surface changes in the cell cycle
Regulation of DNA (cytosine 5) methyltransferase 1 in the cell cycle and its role(s) in doxorubicin mediated micronuclei formation
... and therefore must be tightly regulated in the cell cycle Interestingly, DNMT1 expression is inversely correlated with the cell cycle inhibitor p21WAF1 protein in mammalian cells, which is independent ... increase in cell death in MCF7 cells 127 36 Induction of micronuclei correlates with a decrease in cell viability and increase in cell death in MRC5.SV40 cells 128 xii 37 Immunostaining of MCF7 cells ... structure consisting of the C-terminal catalytic domain linked to the N-terminal regulatory domain through a lysine- and glycine-rich (KG) linker domain The C-terminal catalytic domain is highly...
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Báo cáo khoa học: Site-specific phosphorylation of MCM4 during the cell cycle in mammalian cells pot
... dephosphorylated during the HeLa cell cycle in a site-specific manner Cyclin-dependent protein kinase is involved in the phosphorylation of MCM4 To determine which kinase is involved in the phosphorylation ... is in contrast to results shown in Fig 5, in which the phosphorylated MCM4 in a cell increases during these periods, indicating that phosphorylated MCM4 is detached from chromatin as the cell cycle ... recognized the retarded MCM4 prepared from cells in the M phase, indicating that these sites are indeed phosphorylated in the M phase in HeLa cells We classified the mode of phosphorylation into two...
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Báo cáo khoa học: Collective behavior in gene regulation: The cell is an oscillator, the cell cycle a developmental process doc
... If by treating cells with a drug such as phenelzine and following the changes that occur in the surface as the system responds, we have at least the beginnings of a map of the coupling and ⁄ or ... the 40-min cycles (Fig 3A,C) are similar to one another in forming a bowl or conical shape around the steady state In other projections of the phenelzine-treated cells, the increase in cycle time ... as the epithelial cells of the gastro-intestinal tract are similar – if on different time scales In the gastrointestinal tract of mammals the cell- cycle time of a particular cell is in the range...
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Báo cáo Y học: The DNA-polymerase inhibiting activity of poly(b-L-malic acid) in nuclear extract during the cell cycle of Physarum polycephalum pot
... contained in the extracts The inhibitory activity during the cell cycle The inhibitory activity during the cell cycle was measured in the presence of 0.4 U of (added) purified DNA polymerase a and the ... polynucleated giant cell among other cell forms in the life cycle [4] Interestingly, the billions of nuclei in these syncytia participate with high degree of synchrony in the division cycle All of the myxomycetes ... decrease approaching a basal level at h after mitosis Thus, the in vivo and in vitro activities of DNA synthesis corresponded with the minimum of the inhibitory activity in the cell cycle The activity...
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Báo cáo khoa học: " Is there a special mechanism behind the changes in somatic cell and polymorphonuclear leukocyte counts, and composition of milk after a single prolonged milking interval in cows" pptx
... during the subsequent milking interval day The cell output rate thereafter declined but remained significantly increased above the baseline during both DMI and NMI until the last milking of the ... only in day and day Discussion The main findings of the present study were that during the PMI there was a distinct increase in proportion of PMN while the increase in SCC was slight and that the ... at the first milking in the morning of day due to accumulation of milk in the udder In the rest of the study the morning milk yield was not changed compared to before the PMI In contrast to the...
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Characteristics of Leachate from Citrus Groves and their Changes in the Collecting Reservoirs in Matsuyama, Japan
... collected at the middle parts of the grove from points Sampling points St.1 and St.2 are in the same stream, and sampling point St.3 is in the other stream The two streams flow together to be one ... the sampling point St.4 is situated in the joined stream, which is the only stream that flows into the reservoir The reservoir water was also sampled from point Po in the reservoir close to the ... streams flow together from 47 m above sea level The water in the stream is the leachate from the grove and it flows into a collecting reservoir at the foot of the hill The surface area of the reservoir...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... during hypoxia In the absence of differential regulation of a specific nuclear gene coding for the subunits of CytOX, changes in the microenvironment of the cell may induce alterations in the ... significant increase in TN However, both the CytOX activity and heme content were reduced by about 50% in macrophages exposed to hypoxia, thus indicating a major change in the CytOX content in these cells ... Table 2, there was a marked difference in the total cell ATP synthesis as well as mitochondrial respiration-coupled ATP synthesis in macrophages and PC12 cells The rate of ATP synthesis in control...
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Báo cáo khoa học: Nanoparticles can induce changes in the intracellular metabolism of lipids without compromising cellular viability docx
... signaling via the trk receptor in PC12 cells involves caveolin [51], and that caveolin associates with LDs [52] Therefore, NPs may induce the accumulation of lipids in PC12 cells by disturbing the ... al their surface is not fully protected or if they degrade within the biological environment We have studied the effects of QDs on living cells and have reported their internalization, the intracellular ... creates the metabolic state, in which cells are able to synthesize FFAs These newly synthesized FFAs are stored in LDs in the form of triacylgycerols or are oxidized in mitochondria We hypothesize...
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Báo cáo khoa học: Stage specific expression of poly(malic acid)-affiliated genes in the life cycle of Physarum polycephalum Spherulin 3b and polymalatase potx
... spherulin 3a and NKA48 contain only a single domain fold The stability of these two proteins is highly dependent on calcium binding [25] The typical domain motives contain a ‘tyrosine corner’ in the ... express a distinct fragmin-like actin-binding Cell type expression of spherulin 3b and polymalatase protein that controls in vivo phosphorylation of actin by the actin-fragmin kinase Eur J Biochem ... are involved in calcium binding [24] The residues in the conserved tyrosine corners are in bold [24] ‘Greek key’ motifs are highlighted with underlines: single line, first motif; broken line,...
