the dc precision issue
kuffel, e. (2000). high voltage engineering - fundamentals (2nd ed.)
... distance from the rotor, and in the absence of any rubbing contact the efficiency of the machine is about 90 per cent The characteristics of the 600-kV generator are such that the fluctuation in the voltage ... between the h.v generating circuits used and the test results, the layout of these circuits has to be done very carefully The classes of tests may differ from the routine tests, and therefore ... during the non-conducting period One may treat and simulate, therefore, a rectifier within the circuits – independently of the voltage levels – simply by the common symbol for a diode The theory...
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Báo cáo y học: "Ultra-low microcurrent in the management of diabetes mellitus, hypertension and chronic wounds: Report of twelve cases and discussion of mechanism of action"
... 11.5 minutes, which then switched to the opposite polarity for another 11.5 minutes The device was designed to switch the direction of current flow halfway through the cycle The resulting cycle ... chronic disease (21) The device used in the experiment was supposed to deliver electrons to tissues and then saturated free radicals with required electrons The actual tissue regeneration, along ... Studies from the 1980s suggest that microcurrent therapy is effective at relieving the side effects of radiation therapy (25) The investigators have found that direct electrical therapy was effective...
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Tài liệu ECCENTRIC MECHANISM OF FOUR-BAR LINKAGE pptx
... picking , then Open Pick eccentric.prt The assembly is shown below Next, place shaft.prt to the assembly Pick , then Open shaft.prt Pick the axis of the shaft, then select the axis of the center ... the left side of the link As Axis alignment constraint, select the axis A_3 of the left hole of the link, and then pick the axis A_12 of the pin at arm 45 For Translation constraint, select the ... then pick the axis A_4 of the pin at eccentric For Translation constraint, select the back face of the link, and then pick the front large face of the eccentric 44 Click to create another Pin...
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Tài liệu Báo cáo " Mechanism of forming the Dien Bien basin " pdf
... secondary faults The secondary faults played a role of the channel system for the olivine basalt eruption After the basalt eruption, the weathering process and the subsidence process to form the Dien ... basin started On the west side of the basement, the subsidence may take place so quick that the basement slope is steeper and the bed rock is more stable In turn, on the other side the bedrock was ... According to the electronic and seismological cross-sections, there is a shattered zone developed along the long axis of the basin The rock of the east side has been broken much more than that of the...
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Tài liệu Báo cáo khoa học: X-ray crystallographic and NMR studies of pantothenate synthetase provide insights into the mechanism of homotropic inhibition by pantoate docx
... it takes the position of the adenine ring in the ATP-binding site, as shown in Fig The oxygen atoms of the pantoate are spatially coincident with the nitrogen atoms of the adenine ring The O1, ... in the presence of ATP, the His34 backbone HN chemical shift reverted back to the resonance position observed for the free form of the protein The observed changes in resonance positions in the ... ATP to the pantoatebound form of the protein displaces the pantoate from the ATP-binding site The bound ATP is stabilized by a hydrogen bond between the imidazole side chain of His34 and the a-phosphate...
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Tài liệu Báo cáo khoa học: Modeling of tRNA-assisted mechanism of Arg activation based on a structure of Arg-tRNA synthetase, tRNA, and an ATP analog (ANP) ppt
... with the O of the a-carboxyl group rather than the C On the other hand, the interaction with C results in the aminoacylation reaction It is expected that the direct interaction between the the ... of AMP Furthermore, the reported aminoacyl-AMP analogs are bound mainly through the interaction of the aminoacyl moiety with the aminoacyl-tRNA synthetase Therefore, the location of the adenosine ... From the point of view of the stereo structural understanding in the reaction pathway of the transfer of the Arg moiety from the enzymatically synthesized Arg-AMP to tRNA, the facts that the Km...
