 12/09/2015, 08:16

... damaging and telomeretelomerase effects and hence the mechanism of action of TQ in breast cancer cells In addition, it is of interest to investigate the effects of TQ in normal breast epithelial cells ... Black cumin seeds (left) and chemical structure of thymoquinone (right) 23 Figure 10 Growth inhibitory effects of TQ on breast cancer cells 39...

Ngày tải lên: 30/09/2015, 13:41

... responsible for their operation should take this guidance into account when planning, commissioning and organising services for cancer patients The recommendations in the guidance concentrate on ... organisations is permitted without the express written permission of the Institute Guidance on Cancer Services Improving Outcomes in Breast Cancer Manual Update Conte...

Ngày tải lên: 14/02/2014, 22:20

... Surprisingly, however, the protein synthesis inhibitor cycloheximide did not abolish the induction, which suggested that GPR30 is directly regulated by progestins We were not able to locate any progestin ... expressed in MCF-7 cells relatively late, although in a progestindependent manner, we decided to investigate whether MAPK activation is responsible for GPR30 mRNA regulation by p...

Ngày tải lên: 24/03/2014, 00:21

... www-dep.iarc.fr/globocan/globocan.html] Jarvandi S, Montazeri A, Harirchi I and Kazemnejad A: Beliefs and behaviours of Iranian teachers toward early detection of breast cancer and breast self-examination ... behaviors and contribute to subsequent delayed presentation of breast cancer in Iranian women [22] The study did not demonstrate any association between age and pat...

Ngày tải lên: 28/03/2014, 14:20

... support the hypothesis that BRCA1 enhances TRAIL s ability to mediate apoptosis in breast cancer cell lines Discussion There is increasing interest in the association between hypoxia and BRCA1 ... induce apoptosis in breast cancer cells Therefore, we assessed the requirement for functional BRCA1 in TRAIL- stimulated apoptosis HCC1937 cells have...

Ngày tải lên: 30/03/2014, 03:20

... serum protein features of a number of cancers in the near future [47] Translational research in breast cancer Breast cancer Breast cancer is the most common malignancy among women in the Western ... Danish Centre for Translational Breast Cancer Research (DCTB), to fight breast cancer DCTB hosts scientists working in various areas of preclinical cancer res...

Ngày tải lên: 30/03/2014, 15:20

... intravenous injection of DiD-labeled monocytes (a) In vivo optical imaging of a control FVB/n mouse after (a) In vivo optical imaging of a control FVB/n mouse after intravenous injection of DiD-labeled ... or took part in all the experiments and was the primary writer of the manuscript RJK was involved in the in vivo data gathering ST performed or participa...

Ngày tải lên: 18/06/2014, 15:20

... curatively treated breast cancer patients [10] to address whether the EQ-5D is responsive to changes in HRQoL in a population of breast cancer patients in their first year after treatment Methodology ... Conclusion In this study the responsiveness of the EQ-5D was investigated for its use in economic evaluations of health interventions in bre...

Ngày tải lên: 18/06/2014, 19:20

... primary blasts Haematologica 2008, 93:662-669 34 Sharma SV, Haber DA, Settleman J: Cell < /b> line-based platforms to < /b> evaluate the < /b> therapeutic efficacy of < /b> candidate anticancer agents Nat Rev Cancer < /b> ... Gautschi O, Mack PC, Davies AM, Lara PN, Gandara DR: Aurora < /b> kinase inhibitors: a < /b> new class of < /b> targeted drugs in < /b> cancer < /b> Clin Lung...

Ngày tải lên: 18/06/2014, 22:20