the role of the myofibroblast in dupuytren s disease fundamental aspects of contraction and therapeutic perspectives
Báo cáo y học: "Connecting the dots in Huntington’s disease with protein interaction networks" pptx
... DNA-binding domains and transcriptionalactivation domains of transcription factors and independently fusing these domains with candidate interacting proteins [21,22] Constructs encoding these fusion ... large size of Htt and its apparent role in several cellular processes has raised the possibility that Htt serves as a scaffold that arranges protein complexes by modulating the binding of accessory ... Analysis in these simpler model organisms may also discern the role of the novel proteins and interactions in cellular processes and thus help validate the functional predictions from the interaction...
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Báo cáo khoa hoc:" Wnt expression is not correlated with β-catenin dysregulation in Dupuytren''''s Disease" doc
... control tissues Wnt expression profiling in vivo and in vitro using Wnt specific primers To confirm the Microarray data and to assess the relative contribution of each of these 13 Wnts in DD and control ... disease Hand Clin 1999, 15(1):87-96, vii Gudmundsson KG, Arngrimsson R, Sigfusson N, Bjornsson A, Jonsson T: Epidemiology of Dupuytren' s disease: clinical, serological, and social assessment The Reykjavik ... Wnt 11 D2 Pooled W D D2 E M H2 L R T W Control Control Control Disease Disease Disease Disease Disease Disease Disease Disease Disease 5/37 4/17 1/3 0/28 1/4 0/16 0/9 0/16 0/2 2/9 5/22 11/19 9/37...
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Tài liệu Why Has The Cost of Navy Ships Risen - A Macroscopic Examination of the Trends in U.S. Naval Ship Costs Over the Past Several Decades doc
... the costs of SSN-667 to SSN-777, we compare costs of the Sturgeon class to those of the Virginia class The surface combatant pairings represent comparisons of average costs for classes; in particular, ... potential sources of cost escalation for naval ships Perhaps the most obvious is the cost for basic inputs, such as labor, material, and equipment, used in shipbuilding If the costs for these inputs increase, ... fashion and in a way that encompasses as many relevant broad topics as possible Other organizations, such as the Naval Sea Systems Command s (NAVSEA s) Ship Design, Integration and Engineering...
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Tài liệu Why Has the Cost of Fixed-Wing Aircraft Risen - A Macroscopic Examination of the Trends in U.S. Military Aircraft Costs over the Past Several Decades pptx
... comprises all systems such as avionics (electronics to control the aircraft), sensors (such as radar), other mission systems (such as electronic countermeasures, communications, targeting systems, ... present views of some industry representatives on the sources of cost escalation in Chapter Six Next, we discuss some options for addressing cost escalation in Chapter Seven Finally, we present our ... programs The report also provides relationships for developing estimates of T&E costs for future programs In Software Cost Estimation and Sizing Methods, Issues and Guidelines, MG-269-AF, Shari...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... covalent adduct This in turn suggests that UDPNAG assists in the assembly of the proper interactions in the active site by stabilizing the closed conformation of the protein In the closed conformation, ... process and is solely based on the detectability of the peptides of interest We have used this method to show that binding of fosfomycin to the K22 mutant proteins strongly depends on the charge of ... thus shielding the substrates (and ligands) from bulk solvent A detailed thermodynamic study of this process has indicated that the shift of the equilibrium towards the closed conformation is induced...
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The Role of Small and Large Businesses in Economic Development doc
... Source: U .S Census Bureau, Statistics of U .S Businesses Most gross and net new jobs at small businesses stem from existing business expansions rather than from new business startups Small business ... Source: U .S Census Bureau Statistics of U .S Business small-firm class The data, thus, suggest that the effects of migration of small firms into larger size classes and small business failures ... today s economy, so are large businesses There is no clear evidence that small businesses are more effective innovators Further, the innovations of both small businesses and large businesses are inextricably...
