... plasticity [22] Training was shown to evoke a relatively specific increase in cortical excitability for muscles mediating movements in the training direction, and a decrease in cortical excitability ... mechanism of reciprocal inhibition in spinal circuits controlling wrist muscles is complex and unclear pertaining to our findings [33], however we expect that coupled with the repetitive descending ... amplitude following minutes of training, associatedwith wrist movement, in direction opposite to that of original TMSinduced twitch Page of motor skill acquisition [14-19], through unmasking...
... defined epitopes on CII Interestingly, the antibodies directed against distinct epitopes on the triple-helical part of CII correlate with chronic arthritis and induce arthritis relapses Arthritis ... mice Thus, the development of chronic relapsing arthritis in mice, initially induced by CII immunization, isassociatedwith an arthritogenic antibody response to certain CII epitopes Competing ... arthritic score and anti-CII antibody levels increased with time and again confirm that animals developing arthritis had significant levels of anti-CII antibodies To investigate whether the levels...
... SCW -induced arthritis Both acute and chronic joint inflammations were significantly inhibited by apoptotic cell injection – including reduction of swelling and decreased tissue and bone destruction ... apoptotic as determined by Annexin-V staining and 7Aminoactinomycin D exclusion before washing with PBS and intraperitoneal injection into the indicated rats at × 108 cells per animal at the same time ... clinically evident within 24 hours after injection of SCW andis characterized histologically by neutrophil infiltration into the synovium The chronic erosive arthritic stage, on the other hand, is induced...
... CD133 isassociatedwith the activation of stemness-related signal pathway, resistance to apoptosis and bioenergetic stress [17-22] Initially identified in hematopoietic stem cells, CD133 is now ... cells J Clin Onco 2008, 26(17):2821-2827 Monzani E, Facchetti F, Galmozzi E, Corsini E, Benetti A, Cavazzin C, Gritti A, Piccinini A, Porro D, Santinami M, Invernici G, Parati E, Alessandri G, La ... Morrison SJ: Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells Nature 2006, 441(7092):475-482 Yilmaz OH, Morrison SJ: The PI-3kinase pathway in hematopoietic...
... were in agreement with general trade-offs since carbon assimilation increases with increasing N and SLA, and decreases with increasing C and LD (Tab II) It has been suggested that including additional ... to SL and FE species in different tree communities in French Guiana [7, 26], underlying an original non-linear distribution (modal distribution) of this trait along the successional gradient Carbon ... unpublished data) and were classified into three successional groups with regard to growth and dynamic characteristics according to Favrichon [22, 23] This grouping is based on a statistical analysis...
... anti-GPI antibody positive Using these definitions, 23 (12.3%) RA patients were anti-GPI antibody positive, and nine (5.7%) healthy individuals were anti-GPI antibody positive (Fig 2) Statistical ... Anti-GPI antibodies are candidate arthritogenic antibodies In K/B×N mice, polyclonal or two monoclonal anti-GPI antibodies induced arthritis in several strains of mice [16] Moreover, FcγRIII deficient ... ELISA TH participated in clinical assessment TS participated in the full design and coordination of the study, and DG, SI and AT participated in writing the discussion Acknowledgements This work was...
... this finding was not significant on multivariate analysis This isin contrast to our findings where patients with weak COX-2 expression were associatedwith inferior overall and disease specific ... 5-fluorouracil and cisplatin Of the 221 patients, 88 were referred for treatment from a single institution following initial diagnosis of NPC For logistic reasons, only patients from this hospital were included ... staining; 5–8, moderate staining; and 9–12, strong staining For the purpose of statistical analysis, the cohort was grouped into tumors with negligible or weak staining (N = 34) versus tumors with...
... arthritis including covariates Arthritis Rheum 2004, 50:2757-2765 Eliceiri BP, Cherech DA: The role of alphav integrins during angiogenesis: insights into potential mechanisms of action and clinical ... ligands (such as vitronectin, fibronectin, osteopontin, sialoprotein, thrombospondin, fibrinogen, von Willebrand factor, tenascin, agrin, matrix metalloproteinases, and prothrombin) [6] The integrins ... arthritis Ann Rheum Dis 2007, 66:828-831 Spielman RS, McGinnis RE, Ewens WJ: Transmission test for linkage disequilibrium: the insulin gene region and insulindependent diabetes mellitus (IDDM)...
... Methionine metabolism Serine biosynthesis Methionine metabolism, sulfate assimilation Methionine metabolism Sulfate assimilation Methionine metabolism, sulfate assimilation Protein catabolism ... which is required for oxidative protein folding in the endoplasmic reticulum [29] These genes, in addition to functioning in oxidative stress and protein folding, had higher levels of expression in ... persist under different environmental conditions and may be associatedwith phenotypic variation under those conditions This is the case for the sulfur-assimilation/methionine pathway, which is associated...
