stat5a b and stat3 in growth promotion of prostate cancer
Báo cáo khoa học: "Reproducibility of patient setup by surface image registration system in conformal radiotherapy of prostate cancer" pdf
... variations of patient profile mainly due to change in content of bowel and small intestine As a matter of fact, we observed variations > mm in the X axis in out of overweight patients In this regard, ... 6, and The positioning error detected by AlignRT along the axes X, Y, and Z exceeded the value of mm in 14.1%, 2.0%, and 5.1% of measurements and the value of mm in 36.9%, 13.6%, and 27.8% of ... aspects have to be taken into account as prescribed by the ICRU 62 document (ICRU62) that defined in this regard the setup margin and the internal margin around the CTV to obtain the final PTV Methods...
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báo cáo khoa học: "Angiogenesis inhibitors in the treatment of prostate cancer" pdf
... development of small molecules that inhibit tyrosine kinases, primarily by binding the ATP binding domain, has led to investigation of tyrosine kinase inhibitors as angiogenesis inhibitors In general, because ... currently being studied in earlier stages of disease, as well as in combination with chemotherapy Sunitinib Sunitinib is another multitargeting tyrosine kinase inhibitor that inhibits VEGF and PDGF ... effects able to overcome resistance Results of the combination of docetaxel, bevacizumab and thalidomide in prostate cancer are encouraging, as discussed above [50] Dual inhibition is also being investigated...
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báo cáo hóa học: " Aspirin-triggered lipoxin A4 attenuates LPSinduced pro-inflammatory responses by inhibiting activation of NF-B and MAPKs in BV-2 microglial cells" pptx
... paraformaldehyde in PBS and permeabilized with 0.1% Triton X-100 in PBS After rinsing, cells were blocked with 3% BSA in PBS for h and incubated with rabbit anti-NF- B p65 antibodies Page of 12 (1:200, ... LightShift chemiluminescent EMSA kit (Pierce) Briefly, 20 fmol of biotin-labeled, double strand probe was incubated for 20 at room temperature in 20 μl of EMSA binding buffer containing 2.5% glycerol, ... activating stimuli, including LPS and cytokines [46] In this study, ATL was able to inhibit the LPS-evoked degradation of I B- a, nuclear translocation of NF- B p65 and the DNA-binding activities of...
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Báo cáo y học: "Short- and long-term effects of anti-CD20 treatment on B cell ontogeny in bone marrow of patients with rheumatoid arthritis" ppsx
... absolute numbers of B cells in the rituximab-treated and rituximab-naïve patients are shown in Table The accumulation of immature subset of B cells in BM of rituximab-treated patients was proved by a ... P = 0.004) in BM, and by an increase of immature (CD27-IgD) B cells (P = 0.01) The absolute numbers of B cells in the rituximab-treated and tituximab-naïve patients are shown in Table No correlation ... pronounced decrease in frequency of Rituximab depletes immature and naïve B cells in BM To further evaluate the phenotype of B cells escaping rituximab depletion in BM, a combination of CD27 and IgD was...
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Báo cáo y học: "Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis" ppt
... part by grants -in- aid from the Ministry of Health, Labor and Welfare, and the Ministry of Education, Science, Sports and Culture, Japan, and the Japanese Ministry of Education, Global Center of ... mAb for 30 minutes Then, the × 105 B cells were incubated in 96-well with the indicated chemokines with or without pre-coated anti-IgM mAb (2 μg UHB; SouthernBiotech, Birmingham, AL, USA) in ... stained with CD19 and CD27, and the numbers of cells were assessed The percentage of migrated cells was calculated by dividing the number of migrated CD27- or CD27+ B cells by the number of total...
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Báo cáo y học: " Comparison of the efficacy of lamivudine and telbivudine in the treatment of chronic hepatitis B: a systematic review" pdf
... and telbivudine are more widely used in treatment of CHB In this systematic review, we focus on the comparison of the efficay of lamivudine and telbivudine in the Figure Effect of telbivudine vs ... CNKI, WANFANG and VIP databases provide literatures in Chinese The search process was designed to find initially all trials involving terms: “Hepatitis B , “lamivudine”, “telbivudine”,"randomized ... may be less likely to be published and more likely to take longer to be published, which can affect the validity of meta-analysis in this review[22] Besides only publish in English and Chinese...
