The study of GRIM 19 function in mitochondria

... identified including GRIM- 19 Knockout of GRIM- 19 by expression of GRIM- 19 antisense mRNA conferred tumor cells with a strong resistance against IFN/RA-induced cell death Overexpression of GRIM- 19 in ... Like most of mitochondrial Complex I subunits, GRIM- 19 may contain the mitochondrial import signal and the mutation of GRIM- 19 may affect the assembly...

Ngày tải lên: 11/09/2015, 16:07

... (>0.3µM) inhibits the opening of InsP3Rs Thus, during the onset of InsP3Rs opening, the release of Ca2+ increases the sensitivity of InsP3Rs, resulting in a rapid rise in Ca2+ levels Once the Ca2+ ... to the low-affinity sites of calcineurin B and affects the conformation change of both CnB and the regulatory domain of CnA, resulting in the exposure of...

Ngày tải lên: 14/09/2015, 08:57

... nature of goblet cell carcinoids, the location of hormones and the phenotype of endocrine cells Another useful method for simultaneous revealing of mucin secretion and endocrine cell component of the ... with the hypothesis of the dual entodermal and neuroendocrine origin of goblet cell carcinoid [1] The ultrastructural investigation showed that...

Ngày tải lên: 09/08/2014, 07:21

... Assembly on Chinese Education, Singapore: F.S Horslin, Government Printer, 1 956 Chinese Language Review Committee Chinese Language Teaching and Learning in Singapore: Report of Chinese Language ... Commission of Inquiry into Education Singapore; Final Report, Singapore: commission of inquiry into education, 1964 Singpapore Ministry of Education, Speeches ―Minist...

Ngày tải lên: 13/10/2015, 15:56

... 中学从选材开始就让该校的校本课程与规定课程之间的界线泾渭分明。 11 此个案参见 Macklin, Pamela School- based curriculum development : does it work?”, Jolimont: Incorporated Association of Registered Teachers, 20 04 12 同上。 49 2.2 以日常生活语料为题材 与培侨中学一样在选材上颇下功夫的，还有新加坡的新民中学，规定课程制作 ... 刘彩凤〈关于提高校本课程实效性的反思〉，见《华文老师》第 50 期，...

Ngày tải lên: 13/10/2015, 15:56

... 课程教学目标制定得怎样呢？ 27 Tyler, R W Basic Principles of Curriculum and Instruction (Chicago: The University of Chicago, 1950), p3 翻译笔者参阅了张华《课程与教学论》（上海：上海教育出版社，2000），页 95 -96。 28 Ibid 39 3. 2 目标任老师猜 在采访中，笔者发现，老师拿到本校校本课程的教学资料并不是一件难事，有 ... 作为规定课程的补充，以“有针对性的提高学生的华语水平”为使命的新加坡 小...

Ngày tải lên: 13/10/2015, 15:56

... 华文课程与教学法检讨委员会《华文课程与教学法检讨委员会报告书》（新加坡：该委员会）， 20 04 年，页 46。 38 同 29 ，页 - 7。 39 同 36，页 26 。 40 同 32 页 2 41 同 36，页 26 。 42 同 32 页 27 。 43 同 29 ，页 8。 44 同 36，页 27 。 25 对于讲英语家庭越来越多的新加坡，华文课可能是学生接触华文最为重要甚至 是唯一的机会，这无形中使得华文老师所扮演的角色愈发重要了。“在华文教学的 ... 61。 同...

Ngày tải lên: 13/10/2015, 15:56

... of Chinese teaching , The Straits Times, Nov 16 , 2004 Ho Ai Li, “Change in teaching methods can only be good”, The Straits Times, Nov 18 , 2004 45 Neo, Peng Fu Chinese Language Teaching in Singapore: ... Commission of Inquiry into Education Singapore; Final Report (Singapore: commission of inquiry into education, 19 64), p46 同上。 详见 Lim, Tay Boh et al Commiss...

Ngày tải lên: 13/10/2015, 15:56

... STUDY OF THE ASSOCIATED PROTEINS OF STAT3 AND CHARACTERIZATION OF THEIR FUNCTIONS: ROLES OF GRIM- 19 AND PIN1 IN THE REGULATION OF STAT3 ACTIVITY LUFEI CHENGCHEN B Sc (Hons), NUS A THESIS ... fold of human Pin1 37 Figure 3.1 Interaction of Stat3 and GRIM- 19 71 Figure 3.2 Association of endogenous Stat3 and GRIM- 19 75 Figure...

Ngày tải lên: 15/09/2015, 17:10

... compare the safety and efficacy of three bone health Plans using three independent sequentially enrolled groups of healthy women 40 years of age and older The primary outcome measure was changes in ... reviewed in the meta-analysis cited above As for the unusual finding of the increased BMD levels found in the three study groups, the superiority...

Ngày tải lên: 25/10/2012, 11:10

... Dalat 2.2.2 Chức năng, hiệu suất Marketing du lịch Dalat: Stephan Haeckel, giám đốc Viện Kinh doanh IBM, quan niệm “tương lai Marketing “một” chức doanh nghiệp, mà “cái” chức doanh nghiệp” Marketing ... Chiến lược Marketing 1.1.3.3 Chiến Lược Marketing du lịch 1.2 Vai trò chiến lược Marketing du lịch đ a phương 1.2.1 Vai trò chiến lược Marketing du lịch cho đ a phương ... lên...

Ngày tải lên: 08/04/2013, 17:02

... of insulation of an IDI diesel engine The indicated power increased at the adiabatic case 30% and 22.5% in part and full loads respectively Although in the EGR applying case, performance characteristics ... also worked as a Professor and Head of department in the Department of Mechanical Engineering, Vidya Vikas Institute of Technology, Andhra Pradesh,...

Ngày tải lên: 05/09/2013, 16:11

... Khanaqin Haditha 34 H-1 Hit 160 Km Ramadi Rutbah Baghdad Habbaniyah 33 Karbalaa AL-Hillah Kut AL-Hai Nukhaib Najaf 32 Diwaniya Amarah Semawa Nassriyah 31 Basrah AL-Salman Bussaya Shaibah Fao 30 39 ... same four points as shown in Figure Zakho 37 Rabiah Salahaddin Sinjar Mousl Tallafar Arbil 36 Sulaimaniyah Kirkuk Chamchamal Baiji 35 Tikrit Latitude ( Degree ) Ana Samarra AL-Qaim Khanaqin Ha...

Ngày tải lên: 05/09/2013, 17:03

... that EFL teachers at high schools in Nghe An had been facing a lot of difficulties in teaching listening in general and in teaching listening sections in "Tieng Anh 11" in particular The prominent ... displayed an evaluation of the pilot teaching as an evidence of effective application of listening strategies, teaching aids as well as i...

Ngày tải lên: 14/12/2013, 00:41

... 2 vinh university foreign language department == ==  == == the study of positive politeness strategies manifested in conversations in "wuthering heights" graduation thesis Field: Linguistics ... 2.1 Positive politeness strategies manifested in conversations in “ Wuthering Heights The frequency of occurrence of positive politeness str...

Ngày tải lên: 18/12/2013, 21:45