... effects on therateof latency transition (Table 2) Therefore, besides the M at position 149, deviations from the serpin consensus in the hF/s3Aloop of PAI-1 does not contribute to therateof latency ... 5), andthe salt-bridge between E132 and R135 [18] contribute to the thermodynamic stability ofthe stressed conformation and/ or are important for the positioning of hF in a way delaying the ... mimicking the effect ofthe K325A substitution (Fig 5) Of note is that the side chain of E285 forms a hydrogen bond to the backbone ofthe hF/s3A-loop in PAI-1stab [18] (Fig 5) and in contrast with the...
... or the other, this was an issue of relevance only to specialists The lack of education restricted the number of producers and consumers of cultural objects and hence the size and influence ofthe ... version ofthe space of flows, the maritime world of long distance trading, is still very present 72 The Status of Objects in the Space of Flows The space of flows - now and then - consists of three ... people and information In pre-industrial manufacturing, the function ofthe work bench andofthe office were barely separated Rather, they were one andthe same This was efficient was long as the...
... (2000) and Crossing the Quality Chasm (2001) In the face ofthe growing awareness generated about thenatureand implications ofthe gap between healthcare practice andthe evidence base, the IOM ... by the authors to document the proceedings ofthe 2007 IOM Annual Meeting EVIDENCE-BASED MEDICINE ofthe national domestic agenda, the choice of EBM by the IOM Council as the theme ofthe ... ways of meeting the need, provides the back-drop for the discussions at the 37th Annual Meeting ofthe Institute of Medicine (IOM) Entitled Evidence-Based Medicine andthe Changing Natureof Health...
... unification ofthe fundamental forces, probe the origins of mass, uncover the dynamic natureofthe “vacuum” of space, deepen the understanding of stellar and nuclear processes, and investigate thenature ... Principle The Secretary of Energy andthe Director ofthe National Science Foundation, working with the White House Office of Science and Technology Policy andthe Office of Management and Budget and ... suggests that these impending discoveries may transform our understanding ofthe origin of matter and energy andthe ongoing evolution ofthe universe The limitations ofthe Standard Model are...
... Shin 2007) The fluctuations of credit in the context of secured lending expose the fallacy ofthe lump of liquidity in the financial system The language of liquidity suggests a stock of available ... funds and consisted of reverse repos in addition to other types of collateralized lending Much of this collateralized lending was short term, often overnight The other feature ofthe asset side of ... Abstract The financial crisis of 2007-09 highlighted the changing role of financial institutions andthe growing importance ofthe “shadow banking system,” which grew out ofthe securitization of assets...
... Fig Band structure of (1 0), (1 0) and (1 1) Ge nanowires with D$20 A ofthe band gap and determines the overall natureofthe nanowire band structure Si (100) Ge (100) where mà and mà are the ... shows the distribution ofthe G, X and L states between the A and B planes in the (1 0), (1 0) and (1 1) unit cells In the (1 0) and (1 1) bulk unit cells, the X ðLÞ points are clearly on the A ... for the other two stacking directions which we are considering Examining the band structure of (1 0), (1 0) and (1 1) bulk unit cells, we can then use the above argument to determine whether the...
... indicates, the innovation to profits is based on innovations to the exchange rate, nominal interest rate, andthe foreign and domestic loan default rates Both the sign and magnitude ofthe coefficients ... actual rateof return on the market portfolio, e is the actual rateof appreciation in the foreign-currency value ofthe domestic currency, and r is the actual percentage rateof change in the domestic ... picture ofthe effect of exchange rates on bank stock returns In the money-center equation the coefficient ofthe exchange rate variable is significant at the 0.01 level whereas the coefficient of the...
... Christ’s human nature are systematically driven, and vary principally with a theologian’s estimates ofthe purposes and proprieties ofthe Incarnation on the one hand andofthe multiple and contrasting ... chief of its members, andthe one that functions to influence the senses and motions ofthe others Analogously, Christ is head ofthe Church, but both of His natures are involved He is ofthe same ... with the mutual interaction of soul and body on the one hand andofthe soul’s powers on the other Bonaventure begins with the dolor that is the sorrow of a soul that is really suffering with the...
