urine formation by the kidneys ii tubular processing of the glomerular filtrate
Báo cáo Y học: Suppression of apolipoprotein C-II amyloid formation by the extracellular chaperone, clusterin potx
... amyloid formation by apoC -II in the presence of various concentrations of clusterin (Fig 1) For apoC -II alone, amyloid formation occurs slowly over days at room temperature The presence of increasing ... 30 : molar excess of apoC -II to clusterin (Fig 1B) The specificity of the inhibition of amyloid formation by clusterin was assessed in control experiments using BSA The presence of BSA (100 lgÆmL)1) ... from the data in Figs and that clusterin inhibits apoC -II aggregation Amyloid fibril size is reduced by the presence of clusterin The effect of clusterin on the aggregation-state of apoC -II amyloid...
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Tài liệu Báo cáo khoa học: Membrane targeting and pore formation by the type III secretion system translocon pdf
... essential for the injection of type III effectors into the target cytoplasm and therefore are considered to be the first substrates secreted by the T3SS needle upon cell contact In the absence of external ... to the first, ‘three-tiered ring’ model, the scarcity of information with respect to the mode of assembly of the three proteins suggests that it is still early to discard the possibility of the ... function appears to be the only one that is common to all bacteria In Yersinia, the increased synthesis of LcrV triggered by the activation of the system leads to the titration of LcrG, which binds...
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báo cáo hóa học:" Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx Chi Zhang" pptx
... expression of type I collagen (Col1a1) in the condensed mesenchyme of the membranous skeleton and the periosteum and mesenchyme of the endochondral skeleton is severely reduced Expressions of the osteoblast-specific ... regulator of postnatal bone mass 11 Dlx5 delayed ossification of the roof of the skull and abnormal osteogenesis positive regulator in OB differentiation 12 reading frame (ORF) and 3-prime UTR The ... Osx-null embryos the number of TRAP-positive cells appear to be reduced compared to wild-type embryos In long bones of Osxnull embryos cells from the periosteum invade the zone of the hypertrophy...
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Biofilm formation by sulfate reducing bacteria and biocorrosion of metals in seawater
... results in changes in the properties of the metal and which may often lead to impairment of the function of the metal, the environment, or the technical system of which these form a part” (Stearns, ... and the corrosion behavior of titanium is investigated Biofilm formation and detachment are observed The morphology of microbial cell, their distribution on the surface and the presence of EPS ... alloying the metals, and the use of biocides and inhibitors This approach will significantly reduce the cost of damage to both the material and product At the same time, the structure integrity of the...
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Tài liệu Báo cáo khoa học: The distinct nucleotide binding states of the transporter associated with antigen processing (TAP) are regulated by the nonhomologous C-terminal tails of TAP1 and TAP2 ppt
... model for the transport cycle of the active TAP variant 2–1C2 The initiation step and the progress of the transport cycle are similar to the hypothesized peptide translocation model of the wild-type ... ARK/Sigma The chimeric TAP construct 1V2 was created by ligation of the 1.6 kb ScaIfragment containing the C-terminus of TAP2 to the 3.8 kb ScaI-fragment containing the TMD and core NBD of TAP1 In the ... ADP-binding state of TAP2 and the C-terminal tail of NBD1 allow binding of ATP to TAP1 Peptide binding leads to a change in the conformation of the TMD, which is transmitted via the core NBD2 to the C-terminal...
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Báo cáo khoa học: Formation of highly toxic soluble amyloid beta oligomers by the molecular chaperone prefoldin pptx
... expressed in the human brain [42], our results suggest a possible involvement of PFD in the formation of toxic Ab oligomers in the cytosol Results Fibrillation of Ab peptide in the presence of PFD ... Examples of the Ab particles shown in (B) Scale bar = 50 nm ined the cytotoxicity of soluble Ab oligomers produced by the addition of PFD Ab aggregates of various concentrations were added to the ... support the notion that PFD participates in the formation of Ab oligomers within the cytosolic compartment In an effort to elucidate the mechanism pertaining to the PFD-induced formation of high-molecular-mass...
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Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx
... at another site, so that the phosphorylation kinetics of one residue can depend on the phosphorylation state of other residues in the protein [8] It is not clear how these factors modulate the ... the shape of the response curve is strongly affected by the two groups of parameters that determine the protein–protein interactions: the concentrations of the enzymes relative to the target protein, ... that the degrees of cooperativity in the binding of kinase and phosphatase to the target are the same The dark areas denote regions of high stimulus sensitivity (high Hill coefficients) The stimulus–response...
