role of oxidative stress in breast cancer

... essential role in the activation of ROS/ Akt signaling and cell invasive phenotype and identify a novel link between RAB35 and MICAL1 in regulating breast cancer cell invasion These findings may ... involved in cancer cell growth and survival regulation [3, 4] MICAL1 has four conserved domains: an N-terminal flavin adenine dinucleotide (FAD) binding domain, a calponin homology (CH) domain, ... determined by immunoblotting assays (Fig 1a) Enhanced motility of breast cancer cells is a critical step in promoting tumor metastasis, but roles of MICAL1 in breast cancer motility remain to

Ngày tải lên: 20/09/2020, 14:58

... major cause of morbidity and mortality in breast cancer patients Brain metastasis is an increasingly common complication in breast cancer patients, possibly a consequence of improvements in systemic ... expression of MMP-1 contributes to the brain colonizing potential of human breast cancer cells in xenograft models of cancer progression Members of the MMP family play important roles in normal ... initiation in the mammary fat pad and its reduction has no effect on proliferation of breast cancer cells in vitro, silencing expression of MMP-1 reduced tumor growth in vivo Inhibition of MMP-1 in 231-BR

Ngày tải lên: 05/11/2020, 08:01

... secretion of follistatin from ER-ve breast tumours that is not seen in ER + ve tumours Follistatin is a paracrine antagonist of activin and both proteins modify breast cancer cell proliferation Activin ... indicate that exogenous neutralisers of activin, i.e follistatin, are responsible for the lack of inhibition of proliferation in response to activin in ER-ve cell lines, rather than absence of/ non ... Follistatin binds to activin preventing binding the type II receptor Phosphorylation at the linker region of Smad2 or smad3 occurs downstream of cytoplasmic proteins such as RAS and nuclear proteins

Ngày tải lên: 30/09/2020, 13:50

... pathway in VSMC and the potential role of oxidative stress We also aimed at evaluating the role of protein kinase C (PKC) in the putative glucose-induced, oxidative stressmediated impairment of the ... phosphorylation induced by the NO/cGMP signalling, underlining the role of oxidative stress in this phenomenon Our working hypothesis was that high glucose increases in a short-term oxidative stress by ... endothelial and in the media layers of the aorta, indicating the occurrence of a PKC-mediated increase of oxidative stress in VSMC, the main component of the media [40] Furthermore, acetylcholine induced

Ngày tải lên: 02/11/2022, 08:46

... repurposed in treating breast cancer ER-case The in vivo validation shows that targeting ACHE gene could inhibit the breast cancer cell line growth, which is a promising result before applying for clinical ... In the prior study [8], by modeling the gene expression dynamic in breast cancer and applying system control theory, we suggested 10 drugs promising for breast cancer repurposing For breast cancer ... synthesizing new compounds Prominent successful examples for drug repurposing include viagra, avastin, and rituxan [6] Informatics Institute, School of Medicine, the University of Alabama at Birmingham

Ngày tải lên: 20/01/2020, 05:25

... of E-cadherin and low expression of vimentin found in HS in comparison to ML Among the predicted features between HS and ML was the involvement of miRNA-9 in this switch Importantly, the bioinformatics ... condition of the tissues in vivo, in regards of i) architectural organization and the processes of glandular lumen formation, ii) cell-to-cell interaction, and iii) the role of cancer genes in cell ... Prediction of the involvement of EMT in HS/ML from the cell microarray data Venn diagram showing the number of genes involved in EMT in both ML and HS from the cell microarray Table (upper right) showing

Ngày tải lên: 17/06/2020, 11:40

... (AR) signaling plays a significant role in subsets of breast cancer Clinical trials testing AR-targeting therapies in breast cancer have been conducted Assessment of AR-signal in breast cancer tissue ... postmenopausal breast cancer Keywords: Breast cancer, Androgen signal, Androgen receptor, PSA Background Breast cancer is the most common malignancy in women worldwide and one of the leading causes of cancer ... diaminobenzidine (DAB) and counter-stained with hematoxylin AR immunoreactivity was detected in the nuclei of breast carcinoma cells, and the percentage of immunoreactive cells, i.e., labeling index

Ngày tải lên: 17/06/2020, 18:57

... committees of the participating hospitals Distribution of breast cancer cells in the ovary The distribution of breast cancer cells in ovarian tissues was evaluated using the original H&E-stained sections ... expression of cell-surface proteins in invasive breast tumors and their corresponding ovarian metastases In patients diagnosed with ductolobular breast cancer, the expression of EMA in the invasive breast ... corresponding ovarian metastases Marker % of positive tumor cells in invasive ductal carcinoma % of positive tumor cells in invasive lobular carcinoma % of positive tumor cells in invasive ductolobular

Ngày tải lên: 19/09/2020, 21:34

... magnitude of the metagenes and prognosis in breast cancer, colon cancer and head and neck cancer (Table 3A and B) However, in kidney clear cell carcinoma and lung adenocarcinoma Winslow et al BMC Cancer ... compartment of breast cancer tumors using global RNA analyses of laser-microdissected tumors followed by bioinformatics expansion by correlation analyses using The Cancer Genome Atlas (TCGA) breast cancer ... poor prognosis in renal clear cell carcinoma and in lung adenocarcinoma but not in other cancers investigated Explorative Cox modeling using gene pairs identified gene sets that in multivariate

Ngày tải lên: 20/09/2020, 18:27

... For classifying the grading of Page of 13 breast cancer, we applied the morphological assessment of the degree of differentiation of breast cancer described by Elston et al [22] Information on ... during bone resorption [13] Improving knowledge about the interaction of breast cancer cells and bone environment could help to determine and to define a subgroup of women and subtypes of breast ... three study groups: invasive ductal breast cancer, invasive lobular and others (comprising medullar, tubular and mucinous breast cancer subtypes) To define the biological breast cancer subtypes,

