Radiation Oncology This Provisional PDF corresponds to the article as it appeared upon acceptance Fully formatted PDF and full text (HTML) versions will be made available soon Intensity-Modulated Radiotherapy for Squamous Cell Carcinoma of the Anal Canal: Efficacy of a Low Daily Dose to Clinically Negative Regions Radiation Oncology 2011, 6:134 doi:10.1186/1748-717X-6-134 Jason A Call (call.jason@mayo.edu) Michael G Haddock (haddock.michael@mayo.edu) J FERNANDO Quevedo (quevedo.fernando@mayo.edu) David W Larson (larson.david2@mayo.edu) Robert C Miller (miller.robert@mayo.edu) ISSN Article type 1748-717X Research Submission date 26 April 2011 Acceptance date October 2011 Publication date October 2011 Article URL http://www.ro-journal.com/content/6/1/134 This peer-reviewed article was published immediately upon acceptance It can be downloaded, printed and distributed freely for any purposes (see copyright notice below) Articles in Radiation Oncology are listed in PubMed and archived at PubMed Central For information about publishing your research in Radiation Oncology or any BioMed Central journal, go to http://www.ro-journal.com/authors/instructions/ For information about other BioMed Central publications go to http://www.biomedcentral.com/ © 2011 Call et al ; licensee BioMed Central Ltd This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited Intensity-Modulated Radiotherapy for Squamous Cell Carcinoma of the Anal Canal: Efficacy of a Low Daily Dose to Clinically Negative Regions Jason A Call1, Michael G Haddock1, J Fernando Quevedo2,David W Larson3, Robert C Miller1* Author Affiliations: Department of Radiation Oncology , Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA Division of Medical Oncology , Mayo Clinic, 200 First St SW, Rochester, MN 55905 , USA Division of Colon and Rectal Surgery , Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA *Corresponding author: Robert C Miller- miller.robert@mayo.edu Email addresses: JC: call.jason@mayo.edu MH: haddock.michael@mayo.edu JFQ: quevedo.fernando@mayo.edu DL: larson.david2@mayo.edu Abstract Background: We aimed to assess outcomes of patients with anal cancer who underwent intensity-modulated radiotherapy (IMRT) and received less than 1.80 Gy/day Methods: We retrospectively reviewed our experience using a low fractional dose (