... groups, and shall further the activities ofthe United Nations for the maintenance of peace (3) Parents have a prior right to choose the kind of education that shall be given to their children ^ ... government of his country, directly or through freely chosen representatives (2) Everyone has the right of equal access to public service in his country (3) The will ofthe people shall be the basis of ... Everyone has the right to the protection ofthe law against such interference or attacks ^ Top Article 13 • • (1) Everyone has the right to freedom of movement and residence within the borders of each...
... Conclusions TheRightsofthe Defence: Lessons from the Nineteenth Century A The Institutional Nature oftheRightsofthe Accused B TheRightsofthe Defence at Trial (i) The Presence ofthe Accused ... coherent understanding of fairness requires recognition ofthe reliance ofthe role ofthe defence (and therefore therightsofthe accused) on the institutional structure ofthe proceedings xx Columns ... involve the interrogation and defence ofthe accused, the hearing and discussion ofthe evidence of witnesses, the examination of all ofthe facts and the assessment ofthe evidence Further, it...
... On the important role of small states in 1944 and later, see Susan Waltz, “Universalizing Human Rights: The Role of Small States in the Construction oftheUniversalDeclarationofHuman Rights, ” ... 2002), 53 On the signiWcance ofthe war for the declaration, see Morsink, TheUniversalDeclarationofHuman Rights, ch 21 For example, in an article describing the drafting ofthe declaration, ... put the point later, a global practice ofhumanrights oVers the hope of constraining one ofthe two main perils of a global political order composed of independent states (The other is the propensity...
... questions of any ofthe villagers The reason for the pictures ofthe front view is because they the walls correctly in the front, but on the sides and the back, as well as the roof, they leave ... to a lack of focus on humanrights protections following natural disasters, the UN HumanRights Council issued the Report ofthe Representative ofthe Secretary-General on humanrightsof internally ... [46] The document recognized the importance ofhumanrights considerations in the context of natural disasters and the humanitarian response: Humanrights are the legal underpinning of all humanitarian...
... humanrights - The awareness ofthe people about thehumanrights and the role of court in protecting humanrights Firstly, the awareness ofthe people about thehumanrights Secondly, the awareness ... under the judging execution ofthe Party - The awareness level ofthe people about thehumanrights and the significance of judging activities in protecting thehumanrights - The belief ofthe ... 2.3.1 The awareness ofthe Party, the state and the people about the role of court in protecting humanrights - The awareness ofthe Party and the state about the role of court in protecting human...
... must therefore look The Charter opens with the words ‘We, the peoples ofthe United Nations’, and not with We, the sovereign States ofthe United Nations That choice ofthe universality ofthe ... in the four means of achievement is exactly commensurate to the same spirit in the four ends It is the humanity of man, in the form ofhumanrights and human dignity, which stands at the core of ... octagon of eight fundamental concepts, the first four representing the ends ofthe Charter and the other four standing for the means to be adopted The position ofhumanrights and human dignity in the...
... for the protection of health or morals or for the protection oftherights and freedoms of others This article shall not prevent the imposition of lawful restrictions on the exercise of these rights ... safety or the economic well-being ofthe country, for the prevention of disorder or crime, for the protection of health or morals, or for the protection oftherights and freedoms of others Article ... democratic society in the interests of public safety, for the protection of public order, health or morals, or for the protection oftherights and freedoms of others Article 10 (freedom of expression)...
... involved either in the assembly ofthe immature HIV-1 capsid, or in the reassembly of CA into a mature capsid The detailed description ofthe structure and conformational dynamics of these interfaces, ... model ofthe NTD hexamer from MLV, the superimposed model ofthe NTD hexamer from HIV-1, the high-resolution X-ray model ofthe modified CA hexamer from HIV-1, and the pseudoatomic models ofthe ... analysis ofthe precise residues and interactions involved in the NTD–CTD interface [46] Most of these involve side chains from helix ofthe CTD which pack against the N-terminal end of helix of the...
... structure of CTD showing the dimeric structure ofthe domain The monomers are depicted in the same colour (blue) and the dimerization helix is highlighted (gold), with the side-chain ofthe sole ... by the X-ray structure ofthe nonmutated-CTD–CAI complex [28] (Fig 2A, main panel) The aromatic moiety of Phe3, together with Leu6 and Ile1, are the residues of CAI with the largest number of ... [36]; the helices are in red, the b-sheets in yellow and the loops in green The circle at the bottom ofthe figure indicates the region where the binding of CAP-1 occurs The figures were produced using...
... as the amino acid numbers The alternative conformations ofthe Trp–Met couple can be observed; the arrows indicate the unidirectional movement ofthe two protein residues upon ligand binding The ... on the hACMSD crystals using the same beamline, clearly indicated the presence of a Zn metal ion bound to the enzyme Analysis ofthe diffraction data set allowed us to assign the crystal to the ... understanding ofthe ACMSD catalytic mechanism is still incomplete In light ofthe reported ACMSD upregulation in the liver of streptozotocin-induced diabetic rats and the suppression of such elevation...
... Sequence ofthe a domain of rhMT-1a, showing the connectivities ofthe four divalent metal cations to the 11 cysteinyl sulfurs The numbering ofthe cysteines (1–11 starting from the N-terminus) and the ... spectra on the right side of Fig are the deconvoluted spectra showing the mass and identity ofthe species detected The deconvoluted spectra on the right side of Fig clearly show the formation of intermediate ... on the preliminary conformation ofthe protein and the coordination properties ofthe incoming metal ions Metallation of apo-a-rhMT-1a with Cd2+ was carried out at pH 7.3 by raising the pH of the...
