state of the art in radiation oncology in the multidisciplinary treatment of head and neck cancer
Báo cáo khoa học: "Prognostic factors for lymph node metastasis from advanced squamous cell carcinoma of the skin of the trunk and extremities" doc
... involving the parotid gland Head Neck 2001, 23:744-748 Joseph MG, Zulueta WP, Kennedy PJ: Squamous Cell Carcinoma of the skin of the trunk and limbs: The incidence of metastases and their outcome Aust ... of the head and neck Head Neck 2006, 28:785-791 O'Brien CJ, McNeil EB, McMahon JD, Pathak I, Lauer CS: Incidence of cervical node involvement in metastatic cutaneous malignancy involving the ... conflicting results, and including head and neck tumors [7,19,20] The only statistically significant clinical variable associated to increased number of lymph node metastasis was the presence of previous...
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Báo cáo khoa học: "Normalization of prostate specific antigen in patients treated with intensity modulated radiotherapy for clinically localized prostate cancer" pot
... obtained the retrospective data from the charts, and wrote the first draft of the paper GDAP and PC conceived of the study, and participated in its design and coordination and helped to draft the ... hormonal therapy and to detect recurrent cancer PSA can be used to determine the efficacy of primary therapy including radical prostatectomy and radiation therapy The PSA nadir after radical prostatectomy ... reason to think more seriously about expanding the role of NAAD therapy in these patients Further study is needed to elucidate whether the rate of PSA normalization is linked to notable endpoints such...
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Báo cáo khoa học: "Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM)" docx
... [13] One main risk associated with surgery is the often inevitable dissection of the vascular supply of the nerve, which leads to severe visual impairment in about 95% of the patients [3] There have ... complained of new headaches, and three of recurrent hyperlacrimation of the irradiated eye, one with change of taste perception None of the patients developed dysfunctions of the pituitary gland, neuropathy, ... previously [17,18] to support the clinical as well as MR-imaging based diagnosis of meningioma Typical examinations for treatment planning are shown in Figure We defined the macroscopic lesion visible...
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Báo cáo y học: "Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma" docx
... Genetic and expression profiles of squamous cell carcinoma of the head and neck correlate with cisplatin sensitivity and resistance in cell lines and patients Clin Cancer Res 2004, 10:8204-8213 Ginos ... status The prevalences of p53, NF-κB, and AP-1 binding sites were observed in the promoter regions of different gene clusters, suggesting their importance for the subgrouping of HNSCCs Increases in ... sites of the matrix metalloproteinase-3 promoter in response to inflammatory cytokines [98] Coordinated binding of ZBP-89, SP1, and NF-κB p65/p50 in the ENA-78 (epithelial neutrophil-activating...
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Báo cáo khoa học: Alternative splicing produces an H-protein with better substrate properties for the P-protein of glycine decarboxylase doc
... insertion of two additional alanyl residues into the N-terminus of the H-protein In conclusion, the substrate properties of the alternatively encoded Flaveria H-protein FtGLDHAA in the P-protein reaction ... structure of pea H-protein showing the N-terminus and the position of the lipoyl arm Fig S2 Overexpression and effects on H-protein of E coli lipoate–protein ligase A Fig S3 Glycine saturation kinetics ... environments In this study, we examined whether the changes to the N-terminus of Flaveria H-protein alter its reactivity with P-protein, the actual glycine-decarboxylating subunit of GDC These experiments...
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Báo cáo sinh học: "High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... cause inter- and intrastrand cross-linking These DNA cross-links are recognized and removed by the nucleotide excision repair pathway which arms to guard the integrity of the genome [15,16] The ... hepatic and renal function (creatinine clearance >60 ml/min), and a computed tomography or magnetic resonance image scan of the head and neck region within three weeks prior to the initiation of treatment ... an H score of more than 1.5 and were thus defined as having a high expression of ERCC1 As can be seen in Table a summary of result of the ERCC1 immunostaining of the cancer cells and its correlation...
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AUDIT TOGETHER WITH INDEPENDENT AUDITORS* REPORT FOR THE PERIOD JULY potx
... entity and not included as part of the reporting entity of the University ' NOTE - Summary of Significant Accounting Policies: Principles of Accounting The financial statements are prepared in accordance ... Policies Continued: Basis of Reporting Continued Use of Estimates The preparation of financial statements in conformity with accounting principles.generally accepted in the United States of America ... estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the financial statements and the reported...
