use of modeling and simulation to optimize dose finding strategies
An Introduction to Modeling and Simulation of Particulate Flows Part 2 pot
... all of the work done by the external and internal forces It is advantageous to decompose the kinetic energy into the translation of the center of mass and the motion relative to the center of ... the system size and tested a model of manageable dimensions A key to comparing a model of normalized dimensions to that of the true model is the concept of dynamic similitude and dimensionless ... overall behavior of the motion, it is advantageous to decompose the kinetic energy per unit mass into the bulk motion of the center of mass and the motion relative to the center of mass: T (t)...
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An Introduction to Modeling and Simulation of Particulate Flows Part 3 pdf
... error and S is intrinsic to the system.18 Our goal is to meet an error tolerance in exactly a preset number of iterations To this end, we write (S( ttol )p )Kd || L+1,0 || = TOL, (3.28) where TOL ... The proportions of the kinetic energy that are bulk and relative motion Top to bottom and left to right, for eo = 0.5, µs = 0.2, µd = 0.1: (1) no near-field interaction, (2) α = 0.1 and α = 0.05, ... The total kinetic energy in the system per unit mass Top to bottom and left to right, for eo = 0.5, µs = 0.2, µd = 0.1: (1) no near-field interaction, (2) α = 0.1 and α = 0.05, (3) α = 0.25 and...
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An Introduction to Modeling and Simulation of Particulate Flows Part 4 pot
... simultaneously to be able to make accurate predictions of the behavior of the flow Accordingly, the present work develops models and robust solution strategies to perform direct simulation of the dynamics of ... behavior to adapt to a different type of behavior within a given time interval The number of genetic strings in the population was set to 20, for 20 generations, allowing total offspring of the top ... field is quite large and encompasses a wide variety of applications, for example, the behavior of flocks of birds, schools of fish, flow of traffic, and crowds of human beings, to name a few Loosely...
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An Introduction to Modeling and Simulation of Particulate Flows Part 5 potx
... size of t lim = 10−2 s and a starting time step size of 10−3 s The tolerances of both fields (TOLr and TOLθ ) for the fixed-point iterations were set to 10−6 and the upper limit on the number of ... Z X Y Z Y X Y Figure 7.5 Top to bottom and left to right, the dynamics of the particulate flow with clustering forces: An initially fine cloud of particles that clusters to form structures within ... strong enough to induce vibratory motion and hence nonmonotone kinetic energy Frames of the flows for cases and 2, for (typical) values of κ = × 106 J/m2 , are shown in Figures 7.5 and 7.6 The plots...
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An Introduction to Modeling and Simulation of Particulate Flows Part 6 pps
... w1 + w + w + w w1 TOLr + w2 TOLθ + w3 TOLrf + w4 TOLθf ; w1 + w + w + w TOLtot = (c) K = def TOLtot Etot,0 Etot,K Etot,0 pKd pK ; (5) IF TOLERANCE MET (Etot,K ≤ 1) AND K < Kd , THEN ... L+1,0 || = TOL, where TOL is a tolerance and Kd is the desired number of iterations.49 If the error tolerance is not met in the desired number of iterations, the contraction constant η is too large ... of mechanical, thermal, and chemical energy in a system, dictated by the first law of thermodynamics Accordingly, we require the time rate of change of the sum of the kinetic energy (K) and stored...
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An Introduction to Modeling and Simulation of Particulate Flows Part 7 docx
... hundreds, or thousands, of scatterers, the direct use of Maxwell’s equations to describe the flow of energy leads to systems of equations of such complexity that, for all intents and purposes, the ... presented to illustrate the overall procedure and to investigate aggregate ray dynamics corresponding to the flow of electromagnetic energy and the conversion of the absorbed energy into heat and infrared ... near-fields: Top to bottom and left to right, the dynamics of the particulate flow Blue (lowest) indicates a temperature of approximately 300◦ K, while red (highest) indicates a temperature of approximately...
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An Introduction to Modeling and Simulation of Particulate Flows Part 8 potx
... presented to illustrate the overall procedure and to investigate aggregate ray dynamics corresponding to the flow of electromagnetic energy and the conversion of the absorbed energy into heat and infrared ... primarily because of the refraction of different wavelengths of light, leading to a dramatic growth in the number of rays of varying intensities and color (wavelength) The inclusion of these effects ... 314.587 Figure 9.14 Top to bottom and left to right, the progressive movement of rays making up a beam (for the best inverse parameter set vector (Table 9.2)) The colors of the particles indicate...
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An Introduction to Modeling and Simulation of Particulate Flows Part 9 pot
... is to develop a simple approach to ascertaining the light-scattering response of large numbers of randomly distributed and oriented RBCs Because the diameter of a typical RBC is on the order of ... Starting from left to right and top to bottom, the progressive movement of rays (1000) making up a beam (n = 1.075) The lengths of the vectors indicate the ˆ irradiance (Zohdi and Kuypers [223]) ... of mechanical, thermal, and chemical energy in a system are governed by the first law of thermodynamics It states that the time rate of change of the total energy, K + I, is equal to the sum of...
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An Introduction to Modeling and Simulation of Particulate Flows Part 10 potx
... elliptocytosis (Eber and Lux [62] and Gallagher [73], [74]) Changes in membrane and cytosolic proteins may affect the state of hydration of the cell and thereby its morphology Millions of humans ... La Ragione, L., and Makse, H 2005 Fluctuations and the effective moduli of an isotropic, random aggregate of identical, frictionless spheres The Journal of Mechanics and Physics of Solids, Vol ... will lead to decreased red cell survival, often accompanied by anemia Genetic disorders of cytoskeletal proteins will lead to red cell pathology, including hereditary spherocytosis and hereditary...
