regulation of gene transcription
báo cáo hóa học: " Astrocyte production of the chemokine macrophage inflammatory protein-2 is inhibited by the spice principle curcumin at the level of gene transcription" pptx
... demonstrate that inhibition of MIP-2 by curcumin occurs at the level of gene transcription The importance of either of these elements in the regulation of inducible MIP-2 gene expression in astrocytes ... http://www.jneuroinflammation.com/content/2/1/8 Figure transcription Curcumin inhibits the activity of MIP-2 at the level of gene Curcumin inhibits the activity of MIP-2 at the level of gene transcription Confluent astrocyte ... pathogenesis of many CNS disorders that are associated with infiltration of neutrophils in the brain[9,10] Experimentally, recruitment of neutrophils to the CNS is followed by a breeching of the...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pptx
... proliferation and angiogenesis; qRTPCR analysis of gene reduction of genes over 24 hours of treatment with FGF-2 shows a significant increase in genes associated with proliferation and angiogenesis Cultures ... mineralization [1] Page of Figure qRTPCR analysis of FGF-2 regulated genes associated with mineralization; qRTPCR analysis of gene reduction of genes over a 24 hours of treatment with FGF-2 shows ... quantification of gene expression was calculated by using 2-(Ct gene T - Ct CPHI T)-(Ct gene hr - Ct CPHI hr) equation, where “Ct gene T” represents the calculated threshold cycle (C t ) of a time point of...
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báo cáo hóa học:" The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization" pdf
... proliferation and angiogenesis; qRTPCR analysis of gene reduction of genes over 24 hours of treatment with FGF-2 shows a significant increase in genes associated with proliferation and angiogenesis Cultures ... mineralization [1] Page of Figure qRTPCR analysis of FGF-2 regulated genes associated with mineralization; qRTPCR analysis of gene reduction of genes over a 24 hours of treatment with FGF-2 shows ... quantification of gene expression was calculated by using 2-(Ct gene T - Ct CPHI T)-(Ct gene hr - Ct CPHI hr) equation, where “Ct gene T” represents the calculated threshold cycle (C t ) of a time point of...
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Báo cáo khoa học: "In vitro dynamics of HIV-1 BF intersubtype recombinants genomic regions involved in the regulation of gene expression" pdf
... including transactivation of viral [16] and host cell genes, regulation of the reverse -transcription process accuracy, viral DNA nuclear import, cell cycle progression, and apoptosis regulation http://www.virologyj.com/content/6/1/107 ... delicate mechanism of regulation of viral gene expression by compensating any losses or gains in transcription levels This mechanism may play a key role in the adaptation process of recombinant variants ... expression Analysis of the major transcription factor binding sites present in the LTR revealed a high conservation of most of them Nevertheless, a remarkable high frequency of sequences harboring...
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Báo cáo khoa học: " In vitro dynamics of HIV-1 BF intersubtype recombinants genomic regions involved in the regulation of gene expression" docx
... including transactivation of viral [16] and host cell genes, regulation of the reverse -transcription process accuracy, viral DNA nuclear import, cell cycle progression, and apoptosis regulation http://www.virologyj.com/content/6/1/107 ... delicate mechanism of regulation of viral gene expression by compensating any losses or gains in transcription levels This mechanism may play a key role in the adaptation process of recombinant variants ... expression Analysis of the major transcription factor binding sites present in the LTR revealed a high conservation of most of them Nevertheless, a remarkable high frequency of sequences harboring...
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Báo cáo y học: "Social regulation of gene expression in human leukocytes" pps
... decreased expression of the GR NR3C1 gene, post-translational modification of GR protein, increased expression of GR antagonists, and decreased activity of GR transcription cofactors [37] In both ... FDR stringency in gene selection (p < 0.0001) NF-κB transcriptional response GR cross -regulation of NF-κB To determine whether increased transcription of immune activation genes in high-lonely ... combinations of promoter length and motif match Bioinformatic indications of a simulatneous decrease in transcription of GR target genes (.53-fold difference) and an increase in transcription of NF-κB/Rel...
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Báo cáo y học: "Genome-wide patterns of carbon and nitrogen regulation of gene expression validate the combined carbon and nitrogen (CN)-signaling hypothesis in plants" pptx
... nitrogen alone [36] Our studies of carbon and nitrogen regulation of gene expression in plants, combined with the studies in fungi, suggest that transcriptional regulation of genes involved in protein ... nitrogen regulation Two examples of Model are shown (genes Y and Z) For gene Y, nitrogen only has an effect in the presence of carbon, while for gene Z, carbon only has an effect in the presence of ... classes represent a broad spectrum of expression patterns that validate each of the six general models for gene regulation This analysis shows that of the 3,652 genes in the analysis, the vast majority...
