the pyruvate dehydrogenase complex in cancer implications for the transformed state and cancer
Tài liệu Báo cáo khoa học: Site-directed mutagenesis of a loop at the active site of E1 (a2b2) of the pyruvate dehydrogenase complex A possible common sequence motif docx
... times and the results are expressed as the mean ± SD Determination of kinetic parameters Km values for pyruvate and ThDP were determined using the DCPIP assay by varying the concentrations of pyruvate ... experienced by the E1aR267A mutant (Table 1) Determination of kinetic parameters Kinetic parameters for the mutant E1s were determined for the substrate pyruvate and the cofactor ThDP using the DCPIP ... Temperature-dependence of the activity in the DCPIP assay of wild-type and mutant E1s E1b chains with the PSBD of the E2 chain To investigate whether this interaction was impaired by the mutations in the E1a subunit,...
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Báo cáo khoa học: Regulation of pyruvate dehydrogenase complex activity in plant cells ppt
... membrane expansion and remodeling In most instances, there is coordinate expression of the E1 and E2 components The transient accumulation of mRNA preceding changes in protein levels and catalytic ... pyruvate dehydrogenase complex activity in autotrophic plant cells Distinct regulatory mechanisms control the activity of mtPDC in the light and plPDC in the dark PS, photosynthesis; PR, the photorespiratory ... developmental and physiological states, and health While there is now a considerable body of knowledge concerning the regulatory complex in animal cells, there is very little comparable information...
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Rural and Micro Finance Regulation in Ghana: Implications for Development and Performance of the Industry ppt
... Ghana and their financial products, from the more formal and licensed to the less formal and unregulated The financial system in Ghana falls into three main categories: formal, semi- formal, and informal: ... qualifying period and collection of the required level of savings, and they continue to save into their individual accounts as they repay the loan The group handles the collection of savings and ... Microfinance Legislation in Uganda and Ethiopia 1a: Micro Deposit-taking Institutions in Uganda The push for a special regulatory niche for microfinance institutions in Uganda came in part from the...
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Báo cáo khoa học: The association of heavy and light chain variable domains in antibodies: implications for antigen specificity pot
... remaining five positions (L41–L44 and L36) are instead located at the interface between the two chains, and the difference in the amino acids occupying them is likely to be related to the packing ... step involved the investigation of whether the structural difference in the packing of the two domains could be ascribed to the presence of specific amino acids To this end, we used the Random Forest ... not the case for the heavy chain V genes There is no intersection between the light chain germlines used in cluster A and those used in cluster B The latter set of germlines is enriched in k-type...
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Báo cáo khoa học: The crystal structure of pyruvate decarboxylase from Kluyveromyces lactis Implications for the substrate activation mechanism of this enzyme ppt
... domains (Fig 2) According to Muller et al [16], these domains are termed the PYR domain (binding the aminopyrimidine ring of ThDP), the R domain (binding regulatory effectors), and the PP domain ... conformational changes within the subunits due to the binding of pyruvamide between the R and the PP domains The dimer reorientation leads to the generation of a closed and an open side in the ... of the cofactors ThDP and Mg2+ at the interface between two subunits The aminopyrimidine ring of ThDP is bound at the PYR domain of one subunit The diphosphate residue is bound to the PP domain...
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Báo cáo y học: "The influence of serum, glucose and oxygen on intervertebral disc cell growth in vitro: implications for degenerative disc disease" potx
... actin (F-actin) was not markedly different in either condition (original magnification ×200) collagen type I and II, whether in monolayer or alginate cultures (Figure 4b) Staining for F-actin was ... that the increased cell proliferation seen in glucose-deprived alginate cultures resulted in the formation of NP cell clusters, which also form through increased cell proliferation in the NP in ... participated in its design and coordination, helped to perform the statistical analysis, and helped to draft the manuscript SS helped to perform the experimental work and the statistical analysis and...
