role of reversal of tumor cell resistance to chemotherapeutic drugs and immunotherapy
Reactive oxygen species mediated regulation of the na+ h+ exchanger, NHE 1 gene expression a new mechanism for tumor cells resistance to apoptotic cell death
... One of the hallmarks of tumor development and maintenance is defiance of tumor cells to execute death signals (Thompson CB, 1995) Thus, a combination of increased proliferation and lack of cell ... differences between Apoptotic and Necrotic types of Cell Death Fig B Death-Receptor mediated Apoptosis Fig C Mitochondial pathway of Apoptosis Fig D Wide array of functions attributed to Reactive Oxygen ... with cells’ resistance to apoptotic cell death As described in the previous section, O2.- can block the Fas-induced cell death in tumor cells The regulation of tumor cells’ sensitivity to death...
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Tumor cell response to drug induced apoptosis is a function of intra cellular redox status 3
... induction of mitochondrial and death receptor induced apoptosis, anti-inflammatory effects involving cytokines, inhibition of androgenic and estrogen receptor activity and in context of this thesis ... sensitivity of cells to apoptotic triggers can depend on the balance of pro- and anti-apoptotic Bcl-2 family of proteins The battle for survival or death hangs in balance to the effect of these death and ... mechanism of H2O2 as follows: In the generation of photo-oxidized novel molecules and to study the effect of of vitamin C in this process Investigate the role of H2O2 and drug induced production of...
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Tumor cell response to drug induced apoptosis is a function of intra cellular redox status 2
... apoptosis of tumor cells Recruitment of Bax to the mitochondria during apoptotic signaling has been linked to the activation of upstream caspase and caspase 8-mediated cleavage of the proapoptotic ... permeability and leakage of pro-apoptotic proteins to the cytosol However, most of these studies seem to imply that the mitochondrial burst of H2O2 is likely to be a downstream effector mechanism ... acts upstream of the mitochondria to signal mitochondrial localization of Bax? To address this, we asked whether mitochondrial translocation of Bax resulted in a second wave of intracellular H2O2...
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Tumor cell response to drug induced apoptosis is a function of intra cellular redox status 1
... ability of DPI or transient transfection with RacN17 to revert the sensitivity of leukemia cells in the presence of RSV to vincristine-induced apoptosis (Fig 6, C and D) The inhibitory effect of low ... intracellular O2Ϫ on exposure of leukemia cells to RSV was mediated through the activity of NADPH oxidase complex and linked directly or indirectly to the apoptosis-inhibitory activity of RSV ... Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondria Cell Death Differ., 10: 1273–1285, 2003 36 Kim, H J., Chang, E J., Cho, S H., Chung, S K., Park, H D., and...
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Báo cáo hóa học: " The role of single N-glycans in proteolytic processing and cell surface transport of the Lassa virus glycoprotein GP-C" ppt
... transported to the cell surface and remain mannose-rich Materials and methods N-glycans play not only an important role in folding and intracellular transport of viral glycoproteins but also are known to ... of GP-2, only GP-C of the mutants S392A and S397A are further cleaved into GP-1 and GP-2 similar to fully glycosylated wild-type GP-C (Fig 2B, lanes and 5, lower panel), whereas no cleavage of ... Figure Cell surface transport of GP-C N-glycosylation mutants Cell surface transport of GP-C N-glycosylation mutants Vero cells were transfected with GP-1 (A) and GP-2 (B) N-glycosylation mutants of...
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báo cáo hóa học:"The role of disclosure in relation to assent to participate in HIV-related research among HIV-infected youth: a formative study" docx
... serve to prepare her to come to know her state They don't have to be told You have to let them grow up to a certain age They will have to be told when they have a sense of understanding and wisdom ... parents and caregivers on the timing of disclosure of the youth's HIV-positive status to the youth in non-research contexts, factors influencing this decision, and anticipated and actual positive and ... informed of their HIV status; and health professionals who provide care and social support to minors with HIV and their families The age eligibility criterion for minors was from eight to 17 years of...