... withand without CpG islands (Supporting information in Additional file 1) should identify those dinucleotides that contribute most to the periodic pattern Interestingly, in CpG island-containing ... profile of purine-purine and pyrimidine-pyrimidine dinucleotides between positions +40 and +200 The raw signal is shown in orange and a 3-bp smoothed distribution is shown in purple (RR) and ... CpG islands, methods for quantifying gene expression and tissue specificity, and the relationship between transcription factor binding site periodicity and dinucleotide periodicity Abbreviations...
... expression was significantly associatedwith histopathological type (p = 0.011) (Table 2) In addition, negative AdipoR1 immunostaining was significantly higher in patients with lymphatic metastasis ... protection against carcinogenesis by affecting insulin sensitivity and inflammatory states, it has direct anti-carcinogenic effects through the AMP-activated protein kinase (AMPK) system Activated ... Tataranni PA Hypoadiponectinemia in obesity and type diabetes: close pg 20 association with insulin resistance and hyperinsulinemia J Clin Endocrinol Metab 2001, 86:1930-1935 [14] Matsuda M, Shimomura...
... Science Center for their kind assistance in the IHC staining; Dr Fan Zhou in Department of Pathology & Laboratory Medicine at Southwest Washington Medical Center, Vancouver, for his kind help in ... Pathology, Peking University School of Oncology, Beijing Cancer Hospital & Institute; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education); Beijing 100142, China 11 12 ... the statistical analysis Results Patient characteristics All patients had complete follow-up information from the Tumor Registry Office in our hospital The clinicopathological characteristics are...
... leukemia blasts derived from individual patients with different clinical status in SCID mice a Leukemia blasts obtained from MA11 at initial diagnosis did not engraft and growth in SCID mice The cells ... pattern in SCID mice, suggesting that the in vitro growth potential of the leukemia blasts is correlated and consistent with their in vivo growth potential Similar to those with ALL, patients with ... (37% with ≥ 10% leukemia cells infiltrating marrow, plus 14% ≥ 1% infiltrating leukemia cells) after intravenous injection of samples from patients presenting with AML into a IL2R NOD/SCID mice...
... multigroup comparisons using Stat View software P < 0.05 was considered as significant Hematoxylin and Eosin (H&E) staining and mean linear intercept analysis SIRT1 deacetylase activity assay SIRT1 ... and then destained h with destaining solution (50% methanol, 10% acetic acid) Gels were washed in distilled water for 20 minutes and then scanned The intensity of bands was quantified using image ... decline in lung function and aging in cardiopulmonary comorbid conditions We determined the inflammatory response, oxidative stress (lipid peroxidation products), levels/ activities of matrix metalloproteinases...
... multigroup comparisons using Stat View software P < 0.05 was considered as significant Hematoxylin and Eosin (H&E) staining and mean linear intercept analysis SIRT1 deacetylase activity assay SIRT1 ... and then destained h with destaining solution (50% methanol, 10% acetic acid) Gels were washed in distilled water for 20 minutes and then scanned The intensity of bands was quantified using image ... decline in lung function and aging in cardiopulmonary comorbid conditions We determined the inflammatory response, oxidative stress (lipid peroxidation products), levels/ activities of matrix metalloproteinases...
... cytokines, inducing the production of tissue factor, prothrombin conversion to thrombin, and fibrin production Fibrinolysis is impaired due to increased production of plasminogen-activator inhibitor ... separating into four groups with equivalent number of patients IL-1ra - interleukin-1 receptor antagonist; IL-6 - interleukin-6; IL-8 - interleukin-8; IL-10 - interleukin-10; TNF-a - tumor necrosis ... the premise that tissue hypoxia in severe sepsis and septic shock isassociatedwith increased apoptosis, suggesting that the ill effects resulting in cell death may be mitigated by resolution of...
... Introduction: Cardiovascular disease (CVD) is the leading cause of death in patients with inflammatory polyarthritis (IP) especially in seropositive disease In established RA, insulin resistance (IR) ... arthritis, Insulin Resistance factor, Early inflammatory Introduction Cardiovascular disease (CVD) remains the leading cause of death in patients with inflammatory polyarthritis (IP) andis particularly ... level of insulin production and therefore islet cell destruction is unlikely to be the mechanism by which this insulin resistance isinduced We did not find any significant contribution of therapy...
... and only when hemodynamic instability invasive monitoring is required However, these endpoints have revealed the inadequacy of relying solely upon vital signs in resuscitation of critically ill ... or prior congestive cardiac failure, previous clinical indication of ischemic heart disease (previous myocardial infarction, ST–T depression during stress testing or Q-waves on electrocardiogram), ... acidosis [6,8–10,25] In addition, the use of lactate as an endpoint of resuscitation is based on a substantial body of literature, including multiple prospective studies in trauma patients, in...
... control with intravenous insulin isassociatedwith a significant reduction in postoperative renal impairment and injury according to the RIFLE criteria in non-diabetic cardiac surgical patients ... angiotensin-converting enzyme inhibitors is unknown to us Similarly, the apparently improved survival of diabetics using angiotensin-converting enzyme inhibitors is remarkable Whether this is clinically ... glucose levels than on the dose of insulin administered in critically ill patients [22] Implementing tight glycemic control isassociatedwith an increased risk of hypoglycemia A recent meta-analysis...