... recipient following pRBC administration [12] On the other hand, residual donor whiteblood cells could promote T -cell activation [29,30], which, in turn, could result in subtle changes in the ... immunomodulation: fact or fiction? Blood 2001, 97:1180-1195 30 Lee TH, Stromberg RR, Heitman J, Tran K, Busch MP: Quantitation of residual white cells in filtered blood components by polymerase chain ... cytokine response in an in vitro model of blood transfusion Anesthesiology 2002, 97:1102-1109 Fransen E, Maessen J, Dentener M, Senden N, Buurman W: Impact of bloodtransfusions on inflammatory mediator...
... function as well as erythrocytes metabolism Homocysteine and red blood cells 2.1 Red blood cells oxidative-reducing balance Red blood cells are responsible for oxygen transport from lung to tissues ... membrane with 10-20 nm thickness and thicker than the other blood cells, rich from glycoproteins that are mainly receptors for cell- cell and cell- vessel interactions(1, 8) b Platelet Unit Membrane: ... identifiable function of Red Blood Cells (RBC) is the delivery of Oxygen In mammals, RBC is a unique cell because: It does not have cellular organelles like any other cells in the body It has...
... waiver of written informed consent (# 09-953) Red bloodcell transfusion characteristics Packed red bloodcell units were obtained from the blood bank (St John’s Mercy Medical Center) None of ... of red blood cells A release of a number of substances occurs during storage resulting in such adverse systemic responses as fever, cellular injury, alterations in regional and global blood flow, ... Rush BFJ: Decreased red bloodcell deformability and impaired oxygen utilization during human sepsis Am Surg 1993, 59:65-68 37 Baskurt OK, Gelmont D, Meiselman HJ: Red bloodcell deformability in...
... red cell concentrates during storage is prevented by prestorage whitecell reduction Transfusion 1997, 37:678-684 Anniss AM, Sparrow RL: Storage duration and whitebloodcell content of red blood ... [13]) also may contribute to these discrepancies [31] Safety concerns of bloodtransfusions Impact on outcome Red bloodcelltransfusions have been associated with worse outcomes in several populations ... M, Boyce NW: Appropriateness of red bloodcell transfusion in Australasian intensive care practice Med J Aust 2002, 177:548-551 Scharte M, Fink MP: Red bloodcell physiology in critical illness...
... Blood Group Antigens 92 ABO Blood Group 92 Rh Blood Group 97 P Blood Group 98 Lutheran Blood Group 99 Kell Blood Group 99 Lewis Blood Group 100 Duffy Blood Group 101 Kidd Blood Group 102 LW Blood ... abnormalities in blood cells as the pathogenesis of blood diseases, recognition of these blood cells is an absolute prerequisite For this purpose, invention of instruments to identify such small blood corpuscles, ... Yoshihito Yawata Cell Membrane Cell Membrane: The Red BloodCell as a Model Yoshihito Yawata Copyright c 2003 WILEY-VCH Verlag GmbH & Co KGaA, Weinheim ISBN 3-527-30463-0 Yoshihito Yawata Cell Membrane...
... used to identify markers of responsiveness in the peripheral blood mono- Page of 11 (page number not for citation purposes) nuclear cells (PBMCs) However, the number of such studies is still very ... rheumatoid arthritis patients as responders versus non-responders Transcripts in peripheral blood mononuclear cells from six respondpatients as responders versus non-responders ers (R) or seven non-responders ... validation subsets (subset in text and Tables and 3) In any given sample of peripheral blood mononuclear cells, the abundances of informative transcripts were determined by qRT-PCR and normalized...
... two concurrent events, namely blood loss and red bloodcell dilution due to positive fluid balance result in precipitous hematocrit drop and need for allogeneic blood Hemodilution has been identified ... units) blood product exposure and reduced long-term survival [3] As the risk of transfusion-associated adverse outcomes may depend on the amount of transfusion [4], reduction of bloodtransfusions ... http://www.cardiothoracicsurgery.org/content/5/1/7 Background Cardiac surgery is a major blood product consumer Data from many studies suggest that bloodtransfusions are associated with increased morbidity and mortality...
... of cardiac surgery, parenchymatous cells such as cardiomyocytes contribute to the systemic inflammatory reaction by producing cytokines, circulating blood cells, in particular leukocytes, are ... of blood cells to LPS • Cardiac surgery in newborn infants might lead to an anti-inflammatory shift of the cytokine balance • In this series, postoperative complications related to decreased blood ... detection limit of this method is mg dl-1 Ex vivo stimulation Whole blood culture was performed as described previously [12] Blood (1 ml) was withdrawn under sterile conditions from a peripheral...
... nondiagnostic blood loss and blunted erythropoietic response in the anemia of medical intensive care patients Crit Care Med 1999, 27:2630-2639 Anonymous: Consensus conference Perioperative red bloodcell ... interval; ICU, intensive care unit; LOD, Logistic Organ Dysfunction; OR, odds ratio; RBC, red bloodcell One of the most important factors associated with post-ICU transfusion of RBC was sepsis ... mean ± standard deviation ICU, intensive care unit; LOD, Logistic Organ Dysfunction; RBC, red blood cell; SAPS, Simplified Acute Physiology Score Page of (page number not for citation purposes)...
