using eeg and meg to understand brain physiology in alzheimer s disease and related dementias
Báo cáo y học: "Using theories of behaviour to understand transfusion prescribing in three clinical contexts in two countries: Development work for an implementation trial" pps
... to conduct interviews about 'not transfusing.' Preliminary discussions with consultants in the chosen contexts established that the alternative to transfusing is continued monitoring of the patient, ... scales to assess elements of the identified psychological theories Responses will be elicited using a seven-point Likert scale The content for these questions assessing specific beliefs regarding the ... theory is essential for understanding the likely mechanisms of behaviour change This informs questions such as how best to deliver and optimise the techniques Modelling the process or outcomes involves...
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báo cáo khoa học: " Using theories of behaviour to understand transfusion prescribing in three clinical contexts in two countries: Development work for an implementation trial" pptx
... to conduct interviews about 'not transfusing.' Preliminary discussions with consultants in the chosen contexts established that the alternative to transfusing is continued monitoring of the patient, ... scales to assess elements of the identified psychological theories Responses will be elicited using a seven-point Likert scale The content for these questions assessing specific beliefs regarding the ... theory is essential for understanding the likely mechanisms of behaviour change This informs questions such as how best to deliver and optimise the techniques Modelling the process or outcomes involves...
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Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc
... Huntington related diseases, and various forms of a-synuclein associated with Parkinson disease and synucleinopathies [27] Taken together with the findings that mTOR phosphorylated at the Ser2481 ... phosphorylate eEF2 in its N-terminus (Thr56) that subsequently blocks eEF2 binding to ribosomes, resulting in decreased rates of protein synthesis Dephosphorylation of eEF2 relieves its translational ... CA4 sectors, and the entorhinal and temporal cortice (Fig 4D), but weak staining in the granule layers of the dentate gyrus (not shown) In contrast, in control brain slices there was weak stainings...
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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
... findings to the human disorders, distinct differences remain These models may be appropriate for studying some aspects of a disease process, while less suitable for others To determine the significance ... the Alzheimer' s disease brain Brain Res Mol Brain Res 2000, 81:7-18 Janus C, Phinney AL, Chishti MA, Westaway D: New developments in animal models of Alzheimer' s disease Curr Neurol Neurosci ... classical pathway in Alzheimer brain Brain Res 1997, 769:391-395 Walker DG, McGeer PL: Complement gene expression in human brain: comparison between normal and Alzheimer disease cases Brain Res...
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báo cáo hóa học: " Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer''''s disease" pdf
... Increased neuronal COX-2 expression leads to increased expression of cell cycle mediators in post mitotic neurons, as shown using a transgenic mouse model with increased neuronal COX-2 expression ... pathological disease state and investigated brain area, methods of analysis, as well as technical issues The data presented in this study are in agreement with the findings of Yermakova and O'Banion ... Demographic characteristics of the cases used in this study Shown are differences between groups of the cases used in this study [PMI post-mortem interval, SD standard deviation] Braak score for neurofibrillary...
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báo cáo hóa học: " Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer''''s disease" potx
... the levels of the two extreme groups Similar results were obtained when the analysis was carried out using LSS scores as proxy of status (p < 0.025, lowest vs highest LSS scores) As shown in Figure ... clinical diagnosis of probable Alzheimer' s disease [10] All participants underwent a physical examination, blood tests and neuroimaging assessments They also underwent cognitive assessments using the ... disease (AD), oxidative stress is one of the earliest events occurring prior to the onset of symptoms and it has been recognised as an essential contributor to the pathogenesis and progression...
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báo cáo hóa học: " The contribution of activated astrocytes to Ab production: Implications for Alzheimer’s disease pathogenesis" pot
... BACE1 in astrocytes To gain insight into the signaling pathways responsible for the TNF-a+IFN-g-stimulated increases in astrocytic APP, BACE1 and Ab, we used inhibitors against Page 14 of 17 two signaling ... thus creating a vicious cycle Evidence in favor this hypothesis exists, in that Ab42 is capable of stimulating astrocytes to secrete proinflammatory cytokines, and conversely cytokine combinations ... as concentrated stock solutions according to respective manufacture s instructions The final concentrations of inhibitors in media applied to astrocytes were the following: 1400W (iNOS inhibitor):...
