zoom in array comparative genomic hybridization acgh to detect germline rearrangements in cancer susceptibility g
báo cáo khoa học: "Genomic profiling of plasmablastic lymphoma using array comparative genomic hybridization (aCGH): revealing significant overlapping genomic lesions with diffuse large B-cell lymphoma" ppt
... Recurring (common) segmental gain or loss (occurring in at least cases) were detected on all autosomes except chromosome 12, ranging in size from 0.7 Mb to 15.9 Mb for gain and from 0.5 Mb to 16.4 ... occurring commonly in oral cavity of AIDS patients In the PL cases, segmental gains and losses ranging in size from 0.2 Mb to 37.7 Mb and 0.2 Mb to 27.7 Mb, respectively, were detected in all ... Collins C, Kuo WL, Chen C, Zhai Y, Dairkee SH, Ljung BM, Gray JW, Albertson DG: High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays Nat Genet...
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Báo cáo hóa học: " Chromosomal 16p microdeletion in Rubinstein-Taybi syndrome detected by oligonucleotide-based array comparative genomic hybridization: a case report" doc
... up to 560kb to 650kb and including the 5′- and 3′-flanking regions of the Crebbp gene [4,8,9] Recently, intragenic deletions were detected in two RSTS patients using an exon coverage microarray ... conventional techniques in the screening and detection of clinically significant genomic imbalances in the human genome Array- CGH is a reliable and powerful tool in the investigation of rare genetic conditions, ... neurosurgical decompression These evidences demonstrated that microdeletion involving neighboring genes to Crebbp gene might be responsible for the additional features in RSTS In addition, our finding...
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Báo cáo y học: " Ring chromosome 13 syndrome characterized by high resolution array based comparative genomic hybridization in patient with 47, XYY syndrome: a case report." doc
... 2National Engineering Research Center for Beijing Biochip Technology, Beijing 102206, PR China Kallioniemi A, Kallioniemi OP, Sudar D: Comparative genomic hybridization for molecular cytogenetic ... technological assistance Author details Department of clinical genetics department, Guangzhou Women and Children’ Medical Center, Guangzhou Medical College, Guangzhou, Guangdong 510623, PR China ... diagnosis In this study we use the high resolution aCGH to screen the whole genome and identified an 8.5 Mb terminal deletion of chromosome 13 to demonstrate the application of aCGH in clinical...
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Báo cáo y học: "Array comparative genomic hybridisation-based identification of two imbalances of chromosome 1p in a 9-year-old girl with a monosomy 1p36 related phenotype and a family history of learning difficulties: a case report" pps
... genomic target sequences is interpreted using an integrated suite of bioinformatic tools In comparison to conventional cytogenetic techniques, aCGH enables a more precise examination of the genome, ... they have no competing interests Conclusion It is apparent that with the advent of aCGH as a diagnostic tool for detecting unbalanced genomic rearrangements, it will become easier to correlate specific ... accurately map breakpoints means that aCGH has become an efficient strategy in identifying candidate chromosomal loci and genes This case report highlights the use of aCGH not only to detect submicroscopic...
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phương pháp phân cụm sử dụng marker tren dữ liệu Comparative Genomic Hybridization
... (overlapping) liu chia s ti: wWw.SinhHoc.edu.vn Cho mu CGH X v Y Hai phõn on t mu l chng chộo (overlapping) nu chỳng cú cựng giỏ tr ti ớt nht mt khong gen ging Vớ d 26 Ti liu chia s ti: wWw.SinhHoc.edu.vn ... dng phng phỏp phõn cm nhúm cỏc bnh nhõn cú mu quang sai ging vo cựng mt cm Trờn c s ú, chỳng tụi nghiờn cu Phng phỏp phõn cm s dng marker trờn d liu Comparative Genomic Hybridization (CGH) Ti ... DIN MARKER Khỏi nim Marker l mt khong gen quan trng i din cho mt vựng bin i hi quy (recurrent alteration - hp cỏc quang sai cú cựng tỡnh trng m nhiu mu CGH th hin chỳng) Mi marker c i din...