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Báo cáo y học: "The role of T cell interleukin-17 in conducting destructive arthritis: lessons from animal models" pps
... interrelationship of IL-17 with receptor activator of NF-κB ligand (RANKL), IL-1, tumor necrosis factor (TNF) and the modulatory role of IL-4 and osteoprotegerin (OPG) is presented OC, osteoclast positive and ... overview of interleukin-17 (IL-17) in relation to other key cytokines in the pathogenesis of arthritis RANKL, receptor activator of NF-κB ligand; TNF, tumor necrosis factor inactivation of IL-17 ... pathogenesis of RA (Fig 1) Role of IL-17 in T cell immunity and/ or propagation of joint inflammation In arthritis, IL-17 is a pro-inflammatory cytokine thought to contribute to the joint inflammatory...
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Báo cáo y học: "The role of tumor necrosis factor-alpha in systemic lupus erythematosus" pdf
... IL-6 for B cells (B) and IL-18 for cytotoxic T cells (Tc) On the other hand, chronic TNF exposure leads to the disassembly of T -cell receptors (TCR), thus inhibiting T -cell responses, and induces ... a wide variety of immunoregulatory (left) and pro-inflammatory actions: TNF is involved in the maturation of dendritic cells (DC) and activates endothelial cells (EC) and immune cells (black lines) ... exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis...
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báo cáo khoa học: " Mapping of A1 conferring resistance to the aphid Amphorophora idaei and dw (dwarfing habit) in red raspberry (Rubus idaeus L.) using AFLP and microsatellite markers" ppt
... reported sources of resistance, we will need appropriate markers in order to establish the genetic composition (number of resistance genes and level of homozygosity) of parental lines and resistant ... has been used to map the major gene H which determines cane pubescence to linkage group of the Rubus genome and also to confirm the close association of that gene with resistance to cane botrytis ... 120 of the marker loci were mapped and significant deviation from the expected 1:1 and 3:1 ratios was detected at 25 of these A total of 118 of the 136 molecular marker loci that segregated and...
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Báo cáo y học: " In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy" docx
... similar to in vitro and in vivo studies that aim to mimic a mixed population of Tx and UNTx cells to the development of HIV resistance [31,32] and is in contrast to others which pre-select cells to ... sites, and was pre-run for 100 days to mimic the natural course of infection prior to gene therapy This enabled HIV to accumulate random mutations and develop into a pool of variant strains to simulate ... CD4+ T cells (referred to as Tx in the model) This model generated a longitudinal description of the expansion of both Tx cells, and infected cells, while monitoring the development of resistance...
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Báo cáo y học: "HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat" pps
... the selection of maturation inhibitor resistance [20] To better understand the effect of PI therapy on viral susceptibility to maturation inhibitors, we set up a maturation inhibitor model system ... the viruses in SupT1 cells in absence of inhibitor and monitoring p24 production[28] Error bars indicate the standard deviation Replication of NL4-3 is comparable to that of HXB2 (not shown) Fun ... use of maturation inhibitors We used bevirimat in a model system to study the impact of PI therapy on the development of resistance against maturation inhibitors To date, no direct cross-resistance...
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the role of fgfr3 mutation in tumour initiation, progression and invasion of urothelial cell carcinoma in mice
... Cytokeratin-18 (CK18), Cytokeratin-20 (CK20) and Uroplakins Intermediate cells are oriented perpendicular to umbrella and basal cells and can stretch into 1-4 layers They express p63, Shh, and occasionally ... 2011), suggesting the presence of urothelial stem cells Stem cells are unspecialised cells that have the ability to self-renew and to differentiate into several cell types (Weiner, 2008) In other ... E11 and E13 and are marked by the expression of Foxa2, p63, Shh and Uroplakin Fate-mapping suggested that P-cells are the progenitors of intermediate cells, which are present in the embryonic and...
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Role of stathmin 1 in colorectal cancer metastasis and chemo resistance
... stably-transfected cell 28 Figure 3-2: Morphology of STMN1 KD and SC cells 29 Figure 3-3: Morphology of STMN1 OE and vector control cells 30 Figure 3-4: Panel of stable STMN1 KD and OE cell lines ... Morphology of STMN1 OE and vector control cells Representative images OE and respective vector control cells were seeded at equal cell density with 400 µg/ml G418 selection and allowed days to reach ... vector and empty vector control as described in Sections 6.1.3 and 6.1.5 Uptake and transient expression of STMN1 were monitored days post transfection, while cells with stable integration of...