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Possible Strategies for Listening Comprehension: Applying the Concepts of Conversational Implicature and Adjacency Pairs to Understand Speaker Intention in the TOEFL Listening Section doc
... utterances in discourse (Eggins & Slade, 1997) Questioning an old assumption that to say something is always and simply to state something, Austin (1962) argued that in some cases to say something is ... illustrated in the two mock tests In a 20-minute class discussion, four student representatives integrated and presented the opinions of each group to the class I asked them to discuss such issues as whether ... discussed among themselves, then presented the results in front of the class The issues I proposed to them for the discussion were as follows: Were the series of listening strategies applying...
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Using comepensation attenuated genetics to understand underlying networks governing cellular robustness
... cytosolic domains This is supported by studies which showed that BiP-UPR sensor complexes present in unstressed cells dissociate upon induction of ER stress In addition, BiP overexpression was ... types of stress conditions as well, such as exposure to heavy metals and cytotoxic chemicals (NeuhausSteinmetz and Rensing 1997), oxidative insults, ischaemia/reperfusion and hemorrhagic shock ... ATF6 stress sensors in metazoans In higher eukaryotes the number of ER stress sensors has increased in proportion with the increased demand and complexity of multicellular organisms In mammals there...
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Experimental study of passive cooling of building facade using phase change materials to increase thermal comfort in buildings in hot humid areas
... phase is called sensible heat storage However, in order for sensible heat storage to be effective in modern buildings, a number of problems arise such as high cost, excessive mass and undesirable ... 2009-2010) Since it is like summer all year around, cooling is the main issue regarding buildings in Madurai Most of the buildings are built with Reinforced Concrete Slabs (RCC) as roofing system and ... moderately successful attempts in the 197 0s and 198 0s to use different types of organic and inorganic PCMs to reduce peak loads and heating and cooling energy consumption [16] Recent research has shown...
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Tài liệu Báo cáo khoa học: "Using Automatically Transcribed Dialogs to Learn User Models in a Spoken Dialog System" doc
... test set The normalization is to allow for easier comparison across data sets of differing sizes We repeated this entire process (generating training and test sets, estimating and evaluating user ... directory This system is currently in use in a large company with many thousands of employees Users call the directory system and provide the name of a callee they wish to be connected to The system ... synthetic dialogs by following the probabilistic process depicted in Figure In this way, we were able to create synthetic training sets of varying sizes, as well as a test set of 1000 dialogs Each generated...
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Báo cáo khoa học: "Using Conditional Random Fields to Predict Pitch Accents in Conversational Speech" pptx
... Processing B Taskar, C Guestrin, and D Koller 2004 Maxmargin markov networks In Proc of Advances in Neural Information Processing Systems P Taylor 2000 Analysis and synthesis of intonation using the ... EMNLP and VLC V Punyakanok and D Roth 2000 The use of classifiers in sequential inference In Proc of Advances in Neural Information Processing Systems F Sha and F Pereira 2003 Shallow parsing with ... labeling setting using CRFs (Lafferty et al., 2001) The rest of the paper is organized as follows: In Section 2, we introduce CRFs Then, we describe our corpus and the variables in Section and Section...
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Báo cáo khoa học: Selecting cells with different Alzheimer’s disease c-secretase activity using FACS Differential effect of presenilin exon 9 deletion on c- and e-cleavage doc
... [31] To test the latter hypothesis other inhibitors were also applied in the COS-7 cell fluorescence assay, including in particular proteasome and caspase inhibitors The inhibitors lactacystin (0.5 ... fluorescence We show the application of this assay to the testing of c-secretase inhibitors and PS1 mutants This assay allows for the first time the selection of cell populations and single cells ... not shown) The effect of the c-secretase inhibitors was also studied in CHO cells to confirm our findings in a different cell line The inhibitors were 2–10 times less potent in CHO cells 500 M F Sernee...
