risk assessment and addressing uncertainty in pharmaceutical new drug discovery and development
Practical industrial safety, risk assessment and shutdown systems, elsevier (2003)
... Hazards and risk reduction 2.1 Introduction In this chapter we are going to build up an understanding of hazards and risk and look at some methods available for identifying and quantifying them in ... system and human factors Information acquired in step Description of and information relating to the hazard and risk analysis Description of, and information relating to, the hazard and risk analysis ... engineering disciplines, e.g process engineer, instrument engineer, software engineer, maintenance manager and Introduction 21 maintenance technician are all required to work to the same standard...
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Communicable disease risk assessment and interventions ppt
... tissues or urine of infected animals and occasionally through ingesting food contaminated with urine of infected animals and droplet aerosol inhalation of contaminated fluids Increased risk is associated ... communication links and other essential service infrastructure, especially water and power supplies Such damage will hinder and complicate assessment and response efforts and increase the risk of infectious ... food in a more sustainable way (e.g seed distribution, land/crop management, income generation activities) and to institute appropriate child feeding and caring practices, including diversifying...
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Financing Pulp Mills An Appraisal of Risk Assessment and Safeguard Procedures potx
... focusing on ensuring minimum standards are effectively upheld in new projects, and another focusing on raising standards in existing projects To better understand to how pulp projects obtain funding, ... a need for training and technology upgrades in Colombia, upgrading and modernization in Mexico, Chile and Argentina (mainly for paper grades), and industrial forest development in Mexico to replace ... the WB maintained some in uence in the field by giving GEF grants The GEF was a major instrument in maintaining World Bank involvement in forestry after it adopted its 1991 Forest Strategy In the...
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EVENT SAFETY RISK ASSESSMENT AND EVENT MANAGEMENT PLAN pot
... financial loss EVENT SAFETY RISK ASSESSMENT - (SMALL TO MEDIUM SIZED COMMUNITY EVENTS) RISK ASSESSMENT MATRIX RISK RATING The risk matrix determines a risk rating’, based on the likelihood and ... COMMUNITY EVENTS) RISK ASSESSMENT Risk assessment is the process of estimating the potential effects or harm of a hazard to determine its risk rating By determining the level of risk, event organisers ... design improvements • Administrative – by ensuring safe operating procedures are in place, and that effective training, induction and monitoring is available to all in the workplace • Personal...
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Risk Assessment and Risk Management, II doc
... reality, are inherently uncertain • Deterministic modeling is relatively simple and is less demanding of time and resources • Stochastic modeling is more realistic and quantifies uncertainty • Monte ... by deterministic modeling – Most concerns about stochastic modeling apply equally or more so to deterministic modeling • Stochastic vs deterministic risk modeling – Stochastic risk modeling is ... 2x10-6 (2 in one million) 5x10-7 (5 in ten million) 8x10-6 (8 in one million) 1.0x10-3 (1 in one thousand) >> 99.9th%ile (bounding est.) 120x Principles of Environmental Toxicology 14 Principles...
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Risk Assessment and Risk Management, I pps
... • Exposure and toxicity assessment integration • Uncertainty analysis – Risk summary – Risk interpretation Risk Description • Risk summary • Interpretation of significance 39 40 Principles of ... Toxicology Risk Characterization Risk Characterization • Risk estimation Analysis – Exposure and toxicity assessment integration – Uncertainty analysis EPA Risk Characterization • Risk description Risk ... Principles of Environmental Toxicology Risk Triad Principles of Environmental Toxicology Risk Assessment • Ecological Risk Assessment (ERA) • Human Health Risk Assessment Principles of...
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Risk Assessment and Indoor Air Quality - Chapter 1 docx
... Overview What Is Risk Assessment? Indoor Air Risk Assessments Important Indoor Air and Risk Assessment Definitions The Origins of Environmental Risk Assessment A Environmental Risk Assessment Prior ... was significant uncertainty at that time both in assessing risks and in understanding the meaning of risk assessments Notwithstanding, because of the closed environment nature of indoor air exposures, ... specific actions in preventing or controlling exposure, using control measures, monitoring exposures, conducting health surveillance, and providing information, instruction, and training In addition,...
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Risk Assessment and Indoor Air Quality - Chapter 2 ppt
... decision making As discussed in Chapter 1, useful insights into the rational use of risk assessment and risk management were added recently (NRC 1994; Commission on Risk Assessment and Risk Management ... 1997 Risk Assessment and Risk Management in Regulatory Decision Making Environmental Protection Agency (EPA) 1976 Interim procedures and guidelines for health risks and economic impact assessments ... all risk assessment questions There are and almost always will be substantial scientific uncertainties in environmental risk assessment In addition, making policy and public health decisions using...
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Risk Assessment and Indoor Air Quality - Chapter 3 ppt
... allergic disease in children, Clinical and Experimental Allergy 25(3):52–55 Chapman, M.D et al 1995 Immunochemical and molecular methods for defining and measuring indoor allergens: In dust and air, ... neurotoxin “involves examining all available experimental animal and human data and the associated doses, routes, timing, and durations of exposure to determine if an agent causes neurotoxicity in ... heptachlor, aldrin, chlordane, and dieldrin, may result in headaches, dizziness, muscle twitching, weakness, tingling sensations, and nausea (EPA 1995b) Long-term exposure may cause liver and central...