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Báo cáo y học: " Does psychopathology at admission predict the length of inpatient stay in psychiatry? Implications for financing psychiatric services" ppsx
... special training in performing these ratings and they were performed as well as possible in the routine Warnke et al BMC Psychiatry 2011, 11:120 http://www.biomedcentral.com/1471-244X/11/120 clinical ... admission had a minor influence on the length of stay as well, which is in line with previous findings taking several hospitals in a whole catchment area into account while controlling for the factor ... we were interested in finding implications for future financing of inpatient psychiatry Methods Catchment area and central psychiatric register Up to the year 2009, the catchment area of the Psychiatric...
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báo cáo khoa học: " Characteristics of inmates witnessing overdose events in prison: implications for prevention in the correctional setting" doc
... behaviors include sharing needle equipment, not cleaning needle equipment before injecting, reusing water, backloading, doesn't clean skin prior injecting, sharing cooker and cotton and reusing needles ... within the correctional system and warrant assessing the feasibility and the effectiveness of peer interventions among drug users in prison In spite of the difficulties in accepting drug use in ... Miguel Pereira and staff, for giving us access to conduct the study in the prison setting and for their disposition to take into account data derived from our studies in formulating health policy...
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Báo cáo y học: "Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery" doc
... ligand-protein binding Power-law behaviors of ligand-protein binding The number of ligands (N) decays with an increase in the number (L) of (a) domains and (b) folds that bind the ligand and ... release during ligand binding may meet the free energy demand during protein folding It is tempting to examine the conjecture of ligand-induced formation and/ or folding of primordial proteins through ... binding of ligands with primordial proteins would also be a critical step in the origin of life Thus, it is intriguing to explore the chronology of ligand-protein binding and answer the following...
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THE ROLE OF PYRUVATE DEHYDROGENASE KINASE IN GLUCOSE AND KETONE BODY METABOLISM
... OF PYRUVATE DEHYDROGENASE KINASE IN GLUCOSE AND KETONE BODY METABOLISM The expression of pyruvate dehydrogenase kinase (PDK) and are increased in the fasted state to inactivate the pyruvate dehydrogenase ... palmitate, on the other hand, inhibits Akt/protein kinase B [41] Both of these lipid derivatives turn off the insulin signaling cascade and prevent insulin stimulated glucose uptake, resulting in less ... glucose levels in the PDK4 KO and DKO mice but not in the PDK2 KO (Figure 5C) Since glucose and insulin levels were lower in the DKO mice during the glucose tolerance test, an insulin tolerance...
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Democratization in taiwan implications for china”
... integrity, and safeguarding the fundamental interests of the Chinese nation Article There is only one China in the world Both the mainland and Taiwan belong to one China China's sovereignty and ... Treaties and other international agreements For all purposes, including actions in any court in the United States, the Congress approves the continuation in force of all treaties and other international ... sharing the same interest in maintaining the stability and status quo situation at least in the short term For the China, though the recovery of Taiwan is a must for any Chinese leaders, a forceful...
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Systematic bias in estimates of reproductive potential of an Atlantic cod (Gadus morhua) stock: implications for stock–recruit theory and management pptx
... alternative indices of reproductive potential should therefore determine whether the change point estimated for the alternative index gives a divergent assessment of whether the stock is inside (above the ... predict wl ranging in cm increments between 50 and 140 cm for each year These model-derived values of wl were then treated as the observed weights for the prespawning females in the stock for that ... were transformed to nl using the combined (Russian and Norwegian) age–length keys (ALK) that are described in detail in Marshall et al (2004) These combined ALK were estimated for each year in the...
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Evaluating impacts of air pollution in China on public health: Implications for future air pollution and energy policies pptx
... in Zaozhuang which supplies 2% of total energy needs (10% of the energy needs in the residential and commercial sectors) in three surrounding municipalities—Jining and Linyi in Shandong Province ... representative of China Given that the in ation rate in China between 1998 and 2000 was À1% and that the per capita income in China is projected to increase from Table Valuation of morbidity for China (2000 ... population We include the same age groups for individual health endpoints as in the original studies We use the age distribution of the national Chinese population (China Statistics Administration,...
