src estrogen receptors and receptor tyrosine kinases in breast cancer

... against PI3K, Src family kinases and Btk on the tyrosine phosphorylation of Akt Effect of3 Effect of inhibitors against PI3K, Src family kinases and Btk on the tyrosine phosphorylation of Akt ... the zymosaninduced tyrosine phosphorylation of PLCγ2 In agreement with previous findings [3], inhibition of PI3K with wortmannin did not cause such inhibition (Fig 4B) MAP kinase-independent ... Mnk-1 is coordinately regulated by the MAP kinases ERK and p38 and inhibition of both of these MAP kinases severely inhibits zymosan-induced arachidonate release [4] However, separate inhibition...

Ngày tải lên: 11/08/2014, 08:21

... exercise training and natural killer cell cytotoxic activity in breast cancer patients Int J Sports Med 1995;16:334-7 Stoll BA Diet and exercise regimens to improve breast carcinoma prognosis Cancer ... other diseases, and extending survival in cancer survivors Preliminary research suggests that exercise may be an effective intervention for enhancing QOL in cancer survivors and that this effect ... few in number, however, and of limited quality Further research using rigorous methodology is needed to definitively answer questions concerning the role of exercise in enhancing QOL in cancer...

Ngày tải lên: 08/08/2014, 16:23

... Stefanick ML: Influence of a diet very high in vegetables, fruit, and fiber and low in fat on prognosis following treatment for breast cancer: the Women's Healthy Eating and Living (WHEL) randomized ... contraceptives and prognosis in breast cancer: effects of duration, latency, recency, age at first use and relation to parity and body mass Page of 39 40 41 42 index in young women with breast cancer ... new era in breast cancer Invasion, size, and nodal involvement dramatically decreasing as a result of mammographic screening Arch Surg 1996, 131(3):301-308 Fisher B, Slack NH, Bross ID: Cancer...

Ngày tải lên: 09/08/2014, 03:21

... TNBC TNF TSS UTR WT Xist Interleukin Interleukin Ingenuity pathway analysis NF-κB inhibitor α Jumonji D3 Lymphotoxin β Maltose-binding protein Methyl-CpG binding domain proteins Micro RNA Messenger ... emerged, for instance claudin-low breast cancer (Table 1.1 and Table 1.2) (Peddi et al., 2012) In this thesis, my focus will be on the basal-like and luminal breast cancer in general Intrinsic subtypes ... essential roles in promoting breast cancer in general, including both BLBC and luminal breast cancer (Cleator et al., 2007; Santana-Davila and Perez, 2010) For example, PI3K/AKT/mTOR and Ras/MEK/MAPK...

Ngày tải lên: 09/09/2015, 17:53

... ligand-binding domain with two cysteine-rich regions, a hydrophobic short transmembrane domain, and an intracellular domain that contains a catalytic tyrosine kinase domain and a carboxyl terminal ... 0, in which cells containing

Ngày tải lên: 11/09/2015, 10:06

... reduce ERa and SP1 protein levels in pancreatic cancer cells [33] Estrogen receptors (mainly ERa and ERb) constitute a group of ligand-activated nuclear receptors that are activated by estrogen ... diseases, including cancer, miRNAs have been considered to be potential drug candidates or therapeutic targets [10] Breast cancer is one of the most common and prevalent cancers in women and a leading ... regulator of ESR1 encoding estrogen receptor a (ERa) and demonstrated that miR-22 is frequently downregulated in ERa-positive human breast cancer cell lines and clinical samples In addition, further...

Ngày tải lên: 22/03/2014, 21:20

... the kinase selects primarily acidic residues (including phosphotyrosine and phosphothreonine) and asparagine, and is also tolerant of hydrophobic residues such as leucine and isoleucine (Fig and ... starting model in order to obtain initial phasing [27] Manual rebuilding was performed using wincoot [28] and refined using refmac [29,30] in the ccp4i program suite [31] The coordinates and structure ... ephrin receptor tyrosine kinase A3 (EphA3) Structure 16, 873– 884 21 Hubbard SR (1997) Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and...

