regulation of growth hormone gene

... regarding regulation of the GnRH-II gene Regulation of GnRH gene expression The GnRH-I promoter In view of the fact that GnRH is essential for reproductive processes, understanding the control of its ... sequence of GnRH-II in a wide range of species and over millions of years of evolution suggests the importance of this neuropeptide The tissue distribution pattern of GnRH-II is dissimilar to that of ... actual complexity of gene regulation in the brain or other organs Only recently has the development of various transgenic mice enabled the investigation of GnRH gene expression and regulation in...

Ngày tải lên: 16/03/2014, 04:20

... [43] Roles of ABPs in the regulation of muscle-specific gene expression The cytoplasmic dynamics of the actin cytoskeleton have been shown to regulate the subcellular localization of some transcription ... effects of STARS, its target genes are expected to be highly active, irrespective of the polymerization state of actin However, STARS would be expected to further augment the expression of these genes ... activity, disruption of the AR–ABP interaction may be an important strategy by which to regulate AR-mediated growth of prostate cancer cells The expression of selective ABPs may offer a growth advantage...

Ngày tải lên: 07/03/2014, 01:20

... amounts of normalized messenger RNA were plotted as a function of time and the slope of this curve was used to calculate the interval period of time within which half of the original amount of mRNA ... compared to that of the Cyr61/CCN1 gene Specificity of these hybridization signals was established by lack of hybridization signals to the pCRII insertless vector Transcription of the GAPDH gene served ... apparent regulation of Cyr61/CCN1 gene expression through RhoA and SAPK p38 cascades is associated with the actual activation of these pathways or merely a result of nonspecific side-effects of the...

Ngày tải lên: 08/03/2014, 08:20

... during hormone- induced down -regulation and the subsequent recovery in rat corpus luteum Endocrinology 135, 1044–1051 Segaloff DL, Wang HY & Richards JS (1990) Hormonal regulation of luteinizing hormone ... of LHR mRNA to MVK The inhibitory effect of mevalonate was found to be less pronounced when compared with that of ATP There was a significant decrease at a concentration of ATP or mevalonate of ... studies have shown that binding of MVK to LHR mRNA suppresses the translation of mRNA in vitro [14] As the mutation of any of the four amino acids at the active site of MVK decreases its binding...

Ngày tải lên: 16/03/2014, 06:20

... upstream region of the diphtheria toxin (tox) gene of C diphtheriae and the desA gene of S pilosus Several putative iron boxes were found by bioinformatics analysis upstream of 10 different ORFs ... transcriptional control of the desferrioxamine cluster In this study, we report the deletion of the first gene of the desABCD gene cluster (desA) in S coelicolor A3(2), which caused cessation of desferrioxamine ... desferrioxamine gene cluster expression of the des cluster is mediated by the DmdR1 regulator Results Deletion of the desA gene of S coelicolor blocks desferrioxamine biosynthesis The organization of the...

Ngày tải lên: 16/03/2014, 11:20

... important in the control of eukaryotic cell growth [19] Further emphasizing the importance of TOR in growth- rate control, the study found that 72.5% of growth- rate-regulated genes were also responsive ... visualize the details of the experiment in the form of a matrix, as shown in Figure This experimental design is able to separate out the control of cell growth rate in terms of gene expression, protein ... Regenberg et al [10] Castrillo et al also observed upregulation of stress-responsive genes with lower growth rates In this study, transcription of genes involved in Volume 6, Article Ramanathan and...

Ngày tải lên: 06/08/2014, 18:21

... serum growth hormone to somatostatin ratio is skewed upward in rheumatoid arthritis patients Front Biosci 2004, 9:1660-1664 Denko CW, Malemud CJ: Role of the growth hormone/ insulinlike growth ... concentrations of adenohypophyseal hormones are generated by distinct amplitude and/or Page of (page number not for citation purposes) 23 24 25 26 27 28 29 30 31 32 frequency modulation of underlying ... consider any results of interest to be hypothesis-generating, in that they require confirmation in an independent, larger group of patients Additionally, the relative homogeneity of our study population...

