2mechanisms underlying er loss in breast cancer
báo cáo khoa học: "ShRNA-mediated gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF-7 in vitro" pptx
... recovered positive in ER- negative human breast cancer cell lines MDA-MB231, and protein levels of MMP-9 and CyclinD1 were down-regulation (P < 0.05) However, in ER alpha-positive breast cancer ... were down-regulated(*P < 0.05) But in ERapositive breast cancer cells MCF-7, protein levels of ER alpha, MMP-9 and CyclinD1 had no distinct difference in three groups (P > 0.05) MTA1 in two breast ... gene silencing of MTA1 influenced on protein expression of ER alpha, MMP-9, CyclinD1 and invasiveness, proliferation in breast cancer cell lines MDA-MB-231 and MCF7 in vitro Journal of Experimental...
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Tài liệu Guidance on Cancer Services Improving Outcomes in Breast Cancer pdf
... Co-ordinating Group Cancer Services Co-ordinating Group 2000 22 Dewar JA, Twelves CJ, Thomson CS for the Scottish Breast Cancer Focus Group and the Scottish Cancer Therapy Network Breast Cancer in ... from breast cancer in England and Wales in 2000 (Table 1), breast cancer survival rates are higher than those for any other major cancer in women except endometrial cancer and have been improving ... six extra breast cancers per thousand women, increasing the individual risk over 20 years (age 50 to 70) from one in 22 to one in 19.12 Berrino F et al Survival of Cancer Patients in Europe:...
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European guidelines for quality assurance in breast cancer screening and diagnosis pot
... population, in co-operation with cancer registries and clinicians, This includes cancers diagnosed outside screening (interval cancers, cancers in non attenders, cancers in women not invited) All ... screening should be established in line with the routine screening interval, taking into consideration that most programmes not succeed in keeping the routine screening interval for each individual ... 20:53 Pagina 24 EPIDEMIOLOGICAL GUIDELINES FOR QUALITY ASSURANCE IN BREAST CANCER SCREENING Table 8: Mode of invitation Mode of invitation Initial screening* Invitation Reminder Interval* (yes/no)...
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Targeting New Pathways and Cell Death in Breast Cancer Edited by Rebecca L. Aft docx
... known HER ligands bind directly to HER2 with high affinity, heregulin, a cytokine secreted by the breast stromal cells, can activate HER2 by inducing or stabilizing heterodimers with other HER receptors ... growth of breast cancer cells, to trigger the apoptotic signaling in breast cancers, thus switching the estrogenic hormones from potential mitogens to apoptosis inducers in breast cancers (Shi, ... activity in treatment of breast cancers in a phase I trial, and conferred therapeutic benefits in combination with chemotherapy in triple-negative breast cancers without an increase in normal...
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Báo cáo Y học: Progestin upregulates G-protein-coupled receptor 30 in breast cancer cells pot
... angiotensin II type 1, interleukin and C-C chemokine receptors Chemokines [27,28] and angiotensin II [29] have both shown growth-inhibiting properties with different cancers Interestingly, an ... other genes These were expressed in MPA-treated cells, but not in the control cells at either 24 or 48 h in differential display analysis Progestins upregulate GPR30 mRNA in MCF-7 breast cancer ... progestin-induced growth inhibition in breast cancer cells Figure 2A shows that GPR30 mRNA expression correlated with cell growth as the dose of MPA increased; this further indicated progestin-dependent...
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Delayed presentation in breast cancer: a study in Iranian women docx
... delay in operable breast cancer patients Eur J Cancer Prev 2001, 10:53-59 Ebrahimi M, Vahdaninia M and Montazeri A: Risk factors for breast cancer in Iran: a case-control study Breast Cancer Research ... patients with breast cancer presented to a doctor earlier [28] Finally, it is worth noting that there were several limitations inherent in this study and the findings cannot be generalized beyond ... diagnosed breast cancer patients who were admitted to a university hospital or attending a breast clinic in Tehran, Iran were interviewed following their surgery or first course of chemotherapy between...
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Báo cáo khoa học: BRCA1 accumulates in the nucleus in response to hypoxia and TRAIL and enhances TRAIL-induced apoptosis in breast cancer cells pdf
... to increase We observed an increase in HIF-1a protein, and thus were confident that the cells were being maintained in a low-oxygen environment and were responsive to low oxygen There is also increasing ... or enhancer for its biological activity Finally, our experiments were performed in the presence of 1% serum, whereas other studies were performed in 10% serum With the low level of in vivo toxicity ... tissue oxygen distribution in breast cancers by computerized O2 tension measurements Cancer Res 51, 3316–3322 Semenza GL (2003) Targeting Hif-1 for cancer therapy Nat Rev Cancer 3, 721–732 Kim M, Park...
