... protocol, we could alsoshow that no preference for any of the two isoforms can be detected forepothilone A, a potentially very interesting drug for which no data aboutthe emergence of resistance is ... For simulations involving epothilone, wetook advantage of the availability of the 1TVK struc-ture, which contains the structure of a tubulin dimercomplexed with epothilone A [24]. 1TVK was ... significant differencein binding energies of epothilone for the two isoforms.These observations, together with the data reported inTable 2, suggest that epothilone A is able to interactwith similar...