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Tài liệu Báo cáo khoa học: Hypoxic resistance to articular chondrocyte apoptosis – a possible mechanism of maintaining homeostasis of normal articular cartilage pdf
... decrease in the number of chondrocytes, as they are the only resident cells in articular cartilage Chondrocytes regulate the enzymatic breakdown of the extracellular matrix, thereby maintaining the equilibrium ... between synthetic and degradative processes in the cartilage [1] Therefore, the metabolic and structural changes of chondrocytes in the articular cartilage play a significant role in the initiation ... four times with water and then dried The cells were then lysed with 1% SDS solution and the absorbance was measured at 550 nm The cell viability was calculated based on the relative dye intensity...
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Tài liệu Báo cáo khoa học: Mechanism of dihydroneopterin aldolase NMR, equilibrium and transient kinetic studies of the Staphylococcus aureus and Escherichia coli enzymes docx
... was obtained in the absence of the protein The data set obtained in the absence of the protein was then subtracted from the corresponding data set obtained in the presence of the protein after ... Furthermore, the kcat values for the aldolase and epimerase activities are significantly lower than the rate constants of the chemical steps A critical issue in the kinetic analysis is whether the reaction ... only a small fraction is in the correct form for the reaction [19,20] To further investigate the issue of the reversibility of the DHNAcatalyzed reaction, we ran the reverse reaction with our...
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Tài liệu Báo cáo khoa học: Catalytic mechanism of SGAP, a double-zinc aminopeptidase from Streptomyces griseus pdf
... Open issues regarding the catalytic mechanism underlying SGAP include the exact binding mode of the hydroxide to the metal ions, the proton pathway in catalysis and the specific involvement of the ... less affected by the pH The point of intersection of the two regions is the kinetic pKa of the ionizing groups on the ES complex [51] As the proton dissociation constant is a thermodynamic parameter, ... depends of course on the rate-limiting step in the reaction, which could include the protonation or deprotonation steps and ⁄ or the generation of the nucleophile and the collapse of the tetrahedral...
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Tài liệu Báo cáo khoa học: Antifungal effects and mechanism of action of viscotoxin A3 docx
... by the insertion of the protein and modulation of the lateral pressure, as has been reported for other proteins [41] Moreover, these results confirm that VtA3 affects the whole structure of the ... the other hand, depletion of Ca2+ caused by external EGTA in the millimolar range did not reduce H2O2 production by VtA3 All these data suggest that the FEBS Journal 273 (2006) 72–83 ª 2005 The ... concentration induced by the presence of VtA3 is related to either cell viability or H2O2 production or both, we treated the spores with VtA3 in the presence of the Ca2+ chelator Bapta-AM The results are...
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Tài liệu Báo cáo khoa học: Manipulation of prenyl chain length determination mechanism of cis-prenyltransferases ppt
... al Furthermore, His-237 of Rv1086 downstream of the conserved region V was found at the corresponding position for Leu ⁄ Phe residue in other cis-prenyltransferases To investigate whether these ... for the allylic substrate with the structural P-loop motif This hypothesis agrees with the fact that in the prenyltransferase reaction by Rv1086 in vitro, GPP and neryl diphosphate (C10) were the ... Based on these results, they proposed that Leu137 functioned as the floor of the tunnel to block further elongation of polyprenyl products This proposed model seems to be analogous to the chain-length...
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Tài liệu Báo cáo khoa học: On the mechanism of action of the antifungal agent propionate Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans doc
... measured together in the same assay The data indicate that the presence of propionate in the medium reduces the activity by % 50% in the wild-type as well as in the DmcsA strain Therefore it ... grown only on glucose there was no significant difference between the wild-type and the DmcsA strain In the presence of only acetate there was no difference between the strains; the approximate growth ... compensates for the initial decrease of the oxaloacetate concentration in the equilibrium due to the accumulation of NADH [25] Lineweaver–Burk diagrams were obtained by use of the worksheet of the program...
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Tài liệu Báo cáo khoa học: nsights into the reaction mechanism of glycosyl hydrolase family 49 Site-directed mutagenesis and substrate preference of isopullulanase doc
... 20–564), and the model is composed of residues 25–540 The overall structure of the model of IPU and the mutated residues in this study are shown in Fig To elucidate the mechanism of the substrate ... respectively Therefore, even if the a-(1fi6)-linked glucose units enter to the active cleft of IPU as shown in Fig 4A, it would be impossible for the substrate to be retained in the cleft In the model ... base (activating the nucleophilic water molecule) in the first step of the reaction A carbonium ion intermediate subsequently forms, and is further attacked by the water molecule The study of site-directed...
