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Báo cáo khoa học: The signature amidase from Sulfolobus solfataricus belongs to the CX3C subgroup of enzymes cleaving both amides and nitriles Ser195 and Cys145 are predicted to be the active site nucleophiles pot
... One of its amino ˚ groups is about 2.6 A from the Oc atom of Ser171 ˚ and 2.5 A from the thiol group of Cys145 4720 Even taking into account all of the limitations of molecular models of proteins ... putative triad are in the correct relative orientation In our model, the Oc atom of Ser171, the amino group of Lys96 and the thiol group of Cys145 are sufficiently close to each other to form a catalytic ... conserved in a restricted group of signature amidases Partial alignment of amidase sequences containing a second CX3C motif From top to bottom (with database accession numbers in parentheses):...
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Báo cáo y học: " What work has to be done to implement collaborative care for depression? Process evaluation of a trial utilizing the Normalization Process Model" doc
... understanding the workability (capable of being put into operation) and integration (assimilation into practice) of a complex intervention and demonstrated how this can used to understand trial ... suppose, [I] learned to listen to what was not being said rather than what was being said and sort of trying a bit more to pay attention to the silences a little Trying to pick up more when people ... of the project or not usually included in publication of results of a trial) that needs to be done to make a collaborative care intervention for depression in primary care both workable and integrated...
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báo cáo khoa học: " What work has to be done to implement collaborative care for depression? Process evaluation of a trial utilizing the Normalization Process Model" potx
... understanding the workability (capable of being put into operation) and integration (assimilation into practice) of a complex intervention and demonstrated how this can used to understand trial ... suppose, [I] learned to listen to what was not being said rather than what was being said and sort of trying a bit more to pay attention to the silences a little Trying to pick up more when people ... of the project or not usually included in publication of results of a trial) that needs to be done to make a collaborative care intervention for depression in primary care both workable and integrated...
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CONFLICTS OF INTEREST IN THE HOLLYWOOD FILM INDUSTRY: COMING TO AMERICA - TALES FROM THE CASTING COUCH, GROSS AND NET, IN A RISKY BUSINESS pdf
... shrsoh1 Fohduo| hdfk prylh surmhfw uhtxluhv d frqvlghudeoh dprxqw ri frruglqdwhg dfwlrq1 Wkh vhfrqg nh| fkdudfwhulvwlf ri wkh prylh exvlqhvv lv wkdw prylh0pdnlqj uhtxluhv vxe0 vwdqwldo xs0iurqw frvwv ... zkr rwkhuzlvh kdyh ihz zd|v wr glvwlqjxlvk rqh qhzfrphu iurp dqrwkhu1 Dffruglqj wr wklv ylhz/ kdqn|0sdqn| wkrxjk frpprq lv qrw uhdoo| frhuflyh exw uhsuhvhqwv txlg sur txr h{fkdqjhv1## Wkrxjk wkh ... wkrvh lq wklv exvlqhvv/ dqg txlg sur txr vh{ pd| eh rqh ri wkh frpprglwlhv1 Lq dq| fdvh frpsodlqwv wr wkh Htxdo Hpsor|phqw Rssruwxqlw| Frpplvvlrq duh uduh/ dqg vxlwv xqghu Fdoliruqld odz #& duh...
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báo cáo hóa học: " Measuring disease-specific quality of life in rare populations: a practical approach to cross-cultural translation" potx
... differently in each country and was often back translated to "rarely." For example, when "seldom" was translated into French it became 'rarement,' in Spanish it became "raremente," and in German it became ... naive and informed translators are required ≥ Independent translations ≥ Professional translators NSTL Professional translators (NSTL) Translators naïve to SF36 Both naive and informed translators ... Pre-testing To ensure equivalence in linguistic, cultural and clinical context, cognitive debriefing was conducted in each of the countries following the methods described by Jobe[6] The clinical...
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báo cáo hóa học:" Measuring disease-specific quality of life in rare populations: a practical approach to cross-cultural translation" docx
... differently in each country and was often back translated to "rarely." For example, when "seldom" was translated into French it became 'rarement,' in Spanish it became "raremente," and in German it became ... naive and informed translators are required ≥ Independent translations ≥ Professional translators NSTL Professional translators (NSTL) Translators naïve to SF36 Both naive and informed translators ... Pre-testing To ensure equivalence in linguistic, cultural and clinical context, cognitive debriefing was conducted in each of the countries following the methods described by Jobe[6] The clinical...
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Báo cáo y học: "Clinical and immunological effects of Rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study" doc
... decrease in lymphocytes bearing GITRL favors an increase in the number and function of regulatory cells In this regard, we have recently found that the inflammatory cell infiltrate of thyroid autoimmune ... regarding the in vivo effect of Rituximab on regulatory cells and apoptosis of T lymphocytes are interesting and that its possible role in the putative effect of this biological agent in SLE ... (a), and representative histograms of flow cytometry analysis are shown in (b) The arithmetic mean is indicated with a horizontal line and the standard deviation with a vertical line Numbers in...
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Subcellular compartmentalization of CD38 in non hematopoietic cells a study to characterize its functional role in mitochondria 2
... the mitochondria as well as implying the location of the catalytic domain of enzyme molecule to be extruding to the cytosolic region Four distinct compartments can be distinguished within mitochondria: ... change in the red peak (a), corresponding to the J-aggregates following the uptake of the JC-1 dye into isolated mitochondria being energized by 10mM succinate Green arrow-50µg of mitochondria and ... Compartments Following investigation into endocytosis of human CD38 molecule in normal lymphocytes and a number of leukemia- and lymphoma-derived cell lines, Funaro et al (1998) postulated that internalization...