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Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... promiscuous 4¢-phosphopantetheinyl transferase Sfp from Bacillus subtilis and fluoresceinyl CoA [23] The successful 4¢-phosphopantetheinylation of DptF was monitored by the in- gel fluorescence of the ... domain is one of the few ACPs in which valine replaces isoleucine (I) or leucine (L) in the conserved sequence To determine whether DptF is the putative partner of DptE, we expressed dptF using the ... peptides, condensation of the fatty acid with the N-terminal tryptophan of the nonribosomally synthesized peptide is necessary Here, we report the results of a steady-state kinetic analysis of DptE...
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The Role of Gestures and Facial Cues in Second Language Listening Comprehension pptx
... responses Results and Discussion To give the reader a better idea of the types of gestures the participants saw in the lecture, discussion of the results begins with a description of these gestures, ... and comprehension as well as output Sueyoshi and Hardison 689 Conclusion The results of the present study suggest the need for further investigations of the role of visual cues in L2 listening ... between the two visual-stimulus conditions is the presence of gestures associated with the semantic, and in the case of beats, prosodic components of the lecturer s speech Participants in this stimulus...
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Bringing the Hidden Giants to the Footlight: the Role of Savings and Retail Banks in Increasing the Level of Access to Financial Services docx
... banking system The microcredit schemes of savings banks Although savings banks are savings mobilisation specialists, it is misleading to think about them as savings-only institutions Research has ... to serve this segment In spite of this, financial institutions should remain accessible for the most basic products, such as the passbook savings account This product is standard of the savings ... disbursing of loans and collecting loan repayments Another promising track for savings banks is to invest their savings deposits in microfinance institutions by specialising 18 Microfinance Information...
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The Role of Savings and Wealth in Reducing ―Wilt‖ between Expectations and College Attendance pdf
... that sums separate values for a business, checking or savings accounts, real estate, stocks, and other assets, and subtracts out credit card and other debt In this analysis, net worth does not include ... appropriate (SAS Institute Inc., 2008) To account for the survey design of the PSID, we estimate a series of logistic regressions across seven models using PROC SURVEYLOGISTIC (SAS Institute Inc., 2008) ... These findings suggest that the process of accumulating school savings may have effects apart from financing school Conley (2001) finds that a doubling of net worth results in an 8.3% increase...
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Báo cáo khoa học: Structure, expression and regulation of the cannabinoid receptor gene (CB1 ) in Huntington’s disease transgenic mice ppt
... gene in HD mouse brain This supports the hypothesis that the rate of transcription of CB1 in the striatum of symptomatic R6/2 mice is similar to the rate of transcription in regions of the brain ... levels of specific transcripts such as CB1 in striatal neurons Since it is known that the length of the CAG repeat affects the onset of HD in humans and in mice, we first confirmed that the rate of ... expression of CB1 in the striatum vs the cortex or expression of CB1 in transgenic HD mice To test the hypothesis that expression of mutant huntingtin decreased CB1 transcription, we measured the...
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Báo cáo khoa học: Tertiary structure in 7.9 M guanidinium chloride ) the role of Glu53 and Asp287 in Pyrococcus furiosus endo-b-1,3-glucanase pot
... their involvement in interactions with cations offers new perspective in the analysis of the contribution of ions as cofactors in protein folding [38] and in the design of variants of proteins with ... a simple two-state mechanism, as suggested by the lack of coincidence of the changes in relative uorescence intensity and in k and by the hysteresis of the reversibility process (Fig 4) At the ... the uorescent probe ANS The uorescence emission spectrum of ANS in the presence of all the variant proteins in 7.9 m GdmCl shows a modest, twofold increase in intensity compared to that in native...
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Báo cáo khoa học: The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein ppt
... metalloprotease was responsible for the shedding of pro-TGFa [18] In this study we have investigated the role of ADAM10 and TACE in the shedding of ACE using an antisense oligonucleotide (ASO) approach ... exposure in either the untransfected SH-SY5Y cells or in the APP695-transfected cells, indicating that the effect of APMA on ACE shedding was not as a result of over-expression of the protein ... transfected with the ASOs and then exposed to APMA and the levels of soluble ACE in the medium examined (Fig 5) APMA caused a twofold increase in the shedding of ACE from the mock transfected SH-SY5Y...