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Báo cáo khoa học: Towards discovery-driven translational research in breast cancer pdf
... other hand, is expected to yield superior classification of serum protein features of a number of cancers in the near future [47] Translational research in breast cancer Breast cancer Breast cancer ... This integrated approach should lead to a better understanding of the underlying biology of living cells and organisms, resulting in turn in a more effective translation of basic discoveries into ... Translational Breast Cancer Research (DCTB), to fight breast cancer DCTB hosts scientists working in various areas of preclinical cancer research (cell cycle control, invasion and microenvironmental alterations,...
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báo cáo hóa học:" Optical imaging of the peri-tumoral inflammatory response in breast cancer" docx
... lower incidence of breast cancer [1,2] It has also been noted that as breast cancer progresses, there is a corresponding increase in the number of leukocytes, both of lymphoid and myeloid origin, ... human breast cancer Clin Cancer Res 2000, 6:3282-3289 Jin H, Su J, Garmy-Susini B, Kleeman J, Varner J: Integrin alpha4beta1 promotes monocyte trafficking and angiogenesis in tumors Cancer Res 2006, ... adaptive and innate immune cells during breast cancer progression Breast Cancer Res 2007, 9:212 Balkwill F, Charles KA, Mantovani A: Smoldering and polarized inflammation in the initiation and...
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Báo cáo hóa học: " In vivo evidence of htid suppressive activity on ErbB-2 in breast cancers over expressing the receptor" potx
... expression are inversely correlated in breast cancer either primary (p < 0.0001) or metastatic (p < 0.023), in primary non -breast tumors (p < 0,007) and in breast tumors generated in HER-2/neu transgenic ... anticancer activity of the hTid proteins occurs through the interference with multiple oncogenic pathways by binding and modifying functions of key molecules maintaining intracellular signalling ... lesions) were characterized by positive staining ranging from moderate to intense staining In the context of the potential association of htid expression with the biology of human breast cancers of...
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báo cáo hóa học: " Responsiveness of the EQ-5D in breast cancer patients in their first year after treatment" ppt
... measurement in randomized clinical trials in breast cancer – taking stock Journal of the National Cancer Institute 2003, 95(4):263-281 Montazeri A: Health-related quality of life in breast cancer patients: ... requiring hospital visits There were no age restrictions Patients were included in the trial after finalizing treatment and after giving written informed consent Treatment included surgery and/or ... M, Dehing C, Lambin P, Boersma LJ: Follow-up after curative treatment for breast cancer: why we still adhere to frequent outpatient clinic visits? Eur J Cancer 2007, 43(4):647-653 Koinberg IL,...
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TARGETING NEW PATHWAYS AND CELL DEATH IN BREAST CANCER pot
... known HER ligands bind directly to HER2 with high affinity, heregulin, a cytokine secreted by the breast stromal cells, can activate HER2 by inducing or stabilizing heterodimers with other HER receptors ... growth of breast cancer cells, to trigger the apoptotic signaling in breast cancers, thus switching the estrogenic hormones from potential mitogens to apoptosis inducers in breast cancers (Shi, ... activity in treatment of breast cancers in a phase I trial, and conferred therapeutic benefits in combination with chemotherapy in triple-negative breast cancers without an increase in normal...
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Báo cáo y học: "Physical Exercise and Quality of Life in Breast Cancer Survivors" potx
... understand a population’s health status [22] There is a growing interest in the possible role of exercise in enhancing QOL, reducing recurrence and other diseases, and extending survival in cancer ... SL Moderate exercise training and natural killer cell cytotoxic activity in breast cancer patients Int J Sports Med 1995;16:334-7 Stoll BA Diet and exercise regimens to improve breast carcinoma ... prognosis Cancer 1996;78:2465-70 Courneya KS Exercise interventions during cancer treatment: biopsychosocial outcomes Exerc Sport Sci Rev 2001;29:60-4 McTiernan A Physical activity after cancer: physiologic...
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báo cáo khoa học: "Clinical significance of preoperative serum interleukin-6 and C-reactive protein level in breast cancer patients" pot
... invasion begins with inflammation around cancer cells Thus, it has been reported that serum CRP levels are higher in cases of invasive cancer than in cases of non-invasive cancer [8,9] The principal ... TNM staging system of breast cancer thus indirectly correlating with the prognosis of the patient CRP estimation does not seem to be very useful in evaluating the patient with breast cancer, though ... Orditura M, Auriemma A, Infusino S, Roscigno A, Catalano G: Serum levels of interleukin as a prognostic factor in advanced nonsmall cell lung cancer Oncol Rep 1998, 5:649-652 Erlinger TP, Platz EA,...
