1estrogen receptor in breast cancer

... and C-C chemokine receptors Chemokines [27,28] and angiotensin II [29] have both shown growth-inhibiting properties with different cancers Interestingly, an orphan receptor (GPR41 in the rat), ... progestin administration was thus associated with the beginning of growth inhibition by progestins GPR30 mRNA is regulated according to the dose of progestin, which also correlated with progestin-induced ... steroid hormones Progestin administration causes an initial increase in cell proliferation lasting about 12–24 h and subsequent GPR30 and progestin (Eur J Biochem 269) 2489 inhibition of proliferation...

Ngày tải lên: 24/03/2014, 00:21

... ferently, using the anti-ErbB-2 antiserum cross reacting with the murine receptor resulted in a faint stain of the cytoplasm and rarely in staining of the membrane of the tumor cells (Figure 3B) In the ... E-Cadherin mediated signalling or the Inhibitor of IKB in the NFκB signalling [11], crucial for driving the expression of regulators of cell cycle control, or ii) binding to receptors mediating the ... signalling in both breast and non -breast tumors over expressing the kinase Furthermore, since the inverse correlation of the expression levels of the two genes is highly significant in human breast...

Ngày tải lên: 18/06/2014, 16:20

... estrogen receptor 1.2 RET gene 1.2.1 RET and its isoforms 1.2.2 RET gene and its role in human physiology 1.3 Long range chromatin interactions 1.3.1 Estrogen receptor binding sites in breast cancer ... sequencing), we generated a global map of ERα binding sites in the genome of MCF7 breast cancer cell line From this dataset, we identified two ERα binding sites near the RET (rearrangement during ... human genome revealing the exact positions of estrogen receptor binding site (ERBS) In addition, ChIP-Seq also contains information on the density or strength of receptor binding Based on such...

Ngày tải lên: 05/10/2015, 21:29

... Clinical breast examination in primary care Each primary care team should include at least one practitioner who has had specific training in carrying out clinical breast examination (CBE) in ... to breast clinics for investigation of possible or suspected breast cancer are referred by GPs; the remaining 20% are identified by routine screening For historical reasons, breast screening in ... Co-ordinating Group Cancer Services Co-ordinating Group 2000 22 Dewar JA, Twelves CJ, Thomson CS for the Scottish Breast Cancer Focus Group and the Scottish Cancer Therapy Network Breast Cancer in...

Ngày tải lên: 14/02/2014, 22:20

... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... continuing advances in technical and professional knowledge Certain principles remain just as important in diagnosis as they are in screening Training, multidisciplinary teamwork, monitoring...

Ngày tải lên: 15/03/2014, 00:20

... consumption and breast cancer risks for ER-positive and ER-negative breast cancers In this study, we examine the association between coffee consumption and postmenopausal breast cancer risk in a large ... effect of caffeine intake on breast cancer risk for Li et al Breast Cancer Research 2011, 13:R49 http:/ /breast- cancer- research.com/content/13/3/R49 Page of 10 Table Validation results in the German ... follow-up Int J Cancer 2008, 122:2071-2076 30 Ishitani K, Lin J, Manson JE, Buring JE, Zhang SM: Caffeine consumption and the risk of breast cancer in a large prospective cohort of women Arch Intern...

Ngày tải lên: 22/03/2014, 17:20

... pathway was demonstrated in tamoxifen-stimulated breast cancer tumors by inducing the death receptor Estrogen-Induced Apoptosis in Breast Cancer Cells: Translation to Clinical Relevance Fas with ... efficient in apoptosis induction DNA-damaging agents like doxorubicin, etoposide, cisplatin or bleomycin may induce apoptosis via both extrinsic and intrinsic apoptotic pathways (Fulda & Debatin, 2006) ... fusion gene encoding the chimeric protein of caspase-8 and the ligand-binding domain (LBD) of ERα and introduced the gene into breast cancer cell lines (Zhao et al, 2011) Upon administration of...

