the roles of neuronal mhc class i molecules in brain development and plasticity
Investigation into the roles of ataxia telangiectasia mutated gene product, in multiple BRCA backgrounds
... (Lavin and Kozlov, 2007) It is likely that mutations mapping to the kinase domain possibly cause inactivation of the PI3-kinase activity and gives rise to AT Sequence alterations in ATM immediately ... cytoplasm for its degradation, resulting in nuclear accumulation and stabilization of p53 in response to IR p53 induces the transcription of Cdk inhibitor p21 which inhibit Cyclin dependent kinase (Cdk2), ... signaling efficiency, sensitivity to therapy, cell cycling and transformability ATM missense and deletion near the PI3-kinase domain was created by BAC recombineering and used to transfect into...
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Báo cáo khoa học: "the Role of Non-Timber Forest Products (NTFPs) in Livelihood Strategies and Household Economies in a Remote Upland Village in the Upper Ca River Basin, Nghe An, Vietnam" pdf
... Households in Tha Lang Hamlet In this analysis, livestock raising was chosen as a key indicator of the intensification strategy, since this activity often needs an initial large input of money, which ... Linh (Master in EU Environmental Policy, University of Wisconsin, US), Ms Amanda Allbritton (Master in Economics, University of Purdue, US) and Mr Tyler McKinley (BSB in Finance, University of ... collected, the farmers considered medicinal plants the most important product; since there are no medical stations nearby, these are the main source of medicine in the hamlet A diverse array of medicinal...
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Analysis of regulator of g protein signaling (RGS) function in growth, development and pathogenicity of magnaporthe grisea 1
... potential for signaling (Malbon 2005) Since the initial identification of the role of G proteins in development in 1988, these signaling cascades have since been implicated in development of various ... family of regulatory proteins whose members can bind to activated Gα proteins and stimulate their intrinsic GTPase activity leading finally to the termination of the signaling event The identification ... S cerevisiae mating will be discussed in chapter 1.2.2.2 in detail Study of S cerevisiae mating leaded to the identification of the first mitogen-activated protein kinase (MAPK) signaling cascade,...
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Analysis of regulator of g protein signaling (RGS) function in growth, development and pathogenicity of magnaporthe grisea 2
... ARSICQRFLEARLIESADGKLQQVYTMKGSVWQLTPKGIAILDQFCSKNGIQQKQVAELI ARSVCQRFVDARFIEPVDGKALPIFPLKGALFQLTPKGINILQRFCQRNGITARHVIDVL GTSKKIVIKYTFTTKAIWQWIMDCTDIMHVKEAVSLAALFLKTGLIVPVLLQPSRTDKKK Rgs1 Cprgs-1 FlbA Sst2 ... QQDRAYTAQYPGSQLFQPTKHSIYQITPNGKDLINGMNSRGRTSDAESTPRDHKPNEKLP QEDKGYPQPDASIVVFQPSKYAIYGITERGQRVCG -WIARDKSRETFYDNRGMP LIDSKHCDKKSNTSTSKNNIVKTIDSALMKQANECLEMAYHIYSSYIMIGSPYQLNIHHN Rgs1 Cprgs-1 FlbA ... GLVGVKMAKERKINDKIYMNTFTGK-AAVDWLMDCSTTIERRETVLIAELFVKYGLITML GFSQDMLISSSNLNKLDYVLTDPGMRYLFRRHLEKELCVENLDVFIEIKRFLKKMTILKK Rgs1 Cprgs-1 FlbA Sst2 467 272 479 466 QQDRSHIQQFPGCQVFQPTKHAIYHMTSKGKDMINGSVPRGRASEGDATHSATHRHG-VA...
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Analysis of regulator of g protein signaling (RGS) function in growth, development and pathogenicity of magnaporthe grisea 3
... Figure 28 Inductive Non-inductive _ Figure 29 Figure 30 Inductive Non-inductive _ Figure 31 B A Figure 32 A B Figure 33 A B Figure 34 mgb1D WT _ rgs1Dmgb1D magB G183Smgb1D Figure 35 Figure ... rgs1Dmgb1D magB G183Smgb1D Figure 35 Figure 36 MG010315 MG010105 MG09134 Control: Gamma actin MG03982 MG01173 MG01630 Figure 37 A B ...
