the role of the forensic epidemiologist in the medical examiner s or coroner s office
Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf
... poor spatial resolution It is still necessary to require administration of intravenous contrast media for assessment of the lesion boundaries and tumor perfusion For ADC to be used in a clinical ... vis-a-vis surrounding organs DWI clearly discriminates the abnormal signal intensity of peritoneal dissemination from the signal arising from surrounding organs such as the bowel (Figs 9, 10) Fujii ... simultaneously to acquire MR data Each of these detectors contains spatial information that can be used as a substitute for time-consuming phase-encoding steps, thereby allowing both the acquisition...
- 16
- 830
- 0
Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... control strain We also tested the targeting to mitochondria of Su9-DHFR, in which the presequence of ATPase subunit of Neurospora crassa was fused to a passenger protein, DHFR As seen in Fig 5A, the ... yeast strains containing high copy levels of various CYP cDNAs as described previously [20] Briefly, yeast strains expressing various CYPs were grown on selective synthetic medium in the presence ... and cloned into the same sites of yeast vector 5¢ BamH1 sense and 3¢ HindIII antisense primers were used to amplify the DHFR ⁄ 1A1 and cloned into the same sites of yeast vector The point mutant...
- 16
- 650
- 0
Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... adduct This in turn suggests that UDPNAG assists in the assembly of the proper interactions in the active site by stabilizing the closed conformation of the protein In the closed conformation, ... proteins This was interpreted as a lack of fosfomycin binding to these mutant proteins [12] Binding of fosfomycin to either wild-type MurA or the K22 mutant proteins in the absence of UDPNAG is ... From this it would follow that R120 is an important residue in the stabilization of the closed conformation of the protein This hypothesis can be tested by assessing the extent of the conformational...
- 9
- 707
- 0
Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... of their capabilities to inict DNA strand scission in the presence of ascorbate/O2 [192,243] The process was shown to be sensitive to the action of superoxide dismutase or catalase, implicating ... metalloporphyrin models Synthetic metalloporphyrins (Fig 3) were selectively tailored as models of the P450 active site to gain more detailed insight into the mechanistic basis of oxygen transfer ... these ndings raised serious questions as to the commonness of the oxygenating species operative in the NADPH- and hydroperoxide-sustained hydroxylations In fact, evidence has been provided for the...
- 26
- 746
- 0
Tài liệu The Role of Public Regional Universities in Community and Economic Development doc
... opportunities Shippensburg University Small Business Initiative in the Frehn Center for Management; offering information and assistance to individuals and groups planning to start a new business Best ... businesses in securing PennDOT contracts Best Practice Highlights Clarion University Support for Entrepreneurial and Existing Businesses – business accelerator/entrepreneurial initiatives; helping ... Partnerships linked to community and non-profits Corporate Alliances Specific and direct sponsorships or partnerships with area businesses Collaboration with Other Educational Institutions Partnerships...
- 29
- 654
- 0
Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... when the side-chain at residue 169 was changed (Fig 3A) These results suggest that the side-chain at residue 169 is responsible for the solvent accessibility of His210 The size of the side-chain ... (Asp102 for trypsin number) forms a solvent-inaccessible hydrogen bond with the side-chain of a conserved serine at the position of subsite S1 In API, His210 is also located in a solventinaccessible ... basis of substrate specificity in the serine proteases Protein Sci 4, 337–360 Czapinska, H & Otlewski, J (1999) Structural and energetic determinants of the S1 -site specificity in serine proteases...
- 7
- 603
- 0
Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... protocol used for the expression of enzymes used has been previously described [16] RESULTS Choice of amino-acid substitutions Based on sequence comparisons, in most alkaline phosphatases, the dipeptide ... mesophilic sequences The mutagenesis targets were residues Trp260 and Ala219 of the catalytic site and His135 of the Mg2+ binding site The most striking result was the loss of the psychrophilic ... slight variations of its amino-acid sequence Crystallographic studies of the mutants, aiming to further test the hypotheses about the structural basis of kinetic findings, are in progress ACKNOWLEDGEMENT...
- 6
- 488
- 0
Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... promiscuous 4¢-phosphopantetheinyl transferase Sfp from Bacillus subtilis and fluoresceinyl CoA [23] The successful 4¢-phosphopantetheinylation of DptF was monitored by the in- gel fluorescence of the ... synthesized peptide is necessary Here, we report the results of a steady-state kinetic analysis of DptE The aim of this kinetic study was to determine the specificity of DptE for various fatty acids ... synthase-like enzymes or substrates from the primary metabolism with NRPSs or PKSs, as shown for aflatoxin produced by the fungi Asparagillus parasiticus and A flavus [39,40] In this example, the...
- 12
- 674
- 0
Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx
... concentrations was included in the culture supernatant before ELISA The results for the OS ELISA of the representative clones are shown in Fig 3B While some clones showed a similar, or even superior, ... antigendependent increase in absorbance, others showed a decreased or diminished antigen-dependency To evaluate the OS-fitness of the clone, the ratio of the specific absorbance in the presence of 10 lgÆmL)1 ... At least for these antibodies, the role of the VL domain might be to increase the affinity by supporting the VH domain The phenomenon may also be observed in the chain shuffling experiments As antigen-induced...
- 11
- 462
- 0
Báo cáo khoa học: "The Role of Lexico-Semantic Feedback in Open-Domain Textual Question-Answering" ppt
... semantic form Step 3: The assessment of the similarities of dependencies In the third step, two classes of similar dependencies are considered, generating unications of the question and answer semantic ... marked accordingly Step 2: The identication of the question concepts The second step identies the question words, their synonyms, morphological derivations or WordNet hypernyms in the answer semantic ... Section presents the approach of devising keyword alternations whereas Section details the recognition of question reformulations Section evaluates the results of the Q&A system and Section summarizes...
- 8
- 508
- 0
Báo cáo " THE ROLE OF GIFT RECIPIENT PERCEPTION IN CHANGING BRAND ATTITUDES AND GIVER - RECIPIENT RELATIONSHIP " potx
... is located in the social definition of roles and statuses, not in the feeling-state of one or another type of personality” (p.6-7) Whereas sociological ambivalence in conceptualized as resulting ... history in other disciplines – notably, psychology and sociology (Otnes, Lowery and Shrum 1997) Up to date, the research of Otnes and co-authors (1997) is the most significant study in consumer ... and graduation Bussey (1967), in a study in the U.K., found that the most popular occasion is Christmas, which is followed by birthday This finding is just reverse of the finding of Belk (1973)...
- 10
- 482
- 0
The Role of Savings and Wealth in Reducing ―Wilt‖ between Expectations and College Attendance pdf
... worth in the PSID is a continuous variable that sums separate values for a business, checking or savings accounts, real estate, stocks, and other assets, and subtracts out credit card and other ... These findings suggest that the process of accumulating school savings may have effects apart from financing school Conley (2001) finds that a doubling of net worth results in an 8.3% increase ... estimate a series of logistic regressions across seven models using PROC SURVEYLOGISTIC (SAS Institute Inc., 2008) Because a small portion of households have more than one young adult living in...
- 22
- 515
- 0
Báo cáo khoa học: The role of glucose 6-phosphate in mediating the effects of glucokinase overexpression on hepatic glucose metabolism pdf
... changes in glucose phosphorylation S4 048 causes inactivation of phosphorylase As the elevation of Glc6P causes inactivation of phosphorylase in hepatocytes [14], the increase in Glc6P caused by S4 048 ... ¼ 18) or 20 mm glucose (1.5 ± 0.1 vs 1.5 ± 0.1) These results suggest that the increase of Glc6P in the presence of S4 048 was caused by the inhibition of Glc6P hydrolysis in the absence of detectable ... activation of synthase and inactivation of phosphorylase (conversion of phosphorylase-a to phosphorylase-b, Fig 1) As phosphorylase-a is a potent allosteric inhibitor of glycogen synthase phosphatase,...
- 11
- 503
- 0
Báo cáo khoa học: "Examining the Role of Linguistic Knowledge Sources in the Automatic Identification and Classification of Reviews" doc
... documents (particularly the short ones) have all zeroes in them In other words, none of the bigrams from the training set appears in these reviews This suggests that the main problem with the bigram ... of the feature lists sorted by WLLR confirms our hypothesis that each of the two classes has its own set of distinguishing features Experiments with the book domain To understand whether these ... Perhaps more importantly, an analysis of these results show that the various types of features interact in an interesting manner, allowing us to draw conclusions that provide new insights into...