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Báo cáo y học: " Detrimental effects of albuterol on airway responsiveness requires airway inflammation and is independent of b-receptor affinity in murine models of asthma" pdf
... nebulizer (Beetle Neb, Drive Intl LLC, NY) Zrs was then measured every 10 s for Next, two deep sighs were delivered again and two baseline recordings of Zrs were obtained followed by methacholine ... to induce increased permeabilization of the epithelial lining [47] with subsequent hyperresponsiveness to inhaled methacholine, which in turn is probably due to increased epithelial permeability ... SS, Norton RJ, Rinaldi LM, Bates JHT, Sobel BE, Irvin CG: Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness J Clin Invest 2004, 114:104-111...
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The difficulties and some solutions to improve for speaking skill of level b english students in the center of foreign languages and informatics at ca mau community college
... N of Ts % What you A Difficult and boring 65 think of the B Difficult but interesting 20 C Interesting and stimulating 13 D Easy and boring 47 materials used for teaching and learning speaking ... laziness H Others (please specify) What you think of the materials used for teaching and learning speaking skill at COFI? A Difficult and boring C Interesting and stimulating B Difficult but interesting ... Speaking is an interactive process of constructing meaning that involves producing and receiving and processing information (Florez, 1999, p.1) It is often spontaneous, open-ended and evolving (ibid,...
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The role of cyr61 and LASP1 in growth and metastasis of human hepatocellular carcinoma
... followed by two actin binding sites and a C-terminal src homology SH3 domain (Figure 1.3) The actin binding domain is believed to be functioning as a mediator for protein-protein interactions between ... primers used in CHIP-qPCR……………………………… 77 xiii Abbreviations ABBREVIATIONS AFB1 aflatoxin B1 AFP alpha-fetoprotein APS ammonium persulfate Arg Arginine BM basement membrane bp base pair BSA bovine serum ... adhesion kinase (FAK) and vinculin to focal contacts (Sastry and Burridge 2000; Calderwood and Ginsberg 2003) The α-actinin, a cytoskeletal protein that is phosphorylated by FAK, binds to vinculin and...
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Study of the associated proteins of STAT3 and characterization of their functions roles of GRIM 19 and PIN1 in the regulation of STAT3 activity
... DNA-binding domain resembles an eight-stranded β-barrel, where several loops between the β strands of this domain participate in DNA-binding Between the DNA binding and SH2 domain is the linker region, ... proteins inhibit JAK/STAT signaling activated by IL-6 family cytokines, growth hormone and 23 Chapter 1: Introduction interferons, basically through binding to the tyrosine kinase domain of JAK and ... expression of various genes RA inhibits growth of certain types of cancer and is effective in the prevention of primary cancers, and is used in clinical therapy (Love and Gudas, 1994) A combination of...
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The role of small GTPases rap1 and rhoa in growth hormone signal transduction
... ligand-binding domain of GHR is generated by two separate mechanisms dependent of the species: proteolytic shedding in human and rabbits; alternative splicing of the GHR mRNA in rat and mice (Baumann, ... regulated kinase xii EtBr ethidium bromide FAK focal adhesion kinase FBS fetal bovine serum FGF fibroblast growth factor FITC fluorescein isothiocyanate G protein guanine-nucleotide binding protein GAP ... second cysteine in the N-terminal fibronectin domain, 4) a WSXWS-like motif in the C-terminal fibronectin domain (YXXFS in the mammalian GHR), 5) absence of a canonical tyrosine kinase consensus...
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The Duality of Memory and Communication in the Implementation of a Multiprocessor Operating System
... to be used by smart compilers The BBN Butterfly [2] is an example of a commercial NUMA Communication between CPUs in the Butterfly is by means of a Butterfly Switch, the complexity of which increases ... be built, maintained and accessed using these techniques 8.1 Emulating Operating System Environments During the 1960’s the notion of a virtual machine base for operating systems development became ... engaged in a project to build a distributed speech understanding system called Agora [3] This work is being done on Mach and currently makes use both of Mach memory sharing and message passing Both...