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Tài liệu Báo cáo khoa học: The mechanism of a-proton isotope exchange in amino acids catalysed by tyrosine phenol-lyase doc
... in the active site; (b) the statistical factor taking account of the ratio of protons and deuterons on the considered group when the latter is polyprotic; (c) the degree of restriction of the ... errors In the limits of these errors, the rates for the normal and deuterated substrates did not differ, thus, there was no reason to assume the existence of any internal return, and the respective ... data [15,16] the abstraction of the a-proton is most probably effected by the e-amino group of lysine 257, which forms the aldimine bond with the carbonyl group of the cofactor, PLP, in the holoenzyme...
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Tài liệu Báo cáo khoa học: Unraveling the catalytic mechanism of lactoperoxidase and myeloperoxidase A reflection on some controversial features Elena Ghibaudi and Enzo Laurenti docx
... and their spectra are likely identical as these two intermediates differ only for the presence of the radical aa+• in the former Based on the evidence presented above, it should be clear that the ... and MPO They deal with the the major importance of catalase activity in MPO with respect to LPO, the different sensitivity of the enzymes to Cpd III inactivation and the redox potential of the chemical ... in the presence of H2O2 alone, a non-physiological condition We believe that the absence of direct evidence of the radical in the presence of cosubstrates limits the validity of extrapolating the...
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Tài liệu Báo cáo khoa học: A role for the intersubunit disulfides of seminal RNase in the mechanism of its antitumor action docx
... plateau These data indicate that the cell sulfhydryls responsible for the exchange with the protein disuldes are located in the plasma membrane Furthermore, they show that, as proposed in the hypothesis ... occurring between cell sulfhydryls and the mixed disulde bonds present in the monomeric derivative We further investigated whether the MSSAE and MSSG monomers conserved the acquired dimeric structure ... [11] Together with the results described above, they conrm that MSSAE monomers dimerize outside the cells, and are internalized as dimeric BS-RNase As the dimerization event occurs outside the cells,...
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Tài liệu Báo cáo khoa học: Mechanism of protection of peroxidase activity by oscillatory dynamics docx
... termination of the degradation of the enzyme [12], because the inhibition of the reaction also blocks the formation of free radicals [28] Thus, the inactivation of the enzyme can be ascribed to the presence ... the origin of the phenomenon The reason is of course that the changes in concentrations are inherent to the reaction system (i.e they depend on the entire network of elementary reactions) rather ... crucial role in the dynamics of the peroxidaseoxidase reaction [13], and therefore they not appear in most detailed models of the reaction The pronounced dependence of the stability of the enzyme...
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Tài liệu Báo cáo Y học: Insights into the reaction mechanism of Escherichia coli agmatinase by site-directed mutagenesis and molecular modelling ppt
... of the manganese ions This, together with the fact that the positions of other Fig Scheme of the binuclear manganese cluster and the localization of the side-chains of Asp153 and Asn153 in the ... Note the shorter extension, in the case of E coli agmatinase, of the loop indicated by the letter a differed in these areas A more specific difference concerned a loop located at the entrance of the ... indicating that the environment of tryptophan residues is essentially conserved in the mutant enzyme On the other hand, the absence of major differences in the CD spectra of the wild-type and...
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Tài liệu Báo cáo Y học: Dynamic mechanism of nick recognition by DNA ligase ppt
... conservatismÕ, being rather independent of the primary sequence [74] The presence of mismatches at the 5¢-PO4 side of the nick destabilizes the A-form helix increasing the DNA hydration, because the water ... occupy the position apical to the leaving AMP and the nick sealing would be inhibited The latter agrees with the fact that the DNA ligase joins 5¢-RNAÆDNA to the 3¢-DNAÆDNA poorly, leading to the ... usually bent at the junction [49,50], so the induced bending by the protein stabilizes the A-form [42,51,52] Another reason for the relative stability of A-form dsDNA in complex with the DNA polymerase...
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