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Báo cáo Y học: Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae ppt
... importance of this structure is reflected in the high conservation of the sequences forming the pin in the majority of bacteria with the exception of two Mycoplasma species and one of Ureaplasma In the ... using MpRuvA (Fig 5B, lanes l–r) The only complexes seen were those formed by the binding of RuvC alone or of a double tetramer of MpRuvA (complex II) The absence of MpRuvA complex I may be significant, ... MpRuvA blocking the access of other junction processing enzymes such as RecG [24] Expression of MpRuvA also reduced survival of the ruv+ AB1157 strain (Fig 6B) However, the effect was rather modest...
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Báo cáo khoa học: De novo synthesis, uptake and proteolytic processing of lipocalin-type prostaglandin D synthase, b-trace, in the kidneys pptx
... PGD2 ⁄ L-PGDS in the kidney possibly attenuates the progression of kidney damage In some renal diseases, the increase in the biosynthesis of L-PGDS in the kidney may be a type of adaptation mechanism ... exposed on the surface of the molecule However, in the soluble form, the affinities of MAb10A5 for native L-PGDS were lower than those for the recombinant protein, suggesting that the C-terminal ... 2A) The comparison of the amino acid sequences revealed that the sequences of the antigenic regions recognized by MAb-5C11, MAb-1B7 and MAb-10A5 were also highly conserved in both species The...
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Báo cáo khoa học: Monitoring the prevention of amyloid fibril formation by a-crystallin Temperature dependence and the nature of the aggregating species pdf
... increased by 0.05 ngÆmm)2 and the density decreased by 0.0167 gÆcm)3, from the start of the experiment By the end of the measurement, the thickness had increased by 0.342 nm, the mass had increased by ... during the entire experiment (Fig 5), i.e the thickness of the layer decreased by 0.014 nm, the layer density decreased by only 0.0086 gÆcm)3, and the mass decreased by 0.03 ngÆmm)2 The process of ... other prefibrillar intermediates, culminating in formation of the mature fibril [24] The increasing a-Crystallin and amyloid fibril formation complexity of these structures is paralleled by conformational...
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Báo cáo khoa học: Interaction with model membranes and pore formation by human stefin B – studying the native and prefibrillar states docx
... than the native state [11] In the present study, we compare the behaviour of the Y31 isoform of stefin B studied previously, wild-type stefin B and a mutant G4R of the wild-type The G4R mutant of the ... was followed for 30 The permeabilization induced by the proteins was expressed as a percentage of the maximal permeabilization obtained at the end of the assay by the addition of Triton X-100 to ... of G4R The ionic current flowing through the membrane upon addition of 3–4 lM of native G4R Similar results were obtained with the prefibrillar form of G4R The traces were acquired at +100 mV The...
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Báo cáo khoa học: In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS–HSP90 heterocomplex pot
... aorta The level of HSP90 and the type of NOS isoform present in rat brain and aorta were determined by immunoblotting (Fig 1) In brain, nNOS was the most preferentially expressed isoform, together ... in these digestion processes was demonstrated by the protective effect on both HSP90 and NOS degradation of the administration to the HSD-treated NMS animals of C.I.1 (Fig 5) In the brain of ... to explore the relationship between the HSP90 to NOS ratio and the formation of calpainresistant heterocomplexes, we first studied, by immunoprecipitation analysis, the association of the two proteins...
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Báo cáo khoa học: Nop53p interacts with 5.8S rRNA co-transcriptionally, and regulates processing of pre-rRNA by the exosome ppt
... extension of the 7S pre-rRNA and formation of the mature 5.8S rRNA [13] Interestingly, despite being directly involved in the late steps of processing, depletion of essential subunits of the exosome ... indicating that these RNAs are not efficiently processed or degraded by the exosome in the absence of Nop53p In order to determine whether the effect of Nop53p depletion on 5.8S processing by the exosome ... degrade RNA by itself, its presence stimulates the RNase activity of the exosome It is possible that the stimulation of the exosome activity is due to recruitment of the complex to the substrate...
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Báo cáo hóa học: " Effects of rehydration nutrients on H2S metabolism and formation of volatile sulfur compounds by the wine yeast VL3" docx
... previous hypothesis of distinct effects for each of the treatments and further suggest the presence of an additional nutrient factor regulating the formation of H2S Confirmation of the microarray ... observations at the sampling point where the addition of rehydration nutrients induced the formation of H2S while the addition of DAP delayed it Page of 11 (Figure 1c) Nonetheless, these results ... concentration of higher alcohols was decreased (Additional file 1) Further characterisation of the effect of rehydration nutrients on the formation of volatile sulfur compounds was obtained by monitoring...