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Organizing pairwork and groupwork in the context of high school classrooms at pham van nghi upper secondary school, nam dinh province: A case study
... teaching speaking, teaching reading, teaching listening, teaching grammar and teaching writing, the researcher has to design the Classroom Observation Sheet before observing classes.The classes observed ... work in language classes 50% of them saw the benefits of these activities in making class more interesting and 50% consider pairwork and groupwork helping in motivating students and learning process ... still something to change situation The teacher should establish certain rules at the beginning of the school year and be very strict about them After sometime the good habit of speaking only English...
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Globalism and regionalism in the protection of the marine environment
... adoption in 1995 of the non-binding Washington Declaration and the Global Plan of Action for the Protection of the Marine Environment from Land-Based Activities,29 but this neither sets global standards ... on land-based (including airborne) sources of pollution, and in the practice of states on these Here, although the negotiation of global rules and standards is encouraged by its Articles 207 and ... members of the British Commonwealth should probably not be described as ‘regional’ in any sense These descriptions are probably of more use in understanding how a particular region comes to be...
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Language and alterity in the thought of Levinas
... meaning of being and that at the same time retain the inscription of the trace In analysing the said, Levinas brings to the fore the intrinsic binarism of being, what he terms its amphibology Being, ... disclosed in terms of the ontological difference, the difference between Being and beings Yet it is precisely Heidegger’s interpreting of Being as active, as the power of Being, rather than turning ... be shown that is ‘the mark of everything that is present’.27 The ‘moving force’ of the showing of saying that brings beings into their own is owning or appropriation that yields the opening of...
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The victorious laugh of love, frienship, justice and commonsence in the merchant of venice by shakespeare
... father and daughter When Jessica elopes and brings his jewels and money with her, he is paintful and insane and wanders in the streets of Venice but he is convulsed with pain because of losing money ... say in choosing a husband She wants to have freedom in choosing a marriage partner She has progressive thoughts of choosing her husband Standing in front of Bassanio, she feels wonderful things ... interested in, exalted than in this period 1.2 Renaissance : The discovery of the world and humanbeings People began to think differently about the universe and the place of humanbeings within it...
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Tài liệu Báo cáo " synthesis, cloning and expression in escherichia coli of a gene coding for Mcoti-ii " ppt
... of the obtained recombinant fusion protein should be about 58 kD ( the sum of 55 + 3.4kD of MCoTI-II) As seen on Fig 10 the 58 kD protein band was found in induced sample as the major band, acounted ... it and purified following IMPACT-CN system manufactures instruction by using chitin beads column chromatography The obtained purified recombinant MCoTI-II showing inhibitory activity against ... and Laskowski M., Jr The squash family of serine proteinase inhibitors Amino acid sequences and association equilibrium constants of inhibitors from squash, summer squash, zucchini and cucumber...
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Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx
... member of the CPT1 class of enzymes and was shown to bind malonyl-CoA [47] Interestingly, its tissue distribution was restricted to the brain Being a malonyl-CoA binding protein that is restricted ... concentrations and (b) inhibit AMPK thus derepressing ACC The increase in malony-CoA is thought to allosterically inhibit CPT1c to mediate changes in feeding behavior and body weight ACC, acetyl-CoA carboxylase; ... maintaining a lower food intake This is accompanied by a suppression in energy expenditure These data suggest that CPT1c can integrate carbohydrate and lipid nutrient sensing in the brain and...
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Tài liệu Báo cáo khoa học: Osmosensing and signaling in the regulation of mammalian cell function docx
... Thus, integrin-dependent cell volume sensing and signaling integrates into the overall context of insulin signaling Similarly, sensing of glutamine-induced hepatocyte swelling by integrins feeds into ... [12–14] Integrin-inhibitory peptides exhibiting an arginine-glycine-aspartic acid (RGD) motif abolish hypoosmotic osmosignaling towards Src-type kinases, mitogen-activated protein kinases (MAPKs) and ... Osmosensing and signaling in mammalian cell function F Schliess et al [7] On the other hand, hyperosmotic shrinkage prevents insulin-induced hepatocyte swelling and proteolysis inhibition, indicating...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam nội dung cụ thể cho từng kĩ năng ở từng cấp độ xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng 9 tr 25