Gene regulation of snake venom prothrombin activators

... and therefore, understand the gene regulation of snake venom prothrombin activators This recruitment of trocarin D from TrFX is one of the many instances which snake venom toxins have evolved from ... “molecular fossil” of the evolution of venom prothrombin activators from blood coagulation factors (Reza et al 2006) A phylogenetic tree of the snake venom...

Ngày tải lên: 11/09/2015, 10:03

... after incubation of myelin with phospholipase A in the presence of acetylated trypsin Extensive splitting and dissociation of the myelin lamellae can be seen after incubation with trypsin and phospholipase ... phosphohydrolase activity on incubation ofpurified myelin with snake venom, phospholipase A and lysophosphatidyicholine in the presence or...

Ngày tải lên: 24/10/2014, 07:18

... confirmed by Lin-54 binding to the CHR, cooperating with E2F4 binding to the CDE in EMSAs in vitro [86] ChIP experiments on the Cdc2 gene also provided insights into the association of other cell cycle ... proteins with the promoter E2F4 binding during the cell cycle coincides with the binding of p107 or p130 [61,85] Another E2F site distal to the E2F ⁄ CDE acts...

Ngày tải lên: 16/02/2014, 09:20

... preponderant role of p38 in the regulation of gene expression at the level of mRNA stability The p38 MAP kinase is now known to stabilize a wide range of mRNAs including those encoding TNF-a, interferon ... organization of the actin cytoskeleton and the superinduction of the CTGF/ CCN2 gene Rho-like GTPases play a pivotal role in orchestrating changes...

Ngày tải lên: 19/02/2014, 16:20

... and 3) Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational regulation, ... start sites initiating biosynthesis of the 88, 77, 74 and 63 kDa iPLA2c isoforms Instead, based on current information about iPLA2c and its splici...

Ngày tải lên: 19/02/2014, 16:20

... through the same GA motif Sp1 and Sp3 bound to the same cis-element in the promoter of the gene for Dnmt1 Therefore, we next examined whether activation by Sp1 or by Sp3 affect expression of the gene ... stimulated by either pPacSp1 or pPacUSp3 (Fig 4C,D) These results indicate that both Sp1 and Sp3 enhanced transcription from the Dnmt1 promoter...

Ngày tải lên: 22/02/2014, 07:20

... 2675 Actin and ABPs in transcription regulation B Zheng et al Table Role of nuclear actin- binding proteins interacting with the androgen receptor AR, androgen receptor; LBD, ligand-binding domain ... STARS-interacting proteins These novel proteins contain four LIM domains and a C-terminal villin headpiece domain, which mediates actin- binding in several proteins,...

Ngày tải lên: 07/03/2014, 01:20

... FEBS Regulation of hPDK2 and hPDK4 gene expression Investigations into the role of PPARa and PPARd in regulating PDK expression have been performed in human skeletal muscle cells [17,18] In human ... The alpha -isoform of glycogen synthase kinase- 3 from rabbit skeletal muscle is inactivated by p70, S6 kinase or MAP kinase- activated protein kinase- 1 in...

Ngày tải lên: 07/03/2014, 17:20

... downstream of the R2 transcription initiation site are important for proper initiation of mouse R2 transcription Fig Both the R2 TATA-box and TBP are required for transcription from the R2 promoter ... further downstream from the R2 transcription start site, nucleotides +43 to +22 relative to the major transcription start site an...

Ngày tải lên: 08/03/2014, 02:20

... nature of the intracellular signaling pathways that link S1P signaling to Cyr61/CCN1 gene expression and showed that the activation of RhoA GTPase and p38 MAP kinase pathways is required for Cyr61/CCN1 ... indicate that activated RhoA regulates the Cyr61/CCN1 promoter activity through the AP-1 and CREB transcription factors The molecular steps betwe...

Ngày tải lên: 08/03/2014, 08:20

... number of protein toxins have been purified and characterized from snake venoms [1,2] and snake venoms typically contain from 30 to over 100 protein toxins Some of these proteins exhibit enzymatic ... shown Enzymatic toxins from snake venom monomeric counterparts ncHdPLA2s were isolated from Crotalinae and Viperinae snakes They consist of a basic toxic PLA2...

Ngày tải lên: 14/03/2014, 22:20

... regulation of the GnRH- I and GnRH- II genes; for instance, there are different effects of the steroid hormones E2 and P4 on the two GnRH genes Therefore, it is possible that the two forms of GnRH ... the GnRH- I promoter, and there are only a few regarding regulation of the GnRH- II gene Regulation of GnRH gene expression The GnRH- I promoter In v...

Ngày tải lên: 16/03/2014, 04:20

... (forward, 5¢-AAG GCT TAC CAC GAG CAG CTA TCA-3¢; reverse, 5¢-ACA GGC CAT GTA CTT TCC GTG TCT-3¢) and tobacco (forward, 5¢-ATG AGA GAG TGC ATA TCG AT-3¢; reverse, 5¢-TTC ACT GAA GGT GTT GAA-3¢) a- tubulinspecific ... VGCfEVY switch in regulating the expression of a zinc finger protein transcription factor isolated from Arabidopsis thaliana (AtZFP11) in both Arabidopsis and tobac...

Ngày tải lên: 16/03/2014, 06:20

... retinoic acid (RA) treatments on GnRH II promoter activity To investigate the in vivo effect of RARa and RXR on the transcriptional regulation of the hGnRH II gene, the expression vector of human ... on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells In vivo effect of RARa and RXRa with their ligands, ATRA and 9-...

Ngày tải lên: 16/03/2014, 10:20

... explaining the regulation of desA expression by binding of DmdR1 to the iron box The same overlapping was found in S pilosus DmdR1 binds to the promoter region of desABCD in both S coelicolor and ... regulation is mediated by binding of the regulatory protein DmdR1 to the iron box located in the promoter region of the...

Ngày tải lên: 16/03/2014, 11:20