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Báo cáo khoa học: "Effect of a feedback control by early secondary xylem formation on the outcome of competition between leafy shoots in apple (Malus x domestica Borkh.)" ppt
... from the presence of a third bud and from the direction of this deviation Fig displays the distribution of the degrees of dominance in selected subpopulations where deviation infringes upon the ... (top) or on the larger one (bottom) and where bud is favored by the presence of bud (left) or bud by that of bud (right) Anatomical investigation gives a pos- interpretation of these rather surprising ... dominance of this latter; whereas bud near bud favors the occurrence of a fork (Jebari and Crabbe, 1984; Crabbe, 1985) This is, however, further complicated by the frequent helical deviation of the...
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Báo cáo lâm nghiệp: "Ultrastructural and biochemical changes at the preinfection stage of mycorrhizal formation by two isolates of Pisolithus tinctorius" ppt
... comparison of the early events of infection between E urophylla and both strains of P tinctorius shows important differences at the interface Indeed, it seems that the plant reacts to the presence of ... with strain was in evidence at the surface of the fungal plasmalemma as well as in the vacuoles The plasmalemmal activity was detected when the hyphae were close to the roots, while it was nearly ... surface Where the hyphae are in contact with the root, a thickening of the host plant cell wall can be observed, resulting from deposition of dense granular or fibrillar materials on the internal...
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Báo cáo y học: "In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype" pdf
... stratify the patients in any case control study by IIM subtype We therefore test the hypothesis that HLA class II associations differ between PM and DM, and investigate the contribution of serological ... determination of the presence of the antibody The presence of anti-SRP, anti-U3RNP and the rare anti-tRNA synthetases (anti-PL-7, anti-PL-12, anti-EJ, anti-OJ, anti-KS) were confirmed by RNA immunoprecipitation ... DQB1*02 In light of this, a 'relative predispositional effect' test was performed to examine whether the effect of other alleles had been masked by the relatively increased frequency of these alleles...
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Báo cáo y học: "Identification of proteases employed by dendritic cells in the processing of protein purified derivative (PPD)" pdf
... pepstatin A had primarily inhibited the processing events Functional role of cathepsin D/E in the processing of PPD by XS52 DC To identify the protease(s) inhibited by pepstatin A, XS52 DC were pretreated ... Journal of Immune Based Therapies and Vaccines 2004, 2:8 DCI E-64 100 80 40 20 Cathepsin D/E Cathepsin C Cathepsin A Chymotrypsin BLT Esterase Cathepsin L Cathepsin J Cathepsin H 0 Cathepsin A Cathepsin ... Cathepsin L Cathepsin J Cathepsin H Cathepsin D/E Cathepsin C Chymotrypsin BLT Esterase Cathepsin A Chymotrypsin BLT Esterase Cathepsin L Cathepsin J Cathepsin H Cathepsin D/E Cathepsin C 20 20...
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báo cáo khoa học: " Insight into the early steps of root hair formation revealed by the procuste1 cellulose synthase mutant of Arabidopsis thaliana" doc
... [4,5] The formation of double hairs by a proportion of prc1-1 epidermal cells (Fig 2E) indicates that the control of the site of hair initiation is affected To test this, the position of hair formation ... root hair formation in wild-type and can result in the restoration of hair formation in rhd6 [6] This raised the question of whether the partial restoration of hair formation in rhd61 by prc1-1 ... to the expression pattern or activity of one of the other CesA proteins or other important factors cannot be ruled out However, alteration of the cellulose composition of the cell wall is not the...
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Báo cáo y học: " Processing sites in the human immunodeficiency virus type 1 (HIV-1) Gag-Pro-Pol precursor are cleaved by the viral protease at different rates" ppt
... products The presence of these paired products suggests that dimerization of the RT-containing processing intermediate occurred early in the processing cascade, consistent with the results of others ... domains The other feature of the system we have used is the reliance of protease cleavages in trans Use of trans protease on the full length precursor allows for the clear evaluation of generation of ... consisting of discrete intermediates We have used three strategies to assign the cleavage sites that define the ends of the processing products The first we assigned the products based on the known processing...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct mở máy động cơ rôto dây quấn hệ số công suất cosp fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008