... results of this study provide the first formal estimates ofthe joint effect of derivative exposures on the systematic interest rateand exchange rate risks of U S banks The rest ofthe paper ... excess rateof return of stock i over the risk-free rate q at time t, Rmt is an excess rateof return on market portfolio over the risk-free rate, rt is the interest rate risk factor measured by the ... examine thenatureof these covariances in more detail To this end, suppose beginning ofthe period The bank’s net asset at the end ofthe period in dollar terms is (6) where q and q* are interest rate...
... months and t + 12 months forms a direct measure ofthe accuracy ofthe individual forecasts To measure the volatility of interest rates I calculate the standard deviation of interest rates using ... interest rates, I also incorporate the standard deviation of interest rates into the dataset Transparency is unlikely to be the only determinant of either predictability or volatility Therefore, ... meaningful considering the average standard deviation of 0.5%-point reported in Table The evidence for the impact of transparency on the standard deviation of interest rates for the t to t + 12 period...
... 2.5 h, the thickness increased by 0.212 nm, the mass increased by 0.05 ngÆmm)2 andthe density decreased by 0.0167 gÆcm)3, from the start ofthe experiment By the end ofthe measurement, the thickness ... fluorescence The subsequent plateau phase is associated with a decrease in the concentration of small species, or the aggregation and precipitation of fibrils [37] The kinetics of these three stages ofthe ... temperature-dependent interaction of amyloid-forming proteins with sHsps In particular, we examined the effects of temperature on the fibrillation rateof j-casein and a-synuclein andthe efficiency of a-crystallin...
... PROBLEMS OFTHE BURGESS SHALE -the ORIGIN OFTHE BURGESS FAUNA -the DECIMATION OFTHE BURGESS FAUNA CHAPTER IV Walcott's Vision andtheNatureof History -the BASIS FOR WALCOTT'S ALLEGIANCE TO THE ... expresses the duality of our wonder at the beauty ofthe organisms themselves, and at the new view of life that they have inspired _Opabinia_ and company constituted the strange and wonderful life of ... about thenatureof history andthe overwhelming improbability of human evolution under themes of contingency andthe metaphor of replaying life's tape It focuses upon the new interpretation of the...
... e.g sect ofthe ‘Introduction’, sect andofthe ‘First Set of Variations’, and sect ofthe ‘Second Set of Variations’ However, the main difference between the argument of this book and Moore’s ... about the circumstances By contrast, the best explanation ofthe forming ofthe belief by the scientist must, indispensably, mention the presence ofthe proton in both the aetiology andthe justification ... exactly the right place Agents have moral beliefs and any argument critical ofthe objectivity of those beliefs will be pitched at the meta-level ofthe best explanation ofthe holding of them The...
... or the Amish, Icelanders or indigenous groups in Brazil, all of whom confront the interventions of geneticists They also involve the genomes ofthe dog, the cloned sheep, andthe chimpanzee, and ... presents the revised versions ofthe papers and reflects what transpired during our time together at Teresópolis It offers not only a unique appraisal of issues and problems ofthe age of genetics and ... around dwarfism The practices and discourses ofthe Little People of America, andofthe scientists and physicians they engage, reflect a new convergence of genetic normalization and biotechnological...
... and his team and their explanatory theory, namely, the discovery of high levels of xii PREFACE iridium at the K/T boundary and their theory of extraterrestrial impact to explain both it andthe ... class, on the other hand, then it could possibly be the subject of laws ofnature It need not be the subject of laws of nature, but the possibility is not precluded, given the common view of laws ... transcend not only their social milieu but also the science of their time There is no finer example of this than Darwin This is the grand theme of Michael Ghiselin’s The Triumph ofthe Darwinian Method...