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Analysis of regulator of g protein signaling (RGS) function in growth, development and pathogenicity of magnaporthe grisea 4
... Solvent 10mM 8-Br-cAMP 10mM 8-Br-cAMP _ B WT rgs1D Figure 45 Appressorium formation on inductive membrane (%) Appressorium formation on Noninductive membrane (%) WT 89 1.5 mscL∆ 92 mscS1∆ 87 2.5 ... Figure 39 WT rgs1D Figure 40 Figure 41 Figure 42 _ Figure 43 - Gd + Gd, 1h + Gd, 0h + Gd, 2h + Gd, 0.5h + Gd, 3h _ Figure 44 A WT rgs1D Solvent Solvent 10mM...
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Tài liệu Báo cáo khoa học: ¨ Induction of Kruppel-like factor 4 by high-density lipoproteins promotes the expression of scavenger receptor class B type I pptx
... carcinogenesis In normal conditions, the expression of KLF4 mRNA is most abundant in the colon and skin in mice, whereas expression of KLF4 is decreased in intestinal adenomas of multiple intestinal ... regulation of the key lipid binding protein adipocyte protein ⁄ fatty acid binding protein [19] All indicate that KLF4 may play an antiatherosclerotic role, which needs further investigation In summary, ... endothelial activation in response to proinflammatory stimuli [2] Overexpression of KLF4 in J774a macrophages induced the macrophage activation marker inducible nitric oxide synthase and inhibited the...
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Báo cáo khoa học: Roles of the SH2 and SH3 domains in the regulation of neuronal Src kinase functions pptx
... results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain For active n-Src in which the C-tail tyrosine was ... n-Src proteins were able to bind the NR2A C-tail with similar binding affinities in the nanomolar range (Fig 5) This indicates that the ability of n-Src protein to bind to the NR2A C-tail is independent ... intra-molecular interactions with the catalytic domain, and is also critical for active signaling [32] Therefore, it is possible that the SH2 domain is bi-functional in regulation of kinase activity A previous...
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Báo cáo y học: "Activation and detection of HTLV-I Tax-specific CTLs by Epitope expressing Single-Chain Trimers of MHC Class I in a rat model" pptx
... CTL lines with different epitope specificities for further confirming the epitope specificity of SCTs used in this study In addition, it is important to identify new CTL epitopes in rat model of ... or the quantification of IFN-γ production All rats were maintained at the P3 level animal facilities in Laboratory of Animal Experiment, Institute for Genetic Medicine, Hokkaido University The ... expression of MHC- I coupled with an antigenic peptide of interest In addition, a new system has been established to identify virus-specific T cells using the acquisition mechanism of epitope/MHC...
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Báo cáo y học: "MHC class I expression protects rat colon carcinoma cells from hepatic natural killer cell-mediated apoptosis and cytolysis, by blocking the perforin/granzyme pathway" ppt
... possibly contribute to the incomplete killing by hepatic NK cells of arriving colon carcinoma cells in the liver sinusoids, resulting in the formation of liver metastases Materials and Methods Isolation ... from hepatic NK cell-mediated killing; and (ii) showed the involvement of the perforin/granzyme pathway in the mechanism of MHC class I protection Results and Discussion Protection of target ... JC: Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins Biochemistry 1991,...
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The transference of meaning through class of words denoting parts of the human body in english and vietnames
... seeing II III The ability to see A thing like an eye The meaning I ( called the first meaning ) presents the centre of the semantic structure of the word holding it together It dominates over the ... the other meanings The meaning II, III ( called the second meanings ) are associated directly with the meaning I In some cases the second meanings are associated indirectly with the first meaning ... for instance, the meaning III of the below word relates to the meaning I through meaning II Lash : I eyelash; II The flexible leather part of a whip used for hitting people and animal; III A...