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Changes in the Economic Value of Variable Generation at High Penetration Levels: A Pilot Case Study of California pot
... binding in the RT, thus limiting the options for maintaining a balance in RT The combined -cycle vintage (CCGT) modeled in this analysis, for instance, is assumed to not be able to start within ... screening curves without operational constraints were applied Though they not include uncertainty in wind generation in the analysis, they find that the inclusion of operational constraints in investment ... periods rather than always part-loading the resource The tradeoff is the increase in start-up costs to bring the generation offline and then back online at a later point 45 The heat rate curves and the...
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Báo cáo khoa học: Local changes in the catalytic site of mammalian histidine decarboxylase can affect its global conformation and stability pptx
... protect the enzyme against thermal denaturation The increased resistance of the a-FMH-treated protein to thermal denaturation would indicate that the covalent binding of the adduct to the catalytic ... structure in the enzyme, suggesting several interaction points for the adduct within the catalytic center in addition to those established by the internal aldimine alone From the shape of the a-FMH-treated ... induced in HDC by histidine and histidine-analogs involve alterations in the environment of the aromatic amino acid residues of the protein Fig Thermal denaturation of the free HDC holoenzyme and the...
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Báo cáo khoa học: Large conformational changes in the Escherichia coli tryptophan synthase b2 subunit upon pyridoxal 5¢-phosphate binding pot
... [40], indicating the importance of His86 in PLP binding The conformational changes in His86 upon PLP binding may correlate directly with interactions between the N and C domains, leading to the ... while the green squares in the fourth line indicate the hinge region in Ecb The hinge regions, including hinges (residues 48–56), (82–87) and (206–207), were defined using DYNDOM software The asterisks ... triggered by the local conformational changes induced by PLP binding to the active site PLP binding to the apo-Ecb induced the following major conformational changes (a) PLP bound to the N terminus of...
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Báo cáo khoa học: Injection of poly(b-L-malate) into the plasmodium of Physarum polycephalum shortens the cell cycle and increases the growth rate pot
... PMLA-producing white strain manifests a larger increase in the growth rate than the high PMLAproducing yellow strain, while almost no difference between the strains is seen for the cell cycle duration In ... the same for the white and the yellow strains Nevertheless, because the level in the cytoplasm of white plasmodia before injection was very low (Table 1), the relative increase in these strains ... measurements are indicated Transient appearance of histone H1 in the cytoplasm We suspected that the mechanism(s) underlying the increase in the growth rate and the shortening of the cell cycle might...
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Báo cáo Y học: A polymer with a backbone of 3-deoxy-D-glycero -D-galacto -non-2ulopyranosonic acid, a teichuronic acid, and a b-glucosylated ribitol teichoic acid in the cell wall of plant pathogenic Streptomyces sp. VKM Ac-2124 pdf
... glucose and the presence of an unidentified ninhydrin-positive component suggest that the cell wall contains other polymer(s) in addition to ribitol teichoic acid The polymers present in the cell wall ... 0.33 : 0.33 based on the integral intensities of the signals in the 1H NMR spectrum It is likely that the percentages of the teichuronic acid, the Kdn-containing polymer, and the ribitol teichoic ... (III) The percentage of the teichoic acid ( 10 % mass of the cell wall) was calculated from the content of the teichoic acidlinked phosphorus (0.8%) and taking into account the structure of the...
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the changes in the narratots view of sonny
... Sonny.As the story nears completion, a single event brings the narrator out of the second phase and intohis third phase It is in this final pahse that the narrator obtains a true understanding of ... brother He became sensitive to what offended Sonny and took caution to avoid them He was willing tobe interested in what Sonny interested in Finally, he was willing to sit and listen to Sonny instead ... freedom.Finally, during the third phase, the narrator finally started caring about Sonny instead of try tocare for Sonny He no longer saw him as just something to be taken care of, he finally began...
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Báo cáo khoa học: Dynamic association of MLL1, H3K4 trimethylation with chromatin and Hox gene expression during the cell cycle ppt
... methylations during cell cycle in S phase may not be the same as the marks in other phases of the cell cycle (as shown by immunofluorescence staining and western blotting); rather, old marks are ... were localized in the less intense DAPI-stained regions in the nucleus (representing less condensed euchromatin), leaving gaps in the more intense DAPI-stained regions (representing more condensed ... and its interacting proteins during the cell cycle Prior to the analysis of the dynamics of MLL and histone methylation, we synchronized HeLa cells at different phases of the cell cycle using double...
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Báo cáo khoa học: Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site potx
... structural changes in the flaps near the mutated Ile46, and in the interactions of the mutated Thr82 and Val84 with indinavir [18] Local changes in the mutated residues were also observed in the crystal ... and more distal changes propagating to the inhibitorbinding site Fig Structural variation in residues 81–82 near indinavir Stereoview showing the benzyl group of indinavir interacting with residues ... the values in the two mutants Ile50¢ was ordered in all three structures and the side chain fitted well in the S2 binding pocket created by the t-butyl group of indinavir Ile50, on the other hand,...
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Biomechanical Walking Pattern Changes in the Fitand and Healthy Elderly docx
... This finding is hardly surprising because the balance challenges during walking are quite different from those involved in maintaining upright posture During standing, the goal is to maintain the ... Hz The smoothed coordinates then became inputs to the standard link-segment model ing during walking These variables are presented in the Table Results and Discussion In addition to the joint ... with the CG, which is its location in the gravitational axis In the 16 / 341 sagittal plane, even in slow walking, the horizontal momentum of the HAT results in inherent instability The role of the...
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