Ngày tải lên: 09/08/2014, 10:20

... Role of growth hormone in the development of experimental renal scarring Kidney Int 1991, 40(1):29-34 doi:10.1186/1752-1947-5-400 Cite this article as: Samardzic et al.: Effect of growth hormone ... insulin-like growth factor 1; IGFBP-3: insulin-like growth factor binding protein-3; SD: standard deviation; TRP: tubular reabsorption of phosphate; rhGH: recombinant human growth hormone Page of Acknowledgements ... His overnight growth hormone (GH) profiles were normal (> peaks of > 10 μg/L) An audiometry test was also unremarkable In order to confirm a diagnosis of Dent’s disease, molecular genetic analysis...

Ngày tải lên: 10/08/2014, 23:20

... profile of the two grapevine NPR1 genes, detached leaves of Vitis vinifera cv Chardonnay were treated with a solution of BTH (a SA analog) We also monitored the expression of a grapevine PR1 gene, ... the site of primary infection [4] In the past years, considerable progress has been made in the model plant Arabidopsis thaliana in identifying genes that affect regulation of defense gene expression ... isolated in a genetic screen for plants that failed to express PR2 gene after SAR induction [5] NPR1 (Nonexpressor of PR genes 1) has been identified as a key positive regulator of the SA-dependent...

Ngày tải lên: 12/08/2014, 03:20

... the gene expression profiles of peripheral blood cells of RA patients with those of healthy controls and found that a subgroup of RA patients has an increased expression of type I IFN response genes ... response gene activity in the peripheral blood cells of approximately 50% of anti-TNF treatment-naive RA patients [13] This analysis was based on the measurement of the expression of a set of 34 ... B T0 T1 Differential regulation of interferon (IFN) response genes upon tumor necrosis factor (TNF) blockade Figure Differential regulation of interferon (IFN) response genes upon tumor necrosis...

Ngày tải lên: 12/08/2014, 11:22

... transcription of SMC differentiation genes [77] iii Regulation through combination of transcription factors/cofactors The MADS domain of SRF is a docking site for many other transcription cofactors, ... expression following RNAi knockdown of SRF Remarkably, Gene Ontology categorization of CArG element-containing genes revealed that almost half of the validated genes are associated with the actin ... Examples of this type of smooth muscle include the ciliary muscle of the eye, the iris of the eye and the piloerector muscle that causes erection of hair In single-unit smooth muscle, a whole group of...

Ngày tải lên: 24/08/2014, 13:09

... ROLES OF UBIQUITIN IN THE REGULATION OF HEAT SHOCK GENE HSP70B’ EE THIAM HEE, GARY NATIONAL UNIVERSITY OF SINGAPORE 2011 INVESTIGATIONS ON THE ROLES OF UBIQUITIN IN THE REGULATION OF HEAT SHOCK GENE ... (HONS), NUS A THESIS SUBMITTED FOR THE DEGREE OF DOCTOR OF PHILOSOPHY DEPARTMENT OF MICROBIOLOGY YONG LOO LIN SCHOOL OF MEDICINE NATIONAL UNIVERSITY OF SINGAPORE 2011 ...

Ngày tải lên: 10/09/2015, 08:27

... Role of Ubiquitin in Transcriptional Regulation 40 1.5.4 The Proteolytic Role of the Proteosome in the Regulation of Transcription 42 1.5.4 The Non-Proteolytic Role of the Proteosome in the Regulation ... Model of HSP70B’ Regulation 171 List of Symbols None List of Conventions Gene name with only first letter capitalized, i.e Protein Hsf1 Gene name entirely capitalized, i.e HSF1 Protein; often ... outside of the context of proteosomal degradation (Hicke et al., 2005) Each of these modifications has their role in the regulation of transcription In this project we investigated the role of ubiquitin...