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Characterization the role of kinectin in assembly of translation elongation complex to endoplasmic reticulum and its involvement in organelle motility
... the life of the cell to support cellular functions such as modulation of cell shape, cell motility and cell division (Cole and Lippincott-Schartz, 1995; Garrett and Kapoor, 2003; Sato and Toda, ... is a 13-protofilaments tube, each protofilament composed of alternating α-tubulin and β-tubulin molecules (Gelfand and Bershadsky, 1991; Mandelkow and Mandelkow, 1995) The alignment of tubulin ... relevance of kinectin in cells 4.1 To establish kinectin knockdown cells using DNA enzyme and small interference RNA approaches 4.2 To investigate the role of kinectin in intracellular dynamic of mitochondria...
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Exploration of the functional significance of mig 2 in human cancer cell susceptibility to cytotoxic agents and cell growth control a pilot study
... state of insensitivity or decreased sensitivity of a population of cancer cells to drugs that ordinarily cause cell death Two types of resistance have been defined on the basis of the ability of tumor ... Re-expression of mig-2 in mig-2-null cell line HT29 to determine its capability of conferring cell sensitivity to anticancer drugs and to observe the effect of mig-2 on cell behavior Both transient and ... lymphoma cell line EL4 The gene was found to be capable of reversing the acquired drug resistance of the cells against a series of anticancer drugs including etoposide, vincristine, cisplatin, and...
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The role of host cell ether lipids in influenza virus infection
... made to reconstruct the 1918 influenza virus using reverse genetics, to better understand the virulence and lethality of this strain of virus, and ideally to provide insights into the ability to ... applied To cells that were scraped with 500µl chilled methanol, 250µl of chilled chloroform was added to obtain a final ratio of chloroform to methanol 1:2 (volume to volume (v/v)) The cells were ... collected to determine the titer of virus released by plaque assay 27 Materials & Methods 2.3 Lipid Profiling of influenza virus-infected cells 2.3.1 Collection of cells CHO-K1 and NRel-4 cells were...
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Báo cáo y học: "Incidence of Ocular Zoonoses referred to the Inflammatory and Autoimmune Ocular Diseases Service of the University of Parma - Italy"
... 1: Geographical location of the province of Parma (Italy) References Mora P, Vecchi M, Barbera L, Toscani M, Orsoni JG Use of systemic cyclosporin A in a case of severe Toxocara uveitis J Infect ... after a combination of medical treatment and surgery, with a final visual acuity of 40% in the affected eye [1] The only case of Lyme disease affected a 31 year-old farmer and his ocular manifestations...
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THE SIX DISCIPLINES OF BREAKTHROUGH LEARNING: How to Turn Training and Development Into Business Results
... and HR management, and we offer effective and customizable tools to improve workplace performance From novice to seasoned professional, Pfeiffer is the source you can trust to make yourself and ... and other means of making the content easier to read, understand, and use Essential Tools Pfeiffer’s Essential Tools resources save time and expense by offering proven, ready -to- use materials—including ... analysis of the work and workplace to identify the cause of factors that limit performance “The HPT process begins with a comparison of the present and the desired levels of individual and organizational...
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Tài liệu The Art of Creative Thinking: How to Be Innovative and Develop Great Ideas (John Adair Leadership Library) ppt
... degrees of Master of Letters from Oxford University and Doctor of Philosophy from King’s College London, and he is also a Fellow of the Royal Historical Society Recently the People’s Republic of China ... distinguished visitor to Henry Ford’s auto plants met him after an exhaustive tour of the factory The visitor was lost in wonder and admiration ‘It seems almost impossible, Mr Ford,’ he told the industrialist, ... virtually in command of the garrison of Jerusalem and was in the front line for six weeks After national service he qualified as a deckhand and sailed an Arctic trawler to Iceland He then worked...
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Tài liệu Báo cáo khoa học: Role of receptor-mediated endocytosis, endosomal acidification and cathepsin D in cholera toxin cytotoxicity pdf
... endosomes isolated after injection of native CT, and then examined for their ability to bind Cytotoxic action of cholera toxin and cathepsin D antibodies to CT-A and to stimulate exogenous plasma ... where acidotropic drugs and V-ATPase inhibitors had little to no effect on the cytotoxic action of CT [42,43] This may be a reflection of the differences between hepatocytes and other cell types Previous ... at the locus of the lysosomal apparatus Weak bases and proton ionophores have been used in vivo and in vitro to study the role of organelle acidification in the cytotoxic action of CT [5,6] Using...
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