... either loss ofthe epitope or an artifact ofthe blotting procedure The location of peptide 1011 along the primary structure of TC is shown in Fig 4A as sequence with a blue solid underline The ... None ofthe other antibodies recognized the above peptides The smaller synthetic fragments (c, d, e) imitated other segments ofthe CNBr peptide in Fig 4A, but did not inhibit mAb binding to the ... respectively They are deduced in accordance with the maximal mAb heparin effect on the functional activity of TC Arrows show the hypothetical movement ofthe domains after attachment of Cbl, see the...
... to quantify the amount of recovered protein owing to the presence of a high molar excess of BSA remaining in the buffer Therefore, a fixed aliquot ofthe protein was incubated with the indicated ... confirmed the nature of this protein (data not shown) Moreover, the spectrum reported in the figure showed the occurrence of a series of signals that were not interpreted simply on the basis ofthe ... of 70 kDa (marked by an asterisk), recognized to the same extent also by the GT sequence Binding ofthe GT oligomer was not a result of DNA interaction with the more abundant components of the...
... illustrates the overall saddle shape ofthe dimeric structure and the key heparin-binding residues in the N-terminal domain held coordinately by the two subunits on the top ofthe hollow (Fig 1A) The ... established Of two possible dimeric structures of LPL, the head-tohead and the head-to-tail models, the studies ofthe chimeric proteins of hepatic lipase and LPL and the tandem repeat approach of LPL ... and then the energy minimization ofthe model was iterated 300 cycles using the conjugate gradient methods with the program DISCOVER_3 in INSIGHT II To construct the dimeric form of LPL, the...
... indicated by the MD simulations ofthe modelled ternary hGK–Glc– ATP complex In the final structure ofthe simulations, the interactions ofthe adenosine moiety were similar to those observed in the binary ... Fig The Glc binding isotherm for the mutant L146R GST–hGK The enhancement of ITF was measured at 25 °C with increasing concentrations of Glc in the absence (d) and presence (s) of 2.5 mM ATPcS The ... related to the question of whether ATP binds to the Glc-free enzyme and the possibility of a nucleotide-triggered change in protein conformation In this work, we have studied the interaction of ATP...
... model ofthe PRYSPRY domain ofhuman TRIM5a using the known structures ofthe same domain from three other proteins [66–68] Furthermore, these authors showed that alanine mutations at clusters of ... presence of CyPA [48] The exact role of CyPA in the viral lifecycle is unclear and remains a subject of intense debate [49– 51] The significance of this interaction is supported by an alignment of primate ... initiation Synthesis of cDNA initiates from a primer binding site of 18 bases near the 5¢ end of viral genomic RNA The 3¢ terminal end of tRNA is complementary to nucleotides in the primer binding...
... for further study The concentration ofthe proteins was determined by the method of Lowry et al [14] and the purity was examined by SDS/PAGE [15] Assay ofhuman PKIb activity The activity of purified ... regulation ofthe PKI and PKI isoforms ofthe inhibitor protein ofthe cAMP-dependent protein kinase J Biol Chem 272, 20011–20020 Byler, D.M & Susi, H (1986) Examination ofthe secondary structure of ... (Fig 3B) The experimental molecular mass (8468.0 Da) obtained by electrospray MS was in complete accordance with the theoretical mass ofthehuman PKIb (8468.2 Da) [11] The identification ofthe gene...
... electrophoresis ofthe 50-kDa subunit of purified monkey, human and recombinant human PAH (hPAH) has revealed a marked microheterogeneity in which the individual molecular forms ofthe protomer have the same ... 1, none ofthe other Asn residues in the N-terminal regulatory domain are predicted to contribute to the microheterogeneity ofthe wild-type protomer Asn58, which is located at the end of an a-helix ... 3106.455); note, however, the lower S/N ratio ofthe spectra in Fig 4E than in 4B that has an effect on the accuracy ofthe deconvoluted spectrum Lability ofthe Asn residues in the autoregulatory sequence...
... scattering Because ofthe size ofthe emulsion particles, diffusional broadening ofthe flotation profiles is not very large, and variation ofthe diffusion coefficient throughout the distribution ... in the distribution, the mean and the quantiles enclosing 95% ofthe values from the analyses ofthe simulated distributions were determined Apolipoprotein-emulsion binding assay Samples of emulsion ... EggPtdCho/TO fraction in the presence of both apoE isoforms However, a greater increase in the ordinate maximum and area under the curve is obvious in the presence ofthe apoE4 isoform (Fig 7C, open...
... suggest that they may interact with the ‘roof’ and ‘floor’ of a hypothetical ‘verdin binding site’, with the nicotinamide ring forming part ofthe floor If the bound conformation is helical, there would ... 2) All ofthe fixed isomers were substrates for human BVR-A (Fig 4) The spectra of all ofthe fixed isomers exhibited the characteristic immediate FEBS Journal 276 (2009) 4405–4413 ª 2009 The Authors ... Franklin et al A Probing the verdin site of BVR-A and -B Fig Spectra ofthe BVR-A catalysed reactions ofthe locked conformers of biliverdin-IXa The spectra ofthe fixed isomers are shown in (A) 15Z-syn...