solid state nuclear magnetic resonance studies of alkali metal ions in nucleic acids and related systems
Single DNA studies of architectural proteins involved in bacterial pathogenesis and meiosis in saccharomyces cerevisiae
... protein molecules and their interactions with DNA in real-time reactions and the dynamics of their DNA-binding Therefore, my objective of finding the characteristics of protein binding to single ... is an NAP constituting 7–10% of the total protein in Mtb (78) It consists of 205 amino acid residues and contains large amounts of alanine (23.78% of total amino acids) and lysine (18.93%), with ... expression of diverse virulence genes The Nterminus of SsrB contains the site of phosphorylation and the C-terminus consists of a DNA-binding domain Dimerization occurs upon DNA binding and is required...
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Tài liệu Báo cáo khoa học: Enzymatic and electron paramagnetic resonance studies of anabolic pyruvate synthesis by pyruvate: ferredoxin oxidoreductase from Hydrogenobacter thermophilus doc
... characterization of enzymes that transfer electrons to ferredoxins in vivo is of particular importance for the improvement of this coupled assay and also with respect to obtaining a deeper understanding of ... metabolism of H thermophilus Indeed, this would enable the kinetic analysis of the POR reactions in both directions In particular, the reaction rate under physiological intracellular concentrations of ... Fd1 and acetylCoA, the HE-TPP radical intermediate was formed (Figs 3F and 4B), indicating the intermediacy of the HE-TPP radical in both the oxidative and reductive reactions The results obtained...
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Tài liệu Báo cáo khoa học: Steady-state and time-resolved fluorescence studies of conformational changes induced by cyclic AMP and DNA binding to cyclic AMP receptor protein from Escherichia coli ppt
... nucleotide-binding domain to the DNA-binding domain of the protein We have used single tryptophancontaining mutants of CRP The mutations were localized in the N-terminal domain at position 85 or 13 in ... DNA-binding domains and cAMPbinding domains of the protein This nding claries the suggestion derived from the NMR measurements [7] that the C-terminus is closer to the N-terminal domain in apoCRP ... observation and suggest that the binding of cAMP to anti-cAMP-binding sites of CRP leads to the increase in the structural dynamic motion of at least Trp13, which is located in the N-terminal domain of...
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Báo cáo hóa học: " Adenoviruses with an avb integrin targeting moiety in the fiber shaft or the HI-loop increase tumor specificity without compromising antitumor efficacy in magnetic resonance imaging of colorectal cancer metastases" pdf
... Laboratory, Haartman Institute and Finnish Institute of Molecular Medicine, University of Helsinki, Finland 2HUSLAB, Helsinki University Central Hospital, Finland 3Department of Obstetrics and Gynecology, ... Replicating viruses WT -Replicating wild type virus WT-RGD -RGD insertion in HI loop of fiber knob for avb integrin targeting [43] WT-RGDK -Fiber shaft’s KKTK domain mutated to RGDK for avb integrin ... motif into the HI loop of the fiber knob (Ad5lucRGD) or into the fiber shaft KKTK domain (AdTLRGDK) increased the expression of transgene in all tested cell lines in comparison with AdTL Interestingly,...
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Nuclear Magnetic Resonance 2 doc
... Stoichiometry Solid- state Nuclear Magnetic Resonance NMR in solids, like solution -state, relies on the behavior of nuclear spin energy levels in a magnetic field However, the interactions that ... m=+1/2 In liquids, molecules reorient and diffuse quickly, leading to narrow isotropic resonances In solids, the fixed orientation of individual crystallites leads to a range of resonance ... frequencies for anisotropic interactions Solid- state NMR: Magic-Angle Spinning The following anisotropic interactions are dependent on their orientation with respect to the large magnetic field (B0):...
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Nuclear Magnetic Resonance 1 pot
... “Principles of Nuclear Magnetism”, Oxford, 1961 R R Ernst, G Bodenhausen, and A Wokaun, “Principles of Nuclear Magnetic Resonance in One and Two Dimensions”, Oxford, 1987 C P Slichter, “Principles ... certain 1H and 13C J-coupling values fall into make spectral editing and heteronuclear correlation experiments possible!!! J-Coupling: Effects on NMR Spectra Two basic types of coupling – Homonuclear ... Structural and Conformational Analysis J-coupling is widely used (in conjunction with 2D NMR) to assemble portions of a molecule – In this case, the J-coupling is simply detected in a certain range and...