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Subcellular compartmentalization of CD38 in non hematopoietic cells a study to characterize its functional role in mitochondria 3
... selective and progressive removal of the outer mitochondrial membrane by increasing concentration of digitonin Upon increasing the digitonin (dig)/protein (Prot) ratio from to 0.1 the mitochondrial ... digestion of CD38, Tom20 and Bcl -xL were observed prior to addition of digitonin Because the anti-CD38 antibody employed in this study was raised against the C-terminal half of this protein, it can be ... expression of CD38 in astrocytes The immunolabeling was more intense compared to that in the neurons, and was distributed ubiquitously in the perikarya and processes, suggesting an essential role of...
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Subcellular compartmentalization of CD38 in non hematopoietic cells a study to characterize its functional role in mitochondria 4
... Expressed in Mitochondia from Murine Brain A B Figure 4.14 CD38 immunoreactivity in the mouse cerebellum, labeled with goat polyclonal CD38 antibody-sc-7049 A, B: intense CD38 immunostaining labeled ... Immunoreactivity was most intense with mitochondria Varying degree in CD38 immunostaing of mitochondria observed in different compartment Lower panel: immunopositive mitochondria located in Basket cell ... enlargements of the encircled area of the basketcell are shown in the following page Blood vessel was heavily stained with CD38 antibody (arrow) Scale bar: 1, 2µm 186 Chapter Characterization of CD38...
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Subcellular compartmentalization of CD38 in non hematopoietic cells a study to characterize its functional role in mitochondria 8
... presence of specific NAADP binding sites in the brain on both neuronal and nonneuronal cells (Bezin et al., 2006) In view of the results observed in current studies, it would be interesting to investigate ... subdomain of the ER acting as membrane bridges and thus provides direct physical contact to mitochondria It would be interesting to investigate the mechanism of the shuttling of molecule between ... release of proapoptotic factors into the cytosol Following the release of intramitochondrial NAD+ to the cytosol, the immediate NAD+ source becomes substrate to CD38 located on the outer mitochondrial...
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Subcellular compartmentalization of CD38 in non hematopoietic cells a study to characterize its functional role in mitochondria 5
... obtained showed the pattern of internal staining, as opposed to the pattern of staining with CD38 involving the surface of the outer mitochondrial membrane facing the cytosolic side In contrast to ... intense labeling (arrowhead) Scale bar:1µm 190 Chapter Characterization of CD38 Expressed in Mitochondia from Murine Brain 4.2.4.2 Localization of CD38 on mitochondria using immunogold labeling ... granular layer (A), in particular association with mitochondria in varying degree of CD38 staining intensity (B) Notice the the immunostaing is restricted to surface of mitochondria (arrow) Scale...
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Subcellular compartmentalization of CD38 in non hematopoietic cells a study to characterize its functional role in mitochondria
... able to induce the transcription of various cytokines including that of interleukin-1 (IL-1), tumor necrosis factor-alpha and granulocyte-macrophage colony-stimulating factor at levels similar to ... has been shown that Lys-129 of CD38 participates in cADPR binding and that ATP competes with cADPR for the binding site, resulting in the inhibition of the cADPR hydrolase activity of CD38 (Tohgo ... as Ca2+ mobilizing agents independent of IP3 inside cells, this fascinating molecule and its related family continue to prompt investigation and kindle debate A significant number of studies reported...
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Subcellular compartmentalization of CD38 in non hematopoietic cells a study to characterize its functional role in mitochondria 6
... Characterization of CD38 Expressed in Mitochondia from Murine Brain 4.2.5 Determination of the localization of CD38 on mitochondria using Scanning Electron Microscopy (SEM) 4.2.5.1 Determination of the ... labeling of CD38 The insets (A and B) are enlargement of the encircled areas of the isolated mitochondria (A) shows sample viewed in the BEI mode (reverse polarity) All the gold particles appeared ... allow the examination of the localization and quantification of molecule on the surface of mitochondria 196 Chapter Characterization of CD38 Expressed in Mitochondia from Murine Brain A B Figure...
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Subcellular compartmentalization of CD38 in non hematopoietic cells a study to characterize its functional role in mitochondria 7
... Expressed in Mitochondia from Murine Brain dynamic nature of mitochondria within individual cells, including neurons, which could be morphologically heterogeneous and unconnected thus allowing them to ... from Murine Brain might be compromised during organelle isolation For example, cytosolic factors like calmodulin, which has been shown by Lee and co-workers to be required and needs to be present ... would be interesting to investigate the possible relationship between the mitochondrial CD38 and ryanodine receptor A substantial amount of cellular NAD+ pool i.e, ~75% of intracellular NAD+ in...
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The concept of irony in jane austen, with constant reference to virginia woolf
... student makes in order to examine how irony generates a dialectic in Austen: Noticing something askew in one of his flights describing what Elizabeth and Mr Bennet “stand for”, I asked him to say quite ... “could be detached and see things in perspective; and she could enter into things, into other people’s lives, until she became a part of them” (112) Plomer is pointing out that Woolf’s ability to ... relation of their form to content: [Reading]… does not merely consist in sympathizing and understanding It consists, too, in criticizing and judging…it does not help us greatly to read the views of...
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Conclusion - what is to be done
... Dissenting opinions are conducive to dialogue and may even inspire students, in effect calling them by name to see themselves in what they study History shows that minority views today may be the ... success of England in the following century as the premier exemplar of this approach to political economy The profounder sources of what is today termed ‘globalisation’ are to be found in this ... advent of All Souls’ Day (in chapter 5), and many intervening developments All souls had to be equal before all men could be equal before all humans could be equal, in the West Is obedience to globalist...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose