the role of the basal stem cell of the human breast in normal development and cancer
Báo cáo hóa học: " The role of single N-glycans in proteolytic processing and cell surface transport of the Lassa virus glycoprotein GP-C" ppt
... for correct folding and intracellular transport of viral glyco- proteins, as shown for instances for influenza hemagglutinin [19] In order to investigate the importance of the individual N-glycosylation ... transported to the cell surface and remain mannose-rich Materials and methods N-glycans play not only an important role in folding and intracellular transport of viral glycoproteins but also are ... decoration during glycoprotein transport to the cell surface (lane 2) Interestingly, the It can not be ruled out that the use of glycosylation sites and the N-glycan trimming differs between recombinant...
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A Single-Molecule Perspective on the Role of Solvent Hydrogen Bonds in Protein Folding and Chemical Reactions pptx
... unfolding of one of the I27 modules in the chain Unfolding then extends the overall length of the protein, relaxing the pulling force to a low value As the slack in the length is removed by further ... measure the elongation of b-strands A’ and G for unfolding the I27 protein in D2O The pulling coordinate for the separating b-strands is defined as the distance between the first amino acid of strand ... results in a well-defined series of step increases in length, marking the unfolding and extension of the individual modules in the chain.[37] The size of the observed steps corresponds to the number...
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Báo cáo y học: "The role of transposable element clusters in genome evolution and loss of synteny in the rice blast fungus Magnaporthe oryzae" pdf
... 8.8% of the sequence We analyzed the distribution of TEs in chromosome by defining non-overlapping 100 kb intervals across the sequence and measuring repetitive sequence content as the number of ... Recombination rate was measured by identifying the physical locations of nine genetic markers on the chromosome and using them as a basis for delineating eight intervals spanning chromosome The ... be strong enough to force the distribution of TEs into regions of low recombination rate and some force, but not recombination, must be driving the clustering of TEs in the M oryzae genome R16.8...
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HUMAN PERFORMANCE: Role of General Mental Ability in Industrial, Work, and Organizational Psychology docx
... smarts.” We can get closer to the meaning of g, however, by looking beyond the close correlates of g in the domain of human abilities and instead inspect the nature of the tasks that call it forth ... objects (“things”) and machines, independ- 31 Processing information (perceiving, retrieving, manipulating, transmitting) Compiling information, importance of Combining information, importance of Language, ... common themes seen in the debate regarding the nature and importance of the g factor, sources of individual and group differences, and the viability of arguments against g theory We also examine...
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Báo cáo sinh học: " Role of CD151, A tetraspanin, in porcine reproductive and respiratory syndrome virus infection" pdf
... dendritic cells, Schwann cells, epithelial cells, endothelial cells, and muscle cells [43,44,46] In account of our novel observation of RNA binding activity of CD151, we looked for RNA binding domains ... line (ST) and a human rectal tumor cell line (HRT) were used in the study These cell lines obtained from ATCC were already available in our laboratory The cell lines were grown in Eagle's minimum ... [47-49] During endocytosis, lowering of pH in the endosome results in fusion event between viral envelope and endosome [18] possibly involving CD151 Another role of CD151 by virtue of RNA binding ability...
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Báo cáo y học: "Role of regulatory T cells in experimental arthritis and implications for clinical use" potx
... decreases the infiltrate in joints Furthermore, RA patients relapse shortly after withdrawal of anti-TNF-α [19] and thus, despite the dampening of joint inflammation and the reinstatement of fully ... still not cured These strands of evidence seem to play down a hypothetical therapeutic role of CD4+CD25+ Treg in RA Are there further possible avenues to be explored in the area of CD4+CD25+ Treg? ... whether harnessing CD4+CD25+ Treg will represent a viable therapy for RA and other autoimmune diseases in the future Competing interests The author(s) declare that they have no competing interests...
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Biochemical identification and functional characterization of microrna target interactions in growth control and cancer transformation
... capable of identifying the location of the crosslinking and thus more precisely indicate the site of targeting This is achieved by the fact that 4thiouridine incorporation into RNA during co-incubation ... Argonaute domain organization Argonaute proteins are characterized by the presence of three domains: the PAZ domain, the Mid domain and the PIWI domain The PAZ domain forms a binding pocket for the 3′ ... status of the cell is marked by abnormal changes in cellular and molecular activities, then dysfunctions of miRNAs in these cells could be one important contributing factor Indeed, misregulations of...
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the role of wasp family members in dictyostelium discoideum cell migration
... by the inclusion of profilin and αactinin The role of these proteins in promoting actin nucleation and maintaining actin treadmilling is summarised in figure 1.1c How these factors and many others ... on the role of actin in the cytoskeleton 1.2.2 Actin monomer binding proteins Actin that has hydrolysed its ATP remains bound to the resulting ADP and inorganic phosphate with the later being ... In the previous section, the role of actin polymerisation in supporting membrane invagination during CME was described and the role of WASPs and actin polymerisation in CME is summarised in figure...
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Genetic analysis of the role of ARP2 3 complex in border cell migration in drosophila melanogaster
... contains polyproline sequences and interacts with profilin (Chang et al 1997) Since profilin binds to actin monomer, FH1 domains can bind the profilin-G-actin 13 Arp2/3 complex in border cell migration ... the leading edge of migrating cells and in the cell cortex in other cells (Mullins et al 1997) The dendritic nucleation model of actin polymerization is the currently widely accepted scheme of ... nucleators and capping factors High-affinity binding of capping factors determines the length of F-actin and limits the number of free barbed ends, which reduces the rate of G-actin monomer depletion...
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The role of kruppel like factors in embryonic stem cells
... feeders in the presence of serum The conditioned medium can support the normal growth of ES cells in the absence of feeders indicating that fibroblasts are producing signals inhibiting ES cell differentiation ... the Wnt receptor complex inhibits a complex including Axin, Gsk-3 and APC Inactivation of Gsk-3 results in stabilization and accumulation of β-catenin in the cytoplasm and nucleus β-catenin in ... downreguated in the trophectoderm and strictly maintained in the ICM Expression of Oct4 remains in the epibast of pre- and post-implantation embryos, then strictly in the migratory primordial germ cells98...
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The role of TRIP br proteins in the regulation of mammalian gene transcription and cell cycle progression
... Features PHD zinc finger protein PHD zinc finger protein Composite PHD zinc fingerbromodomain proteins PHD zinc finger protein Bromodomain protein PHD zinc finger proteins PHD zinc finger protein Composite ... Prominent examples of PHD zinc finger and/ or bromodomaincontaining proteins The (*) label designates disease-associated PHD zinc finger and/ or bromodomain-containing proteins Conservation of the ... protein function in cell cycle regulation The summation of the above observations and findings has led to the synthesis of a hypothetical model to explain the dual role of hTRIP-Br1 in the regulation...
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Tài liệu Role of diffusion-weighted imaging in the diagnosis of gynecological diseases pdf
... satisfactory in the evaluation of nodal status in this patient group Since the highly cellular tissue in reactive lymph nodes may also show increased intensity, the role of DWI and ADC in distinguishing ... uterine malignancy The ADC values of uterine cancers are lower than of normal tissue On the other hand, in sarcomas the ADC may play a limited role due to a large overlap between sarcomas and ... cervical cancers with nine chemotherapy and/ or radiation therapy, ten controls) Further study using larger numbers of patients is needed to establish the accuracy of ADC measurement in monitoring the...
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Tài liệu Báo cáo khoa học: Mitochondrial targeting of intact CYP2B1 and CYP2E1 and N-terminal truncated CYP1A1 proteins in Saccharomyces cerevisiae ) role of protein kinase A in the mitochondrial targeting of CYP2E1 pdf
... mitochondria-targeting signal in the yeast system Mitochondrial localization of intact CYP2E1 in yeast cells Because of the existing ambiguity in the literature on the nature and extent of CYP2E1 import into ... polyclonal antibody to human FDX1 (Fig 9A), confirming the role of endogenous FDX + FDXR in supporting the activity To further confirm the role of endogenous FDX + FDXR in supporting the catalytic activity, ... < 10% in the a ⁄ c mutant and < 3% in the a ⁄ b mutant, as compared to about 25% in the control strain We also tested the targeting to mitochondria of Su9-DHFR, in which the presequence of ATPase...
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Tài liệu Báo cáo khoa học: Models and mechanisms of O-O bond activation by cytochrome P450 A critical assessment of the potential role of multiple active intermediates in oxidative catalysis doc
... iron-peroxo intermediate [11] The sum of these ndings points at the involvement of more than one active oxidant in the diverse types of P450-catalyzed substrate processing [1215] The goal of the present ... alterations in the environment can cause drastic changes in the reactivity of the active species [76] Further support in favour of the idea of the involvement of a high-valent iron-oxene in P450 ... oxygen into the benzene ring of aniline to yield p-aminophenol [151] Formation of the oxygenating species has been recognized to be facilitated by the binding to HbO2 of aniline and some of its derivatives,...
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Tài liệu The Role of Public Regional Universities in Community and Economic Development doc
... Regional Learning Alliance – workforce development and training/collaborations with business and industry; meeting the training and education needs of businesses within 60 mile radius in Northern Allegheny ... Collaboration with business and government Economic Development Programs and Initiatives Business accelerators and/ or entrepreneurial initiatives Linking teaching and research to business opportunities ... stable supply of knowledge and skills in high need areas Increase the size, diversity of skills and productivity of the labor force Dimensions of Social and Economic Value Regional public institutions...
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Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... 3B) The pK2 increased as the size of the residue at position 169 increased The effect of the size of the residue at position 169 may be related to the solvent accessibility of the side-chain of ... side-chain of His210 increased with the decrease in size of the side-chain at residue 169 (Table and Fig 3A) However, the ASAs of Asp113 and His57 remained constant when the side-chain at residue ... determined as part of the investigation into the shielding from solvent of the electrostatic interaction between Asp113 and His210 With increasing NaCl, the maximum activity decreased, while the...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... with the aim of reducing the spatial constraints originating from the side-chain interactions between Tyr269 and Ala261 (Fig 2C) The main difference between the G261A and G261A/Y269A enzymes is the ... value in this temperature range is considerably lowered On the basis of the model, the behavior of the G261A variant can be interpreted in terms of constraints introduced by the Ala side chain The ... sequences The mutagenesis targets were residues Trp260 and Ala219 of the catalytic site and His135 of the Mg2+ binding site The most striking result was the loss of the psychrophilic character of mutant...
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Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx
... clarify the effect of the interface mutations on the antigenbinding affinity To investigate systematically this unsought relationship between the antigen-binding affinity of Fv and the VH ⁄ VL interaction ... Some single VH domains of anti-protein IgG, including HyHEL-10 and D1.3, were known to retain the specificity and affinity to antigen in itself [7,20] At least for these antibodies, the role of the ... OS-fitness of the clone, the ratio of the specific absorbance in the presence of 10 lgÆmL)1 HEL to that in the absence of HEL was taken as an index To analyze the effect of the type of each FR2...
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Báo cáo khoa học: "The Role of Lexico-Semantic Feedback in Open-Domain Textual Question-Answering" ppt
... does not stem keywords, all the inections of the verb are also considered Therefore, the initial query is expanded into: QUERY(Q209): paper AND clip AND (invented OR ) inventor OR invent OR invents) ... improve the recall of the answer paragraphs For example, in the case of question Q221: Who killed Martin Luther King ?, by considering the synonym of killer, the noun assassin, the Q&A system retrieved ... Cardie, Vincent Ng, David Pierce, Chris Buckley Examining the role of statistical and linguistic knowledge sources in a general-knowledge que stion answering system In Proceedings of the 6th Applied...
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