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Báo cáo y học: "Long term evaluation of disease progression through the quantitative magnetic resonance imaging of symptomatic knee osteoarthritis patients: correlation with clinical symptoms and radiographic change" pps
... the outset of the study based on certain clinical variables: being female, having a high body mass index (BMI), experiencing a higher level of pain and stiffness, and having reduced joint mobility ... use of JSW changes in knee OA studies is such that a minimum follow-up of at least 24 months and a cohort of several thousands is necessary to establish the effect of pharmacological interventions ... Osteoarthritis: MR imaging findings in different stages of disease and correlation with clinical findings Radiology 2003, 226:373-381 Biswal S, Hastie T, Andriacchi TP, Bergman GA, Dillingham MF, Lang...
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Báo cáo khoa học: "Proton nuclear magnetic resonance spectroscopy based investigation on propylene glycol toxicosis in a Holstein cow" potx
... concentrate containing profollowing intake and andof arterial blood developed dyspnea pylene glycol clinical force feeding with concentrate containdid propylene(circle) (triangles)tocow that in two cows ... sulphur-containing compounds produced during fermentation of PG could be the cause of side effects [16] We observed no indications of the presence of sulphur-containing compounds in the NMR spectra ... containing clinical reaction feeding with taining did following (circle) 2) force (triangles) in two cows dyspnea not show intake andglycol to concentrate conCarbon dioxide pressure (pCO2) of arterial...
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Báo cáo y học: "Use of T2-weighted magnetic resonance imaging of the optic nerve sheath to detect raised intracranial pressure" pps
... estimation of ICP and to define thresholds for diagnosing intracranial hypertension In our institution, brain MRI studies are performed for research purposes during the acute phase of traumatic brain injury ... assessed by comparing measurements of ONSD and OND in TBI and healthy volunteers The observers (TG and VN) were blinded to each other's findings, to ICP and to subjects' identity The inter-observer ... difficult when invasive devices are not available Clinical signs of raised ICP such as headache, vomiting and drowsiness are not specific and often difficult to interpret In sedated patients, clinical...
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Nuclear magnetic resonance spectroscopy (NMR)
... INADEQUAT Phổ cho thấy mối tương quan ngang qua nối nhờ phổ cho biết phân tử cacbon kề bên cacbon Phổ 1D 13C INADEQUAT thường sử dụng khó xác định mối lien hệ 13C, 13 C Ngược lại phổ 2D 13C INAQUAT ... (δ6-δ7) x 500 = (δ7-δ8) x 500 = 7.15 làm tròn với số lẻ J = 7.1 Hz cường độ peak nhóm theo %Int = 1:2:1 + Tại singlet peak chọ làm tín hiệu với δ = 1.9907 làm tròn với hai số lẻ δ = 1.99 ppm + Tại ... loại phổ cho biết mối tương quan proton-proton với nhau: proton gem (germinal, hai proton gắn cacbon); proton vic (vicinal, hai proton gắn hai cacbon kề nhau) 2.2 Phổ 1H-13C HETCOR Phổ COSY dị...
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Experimental determination of the nuclear magnetic octupole moment of 137ba
... absorption and stimulated emission of radiation In the case of non-zero detuning, δ, and in the Rotating Wave Approximation (RWA) [54] the probability of being in the |g or |e state for an atom initially ... dashed line It is also worth noting that the |2 ↔ |− transition contains two turning points in its dependence on the magnetic field and the |2 ↔ |+ transition contains one The |− state containing ... within their errors All of this work culminated in establishing a nuclear magnetic octupole moment value of Ω(137 Ba+ ) = 0.05061(56) (µN × b) xi xii List of Publications The main results of this...
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Fast registration of contrast enhanced magnetic resonance images of the breast
... texture instead of a stack of separate 2D textures is that we can invoke the processing of the data using one single rendering pass, instead of multiple rendering passes Figure 4.2 Illustration of ... number of independent parameters Examples of transformations with low degree of freedom are affine, rigid and similarity transforms Transformations with high degree of freedom often are defined using ... only seen in the usual clinical imaging Chapter Introduction timeframe of about 10 minutes after injection in lesions with a combination of high blood flow, high microvascular density and high...