Ngày tải lên: 23/03/2014, 17:20

... delay in operable breast cancer patients Eur J Cancer Prev 2001, 10:53-59 Ebrahimi M, Vahdaninia M and Montazeri A: Risk factors for breast cancer in Iran: a case-control study Breast Cancer ... Medicine 2000, 30:174-177 Montella M, Crispo A, Botti G, De Marco M, De Bellis G and Fabbrocini G et al.: Assessment of delay in obtaining definitive breast cancer treatment in southern Italy Breast ... regarding breast cancer concluded that since older age is a risk factor for both developing breast cancer and subsequent delayed presentation, any intervention program should target older women in...

Ngày tải lên: 28/03/2014, 14:20

... proteins involved in various cellular processes, including inhibition of apoptosis Hypoxia has been reported to inhibit apoptosis induced by tumor necrosis factor-related apoptosisinducing ligand ... Collectively, the data in Fig support the involvement of a TRAIL-dependent process in mediating hypoxiainduced changes in BRCA1 localization TRAIL, but not hypoxia, induces apoptosis in breast cancer cells ... hypoxia in MDA-MB-468 cells (Fig 2B), resulting in a 35% decrease in nuclear BRCA1 relative to the level in normoxic cells in the presence of 2E5 The decrease in C Fig Hypoxia-induced changes in BRCA1...

Ngày tải lên: 30/03/2014, 03:20

... serum protein features of a number of cancers in the near future [47] Translational research in breast cancer Breast cancer Breast cancer is the most common malignancy among women in the Western ... bladder by oral administration of the epidermal growth factor receptor protein tyrosine kinase inhibitor 4,5-dianilinophthalimide Clin Cancer Res 3, 161–168 68 Bellmunt J, Hussain M & Dinney CP (2003) ... (2003) Circulating interleukin-6 predicts survival in patients with metastatic breast cancer Int J Cancer 103, 642–646 62 Bray GA (2004) Medical consequences of obesity J Clin Endocrinol Metab 89,...

Ngày tải lên: 30/03/2014, 15:20

... p-value less than 0.05 Injection of free DiD resulted in no increase in fluorescent intensity within the tumor at any time point post-infusion Figure labeling (a) Optical imaging of DiD-labeled cells ... adaptive and innate immune cells during breast cancer progression Breast Cancer Res 2007, 9:212 Balkwill F, Charles KA, Mantovani A: Smoldering and polarized inflammation in the initiation and ... human breast cancer Clin Cancer Res 2000, 6:3282-3289 Jin H, Su J, Garmy-Susini B, Kleeman J, Varner J: Integrin alpha4beta1 promotes monocyte trafficking and angiogenesis in tumors Cancer Res...

Ngày tải lên: 18/06/2014, 15:20

... measurement in randomized clinical trials in breast cancer – taking stock Journal of the National Cancer Institute 2003, 95(4):263-281 Montazeri A: Health-related quality of life in breast cancer ... oncology clinical research [29-31] It has also been validated [32] and found to be responsive [33] specifically in breast cancer patients and is widely used in breast cancer research investigating HRQoL ... Patients were included in the trial after finalizing treatment and after giving written informed consent Treatment included surgery and/or radiotherapy and/or chemotherapy Followup appointments took...

Ngày tải lên: 18/06/2014, 19:20

... pathway was demonstrated in tamoxifen-stimulated breast cancer tumors by inducing the death receptor Estrogen-Induced Apoptosis in Breast Cancer Cells: Translation to Clinical Relevance Fas with ... efficient in apoptosis induction DNA-damaging agents like doxorubicin, etoposide, cisplatin or bleomycin may induce apoptosis via both extrinsic and intrinsic apoptotic pathways (Fulda & Debatin, 2006) ... fusion gene encoding the chimeric protein of caspase-8 and the ligand-binding domain (LBD) of ERα and introduced the gene into breast cancer cell lines (Zhao et al, 2011) Upon administration of...

Ngày tải lên: 27/06/2014, 11:20

... [22] There is a growing interest in the possible role of exercise in enhancing QOL, reducing recurrence and other diseases, and extending survival in cancer survivors Preliminary research suggests ... research using rigorous methodology is needed to definitively answer questions concerning the role of exercise in enhancing QOL in cancer survivors both during and after treatment [12] Breast cancer ... exercise training and natural killer cell cytotoxic activity in breast cancer patients Int J Sports Med 1995;16:334-7 Stoll BA Diet and exercise regimens to improve breast carcinoma prognosis Cancer...