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báo cáo sinh học:" The role of nurses and midwives in polio eradication and measles control activities: a survey in Sudan and Zambia" pdf
... attributes such as: prevention of diseases; caring for, supporting and comforting clients; continuously assessing and monitoring health needs and responses to interventions; advocacy and education of ... most Nurse-midwives' involvement in activities related to SIAs for polio and measles Roles of nurses and midwives in SIAs for polio and measles The involvement of the nurses and midwives in activities ... midwives were involved in the full range of functions for SIAs and AFP surveillance Survey of nurses and midwives working at health facilities Routine tasks and service conditions of nurses and...
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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
... which inhibit different steps in the complement cascade All of these regulatory proteins are produced in the human brain, but less is known about their CNS synthesis in other species [31] The status ... [96] The PS/APP mouse carries both of these transgenes and has been extensively used as a model for studying processes relating to the formation of SPs Aβ deposition occurs more rapidly in these ... liver is the main source of these proteins in peripheral blood, but they are also synthesized in other organs including the brain [31] Protein fragments generated during activation of the system...
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báo cáo hóa học: " Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer''''s disease" pdf
... characteristics of the cases used in this study Shown are differences between groups of the cases used in this study [PMI post-mortem interval, SD standard deviation] Braak score for neurofibrillary ... deposits (O, A, B, C) Results are expressed as box plots The box represents the interquartile range that contains 50% of the values The whiskers extend from the box to the highest and lowest values ... analysis, as well as technical issues The data presented in this study are in agreement with the findings of Yermakova and O'Banion [17] In an immunohistochemical study they found a decrease in the...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
... http://www.jneuroinflammation.com/content/3/1/30 kinases Lyn and Fyn as well as the tyrosine kinase Syk [30,32,52] Activation of these signaling cascades are linked to the synthesis and secretion of proinflammatory molecules and cytokines ... Furthermore, global inhibition of src-family tyrosine kinases or inhibition of phosphatidylinositol-3 kinase (PI3K) attenuates ROS production These findings suggest that these kinases are involved ... of proinflammatory responses that act in concert to promote the progressive pathophysiology associated with this disease The results summarized in this review suggest that ROS and iNOS released...
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báo cáo hóa học: " Psychometric validation of the revised SCOPADiary Card: expanding the measurement of nonmotor symptoms in parkinson’s disease" potx
... duration) Scale scores were compared across these groups and statistical significance was assessed using the independent samples t-test if the scores were normally distributed and the Mann-Whitney test ... these findings, the following symptoms were anticipated domains for discussion in the focus groups of PD patients with off-time: feelings of anxiety, mood swings, loss of interest, fatigue and autonomic ... Based on the findings of the focus groups, a Revised SCOPA-DC instrument was created by: 1) modifying the instructions and labels for day segments and response options as well as the format of...
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báo cáo hóa học:" Impact of recent life events on the health related quality of life of adolescents and youths: the role of gender and life events typologies in a follow-up study" potx
... and social resources in attenuating the stress of life events J Behav Med 1981, 4:139-157 25 Felsten G: Gender and doping: use of distinct strategies and associations with stress and depression ... part of a risk group In addition, the combination of these two LEs seems to be usual In fact, not only the LCUs sum score determine the effect, it s the undesirability of these LEs what makes respondents ... establish whether genderbased differences exist in such samples Importantly, the associations between LEs and health related outcomes have been generally assessed in cross-sectional design studies...
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Báo cáo hóa học: "Research Article On the Precise Asymptotics of the Constant in Friedrich’s Inequality for Functions " potx
... homogenization theory and in fact this was our original interest in the subject The paper is organized as follows In Section 2, we present and discuss our main results In Section 3, these results are ... lower and the upper bounds for Kε Proofs of the main results and some auxiliary results In Sections 3.1 and 3.2 we discuss, present, and prove some auxiliary results, which are of independent interest ... Keeping in mind these results it is possible to obtain sharp bounds for the constant in Friedrich s inequality Acknowledgments The research presented in this paper was initiated at a research stay of...
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