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Báo cáo y học: "Translational regulation of gene expression" docx
... roles in the regulation of nearly every aspect of gene expression They often display a modular architecture, exert multiple functions and participate in more than one step of the gene- expression ... well as the intricacies of their RNA targets One of the best characterized models of translational control involving cis-acting RNA elements is the regulation of translation of maternally inherited ... ribosome The examples of regulation of protein expression by signaldependent translation (or inhibition of translation) presented at the meeting are consistent with the general prediction that...
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Báo cáo y học: "RNA interference is not involved in natural antisense mediated regulation of gene expression in mammals" docx
... is a translation block or other kind of RNA mediated regulation of gene expression, without alteration of mRNA levels Expression assessment and evaluation of mRNA levels would be recommended as ... Dicer, and the subsequent generation of siRNA The siRNA would then regulate one or both of the SAS transcripts [9,23] In summary, NAT have been proposed to regulate gene transcription, RNA splicing, ... transport, and translation [24] The aim of this study was to explore the mechanism of NAT action Shared complementary regions in exons of NAT imply the probability of cytoplasmic duplex formation, and...
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Regulation of gene expression by esrrb in embryonic stem cells
... regions of the Sall4 gene in ES cells 106 Figure 3.24 Esrrb binds to Oct4 gene in ES cells 107 Figure 3.25 The regulation of Esrrb on ES cell-associated genes 108 Figure 3.26 Expression profiles of ... region of Sox17 gene in ES cells 122 x Figure 3.31 Esrrb binds to Gata6 gene in ES cells 123 Figure 3.32 The regulation of Esrrb on developmental genes 125 Figure 3.33 Expression profile of Jmjd3 ... mapping of Esrrb binding sites 3.4.3 Distribution of Esrrb binding and gene expression profiling 3.4.4 Functional relevance of the target genes 3.4.4.1 Esrrb binds to ES cell-associated genes 3.4.4.2...
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Tài liệu Báo cáo khoa học: The central role of CDE/CHR promoter elements in the regulation of cell cycle-dependent gene transcription pdf
... in the general context of a promoter appears to be relevant because inversion of the site in the human Cdc25C promoter resulted in a deregulation of cell cycle-dependent transcription Deregulation ... the level of gene transcription [3] Interest in control mechanisms of cyclin B1 and cyclin B2 cell cycle-dependent transcription began early [3,30–33] When investigating the regulation of human ... mutation of the CHR leads to a more pronounced deregulation than the alteration of the CDE [40] Another gene tested for its cell cycle regulation is the cellular inhibitor of apoptosis protein gene...
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Tài liệu Báo cáo khoa học: Characterization of human deoxyribonuclease I gene (DNASE1) promoters reveals the utilization of two transcription-starting exons and the involvement of Sp1 in its transcriptional regulation ppt
... delineation of the transcriptional Promoters of human deoxyribonuclease I gene regulation of human DNASE1 may provide clues to the mechanisms underlying ischemia-induced elevation of DNase I activity ... efficiency of Promoters of human deoxyribonuclease I gene mRNA isoforms with different leader exons can differ, and alternative promoter usage can lead to the generation of protein isoforms differing ... No information on the regulation of gene expression in vertebrate DNase I gene, such as characterization of the promoter region and transcription factors responsible for gene expression, has been...
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Tài liệu Báo cáo khoa học: Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics docx
... stabilization of CTGF/ CCN2 mRNA rather than by transcription of the CTGF/CCN2 gene This post-transcriptional control provides an additional means of increasing the expression of the gene and ensuring ... indicating a preponderant role of p38 in Cdc42 signaling as well Role of RhoA GTPase and p38 in transcriptional and post-transcriptional regulation of the CTGF/CCN2 gene In order to determine whether ... prompt termination of the protein synthesis These data add to the growing body of information supporting a preponderant role of p38 in the regulation of gene expression at the level of mRNA stability...