Ngày tải lên: 08/08/2014, 16:23

... invasion begins with inflammation around cancer cells Thus, it has been reported that serum CRP levels are higher in cases of invasive cancer than in cases of non-invasive cancer [8,9] The principal ... TNM staging system of breast cancer thus indirectly correlating with the prognosis of the patient CRP estimation does not seem to be very useful in evaluating the patient with breast cancer, ... significance of interleukin serum levels in patients with ovarian cancer Br J Cancer 1995, 71:354-356 De Vita F, Orditura M, Auriemma A, Infusino S, Roscigno A, Catalano G: Serum levels of interleukin as...

Ngày tải lên: 09/08/2014, 01:24

... tumors originating from the interstitial cells of Cajal, which are pacemaker cells regulating autonomic motor activity in the gastrointestinal tract The majority of the GISTs arise in the stomach ... present with abdominal pain, satiety, obstruction, or GI bleeding However, Figure Pre-operative CT scan showed gastric mass with curvilinear calcification penetrating into surrounding soft tissue ... penetrating into the gastric lumen and pericolic soft tissue Other gastrointestinal tumors may also contain calcification At least three types of calcification have been reported in gastric cancer: ...

Ngày tải lên: 09/08/2014, 01:24

... survival in invasive breast cancers [24] In conclusion, we found that the incidence of sentinel lymph node metastasis in cases of pure DCIS was 0.39% This incidence was lower than that in IDC-predominant ... Rome Breast Cancer Study Group: Sentinel lymph node biopsy in women with pT1a or “microinvasive” breast cancer Breast 2008, 17:395-400 Zavagno G, Belardinelli V, Marconato R, Carcoforo P, Franchini ... IDC-predominant invasive breast cancer had positive sentinel lymph nodes Therefore, the risk of lymph node metastasis was significantly lower in the pure DCIS group than in the IDC-predominant invasive-lesion...

Ngày tải lên: 09/08/2014, 03:21

... new era in breast cancer Invasion, size, and nodal involvement dramatically decreasing as a result of mammographic screening Arch Surg 1996, 131(3):301-308 Fisher B, Slack NH, Bross ID: Cancer ... of the National Cancer Institute early breast cancer trial J Natl Cancer Inst Monogr 1992, 11:27-32 27 Saphner T, Tormey DC, Gray R: Annual hazard rates of recurrence for breast cancer after primary ... 1-98 Collaborative Group; International Breast Cancer Study Group: Predictors of early relapse in postmenopausal women with hormone receptor- positive breast cancer in the BIG 1-98 trial Ann Oncol...

Ngày tải lên: 09/08/2014, 03:21

... Traditional Chinese Medicine Hospital which are the two main hospitals for the treatment of breast cancer in Guilin city of China The specimens were fixed in 10% neutral-buffered formalin (pH7.4) ... herceptin 10 11 12 Parkin DM, Bray F, Ferlay J: Global cancer statistics, 2002 CA Cancer J Clin 2005, 55(2):74-108 Zheng Y, Li DL, Xiang YM, Li XJ: The status and trend of breast cancer incidence in ... Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumab Clin Breast Cancer 2005, 6(3):240-6...

Ngày tải lên: 09/08/2014, 04:21

... detailed investigation Our results showed that there was a single route leading to a single SN in 68% of the patients, multiple routes leading to a single SN in 4%, a single route leading to multiple ... H, Inaji H: Sentinel node biopsy for breast cancer: technical aspects and controversies Breast Cancer 2007, 14:25-30 Giuliano AE, Jones RC, Brennan M, Statman R: Sentinel lymphadenectomy in breast ... blue dye Breast Dis 1998, 8:297-300 De Cicco C, Chinol M, Paganelli G: Intraoperative localization of the sentinel node in breast cancer: technical aspects of lymphoscintigraphic methods Semin Surg...

Ngày tải lên: 09/08/2014, 07:21