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Báo cáo sinh học: "Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma" pot
... staining (data not shown) Her2 staining was scored based on the scoring system applied to breast cancers, with scores of 0,+1, +2, +3 for increasing intensity and “continuity” of staining of the ... difference of antibodies used for staining or method of assessment for determination of Her3 status So far, there are no standardized methods of Her3 staining and scoring, our findings suggest the importance ... quantification of Her3 staining, we scored two compartments of the cell - the cell membrane, using the same scoring system as applied for Her2, and the cytoplasm For the cytoplasmic staining, we scored...
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báo cáo hóa học:" High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... cause inter- and intrastrand cross-linking These DNA cross-links are recognized and removed by the nucleotide excision repair pathway which arms to guard the integrity of the genome [15,16] The ... hepatic and renal function (creatinine clearance >60 ml/min), and a computed tomography or magnetic resonance image scan of the head and neck region within three weeks prior to the initiation of treatment ... an H score of more than 1.5 and were thus defined as having a high expression of ERCC1 As can be seen in Table a summary of result of the ERCC1 immunostaining of the cancer cells and its correlation...
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báo cáo hóa học:" Membranous expression of Her3 is associated with a decreased survival in head and neck squamous cell carcinoma" doc
... staining (data not shown) Her2 staining was scored based on the scoring system applied to breast cancers, with scores of 0,+1, +2, +3 for increasing intensity and “continuity” of staining of the ... difference of antibodies used for staining or method of assessment for determination of Her3 status So far, there are no standardized methods of Her3 staining and scoring, our findings suggest the importance ... quantification of Her3 staining, we scored two compartments of the cell - the cell membrane, using the same scoring system as applied for Her2, and the cytoplasm For the cytoplasmic staining, we scored...
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Báo cáo hóa học: " Unscented Kalman filter with parameter identifiability analysis for the estimation of multiple parameters in kinetic models" pptx
... number), in the order of the highest to the lowest sensitivity To make the adjustment of the net influence of each of the remaining parameters on the already selected parameters, all of the original ... During the UT, sigma points, a minimal set of sample points about the mean, are calculated to capture the statistics of the state model The sigma points are calculated according to the following ... Supplementary data) The vector X is the state vector of the model, values of which are the metabolite concentrations, and X0 is the initial state vector at time t0 The vector θ contains the unknown rate...
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Báo cáo hóa học: " A New MAC Protocol with Pseudo-TDMA Behavior for Supporting Quality of Service in 802.11 Wireless LANs" docx
... Thessaloniki, and in the year 1984 got his Diploma in electrical and computer engineering from the University of Patras He did his postgraduate studies in the University of Bradford in the United Kingdom, ... Kingdom, and he is an M.Phil and Ph.D holder since 1978 and 1985, respectively Currently he is a Member of the academic staff of the Department of Electrical and Computer Engineering of the University ... Papapanagiotou has been studying in the Electrical and Computer Engineering School of University of Patras, Greece, since 2001, and he is currently in his last year of studies His interests include wireless...
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Báo cáo hóa học: " ITERATIVE SCHEMES WITH SOME CONTROL CONDITIONS FOR A FAMILY OF FINITE NONEXPANSIVE MAPPINGS IN BANACH SPACES" docx
... Proof As in the proof of [1, Theorem 1], we proceed with the following steps Step xn − z ≤ max{ x0 − z , a − z } for all n ≥ and all z ∈ F and so {xn } is bounded We use an inductive argument The ... Deutsch and I Yamada, Minimizing certain convex functions over the intersection of the fixed point sets of nonexpansive mappings, Numer Funct Anal Optim 19 (1998), no 1-2, 33–56 K Goebel and W A ... if Q2 = Q If a mapping Q of C into itself is a retraction, then Qz = z for every z ∈ R(Q), where R(Q) is range of Q Let D be a subset of C and let Q be a mapping of C into D Then Q is said to...