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Magnetic resonance spectroscopy correlation with histological analysis in gliomas and structure determination of a hypothetical protein
... reaction kinetics and intra-molecular dynamics of macromolecules Additionally, NMR is efficient in determining ligand binding and mapping interaction surfaces of protein/ligand complexes Since first ... clinical investigators in understanding the role of metabolites in normal and pathological conditions In recent years the biomedical and in vivo applications of 1H spectroscopy have increased, in part ... contains tyrosine while NNI2 does not Tyrosine is an essential neutral amino acid and a precursor of the neurotransmitters epinephrine, nor-epinephrine and dopamine The presence of tyrosine in...
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Tài liệu A REVIEW OF INDOOR AIR POLLUTION AND HEALTH PROBLEMS FROM THE VIEWPOINT OF ENVIRONMENTAL HYGIENE: FOCUSING ON THE STUDIES OF INDOOR AIR ENVIRONMENT IN JAPAN COMPARED TO THOSE OF FOREIGN COUNTRIES pptx
... since 1970 by the “Act for Maintenance of Sanitation in Buildings”; however, small buildings and individual residences are not included, and the substances in indoor air and their concentrations ... MATERIALS In 2003, the Ministry of Land, Infrastructure and Transport of Japan amended the Building Standard Law to control indoor chemical concentrations This regulation restricts the use of formaldehydeemitting ... can meet local needs in dealing with SHS.152) CONCLUSION Healthy indoor air is a fundamental right for people studying in schools, working in of ces and living in residences Indoor air quality...
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Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt
... the N-terminus could increase the binding and affinity for I-Au because of occupation of the P1 pocket Recent thermodynamic and kinetic studies of the binding of TCRs to peptide–MHC ligands suggested ... as in the case of aqueous solution, because of the absence of interactions with the side chains of Asp81 (in the agonist analogue) and Glu82 MD simulations of MBP(74–85), and Ala81MBP(74–85) in ... mode of binding of the MBP(74–85) peptide to I-Au is determined by the occupied MHC anchor positions at P4, P6, and P9 In HADDOCK, electrostatics is used during the docking and in the scoring...
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zen ritual studies of zen buddhist theory in practice nov 2007
... on the institutional and intellectual history of Chan/Zen Buddhism STEVEN HEINE is professor of religious studies and history and director of the Institute for Asian Studies at Florida International ... the repeated action of ritual upon their body and mind Ritual establishes a context of experience in which certain moods dominate and desires, emotions, states of mind, and actions come to the fore ... everything that is going on in the world of multiplicities Even all the polytheistic gods including denizens of the air, of the earth, and of the heavens, and any other beings, who are living only in...
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Báo cáo y học: " “pp65 antigenemia and real time polymerase chain reaction (PCR) based-study to determine the prevalence of human cytomegalovirus (HCMV) in kidney donors and recipients with follow-up studies.”" pptx
... and thermal profile described earlier [17] The intra-assay and inter-assay reproducibility were evaluated using triplicates of plasmid dilutions (101, 103 and 105) corresponding to an input of ... containing × 10 leucocytes prepared from ml of EDTA anticoagulated blood within six hours of receipt of the specimen Smears were fixed in methanol for 10 minutes Immunofluorescence staining was ... (64%) of the recipients were not As a result of the increased use of Gancyclovir prophylaxis, the incidence and severity of CMV disease is significantly reduced However, there is an increasing incidence...
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Báo cáo y học: "Influence of enrollment sequence effect on observed outcomes in the ADDRESS and PROWESS studies of drotrecogin alfa (activated) in patients with severe sepsis" pptx
... sepsis population The use of severity scoring systems in clinical trials may require training and validation of the training to ensure proper collection of severity of illness information Helps to ... purposes) Learning curves have been described in other clinical trials and in clinical practice Halm and colleagues [9] performed a literature review of studies examining the independent relationship ... participated in the conception and design of the study, in the development and conduct of analyses, and in the clinical trials and data collection WLM, JJ, and DRN participated in the conception and design...
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A simplified method for conducting ecological studies of land snail communities in urban landscapes
... Structure and conservation of Sri Lankan land-snail assemblages in fragmented lowland rainforest and village home gardens J Appl Ecol 45:1019–1028 Suominen O (1999) Impact of cervid browsing and grazing ... Land mollusc monitoring scheme A handbook for field and laboratory methods Finnish Environmental Institute Nordic Council of Ministers, Helsinki ´ Walden HW (1981) Communities and diversity of ... complexity of the fauna and the feasibility of studies in this context On the basis of our results, the wooden board method (with a high degree of variability and capturing only a few species) and the...
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