- 8
- 489
- 0
Báo cáo khoa học: The role of cytochrome P450 monooxygenases in microbial fatty acid metabolism pdf
... either pseudogenes or act on different substrates such as long-chain alkanes Other organisms possess several types of enzymes; Al borkumensis contains two alkane hydroxylases and two CYP15 3s [19] ... fatty acids is The role of P450 in microbial fatty acid metabolism an essential step in the alkane assimilation process On the other hand, P45 0s are also involved in the synthesis of special fatty ... subterminal ending (e.g CYP52) Several classes of P45 0s involved in either metabolization or biosynthesis processes and with different regiospecificities are discussed Whenever possible, the internationally...
- 16
- 564
- 0
The Role of Interest Rate Swaps in Corporate Finance doc
... exposure to interest rate risk The Role for Hedging in the Theory of Corporate Finance The foregoing discussion has focused on increased volatility in financial markets as the major factor behind ... swaps have a notional principal of $1, unless otherwise noted Uses of Interest Rate Swaps—Synthetic Financing Firms use interest rate swaps to change the effective maturity of interest-bearing assets ... “free lunch.” As the following discussion will show, the risks responsible for increasing quality-spread differentials not disappear when firms use interest rate swaps Criticisms of the Comparative...
- 20
- 387
- 0
A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical Reactions pptx
... has indeed folded, the force is again increased to unfold the same molecule In the two examples shown in Figures A and B we observe a staircase of unfolding events consisting of step increases ... investigate the molecular mechanisms involved in these processes The dynamics of protein folding and chemical reactions is intrinsically linked to the structure of the transition state By designing ... proteins Indeed, using these techniques, it becomes possible to explore the role of the solvent environment in protein collapse[42] and the dynamics of protein folding.[47] Therefore, in order...
- 12
- 553
- 0
The Role of Digital Identity Management in the Internet Economy doc
... maintained in multiple accounts within the organisation The organisation is in some sense wasting resources and duplicating efforts in maintaining separate profiles with (mostly) the same information ... the role of contractual obligations Business process level: Issues also arise at the business process level, where progress towards the adoption by organisations of common methods for IdM systems ... assist organisations in providing online access to existing services and in offering additional services It can help businesses to build online customer relationships, to improve and customise...
- 22
- 503
- 0
Báo cáo khoa học: Role of calcium phosphate nanoclusters in the control of calcification pot
... 142-SDSKDQDSED -151 161-DSAQDSESEE -170 19- SSSSSSSEER -28 54IISESTEERE -63 65SSISSSEEV -73 5EHVSSSEESI -14 54ASSSSSEESV -63 130ELSTSEEPVS-139 5ESLSSSEESI -14 55GDDSSEEEEE -64 498- DSGSSSESDG -507 P02765 ... 307- SLGSPSGEVS -316 108-SSSTSESYSS -117 2- ESHESMESYE -11 2- SSSEDVSQEE -11 192-ESSSMSSSEE -201 CSN 1S1 Guinea pig P04656 CSN 1S2 Pig CSN2 Human IBSP-II Human MEPE Human Non-SCPPs FETUA Human SPP-24 ... paralogous 2310 Table Identied PC sequences formed by the action of the Golgi kinase and casein kinase on selected secreted phosphoproteins CSN 1S1 , aS1-casein; CSN 1S2 , aS2-casein; CSN2, b-casein; IBSP-II,...
- 16
- 343
- 0
Báo cáo khoa học: Membrane compartments and purinergic signalling: the role of plasma membrane microdomains in the modulation of P2XR-mediated signalling pot
... modulate the input signals in the form of ATP or its degradation products, as well as the specific intracellular signalling outputs from each subclass of receptors Finally, all these different intracellular ... phosphodiesterase in retinal cells [65,66,69,72] In addition to all the components listed above some regulators of G-protein signalling (RGS proteins), responsible for turning off the Ga subunit, ... rafts in neuronal cells regardless of the isolation method used (detergent-based or detergent-free) and the activation status of the receptor [87] In the same study, these authors also reported...
- 11
- 542
- 0
Tìm thêm: xác định các nguyên tắc biên soạn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể điều tra đối với đối tượng giảng viên và đối tượng quản lí điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc mở máy động cơ rôto dây quấn các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu chỉ tiêu chất lượng 9 tr 25