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báo cáo khoa học: "CCR9-CCL25 interactions promote cisplatin resistance in breast cancer cell through Akt activation in a PI3K-dependent and FAK-independent fashion" pptx
... penetrating into the gastric lumen and pericolic soft tissue Other gastrointestinal tumors may also contain calcification At least three types of calcification have been reported in gastric cancer: ... Spurt bleeding from a calcificated gastrointestinal stromal tumor in the stomach J Nippon Med Sch 2005, 72(5):304-307 Balestreri L, Canzonieri V, Morassut S: Calcified gastric cancer CT findings before ... Liegl-Atzwanger B, Fletcher JA, Fletcher CD: Gastrointestinal stromal tumors Virchows Arch 2010, 456(2):111-127 Miettinen M, Lasota J: Gastrointestinal stromal tumors–definition, clinical, histological,...
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Báo cáo khoa học: "Ductal carcinoma in situ and sentinel lymph node metastasis in breast cancer" potx
... not increase local recurrence rate in breast cancer patients Breast Cancer Res Treat 2006, 97:9-15 Peters-Engl C, Konstantiniuk P, Tausch C, Haid A, Hoffmann B, JagoutzHerzlinger M, Kugler F, ... characteristics Sentinel lymph nodes were sectioned at 0.2 cm intervals, and examinations were based on frozen sections in most cases Whether or not metastasis was present was determined intraoperatively ... survival in invasive breast cancers [24] In conclusion, we found that the incidence of sentinel lymph node metastasis in cases of pure DCIS was 0.39% This incidence was lower than that in IDC-predominant...
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Báo cáo khoa học: "Postmastectomy locoregional recurrence and recurrence-free survival in breast cancer patients" pdf
... Thun MJ: Cancer statistics, 2005 CA Cancer J Clin 2005, 55(1):10-30 American Cancer Society: Cancer Facts & Figures 2004 Atlanta, GA, American Cancer Society; 2004 Cady B, Stone MD, Schuler JG, ... Lichter A, Lippman M, Danforth D, Swain S, Cowan K, deMoss E, MacDonald H, Steinberg S, d'Angelo T, et al.: Results of the National Cancer Institute early breast cancer trial J Natl Cancer Inst ... Kjaer M, Gadeberg CC, Mouridsen HT, Jensen MB, Zedeler K: Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy Danish Breast Cancer...
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Báo cáo khoa học: "Comparison of immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) assessment for Her-2 status in breast cancer" ppsx
... in tissue fixation and processing, variable sensitivity and specificity of commercially available antibodies, and differences in scoring criteria with considerable interobserver variability in ... fluorescence in situ hybridization and correlation with immunohistochemistry in a cohort of 6556 breast cancer tissues Clin Breast Cancer 2004, 5(1):63-9 Dybdal N, Leiberman G, Anderson S: Determination ... Traditional Chinese Medicine Hospital which are the two main hospitals for the treatment of breast cancer in Guilin city of China The specimens were fixed in 10% neutral-buffered formalin (pH7.4) for 24...
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Báo cáo khoa học: "Clinical efficacy and problems with CT lymphography in identifying the sentinel node in breast cancer" docx
... Japanese Breast Cancer Society Breast Cancer Res Treat 2000, 63:31-40 Feldman SM, Krag DN, McNally RK, Moor BB, Weaver DL, Klein P: Limitation in gamma probe localization of the sentinel node in breast ... Peterse JL, Olmos RA, de Vries J: Lymphatic mapping with intralesional tracer administration in breast carcinoma patients Cancer 2000, 88:2546-2552 Leong SPL: Selective sentinel lymph node mapping ... aspects and controversies Breast Cancer 2007, 14:25-30 Giuliano AE, Jones RC, Brennan M, Statman R: Sentinel lymphadenectomy in breast cancer J Clin Oncol 1997, 15:2345-2350 Minato M, Hirose C,...
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Báo cáo khoa học: "Reduction of radiation pneumonitis by V20-constraints in breast cancer" pps
... Kuter I, Younger J, Schoenthaler R, Roche M, Powell SN: Risk of pneumonitis in breast cancer patients treated with radiation therapy and combination chemotherapy with paclitaxel J Natl Cancer Inst ... instrument for use in international clinical trials in oncology J Natl Cancer Inst 1993, 85:365-376 21 Sprangers MA, Groenvold M, Arraras JI, Franklin J, te Velde A, Muller M, Franzini L, Williams ... symptomatic RP was rare in this study when 3-D treatment planning, aiming at minimizing V20 to the ipsilateral lung to
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