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An Introduction to Modeling and Simulation of Particulate Flows Part 11 pdf
... Computational design of swarms The International Journal of Numerical Methods in Engineering, Vol 57, 2205–2219 [210] Zohdi, T I 2004 Modeling and simulation of a class of coupled thermo-chemomechanical ... Mathematical, Physical and Engineering Sciences, Vol 361, 1021–1043 [212] Zohdi, T I 2004 Modeling and direct simulation of near-field granular flows The International Journal of Solids and Structures, ... Biomechanics and Modeling in Mechanobiology, Vol 4, 57–61 [222] Zohdi, T I and Szeri, A J 2005 Fatigue of kidney stones with heterogeneous microstructure subjected to shock wave lithotripsy Journal of...
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Modeling and Simulation of Microbial Depolymerization Processes of Xenobiotic Polymers
... appropriate to assume that the time factor of the degradation rate σ (t ) is an exponential function of time σ (t ) = e at +b In view of Eq (12.8) (12.13) 291 292 12 Modeling and Simulation of Microbial ... distribution of PLA before and after enzymatic degradation Residual amounts of PLA after incubation for and 67 h were 40% and 27%, respectively [17, 18] 301 12 Modeling and Simulation of Microbial ... consumption rate and the weight conversion rate from the class of M-molecules to the class of (M − L)-molecules, respectively The first term of the right-hand side of Eq (12.1) is the total weight...
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Báo cáo khoa học: Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase pdf
... regulation of GSK3 and GS To further understand the effects of Li and SB-415286 on cell signalling events we assessed their effects and that of insulin on p70S6K, PKB, p42/p44 MAP kinases, GSK3 and ... establish the importance of GSK3 in the acute regulation of glucose transport in terms of its regulatory control of GS in muscle and fat cells we have investigated the effects of Li and the anilinomaleimide, ... Regulation of GS activity To establish the importance of GSK3 inhibition on GS activity we monitored the effects of insulin, Li, SB-415286 and wortmannin (a PI3K inhibitor) on the incorporation of Ó...
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Báo cáo khoa học: The use of synthetic linear tetrapyrroles to probe the verdin sites of human biliverdin-IXa reductase and human biliverdin-IXb reductase potx
... concentration of cytosolic biliverdin-IXa The paucity of information on the biliverdin binding site has hampered the development of inhibitors of BVR-A With this in mind, and in the absence of a crystal ... reported to form adducts with environmental toxins [15] and endogenous ligands [16] BVR-B is adducted at equimolar stoichiometry by electrophilic metabolites of 1-nitronapthalene [15] and BVR-A ... (v ⁄ v) methanol from the stock solution of ester (blue); addition of 37 lM BSA from a stock solution of 50 mgÆmL)1 produced the red trace and subsequent addition of 50 lM NADPH produced the...
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Case Study in Financial Modeling and Simulation of a Forestry Investment potx
... Analysis of sensitive variables 17 Forestry Modeling Forestry projects are long term Costs and benefits are difficult to predict Growth risks and product types are particular to forestry Modeling ... Forestry Models Establishment:- land, land preparation, plant stock, planting, watering Maintenance:- weed control, fertilizing, pruning and thinning, fire and pest protection Inflows:wood; ... pruning and thinning, poor growth, timber usage and fashion changes Sovereign risk: regulatory changes, taxation changes, uncertain harvest rights Predicting Cash Flows The key growth indicator...
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modeling and simulation of systems using matlab and simulink
... of hypotheses Due to advancements in systems engineering for handling complex systems, modeling and simulation have, of late, become popular Modeling and simulation are very important tools of ... aspects of modeling and simulation of physical as well as conceptual systems It strives to motivate beginners in this area through the modeling of real-life examples and their simulation to gain ... simulation This book aims to • Provide a basic understanding of systems and their modeling and simulation • Explain the step-by-step procedure for modeling using top-down, bottom-up, and middle-out approaches...
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an introduction to network modeling and simulation for the practicing engineer
... Advantages and Disadvantages of Modeling and Simulation 1.2 Comparison of “Homebrew” Models and Simulation Tools 1.3 Common Pitfalls of Modeling and Simulation and Rules of Thumb 1.4 An Overview of Common ... algorithms of smaller components of the larger overall entity or process This book generally uses the combined term M&S to generically refer to the employment of models, simulations, and emulators to ... technology and code development is inevitable, it is recommended that this new custom simulation be developed within existing COMMON PITFALLS OF MODELING AND SIMULATION AND RULES OF THUMB tools/environments...
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Báo cáo hóa học: " Research Article A Framework for System-Level Modeling and Simulation of Embedded Systems Architectures" ppt
... system within a range of hundreds of thousands to a few millions of cycles/s, even in the case of model refinements The last two rows of Table are on the accuracy of system-level simulation based on ... from one to four, the type of processors from MicroBlaze to PowerPC, and the mappings of the six application processes onto these different instances of the platform architecture All of this yields ... into account [12]: maximum processing time in the system, total power consumption of the system, and the cost of the architecture This section aims at giving an overview of the formulation of...
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Báo cáo hóa học: "Multiscale modeling and simulation of nanotube-based torsional oscillators" docx
... f2 J1 l1 where f1 and f2 are the frequencies, J1 and J2 the angular moments of inertia of the metal paddles, and l1 and l2 the length of nanotubes in torsional oscillators and 2, respectively ... missing atoms, we perform bond reconstruction to generate one-atom, two-atom, and/ or cluster-atom vacancy defects Even for the same number of missing atoms, the numbers and locations of vacancy ... one of the macroscopic parameters and is related to the kinetic energy of atoms We believe that the highspeed rotation of the metal paddle drives large vibration of atoms during the torsion of...
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