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Báo cáo hóa học: " Reemergence of dengue virus type-3 (subtype-III) in India: Implications for increased incidence of DHF & DSS" docx
... subtype III of dengue-3 from the present outbreak in northern India in 2003 and its continued dominance again in 2004 indicates the resurgence of dengue-3 in a dominant form The emergence of a newer ... us) revealed the involvement of DEN-3 [6] and was also in agreement with another study [7] Again during the month of September in 2004, dengue reappeared in Delhi and its adjoining areas Like ... Asia including India In the past, the larger and severe outbreaks in India were mostly caused by dengue virus type-2 However, the investigation of 2003 dengue outbreak in northern India (carried...
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Báo cáo y học: "Intervertebral disc cells as competent phagocytes in vitro: implications for cell death in disc degeneration" pptx
... 32, and 48 hours), cultures were fixed in methanol for minutes, before staining with Jenner-Giemsa stain [20] Two hundred cells for each culture were observed and the number counted which had ingested ... peroxide in methanol and further blocking was performed by incubating the sections with normal serum Sections were then incubated with an antibody to CD68 (1:23 in phosphate-buffered saline; Dako, ... 48, and 72 hours Images were taken Figure CD68 immunostaining Immunostaining for CD68 was carried out on bovine NP cells cultured both with and without latex beads for 0, 4, 6, and 24 hours, in...
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Báo cáo y học: "Uses, traditional management, perception of variation and preferences in ackee (Blighia sapida K.D. Koenig) fruit traits in Benin: implications for domestication and conservatio" pptx
... are used for washing In the Pobè region (South-East Benin), it is rather the whole immature fruits that are cut in small pieces and plunged into water for washing clothes According to the interviewees, ... dried mainly for conservation purpose and this is usually the commercialized form at local markets and/ or for shipment toward cities For drying, arils are exposed to the sun during days and thereafter ... sapida soap in Benin Virtue and medicinal properties Number of quotations palm oil depending on the availability Shea butter is widespread in the Northern part of Benin and palm oil in the South...
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Báo cáo y học: " Vascular alterations upon activation of TGFβ signaling in fibroblasts - implications for systemic sclerosis" potx
... signaling, the collagen content of the thoracic aorta was increased and the adventitial and the smooth muscle cell layers were thickened These changes were functionally relevant and resulted in increased ... localization and the kinds of vascular changes in TβRIIΔk-fib mice and also in most other animal models differ from those in SSc patients Derrett-Smith and coauthors describe vascular changes in the aorta ... of the destructive or proliferative vasculopathy in SSc Does altered TGFβ signaling in fibroblasts also result in alterations of the pulmonary arteries, the small arteries and the capillaries and...
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Numerical simulation and optimization of CO2 sequestration in saline aquifers for enhanced storage capacity and secured sequestration
... throughout the domain The equilibrium conditions were then used as the initial conditions for the simulations of interest Table A1 in the Appendix summarizes the details of the domain properties Since ... SAGCS One is the well injectivity and the other is the fracture pressure of the formation matrix The well injectivity is defined in Eq (3); it serves as an indicator of the ability of an injection ... efficiency of GCS by increasing the required injection pressure to maintain well injectivity, and most importantly, it can potentially jeopardize the integrity of the formation matrix Therefore, it becomes...
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Tài liệu Báo cáo Y học: Receptor crosstalk Implications for cardiovascular function, disease and therapy ppt
... modulate the expression and function of other vascular receptor systems, such as the NPs and bradykinin [70,103,104] The interchangeability of the inhibition of the b-AR and the RAS pathways in the ... and OPRs [30] The same pathway has been postulated for the ETA-induced regulation of ANP signalling and gene expression by coupling to both Gi and Gq proteins [36,37] In these interactions, the ... coupling to the Gi protein, indicating that the former pathway may regulate the b-AR signalling downstream of agonist–receptor interactions [10,14] These studies led to the appreciation of the...
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Báo cáo khoa học: "Orthogonal Negation in Vector Spaces for Modelling Word-Meanings and Document Retrieval" ppt
... which contain the term a and not contain the term b More formally, let D be the document collection and let Di ⊂ D be the subset of documents containing the term i Then the results to the Boolean ... described in Section Other forms of Negation in IR There have been rigourous studies of Boolean operators for information retrieval, including the pnorms of Salton et al (1983) and the matrix forms ... meanings We describe the underlying motivation behind this model and define the vector negation and disjunction operations in Section In Section we review other ways negation is implemented in Information...
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