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báo cáo khoa học: "Sentinel lymph node biopsy for high-risk cutaneous squamous cell carcinoma: clinical experience and review of literature" ppsx
... majority of studies, the calculated NPV of SLN biopsy may in fact be overestimated Considering the rarity of this tumor and lack of long-term follow up in the majority of studies, including our ... colloid Skin landmarks were marked to assist intraoperative SLN localization Lymphazurin 1% isosulfan blue was injected intradermally surrounding the primary tumor site at the beginning of the procedure ... invasive perineal squamous cell carcinoma (B) Blue-stained inguinal sentinel lymph node Figure Wide excision of perineal squamous cell carcinoma: H&E staining at 2X (A) and 40X (B) Sentinel lymph...
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Báo cáo khoa học: "Large volume unresectable locally advanced nonsmall cell lung cancer: acute toxicity and initial outcome results with rapid arc" potx
... duration of treatments, reducing the risk of unscheduled and undue interruptions In particular, the authors point out the extension of disease to be greater than other population finding in Scorsetti ... NSCLC We also investigated the possibility of sparing lung tissue, esophagus, heart and spinal cord using RA with the aim of paving the way for further study of dose escalation In the present study, ... 2008 The present study reports the early findings from the treatment of a group of 24 patients affected by advanced lung cancer irradiated with RapidArc The main objective in the initial clinical...
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Báo cáo khoa học: "Recurrence patterns of locally advanced head and neck squamous cell carcinoma after 3D conformal (chemo)-radiotherapy" pdf
... Each local or regional treatment failure site was confirmed pathologically and reviewed within the multidisciplinary head- and- neck team As part of the study, the imaging of the all patients who ... head and neck specialist diagnostic radiologist, to identify the precise site of LRR The radiologist, using information on the imaging demonstrating recurrence, including size of recurrence and ... recurrence at the edge of the PTV was seen in only one patient Uncertainty in the demarcation of the target volumes is one of the major limitations to improving outcomes of HNSCC with radiotherapy The...
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Báo cáo khoa học: "Parotid gland-recovery after radiotherapy in the head and neck region: 36 months follow-up of a prospective clinical study" pdf
... 3DCRT in terms of parotid gland sparing The IMRT technique should therefore represent the standard of care for the treatment of head and neck tumors Parotid-gland-sparing up to mean doses of 26 ... during the head and neck irradiation [29] This is known from studies in centers with the use of helical tomotherapy Due to weight loss and tumor shrinkage especially in head and neck patients the ... reference point in the target volume as described in ICRU reports 50, 62 and 83 Determination of the parotid gland doses The planning target volumes and both parotid glands, the mandible, and the larynx...
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Báo cáo khoa học: "Intensity-Modulated Radiotherapy for Squamous Cell Carcinoma of the Anal Canal: Efficacy of a Low Daily Dose to Clinically Negative Regions" ppsx
... radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and ... and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study J Clin Oncol ... Aided in the design of the study, helped draft the manuscript D.W.L.: Aided in the design of the study, helped draft the manuscript J.F.Q.: Aided in the design of the study, helped draft the manuscript...
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Báo cáo khoa học: " Optimal organ-sparing intensity-modulated radiation therapy (IMRT) regimen for the treatment of locally advanced anal canal carcinoma: a comparison of conventional and IMRT plans" ppsx
... Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of ... three-dimensional cm margin, the anal canal, and the draining lymphatic regions, including the perirectal, internal iliac, external iliac, obturator and inguinal lymphatics in all cases For the five patients ... for the coverage of pelvic and inguinal/femoral nodes in two patients with anal cancer The whole pelvic dose was 36 Gy in 20 fractions The mean dose to the femoral head was 58.3% and 59.5% of the...
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Báo cáo y học: "Adherence with urate-lowering therapies for the treatment of gout" pps
... of the data, and critiquing of drafts of this article BB was involved in the design of this project, analysis and interpretation of the data, and critiquing of drafts of this article MR was involved ... was involved in the interpretation of the data, and drafting of this article IO was involved in the conception and design of this project, analysis and interpretation of the data, and critiquing ... involved in data acquisition, interpretation of the data and critiquing of drafts of this article HF was involved in the analysis of data from this study and interpretation and presentation of results...
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