Ngày tải lên: 21/09/2020, 01:22

... patients with Luminal B breast cancer Conclusions: Cathepsin K induces platelet dysfunction and affects signaling in breast cancer cells Keywords: Cathepsin K, Platelets, Breast cancer, Protease ... thrombin receptor in mouse platelets; however, its role in humans remains uncharacterized [11, 19–21] In this scenario, the link between human cysteine cathepsins and platelet functions in malignant ... proteinases in tumor tissues, including breast, prostate, and colon cancer, and malignant melanomas, have been reported [11, 14] In addition, abnormalities in blood coagulation are common in malignant

Ngày tải lên: 21/09/2020, 02:04

... provide insight into mechanisms of CA in a large cohort of breast cancers The consequences of CA in human cancer also remain unclear CA is a key mechanism of chromosomal instability (CIN), the ... reported in small sample sizes to be a hallmark found in diverse cancer types [3], and is often found early in carcinogenesis, including in precursor lesions of breast cancer [22] Likewise, we find ... lacked co-staining with polyglutamylated Page of 13 tubulin An average of 78 % of pericentrin foci contained this centriolar marker in normal samples compared to an average of 46 % in breast tumors

Ngày tải lên: 21/09/2020, 11:21

... Background Identification of specific therapeutic targets in cancer tissues is essential to select the most appropriate anti -cancer drugs In the case of breast cancer, determining estrogen receptor ... material as routinely used in the clinical setting were selected for immunohistochemistry Immunostaining was performed using routine methods on a DAKO Autostainer (Dako, Carpinteria, CA) For ... controls were included in each batch of immunostains The results of immunohistochemistry were assessed by two pathologists (N.H and R.H.) in a blinded fashion, independently examining the whole

Ngày tải lên: 22/09/2020, 23:39

... estrogen-induced ERK signaling by inducing ID proteins Since AB215 inhibits E2-induced growth of ERα+ breast cancer cells and ERK1/2 signaling, we hypothesized that AB215 induction of ID proteins ... morphogenetic protein, Tamoxifen alternative, Inhibitor of DNA binding proteins, Bio-better, AB215 Background Breast cancer is one of the leading causes of death for women worldwide, particularly in developed ... estrogen signaling by inducing expression of inhibitor of DNA binding proteins (IDs) Specifically, we demonstrate that knockdown of ID proteins attenuates the anti-estrogen effects of AB215 Remarkably,

Ngày tải lên: 14/10/2020, 13:41

... overview of involving in main knowledge of chapter two The concepts of sentence stress are identified clearly according to many points of view Some functions of sentence stress are also found in this ... sentence stress while speaking Some of them about 12.5% often use sentence stress in communication, representation, and reading 25% of them rarely use sentence stress in English speaking competence ... of sentence stress Particularly, the role of sentence stress is emphasized and mainly focused in English intonation patterns Sentence stress is another golden key for speaking and understanding

Ngày tải lên: 08/04/2021, 08:15

... overview of involving in main knowledge of chapter two The concepts of sentence stress are identified clearly according to many points of view Some functions of sentence stress are also found in this ... sentence stress while speaking Some of them about 12.5% often use sentence stress in communication, representation, and reading 25% of them rarely use sentence stress in English speaking competence ... of sentence stress Particularly, the role of sentence stress is emphasized and mainly focused in English intonation patterns Sentence stress is another golden key for speaking and understanding

Ngày tải lên: 05/08/2021, 21:24

... Page of 11 enzymes in cancer are potential targets of several classes of inhibitors, including DNMT inhibitors (DNMTis), HDAC inhibitors (HDACis), and the recently developed inhibitors of histone ... shown to induce re-expression of ESR1 in breast cancer cells [24] So regardless of the type of agent, inhibition of DNMTs results in re-expression of tumor suppressor genes associated with inhibition ... Efficacy of epi-drugs in breast cancer patients The efficacy of DNMTis and HDACis in breast cancer was evaluated in 21 phase I and II studies that enrolled 303 patients with breast cancer (Table 1) In

Ngày tải lên: 02/11/2022, 09:18

... higher in normal breast cell line (MCF10A) than breast cancer cell lines (MCF7, SK-BR-3, and MDA-MB-231) Proliferation rate in breast cancer cell lines Up-regulation of p53 in breast cancer cell lines ... overview of the role of PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer ... the finding of early markers for therapeutic intervention that has disease modifying effect, in hope of bringing down death due to breast cancer In addition, the contribution of PrP to breast cancer...

Ngày tải lên: 12/10/2015, 17:36

... to this kind of stress in referring, proclaiming, and reporting utterances Tonic stress is almost always found in a content word in utterance final position Consider the following, in which the ... clear to you The role of sentence stress in enhancing English speaking competence Sentence stress is the governing stress in connected speech All words have their individual stress in isolation When ... 34 8.1 Final intonation 36 8.1.1 Rising-falling intonation 36 8.1.2 Rising intonation 37 8.2 Non-final intonation 39 8.2.1 Rising-falling intonation...

Ngày tải lên: 17/03/2014, 16:12

... use of vitamin E and vitamin C in combination reduced the prevalence and incidence of AD in an elderly population; however, the use of either of these vitamins alone had no effect [110] Finally, ... gp91phox and an increase in p47phox protein expression in monocytes primed with INFγ [59] Figure Activation of the Rac GTPase Activation of the Rac GTPase GTP-binding of the Rac protein confers an ... src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved in upstream signaling cascades responsible...

Ngày tải lên: 19/06/2014, 22:20