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A comparative analysis of methods to represent uncertainly in estimating the cost of constructing wastew
... Chemical Engineering Communication 41, 299±314 Graves, G W., Whinston, A B., and Hat®eld, G B (1970) Mathematical programming for regional water quality management Department of Interior, Washington ... parameters In order to establish the target of minimum vagueness in the mapping process, a linear programming model must be built up, subject to the minimum required degree of ®tting on each observation ... 115Á72 Keelung Yi-Lan Tan-Shui Guishuic Taichung Yi-Lan Pan-Hsin Tei-Ton Ping-Ton An-Pin erh-ien-hsi tou-fen Hsin-Chu Kaohsiung Hau-Lien Nan-Zu Yung-Kuang Tao-Yuan Ti-Hau Chung-Li Chung-Chou Pa-Li...
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Báo cáo y học: " Comparative genomic analysis of bacteriophages specific to the channel catfish pathogen Edwardsiella ictaluri" pptx
... observed in the ORFs encoding the putative methyltransferases In phage eiAU, ORF6 The majority of the top BLAST hits for these phage genomes are to proteins belonging to lytic phages, including Yersinia ... similar to each other at a genomic level This genomic analysis suggests that these phages are members of a lineage that is highly stable over time and geographic regions The information obtained ... containing 10% glycerol at -80°C In each experiment bacterial strains were grown from the original glycerol stock to maintain low passage number, virulent E ictaluri cultures Isolation of phage...
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báo cáo khoa học: " A new genomic resource dedicated to wood formation in Eucalyptus" pdf
... activity (GO:0016874) isomerase activity (GO:0016853) others binding (GO:0005488) nucleotide binding (GO:0000166) ion binding (GO:0043167) nucleic acid binding (GO:0003676) protein binding (GO:0005515) ... encoding proteins involved in loosening and rearrangement of the cell wall were also present among the EUCAWOOD unigenes, including, for instance, two expansin genes Expansins are thought to directly ... single HCT gene, as in Arabidopsis [41] Interestingly, eight ATP-binding cassette (ABC) transporters were present among EUCAWOOD unigenes, which might be involved in the transport of the lignin...
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Báo cáo y học: "Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli" doc
... supercoiling The points corresponding to the topoisomerase genes gyrA, gyrB, topA and topB are indicated (b) Expanded portion of (a) highlighting those genes classified as significant (p < 0.05) Genes ... supercoiling levels changed dramatically within the first minute (Figure 3) Significant changes in gene expression followed by minutes (Figure 4) We ranked the SSGs according to their correlation to ... of having an AT content similar to the rest of the genome Figure of the expression changes of the supercoiling-sensitive genes Kinetics (see following page) Kinetics of the expression changes of...
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Báo cáo y học: " Comparative genomic analysis of C4 photosynthetic pathway evolution in grasses" docx
... transformation, one strategy is to incorporate the C4 pathway into C3 plants through recombinant DNA technology [84] The strategy succeeds in transferring C4 genes into C3 plants and yielding high levels of ... potential gene homology information defined by running BLAST was used as the input for MCscan [92] to find homologous gene pairs in colinearity The built -in scoring scheme for MCscan is min(-log10E_value, ... PEPC genes in other angiosperms [41,65] This rice gene was classified into the ppc-B1 group [42], found only in the C3 grasses, suggesting that its adaptive evolution is not leading to C4 photosynthesis,...
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Tài liệu StrategieS for SucceSS: How to Write a Grant in Cancer CAM docx
... ways including: • assisting applicants in locating funding opportunities; • directing applicants to grant mechanisms that match the goal or intent of the project and experience of the investigator ... training program director is responsible for selecting the trainees and for administering the program This program does not support residencies T36 MARC Ancillary Training Activities (Grant) Minority ... conducting this particular research in the particular method specified 26 APPENDIX I Budget Mechanisms http://grants.nih.gov/grants/funding/funding_program.htm NCI's budget is organized according to...
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Optical Fiber Sensors to Detect Volatile Organic Compound in Sick Build- ing Syndrome Applications potx
... signal more robust using modulations [17] Depending on the final application, it might be interesting the use of a multi point sensor network able to detect several gases (Fig 2), no just one, ... Transduced light Fig (3) Experimental set up for an evanescent wave sensor, with three different possibilities: removing the cladding (top-left), tapering the fiber (top-right) and bending the fiber ... has to be taken into account both in work and house buildings It is due not only to a single factor, but to a global effect of physical conditions, air quality, chemical pollutants and biological...