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Risk Assessment and Indoor Air Quality - Chapter 4 potx
... are important in the carcinogenic process (Cohen and Ellwein 1990) Increases in cell division rates may lead to increases in the rates of critical mutational events, and an increase in cell division ... populations and on different subgroups within the same population, and that genetic, environmental, and life-style factors are all important in determining risk A central challenge in epidemiology and risk ... discussion, the reader is directed to Greenland and Robins (1986) and Rothman and Greenland (1998) Confounding in epidemiologic studies can be addressed in one of two ways—it can be prevented by...
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Risk Assessment and Indoor Air Quality - Chapter 5 ppt
... VOCs can arise in the indoors (e.g., from painting and cleaning), and be brought into the indoors (e.g., with drinking water and dry cleaning), and VOCs in outdoor air can infiltrate indoors VOCs ... exposure include: urine cotinine resulting from inhalation of tobacco smoke; carboxyhemoglobin resulting from inhalation of carbon monoxide; and lead in blood, teeth, and hair resulting from inhalation ... important indoor exposure sources of benzene include smoking, gasoline fumes from pumping gasoline and from attached garages, products in the home, and painting Clearly, better monitoring and modeling...
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Risk Assessment and Indoor Air Quality - Chapter 6 doc
... has its analogy in carcinogen risk assessment, in terms of qualitative and quantitative assessment, as indicated above A risk assessment that does not include both aspects is incomplete The idea ... would be no tumorigenic effect In formulating its risk assessment guidelines, the EPA was aware of the uncertainty associated with low-level linear risk assessments and took the position that these ... policy (e.g., should benign tumors be included with cancers in estimating the risk? ) The demands for documentation of uncertainty in risk assessments have increased markedly over the last decade...
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Risk Assessment and Indoor Air Quality - Chapter 7 potx
... III DEFINING UNCERTAINTY Uncertainty is a general term indicating the lack of precision in an estimated quantity (i.e., cancer risk for an exposed population) To address uncertainty in risk assessment ... approximate joint uncertainty and variability, Risk Analysis 15(3):411–419 Bogen, K.T., Spear, R.C 1987 Integrated uncertainty and interindividual variability in environmental risk assessment, Risk Analysis ... described uncertainty in risk assessment as a problem that is large, complex, and nearly intractable (NRC 1994) Uncertainty in risk assessment is too pervasive to describe every instance in which...
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Risk Assessment and Indoor Air Quality - Chapter 9 potx
... resulting from low-level exposures occurring indoors and outdoors As such, the reader can readily see how uncertainties in risk assessments arise and are treated PM is a broad class of chemically and ... Significant indoor sources of PM include fuel combustion (e.g., heating and cooking), tobacco smoke, cleaning practices, and infiltration of outdoor air Outdoor PM is regulated by the EPA and state and ... standard Following receipt and review of public comment, including a public hearing if requested, the OSHA promulgates a final standard While the OSHA safety standards require a cost balancing...
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Risk Assessment and Indoor Air Quality - Chapter 10 (end) ppsx
... was development of information to be used in preparing guidance about reducing the health risks of indoor contaminants, including radon, second-hand tobacco smoke, and emissions from building and ... factors influencing, the perception of indoor air quality Sources needing CIAR research include cooking, consumer products including pesticides, heating and cooling systems, building materials, and ... research However, risk assessment guideline documents, in a sense, describe risk characterization as part of the risk assessment process, and risk assessment guidelines continue to undergo development, ...
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Báo cáo y học: " Cost effectiveness of antimicrobial catheters in the intensive care unit: addressing uncertainty in the decision" doc
... related bloodstream infection; ICU, intensive care unit; int/ext, internally and externally coated; MR, minocycline and rifampicin; RR, relative risk; SPC, silver, platinum and carbon Page of ... Australia and New Zealand Intensive Care Society [18] Baseline risk of ICU mortality was 9.8% and 16.1% by hospital discharge Probability of CR-BSI was modeled as increasing in stepwise increments ... life year; MR, minocycline and rifampicin; SPC, silver, platinum and carbon Interpreting the results of cost effectiveness analyses under uncertainty requires decision makers to think beyond conventional...
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Human health and ecological risk assessment and risk management
... concepts in the evaluation of risks Format: Lectures including case studies, and risk assessment exercise, special feature Presentation of IPCS/WHO Risk Assessment Toolkit Teaching material: Hand-outs ... Course Coordinator: Khunying Mathuros Ruchirawat Objectives: Give an introduction to the assessment of risk of chemicals to human health and well-being and the environment, and present the newest ... Agonist - binding to receptor Antagonist - binding of normale ligand blocked Receptors - Ah-receptor Dioxin, PCB estrogen receptor; androgen receptor; thyroid receptor Endocrine disrupting chemicals...
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Bebop assessment and development l1
... ASSESSMENT AND DEVELOPMENT Assessment and Development • • • • • • • Point to and name the family members and the rooms in a house Take a blue crayon and circle the daddy Take a yellow crayon and circle ... eat, mix, and slice Assessment and Development • • • • • Point to and name the community helpers and the places in town Connect the pictures using different colors Find the squares and circle ... correct number Clap hands and stomp feet Assessment and Development • • • • • • • Point to and name the items of clothing Take a yellow crayon and color the T-shirt Take a red crayon and color the sweater...
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Bebop assessment and development l2
... Take a crayon and put it in a pencil case Assessment and Development • • • • • Point to and name the party items and toys Take a green crayon and circle the candles Take a pink crayon and circle ... NOTES ASSESSMENT AND DEVELOPMENT • Find and circle the number 14 • Smile and walk Assessment and Development • • • • • • • Point to and name the objects from around the home Take a black crayon and ... orange crayon and circle the cow Find and circle numbers 17 and 18 Pretend to gallop and swim Assessment and Development • • • • • • Point to and name the food Take an orange crayon and circle the...
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