Ngày tải lên: 16/03/2014, 02:20

... transforming growth factor-β and IL-10 In addition, Gas-6 on apoptotic cells binding to receptor kinases of Tyro family (mer, tyro and axl) downregulate inflammatory cytokines, IL-12 and TNFα during ingestion, ... adaptive and innate immune systems in both responding to infections and inducing autoimmunity Theapeutic implications Toll-like receptors as therapeutic targets As data linking TLR activation and ... (MFG-E)8 and tyro kinases, because alterations in these proteins are associated with autoimmunity Apopotic cells express binding sites for C1q and C3b/bi that can bind to the CR3 and CR4 complement receptors...

Ngày tải lên: 09/08/2014, 10:21

... for generating and maintaining peripheral tolerance, a key component in the prevention of autoimmunity, as well as stimulating immune responses in appropriate settings [3] well as (in the case ... uptake receptors involved in pathogen recognition and self-nonself discrimination [16] Type III complement receptor (CR3), CD11b/CD18, is a β2-integrin that serves both as an adhesion molecule and ... antigen-recognition and antigen-uptake receptors, internalizing and processing for efficient presentation to effector cells CTLRs can also recognize endogenous glycoproteins and can bind cellular adhesion...

Ngày tải lên: 09/08/2014, 13:22

... cocktail containing serine/threonine phosphatase inhibitors and one containing tyrosine phosphatase inhibitors) was also used Protein kinases were digested with lysyl endopeptidase and trypsin and subsequently ... López et al.: Discovering and validating unknown phospho-sites from p38 and HuR protein kinases in vitro by Phosphoproteomic and Bioinformatic tools Journal of Clinical Bioinformatics 2011 1:16 ... the amino acid sequence was inspected to look for indications of why these y/b-ions were missing Peptides lacking a C-terminal arginine or lysine residue, due to a C-terminal position in the...

Ngày tải lên: 10/08/2014, 09:22

... adhesion involves the interaction of leukocyte integrins of the beta subfamily (CD11a, CD11b and CD11c) with endothelial ligand receptors [19] An increase in the expression of those integrins on ... membrane and binds to protein kinase C independent of cell receptor interaction, fMLP and LPS (bacterial agents from Gram-positive bacteria and Gram-negative bacteria, which have distinct receptor ... Care Vol 12 No Martins et al The pathogenesis of sepsis involves a complex interaction between host and infecting microorganism, including bacterial recognition, cell activation and transmigration,...

Ngày tải lên: 13/08/2014, 10:20

... 113 4.2.1.4.6 Standardisation via checking on β-actin 114 4.2.2 Determination of Saturating Doses of Known AKR1C3 Inhibitor and Dimethoxycurcumin and its Potential as AKR1C3 Enzyme Inhibitor 4.2.2.1 ... and T6 (p-value < 0.05) and T5 and T6 (p-value < 0.05), where under T6, which contains 50 µM Dimethoxycurcumin can induce a significant increase in intracellular 3β-Diol, a selective ERβ ligand ... Based on the Singapore Cancer Registry, PCa is ranked as the third most commonly diagnosed cancers in men but ranked sixth in cancer- causing deaths in Singapore between 2008 to 2012 In addition,...

Ngày tải lên: 09/09/2015, 08:14

... C-terminus domain, to expose binding sites for Src- homology-2 (SH2) domain-containing proteins and phosphotyrosine-binding (PTB) domain-containing proteins Adaptor proteins with a SH2-binding domain such ... epitope tag heparin-binding epidermal growth factor protein kinase C-related kinase homology region IQ motif containing GTPase activating protein infrared insulin receptor tyrosine kinase substrate ... regulate activation of Cdc42, including the tyrosine kinase receptors like ErbBs, G-protein-coupled receptors and T-cell receptors (TcR) (19, 22, 59, 60) These receptors receive external signals...