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Báo cáo khoa học: "HOW TO DETECT GRAMMATICAL ERRORS IN A TEXT WITHOUT PARSING IT" doc
... occurs in a grammatical idiom or preferred collocation with surrounding words, then its relative weighting is increased (e .g in the context "fish and ", ch/ps gets a higher collocation weighting than ... electronics manual current should get a higher domain weighting than currant All these factors are multiplied (using appropriate weightings) to yield a relative likelihood rating for each member of the ... has to be done to engineer a generally-acceptable commercial product We are cun-ently looking for sponsors and collaborators for this research: anyone interested in developing the prototype into...
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báo cáo hóa học: " Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008" pot
... J: Symptom distress in newly diagnosed ambulatory cancer patients and as a predictor of survival in lung cancer J Pain Symptom Manage 1995, 10:423-431 Ringdal GI, G testam KG, Kaasa S, Kvinnsland ... functioning were significant prognostic factors of survival Baseline QOL scores added little to clinical factors to predict survival Fielding and Wong [44] 2007 358 liver and lung FACT -G Global ... four 'non-anatomical' prognostic http://www.hqlo.com/content/7/1/102 indicators: symptomatic history, performance status, weight loss and age Adjusting for stage, histological factors and treatment,...
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báo cáo hóa học:" Pain in cancer. An outcome research project to evaluate the epidemiology, the quality and the effects of pain treatment in cancer patients" pptx
... relevant endpoint is the reduction in Adequacy of analgesic-drug therapy: Patient Management index (PMI), categorized in a binary variable according to negative (indicating inadequate analgesic care) ... Index of Pain Management (IPM) that ranges from -3 (a patient with severe pain receiving no analgesic drugs) to +3 (a patient receiving morphine or an equivalent drug an reporting no pain) [19] ... participating centers, with eligible (advanced or metastatic) solid cancers and with pain (related to cancer disease) requiring any treatment are eligible to be included during the study inception...
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Báo cáo hóa học: " Using Intermicrophone Correlation to Detect Speech in Spatially Separated Noise" pdf
... Desired signal θ0 Interfering noise Interfering noise 90◦ Microphone Microphone Figure 1: Signal scenario indicating the ranges of incident angles for the desired signal and interfering noise sources ... Communications Group within the Research Laboratory of Electronics, where he was involved in applications of digital signal processing in hearing-aid design Currently, he is employed as an Engineer working ... in medical engineering from HST (1994) Her research interests include signal processing for hearing aids and cochlear implants, as well as the use of technology in bioengineering education She...
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Scientific report: "Application of PCR to detect the presence of two genes in the genome of rice AtAOS has been genetically modified" pdf
... analysis to detect the introduced gene- AtAOS2 The primer pair employed to detect the introduced genes was: forward primer 5'ACGACCAAGGAGCTGAAGAG-3' and reverse primer 5'-CGCCGGTGGTAGACTAAATG-3' ... (hygromycin phosphotransferase) was: foward primer 5'ACAGCGTCTCCGACCTGATGCA-3' and reverse primer 5'AGTCAATGACCGCTGTTATGCG-3' PCR was carried out according to the PCR Amplification Kit by using ... microbody (MB), mitochondria (MC) In order to increase the level of endogenous JA in rice, we try to over express AOS genes by transforming AtAOS2 gene to the rice genome Fig The octadecanoid...
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Báo cáo y học: "Use of soluble MHC class II/peptide multimers to detect antigen-specific T cells in human disease." pps
... staining reagents using transfected Drosophila melanogaster (Schneider, S2) cells [10,12,13] To foster correct HLA-DR (or DQ) αchain and β-chain pairing and protein folding, these investigators also ... are generated in vitro, multimer staining can be used directly to assess changes in TCR affinity and therefore TCR repertoire In addition, sorting multimer-positive cells has worked well to enrich ... stained T cells can subsequently function in response to antigen, which argues against the idea that multimer binding causes apoptosis of the target T cells Other clinical situations, such as infection,...
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Báo cáo khoa học: "Density of CD4(+) and CD8(+) T lymphocytes in biopsy samples can be a predictor of pathological response to chemoradiotherapy (CRT) for rectal cancer" ppt
... width, fixed in 10% formalin solution, then embedded in paraffin, stained with hematoxylin-eosin, and the grade of tumor response was evaluated by pathologists according to the definitions in the Japanese ... lymphocytes in biopsy samples of primary rectal tumor were evaluated by immunohistochemical staining using affinity purified mouse monoclonal antibodies against CD4 (1F6, mIgG1) and CD8 (4B11, mIgG1) ... the histological level As shown in Figure 2, when the cases were divided by the histological response grade according to the definitions in the Japanese Classification of Colorectal Carcinoma,...
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