Ngày tải lên: 10/09/2015, 08:27

... factors often leads to the recruitment of their co-repressors (Gill et al., 2005) One line of evidence that points towards the role of SUMO in transcriptional regulation is the sumoylation of MBD1 ... chains of several units of this protein was found to be covalently conjugated to substrates of the degradation reaction and that this reaction required the expenditure of ATP The conjugation of this ... 1999) Ufd2a is known to be involved in the degradation of pathological forms of ataxin-3 These forms of ataxin-3 are the cause of a neurodegenerative disorder commonly known as Machado-Joseph disease...

Ngày tải lên: 10/09/2015, 08:28

... Thyroid hormone in larval development 12 1.2.2 Molecular mechanisms of cortisol and thyroid hormones 13 1.2.2.1 Mechanism of action of cortisol 14 1.2.2.2 Mechanism of action of Thyroid hormones ... accurate, 13 definitive examination of ontogenetic questions, and will provide a better understanding of the multiple faces of hormone 1.2.2.1 Mechanism of action of cortisol Small lipophilic molecules ... investigate the ontogeny of amylase gene expression in seabass larvae and mechanism of gene regulation There were three specific objectives: To clone and sequence the α-amylase gene of seabass (both...

Ngày tải lên: 17/09/2015, 17:20

Ngày tải lên: 14/10/2016, 13:21

... prompt termination of the protein synthesis These data add to the growing body of information supporting a preponderant role of p38 in the regulation of gene expression at the level of mRNA stability ... amounts of evidence support an obligatory role for the actin cytoskeleton in the regulation of specific genes by small GTPase proteins The morphology of the actin cytoskeleton upon treatment of the ... expression of the CTGF/ CCN2 gene suggests that a key determinant factor of the effects of actin on CTGF/CCN2 expression is the actual Ó FEBS 2004 Regulatory mechanisms of the CTGF/CCN2 gene (Eur...

Ngày tải lên: 19/02/2014, 16:20

... http://www.ovarianresearch.com/content/3/1/4 Page 10 of 12 were used in this gene discovery process Foxl2 regulation of steroidogenesis appears to be of importance in the ovary, as many of the genes we identified appear ... number of genes shared between KK1 cells and the in vivo mouse data of Garcia-Ortiz et al [7] The number of shared genes increases from the embryonic stages (211&225 genes respectively) to 325 genes ... resulted in a fold activation of the GnRHR gene promoter in transient co-transfections of KK1 cells This was the first demonstration of Foxl2 regulation of the GnRHR gene in ovarian derived cells...

Ngày tải lên: 20/06/2014, 07:20

... somatomammotropin hormone 1; CSH2, chorionic somatomammotropin hormone 2; GH1, growth hormone; GH2, placental growth hormone; GH-CSH, growth hormone- chorionic somatomammotropin hormone gene cluster; ... supply and growth [24,25] GH1, through transcriptional regulation of the gene for insulin-like growth factor-I (IGF1) and related genes, has a critical role in the regulation of postnatal growth ... early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster J Clin Endocrinol Metab 2004, 89(11):5569-5576 Handwerger S, Freemark M: The roles of placental growth...

Ngày tải lên: 11/08/2014, 08:20

... mutation of the CHR leads to a more pronounced deregulation than the alteration of the CDE [40] Another gene tested for its cell cycle regulation is the cellular inhibitor of apoptosis protein gene ... in the general context of a promoter appears to be relevant because inversion of the site in the human Cdc25C promoter resulted in a deregulation of cell cycle-dependent transcription Deregulation ... to that of the CDE, with repression in resting cells and relief from downregulation later in the cell cycle Mutation of the CHR led to derepression of transcription in G0 cells [10] Genes cannot...

Ngày tải lên: 16/02/2014, 09:20