... regionsincluding a large intron 1 ofthe HO-2 gene are required. In summary, the present study has suggested that the reduced expression of HO-2 protein may contrib-ute to the maintenance of intracellular ... the intensity for the a-tubulin signal. Shown are the relativeexpression levels of HO-1 and HO-2 proteins in YN-1 cells (B) and those of HO-2 protein in K562 cells (D). The intensity representing ... HO-1 and HO-2 expression in human cell linesWe initially analyzed the effects of hypoxia on the expression of HO-1 and HO-2 in human cell lines of bone marrow origin, including KG1 myeloid cells,...
... for the dynamic nature ofthe Internet and the information that can be found on it;3. The search for information is often limited to a few Internet services, such as the WWW. Finding information ... either of them. The Internet services ofthe future should aim at exactly the opposite with tailor-made services (and interfaces) for every individual user as the ultimate target. Neither the ... many brokers will permit the easy introduction of innovations and the rapid spread of useful ones. Because ofthe rapid spread, however, the original innovator may gain little market advantage...
... non-lexicalization ofthe concepts, the lack of super ordinates of hyponyms etc. The main contribution of this paper is to draw out the main ways of dealing with the hurdles by investigating how an ... a basic “change of form”, by emphasizing the “intended inthe text” as said “ Translation is rendering a written text into another language inthe way the author intended inthe text.”Hatim ... all the cultural words occurred in his book and put them into the order ofthe most common typesof equivalence to the least common one. The data can be easily find inthe table below:Type of...
... for use in training and testing the neural network. A large training data reduces the risk of under-sampling the nonlinear function, but increases the training time. To improve training, preprocessing ... reliance ofthe ANN631between the predicted value and the measured value. The properties ofthe soil used for training ofthe MANN models are shown in Table 1. Table 1. Properties ofthe ... a number of combinations of input parameters to determine the neural network model that gave the smallest average of the sum square error. There is currently no rule for determining the optimal...
... Search engines are domain-independent in the way they treat gathered information and inthe way they enable users to search in it8. Terms in gathered documents are lifted out of their context, ... informationtasks (such as offering, finding or editing allkinds of information). Many things that are" ;In the future, it [agents]is going to be the onlyway to search the Internet, because nomatter ... the network searching for documents that, in its opinion, could interest the user. The search is driven by a user's profile builtand maintained by the Interface Agent.Refinement of this profile takes...
... compositioninfluence turn-taking, and speaking time distribution. The results of this study indicatethat: (a) the cultural dimension of I-C is a predictor ofthe number of turn-takings and the speaking ... turn-taking and speaking time duration) in small-groupdecision-making meetings. The findings ofthe current study add value to a very extensiveliterature on cross-cultural communicationin examining ... turn-taking and speaking time distribution. Inthe following, the construct of turn-taking behaviors is reviewed.Turn-taking is the ordering of moves that involve any organized interplay of speech acts.A...
... speculators in accounting for the precipitousdecline ofthe domestic purchasing power ofthe mark. Insteadthey direct his attention to the motives ofthe German Reichs-bank in expanding the money ... tell us is that inthe past definite menor groups of men were valuing and acting in a definite way.Whether they will inthe future value and act inthe sameway remains uncertain. All that can ... specificunderstanding be applied is not to diminish the importance of pure economic theory inthe study of history. Indeed, as Misespoints out, economics 14 A History of Money and Banking inthe United...
... needed; the purpose or goal ofthe presentation; a preview ofthe main points ormajor ideas to be covered inthe body. Next, comes the body ofthe presentation. The body is the central part ofthe ... rewriting it for the ear, (3) practising andrevising it, and (4) organizing the visual aids. Once the learner has made an outline ofthe mainpoints, write the presentation. The main purpose of ... due to their poor languageknowledge, or in other words, either inadequate teaching or learning.Basing on the findings, the thesis is concluded with several suggestions for the learners, the teachers...
... awell-defined hyperintensity mass inthe cervical area. The shape of the uterine cervix is distorted inthe DWI (arrowhead). d On the ADC map the tumor is hypointense (arrow) and the normal ... imaging technique (SENSE factor of 2). Imaging time of DWI was 90 s for 20 slices.Detection of uterine malignancy The ADC values of uterine cancers are lower than of normal tissue. On the other ... with uterine leiomyomas and ableeding cyst. a Axial T2-WI shows an area of hypointensity in the center ofthe cystic component (arrow). b On T1-WI with fatsuppression the area inthe cystic...
... intense interest inthe roles of the entire MT family inthe brain, with particularfocus on the role of these proteins inthe injured orneurodegenerative brain.Discovery of GIFAD is a neurodegenerative ... loss in the AD brain. Further investigation ofthe increasedneurotrophic activity ofthe AD brain revealed that itcorrelated with the loss of a specific neuroinhibitoryfactor, rather than the ... suggesting that this MT isoform has different anddistinct functions within the brain. Furthermore, the discovery and continued investigation of this brain-spe-cific MT isoform has led to intense interest...
... cDNAsequences using the RACE method in both strainsrevealed the presence of a single point mutation in 1337 nucleotides of BmIVD. Inthe sku mutant, the 1127th guanine from the start codon was ... acts inthe third step of leucine degradation and the sku mutant accumulates branched-chain amino acids in haemolymph, thismutant may be useful inthe investigation of unique branched-chain aminoacid ... surface of the monomer, pointing toward FAD or its neigh-bouring monomer inthe tetramer. By contrast, the side chain ofthe mutated residue (Val376) pointstoward the inside ofthe helix–loop–helix...
... of PKA inthe mitochondrial targeting of CYP2E1 The role of PKA in mitochondrial targeting of CYP2E1 was investigated using two approaches. The first approach involved measuring the level of mito-chondrial ... microsomes requires the co-translational insertion ofthe newly synthesized proteininto the microsomal membrane, where the N-terminalhydrophobic signal sequence ofthe protein interactswith a ... mitochondria-targeting signal in the yeast system.Mitochondrial localization of intact CYP2E1 in yeast cellsBecause ofthe existing ambiguity inthe literature on the nature and extent of CYP2E1 import into...
... chondrocytes produce various chemokines stimu-lated mainly by in ammatory cytokines, including IL-1b, TNF-a andIFN-c. (B) Chemokines expressed inthe joint recruit leukocytes into the joints. In addition ... regulated mainly by TNF-a. The role of chemokines in RA pathogenesis The chemokines listed above are implicated in RApathogenesis via the recruitment and retention of leu-kocytes inthe joints. In addition ... subclasses include the CC chemokines(where the cysteines are neighboring) and the CXCchemokines (where the cysteines are separated by oneamino acid). The CXC chemokines mainly act on neu-trophils...
... providedfurther insight into the molecular mechanism driving the formation ofthe covalent C115–fosfomycin adduct. Aconservative exchange of K22 to arginine maintains fosfo-mycin binding, while ... arationale for these findings: the side chain amino group of K22 engages in a salt-bridge interaction with the phospho-nate group of fosfomycin (Fig. 5). Clearly, the guanidiniumgroup of arginine can, ... form ofthe protein. The results obtained with the K22V/R120K doublemutant protein point toward a central role of arginine 120 in the conformational process occurring during catalysis.Therefore,...