Ngày tải lên: 14/09/2015, 14:25

... 1.1 Breast cancer and estrogen 1.1.1 Breast cancer and estrogen 1.1.2 Estrogen and its role in human physiology 1.1.3 Estrogen and the estrogen receptor 1.1.4 Molecular mechanism of the estrogen ... estrogen receptor 1.2 RET gene 1.2.1 RET and its isoforms 1.2.2 RET gene and its role in human physiology 1.3 Long range chromatin interactions 1.3.1 Estrogen receptor binding sites in breast cancer ... al 1997) 1.1.3 Estrogen and the estrogen receptor Estrogen functions through binding to the estrogen receptors The estrogen receptor (ER) belongs to a subfamily of the nuclear receptor superfamily...

Ngày tải lên: 05/10/2015, 21:29

... continuing advances in technical and professional knowledge Certain principles remain just as important in diagnosis as they are in screening Training, multidisciplinary teamwork, monitoring and ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual...

Ngày tải lên: 15/03/2014, 00:20

... gene encoding the chimeric protein of caspase-8 and the ligand-binding domain (LBD) of ERα and introduced the gene into breast cancer cell lines (Zhao et al, 2011) Upon administration of estrogen, ... prolonged oestrogen deprivation Br J Cancer 74(8): 1227-1236 Pink, J J and V C Jordan (1996) Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines Cancer ... organs, including mammary glands, in female goats and sheep (Glascock and Hoekstra 1959) This finding was a crucial observation to understand the role of estrogens in processes involving target...

Ngày tải lên: 23/03/2014, 17:20

... type 1, interleukin and C-C chemokine receptors Chemokines [27,28] and angiotensin II [29] have both shown growth-inhibiting properties with different cancers Interestingly, an orphan receptor ... factors and steroid hormones Progestin administration causes an initial increase in cell proliferation lasting about 12–24 h and subsequent GPR30 and progestin (Eur J Biochem 269) 2489 inhibition ... preferentially in endocrine tissues [12–14], and some G protein-coupled receptors are known to be involved in growth regulation The regulation of GPR30 expression in MCF-7 cells was progestin specific and...

Ngày tải lên: 24/03/2014, 00:21

... TRAIL binds to death receptors, DR4 and DR5, and recruits Fas-associated death domain protein to the receptors Caspase-8 is activated and subsequently activates downstream caspases Hypoxia inhibits ... truncated BRCA1 or induce apoptosis in a cell line expressing mutated BRCA1 The data in Figs and suggest that TRAIL can alter BRCA1 localization and induce apoptosis in breast cancer cells Therefore, ... to increase We observed an increase in HIF-1a protein, and thus were confident that the cells were being maintained in a low-oxygen environment and were responsive to low oxygen There is also increasing...

Ngày tải lên: 30/03/2014, 03:20

... ferently, using the anti-ErbB-2 antiserum cross reacting with the murine receptor resulted in a faint stain of the cytoplasm and rarely in staining of the membrane of the tumor cells (Figure 3B) In the ... positive staining for antiTid in 40% of the cases investigated (Figure 1B-D) Correlation between htid and ErbB-2 expression in breast and non -breast tumors over expressing the ErbB-2 receptor as ... pathway and the E-Cadherin mediated signalling or the Inhibitor of IKB in the NFκB signalling [11], crucial for driving the expression of regulators of cell cycle control, or ii) binding to receptors...

Ngày tải lên: 18/06/2014, 16:20

... gene encoding the chimeric protein of caspase-8 and the ligand-binding domain (LBD) of ERα and introduced the gene into breast cancer cell lines (Zhao et al, 2011) Upon administration of estrogen, ... prolonged oestrogen deprivation Br J Cancer 74(8): 1227-1236 Pink, J J and V C Jordan (1996) Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines Cancer ... organs, including mammary glands, in female goats and sheep (Glascock and Hoekstra 1959) This finding was a crucial observation to understand the role of estrogens in processes involving target...

Ngày tải lên: 27/06/2014, 11:20