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A Complete Guide for All Ages: Easy to understand information from the nation’s leaders in women’s health doc
... your health involves understanding your risk factors for different diseases Risk factors are things in your life that increase your chances of getting a certain disease Some risk factors are beyond ... signs of stroke, as well as understanding risk factors, diagnosis, and treatment of stroke Cancer 51 Understanding risk factors, symptoms, important screening tests, and treatment ... cause side effects These include bleeding in the stomach, intestines, and brain If you’re thinking about using aspirin to treat or prevent heart problems, talk with your doctor first Heart Disease...
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Báo cáo khoa học: Increased glucose metabolism and ATP level in brain tissue of Huntington’s disease transgenic mice pdf
... RJ, Rosen BR & Beal MF (2000) Nonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington s disease ... disease mechanisms have been suggested, including transcriptional dysregulation, protein misfolding and degradation, oxidative stress, excitotoxic processes, impairment in intracellular transport ... cerebral metabolism measured using magnetic resonance spectroscopy in transgenic mouse models of Huntington s disease J Neurochem 95, 553–562 42 Jenkins BG, Klivenyi P, Kustermann E, Andreassen OA, Ferrante...
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Expanding Microenterprise Credit Access: Using Randomized Supply Decisions to Estimate the Impacts in Manila * ppt
... outcomes are varied, diffuse, and surprising in many respects Business investment does not increase; rather, we find some evidence that the size and scope of treated businesses shrink We find some ... a small overall decrease In all, we find that increased access to microcredit leads to less investment in the targeted business, to substitution away from labor and into education, and to substitution ... are surprising in that they point to decreases in the number of businesses,19 and in the number of helpers in businesses owned by the household The reduction in helpers is driven by paid (and...
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báo cáo hóa học:" Retinal pigment epithelial cells secrete neurotrophic factors and synthesize dopamine: possible contribution to therapeutic effects of RPE cell transplantation in Parkinson''''s disease" doc
... mg/kg, i.p.) and VM tissues were dissected from embryonic brain and trypsinized into single-cell suspension using sterilized micropipette tips The cells were resuspended in DMEM and Ham 's F12 at ... transplants and mounted to gelatin coated slides Adjacent sections were processed for hematoxylin-eosin (HE) stain and immunohistochemistry The sections were stained against cytokeratin antibody ... tissues and significantly improve AIR in 6-OHDA-lesioned rats To demonstrate the RPE cells survival in the host striatum, we performed HE staining and cytokeratin immunostaining HE staining showed...
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báo cáo hóa học: " ELISA measurement of specific non-antigenbound antibodies to Ab1-42 monomer and soluble oligomers in sera from Alzheimer’s disease, mild cognitively impaired, and noncognitively impaired subjects" pptx
... differences, and the small sample sizes used in some studies In previous ELISA studies comparing these antibodies in AD subjects vs normal controls, only Moir et al [3], Gruden et al [14,15], and Nath ... possible treatment for AD; encouraging results were obtained in two clinical trials in which IvIg was administered to AD patients [22,23] and a multi-site phase trial is in progress In our ELISA ... (NCI) individuals, incorporating all of these procedures, and to perform power analyses on the resulting data to obtain estimates of appropriate group sizes for future studies using this approach...
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báo cáo hóa học:" Using individual growth model to analyze the change in quality of life from adolescence to adulthood" potx
... variability in trajectories by using gender and psychiatric disorder Fourth, we discuss the application of individual growth models including statistical assumptions, centering issues and cohort effects ... for tests of the fixed effects NOTEST prevents the printing results of type tests of fixed effects RANDOM statement contains a list of the random effects, in this case intercept and age class id; ... purposes) Health and Quality of Life Outcomes 2006, 4:10 indicating better QOL 580 subjects were assessed all three times (72.0%), 179 were assessed twice (22.2%) and 46 were assessed at a single...
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