CHARACTERIZING ROLES OF ANNEXIN 1 IN BREAST CANCER DEVELOPMENT BY MASS SPECTROMETRY BASED QUANTITATIVE PROTEOMICS

... tagging for relative and absolute quantification IAA Iodoacetamide ICAT Isotope-coded affinity tagging K0R0 12 C 614 N2-lysine and 12 C 614 N4-arginine K8R10 13 C 615 N2-lysine and 13 C 615 N4-arginine ... Annexin 1. 2 .1: Structure of ANXA1 ANXA1 is one of the members of the annexin superfamily of 13 members (A1-A13) All members of this superfamily have the same principal...

Ngày tải lên: 10/09/2015, 09:04

... majority of patients assessed were those following conservative surgery and irradiation Correlations of Acute skin scoring (RTOG) and fibrotic skin thickness Skin reactions occurring within a time interval ... means of assessing late skin toxicity in postmastectomy breast cancer patients after radiation therapy Huang et al [25] has demonstrated that skin thi...

Ngày tải lên: 09/08/2014, 09:20

Ngày tải lên: 09/08/2014, 09:20

... ZNF704 14 14 Yes Yes No No Yes 3 Yes Yes Yes SK-BR-3 CYTH1 SK-BR-3 DHX35 17 20 EIF3H ITCH 20 38 2 Yes Yes Yes No Yes Yes Yes SK-BR-3 NFS1 20 PREX1 20 Yes KPL-4 BSG 19 NFIX 19 22 14 Yes No Yes KPL-4 ... number of validated expressed fusion genes reported in breast cancer cells so far This indicates the power of transcriptomic profiling by next-generation sequencing in that it...

Ngày tải lên: 09/08/2014, 22:23

... understand of the clinical significance of Pim-1 Figure Expression profile of Pim-1 in bladder cancer cell lines A Expression profile of Pim-1 in bladder cancer cell lines Cell lysate from five bladder ... Pim-1 in bladder cancer cell lines In order to further demonstrate the role and function of Pim-1 in bladder cancer, the expression level of Pim-1...

Ngày tải lên: 10/08/2014, 10:20

... be one of the causes of high expression of the drug-metabolising enzyme CYP1B1 in cancerous tissues [14] Finally, as a tumor suppressor in breast cancer cells, miR-17-5p regulates breast cancer ... Ras-GAP binding proteins (G3BP) Oncogene 2007, 26(29):4209-4215 27 French J, Stirling R, Walsh M, Kennedy HD: The expression of Ras-GTPase activating protein SH3 domain-bind...

Ngày tải lên: 10/08/2014, 10:20

... with HIV-1 has been examined We hypothesize that treatment of expressed breast milk with this microbicide will effectively inactivate HIV-1 in breast milk Efficiency of viral inactivation in breast ... against HIV-1 in breast milk The virucidal activity of SDS against cell-free HIV-1 in breast milk was assessed by adding high titer HIV-1 I...

Ngày tải lên: 13/08/2014, 09:21

... 11 3 6 .1. 4 Mutagenesis 11 3 6 .1. 5 6.2 HCT 116 and E1 cell lines 11 2 Transfection 11 4 Cell-based assays 11 5 6.2 .1 6.2.2 Wound healing 11 5 6.2.3 ... Stathmin- 1 1. 2 .1 The Stathmin family 1. 2.2 STMN1 in microtubule regulation 10 1. 2.3 STMN1 in cell cycle regulation 12 1. 2.4 STMN1 in cancer 14 ... Conclusion and future work 10 7 Chapter Materials...

Ngày tải lên: 09/09/2015, 11:25

... 11 6 11 9 4 .1 The role of Annexin- 1 in the regulation of inflammatory stress 11 9 response 4.2 Conclusion 14 4 4.3 Limitations of the study 14 5 4.4 Future work 14 6 Bibliography 14 8 Summary Annexin- 1 ... for investigation of the basis of the inflammatory stress response The aims of this study are thus, 1) To determine the role...

Ngày tải lên: 01/10/2015, 17:27

... of the role of PrP in breast cancer metabolism in the study model Picture showing different lactate production in normal and cancer situation Schematic overview of the role of PrP in cancer metabolism ... higher in normal breast cell line (MCF10A) than breast cancer cell lines (MCF7, SK-BR-3, and MDA-MB-231) Proliferation rate in breast c...

Ngày tải lên: 12/10/2015, 17:36

... that the adaptive immune system differentially modulates de novo cancer development in an organ-dependent and aetiology-dependent manner The paradoxical influence of the adaptive immune system during ... to be resolved with these powerful approaches is how therapeutically manipulating one arm of the immune system affects the anticancer or cancer- promoting p...

Ngày tải lên: 15/03/2014, 01:20

... [52,53] Pharmacological targeting of matrix metalloproteinases On the basis of the pivotal roles that MMPs and ADAMs play in several steps of cancer progression, the pharmaceutical industry has invested ... threonine and tyrosine kinases, thus contributing to cancer development [11] Roles of MMPs in cancer progression During development of carcinogenesis...

Ngày tải lên: 15/03/2014, 00:20

... processing unit Fig E2 and E3BP domains and their binding interactions E2 subunit domains: L1, N-terminal lipoyl domain; L2, inner lipoyl domain; B, E1 binding domain; I, oligomer-forming, acetyl-transferase-catalyzing ... L2 In a second region at the other end of the L2 domain, mutation of glutamates 16 2, 17 9 and 18 2, and glutamine 18 1 greatly reduces binding...

Ngày tải lên: 17/03/2014, 09:20

... Data Processing and Statistical Analysis The preprocessing of data that included averaging of technical repeats, interpolation of missing or non-aligned points, binning of neighboring points to reduce ... resolution of the analyzer operating in the linear mode or might result in overlapping of ions originating from protein/ peptides of very similar molecular masses In...

Ngày tải lên: 18/06/2014, 15:20