... program for red bloodcelltransfusions JAMA 2003, 289:1941-1949 85 Rigamonti A, McLaren AT, Mazer CD, Nix K, Ragoonanan T, Freedman J, Harringon A, Hare GM: Storage of strain-specific rat blood limits ... mortality risk associated with red bloodcell and blood- component transfusion in isolated coronary artery bypass grafting Crit Care Med 2006, 34:1608-1616 123 Stamou SC, White T, Barnett S, Boyce SW, ... storage on red bloodcell rheological properties J Surg Res 2002, 102:6-12 Tsai AG, Cabrales P, Intaglietta M: Microvascular perfusion upon exchange transfusion with stored red blood cells in norTransfusion...
... Facts about blood and blood banking [http:// www.aabb.org/Content/About _Blood/ Facts_About _Blood_ and _Blood_ Banking ] Ho J, Sibbald WJ, Chin-Yee IH: Effects of storage on efficacy of red cell transfusion: ... red blood cells contain a procoagulant phospholipid reducible by leukodepletion filters and washing Transfus Apher Sci 2008, 38(2):141-147 Sweeney J, Kouttab N, Kurtis J: Stored red bloodcell ... triphosphate in red blood cells during storage Transfusion 2008, 48(6):1081-1089 Tsai AG, Cabrales P, Intaglietta M: Microvascular perfusion upon exchange transfusion with stored red blood cells in normovolemic...
... Peak bilirubin (mg/dL) 0.503 Blood loss (mL/12 hours) 0.156 Red blood cells transfusions No of patients (%) Fresh frozen plasma transfusions No of patients (%) Platelets transfusions No of patients ... from the first blood bag or from a second blood bag No patient received RBCs from more than two blood bags during the operation No leukodepleted blood was used for intraoperative transfusions Data ... the red cell membrane during conventional blood preservation Semin Hematol 1989, 26:307-312 Leal-Noval SR, Jara López I: Do multiple bloodtransfusions predispose for a higher rate of non -blood- related...
... critically ill patients admitted to ICU and as a result, large numbers of patients receive bloodtransfusions • Bloodtransfusions are in short supply, expensive and have deleterious effects on patient ... syndrome: potential role of red cell transfusion Crit Care Med 2005, 33:1191-1198 Zilberberg MD, Carter C, Lefebvre P, Raut M, Vekeman F, Duh MS, Shorr AF: Red bloodcelltransfusions and the risk ... volume of blood from indwelling arterial or central line catheters, blood conservation devices can improve anaemia (Hb) • The present study shows that with restrictive transfusion practice, blood...
... 2005, 2:18 homeostasis in multicellular organisms is maintained by replacing the loss of disposable cells with additional cells It is possible that these disposable cells never reach a mathematical ... to metabolism in human red blood cells J Theor Biol 1996, 179:329-368 Ni TC, Savageau MA: Application of biochemical systems theory to metabolism in human red blood cells Signal propagation and ... 2005, 2:18 version of the first E -Cell system, is now also available [6] E -Cell version 3, which enables multi-algorithm simulation, is the latest version [7] The E -Cell system allows the user to...
... DA: Anemia and red bloodcell transfusion in neurocritical care Crit Care 2009, 13:R89 Smith MJ, Stiefel MF, Magge S, Frangos S, Bloom S, Gracias V, Le Roux PD: Packed red bloodcell transfusion ... [4] Physiological studies have demonstrated improvements in cerebral oxygenation when red bloodcell (RBC) transfusions are used to raise Hb levels in anemic SAH patients, particularly when oxygen ... and blood transfusion in patients with aneurysmal subarachnoid hemorrhage Crit Care Med 2008, 36:2070-2075 Levine J, Kofke A, Cen L, Chen Z, Faerber J, Ellioo JP, Winn HR, Le Roux P: Red blood cell...
... heterogeneity of red blood cells distribution in the network by triggering the effects of red bloodcell screening (103) and plasma skimming (53, 122) shown in Fig 1.10 CELL SCREENING Cell- cell interactions ... SKIMMING Cell- free layer Side branch Figure 1.10: Red bloodcell screening and plasma skimming at an arteriolar bifurcation The black ellipsoid represents a red bloodcell Red bloodcell screening ... red blood cells into contact and spontaneously form multicellular aggregates (64) Due to the shear dependence of aggregates formation, the extent of cell- free layer formation through red blood cell...
... of ID 50 µm in non-aggregating blood suspended in PBS, normal aggregating blood and disease aggregating blood 27 Figure Comparison of relative WSS of blood samples at 40% Hct in microtube ... 50 µm in non-aggregating blood suspended in PBS, normal aggregating blood and disease aggregating blood at four typical pseudoshear rates 29 Figure Relative WSS of blood samples at 40% Hct ... Hematocrit (Hct) is the ratio of the volume of red blood cells (RBCs) to the total blood volume Hct is well known to be a major rheological determinant of blood viscosity and flow resistance [32-34]...