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Tài liệu Báo cáo khoa học: Complex transcriptional and translational regulation of iPLA2c resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization docx
... Translational regulation of iPLA2c in myocardium Owing to the obvious complexity of the regulation of iPLA2c resulting from the combined presence of transcriptional and translational regulation, ... 2004 Regulation of iPLA2c biosynthesis (Eur J Biochem 271) 4717 Fig Genomic map of iPLA2c The intron–exon boundaries of the iPLA2c gene are shown in scale (kb) The 13 exons of the iPLA2c gene ... during adipogenesis and siRNA knockdown of iPLA2c-inhibited adipogenesis [67] Similarly, we demonstrated the dramatic up -regulation of the iPLA2c 63 kDa isoform in adipose tissue of Zucker obese...
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Tài liệu Báo cáo Y học: Regulation of transcription of the Dnmt1 gene by Sp1 and Sp3 zinc finger proteins doc
... 269) sites of initiation of transcription of Dnmt1 [24] might have been a mistake and that there is a single site only [23] To understand the regulation of expression of the Dnmt1 gene in somatic ... expression of the promoter of the gene for p21Waf1/Cip1 [28,29] Therefore, we examined the effect of p300 on the promoter activity of the Dnmt1 gene in the presence of pCMV-Sp1 and of pCMV-Sp3 ... relative to the site of initiation of transcription (+ P1, P2 and P3 indicate the probes 1) used for EMSAs (C) Binding of transcription factors to the Dnmt1 promoter Binding of transcription factors...
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Báo cáo khoa học: Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression docx
... localization of transcriptional regulators by ABPs [5] In addition, some of the mechanisms by which actin affects transcription and its regulation depend on molecular interactions of actin with ... polymerases and components of the transcription machinery in the nucleus The role of actin in transcription and its regulation Actin is both a major cytoskeletal component of all eukaryotic cells ... complexes (PICs) Injection of anti-actin Ig into the nuclei of salamander oocytes results in contraction of the lateral loops and the inhibition of transcription [8] Furthermore, Hofmann & de Lanerolle...
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Báo cáo khoa học: Sequences downstream of the transcription initiation site are important for proper initiation and regulation of mouse ribonucleotide reductase R2 gene transcription ppt
... D (1996) The general transcription factors of RNA polymerase II Genes & Dev 10, 2657–2683 Lee, T.I & Young, R.A (2000) Transcription of eukaryotic protein-coding genes Annu Rev Genet 34, 77–137 ... and also as a repressor of transcription, as a deletion or a mutation of this sequence or addition of TAFII135 antibodies leads to a three- to fivefold up -regulation of transcription from the mouse ... TAFII250-dependent transcription of major histocompatibility class I genes Proc Natl Acad Sci USA 95, 11601–11606 35 Bell, B & Tora, L (1999) Regulation of gene expression by multiple forms of TFIID and...
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Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc
... relatively modest transcriptional regulation of the CTGF/CCN2 gene occurred as compared to that of the Cyr61/CCN1 gene Specificity of these hybridization signals was established by lack of hybridization ... pCRII insertless vector Transcription of the GAPDH gene served as an internal control Regulation of Cyr61/CCN1 gene promoter According to TRANSFAC analysis [27], the promoter of either the human ... amounts of normalized messenger RNA were plotted as a function of time and the slope of this curve was used to calculate the interval period of time within which half of the original amount of mRNA...
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Báo cáo khoa học: Involvement of NF-jB subunit p65 and retinoic acid receptors, RARa and RXRa, in transcriptional regulation of the human GnRH II gene pot
... repression [35,41] The present study discusses the transcriptional regulation of the hGnRH II It is also the first report of differential regulation of the gene in two GnRH IIexpressing cell types It ... activity of hGnRH II gene in JEG-3 cells (Fig 7) Differential effects of ligand-activated RARa and RXRa on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells Over-expression of RARs ... effects of RA treatment on the promoter activity of the hGnRH II gene in TE671 and JEG-3 cells In vivo effect of over-expressing RARa and RXRa on the promoter activity of the hGnRH II gene in...
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Báo cáo khoa học: Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene doc
... FEBS 1115 Regulation of the desferrioxamine gene cluster S Tunca et al Fig Primer extension analysis of the transcription start (TS) point of the S coelicolor desA promoter Comparison of the reaction ... transcriptional control of the desferrioxamine cluster In this study, we report the deletion of the first gene of the desABCD gene cluster (desA) in S coelicolor A3(2), which caused cessation of desferrioxamine ... biosynthesis Transcriptional analysis of this region showed that the genes involved in desferrioxamine production are under iron control The transcription start point of the desA gene was shown...
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