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Tài liệu THE ROLES OF AMINO ACID CHELATES IN ANIMAL NUTRITION pdf
... Xian-Ming, Cao Beijing Agriculture Science Institute Beijing, China Van Ping, Zhou Beijing Agriculture Science Institute Beijing, China Zunino, Hugo University of Chile Santiago, Chile Notice To the ... ncorporated into transferrin, while the remainder is either eliminated in the wastes or fixed in the connective tissues at the site of injection (13) All amino acids are particularly effective metal binding ... absorption and metabolism.(3) The more metabolic processes in which a certain mineral is involved, the greater will be the possibility of its interacting with other minerals Some of these interactions...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... species), NADH (NADH oxidase from Thermobacillus brockii) The arrows indicate the positions of histidine residues in PETN reductase inferred to be involved in ligand binding and counterpart residues ... report of a systematic analysis of the contribution of each histidine residue to binding and catalysis Thus, to ascertain the role of each histidine residue, and to identify any differential contribution ... for steroid ligands in the active site The work emphasizes the need for (i) detailed evaluation of mechanism, and (ii) caution in inferring mechanistic similarities in structurally highly related...
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Tài liệu Báo cáo Y học: Structural and biochemical characterization of neuronal calretinin domain I– II (residues 1– 100) Comparison to homologous calbindin D28k domain I–II (residues 1 –93) pdf
... [50] The chemical shifts of CR I II, Calb I II and Fig ‘Glycine 6’ of the calcium-binding loop is a sensitive indicator of calcium loading Filled bars denote EF-hand loops that bind calcium and ... fragments and q FEBS 2001 Characterization of calretinin domain I – II (Eur J Biochem 268) 6235 NMR data for CR I II indicate that the stoichiometry of calcium binding in CR I II is : Calcium-bound ... Comparison between rat brain calbindin- and calretininimmuno- reactivities Adv Exp Med Biol 269, 211– 214 Rogers, J.H & Resibois, A (1992) Calretinin and calbindin-D28k in rat brain: patterns of...
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Báo cáo khoa học: Post-ischemic brain damage: the endocannabinoid system in the mechanisms of neuronal death ppt
... outcome of transient forebrain ischemia in rats [37] Neuroprotective effects were also obtained in vivo with the endocannabinoid transporter inhibitor AM404 [38] and with the FAAH inhibitor URB597 ... activation in different brain areas has been associated with the modulation of important synaptic plasticity phenomena, such as depolarization-induced suppression of inhibition [66,70], depolarization-induced ... correlate the persistent post-ischemic increase in the levels of striatal anandamide with an increased activity of N-acylposphatidylethanolamine-hydrolyzing phospholipase D and reduced activity and...
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Báo cáo khoa học: Flexible nets The roles of intrinsic disorder in protein interaction networks potx
... regions of the protein involved in interaction with Cdk2 and cyclin A: 1, domain interacting with cyclin A; 2, a linker helix involved in binding both cyclin A and Cdk2; 3, domain interacting with ... explains the ability of p21Waf1 ⁄ Cip1 ⁄ Sdi1 to bind to and to inhibit a diverse family of cyclin–Cdk complexes, including cyclin A–Cdk2, cyclin E–Cdk2, and cyclin D–Cdk4 [124] Thus, the intrinsic ... than maintaining a smaller cell size, the key advantage of intrinsic disorder may lie in providing the molecular basis for the existence, flexibility, and evolution of interaction networks The following...
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Báo cáo khoa học: Delineation of the roles of FadD22, FadD26 and FadD29 in the biosynthesis of phthiocerol dimycocerosates and related compounds in Mycobacterium tuberculosis pptx
... (Table 1) The PCR product was digested with NdeI and HindIII, and cloned between the NdeI and HindIII sites of pMV361e, a pMV361 derivative containing the pblaF* promoter instead of the original phsp60 ... similar Phthiocerol dimycocerosates in M tuberculosis functions in all DIM-producing species, including M tuberculosis FadD29 is specifically involved in PGL biosynthesis During the biosynthesis ... controlled in vivo by specific interactions between FadD29 and PKS15 ⁄ on the one hand, and FadD26 and the FasI system on the other hand Further investigations, including protein interaction studies and...
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The Economics of Small Business Finance: The Roles of Private Equity and Debt Markets in the Financial Growth Cycle potx
... on the increases in size and organizational complexity of the consolidating institutions, also on other dynamic changes in their behavior, including possible changes in organizational institutions ... companies, including providing consulting services and sometimes becoming involved in solving major operational problems, serving on the board of directors, finding and hiring managers, occasionally ... businesses and other financial As noted above, these financial institutions specialize in screening, contracting, and monitoring methods to address information and incentive problems, and we will...
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