quantitative retains information on pi and mr and subsequently gives direct information on ptm because each resolved spot is in principle one protein the information generated from this pool of peptides is often more reliable
Expression dynamics of the hepatic mitochondrial proteome of the sod2+ mouse in response to troglitazone administration
... precipitating the toxic effects of troglitazone under compromised mitochondrial ROS defence This further confirms the contribution of glutathione and inheritable mitochondrial dysfunction in idiosyncratic ... 1998) The inactivation of SOD2 would lead to an increase in O2•- and hence favour the formation of more ONOO- Excessive ONOO- can then inhibit numerous mitochondrial proteins, including SOD2 This ... (Corral-Debrinski et al., 1992a) The accumulation of these deletions and point mutations with aging results in the decline in ETC activity and ATP production In addition to being primary targets of elevated...
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phrasal verbs followed by the -ing form
... left, the other to the right go on go on & goes on going on went on gone on go on p.v When an electrical device or system goes on, it begins to operate A thermostat makes the air conditioner go on ... to look the car over before he buys it Here's the first chapter of my new book; look it over and tell me what you think pick on pick on & picks on picking on picked on picked on pick on p.v When ... project because you have this information The detective said he needs more to go on and asked the public for information The auto company won't recall 75,000 cars because of one accident That's just...
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Báo cáo y học: " Enteritis caused by Campylobacter jejuni followed by acute motor axonal neuropathy: a case report" pptx
... resulted in difficulty in lifting them above his shoulders, and in his legs in difficulty climbing stairs and rising from a low chair During the following days weakness also appeared in his distal ... muscles of his arms Three weeks later he had no muscle weakness and his tendon reflexes were brisk Because of the clinical signs and the history of a preceding gastrointestinal infection, a stool ... prevalence of C jejuni in many geographical areas including Serbia as a triggering organism in the etiology of GBS and other post-infectious sequelae In addition, there is a lack of evidence on serotype...
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40185 prepositional verbs followed by the gerund
... their (share) _ a common context to interpret the other's casual, compact or cryptic speech If you usually keep your windows/doors open, then count (change) the air filter every month ... open, then count (change) the air filter every month We all agree _ your (open) _ the discussion ...
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Tài liệu Báo cáo khoa học: Perturbation of membranes by the amyloid b-peptide – a molecular dynamics study pptx
... around the peptide and tilt their acyl chains, as the protein itself tilts Another contribution to the disordering effect is the restriction of motion along the acyl chains once the lipids have ... around the protein Because this behavior arises as a result of the tilt of the peptide and interactions between the embedded region of the peptide and the acyl chains, it presents an interesting insight ... degree of chain elongation and lipid packing Bachar and Becker [18] divided the lipids in their bilayer into ‘tiers’ based on the distance between the protein and lipid molecule center of mass The...
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Tài liệu Báo cáo Y học: Thermostability of manganese- and iron-superoxide dismutases from Escherichia coli is determined by the characteristic position of a glutamine residue pdf
... Comparison of E coli mononuclear superoxide dismutase molecular features (Top) Stereo view of the superposition of the backbone peptide chain of one subunit of FeSOD (black) and MnSOD (grey) of ... [7] The position of the glutamine residue, which is structurally equivalent in the enzymes, is contributed by the N domain of FeSODs (Q69) and the C domain of MnSODs (Q146) Exceptions to this ... Expression of GST-SOD proteins was high, corresponding to approximately 40% of the total cell protein (results not shown) Single column purification on glutathionesepharose yielded proteins of the...
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Báo cáo khoa học: Glutamic acid residues in the C-terminal extension of small heat shock protein 25 are critical for structural and functional integrity pptx
... strongly on the local environment of the amino acid and is a sensitive probe of conformation in the vicinity of tryptophan residues 5888 The binding of ANS and other hydrophobic probes to a protein ... interaction between the extension and hydrophobic chaperone binding sites, resulting in the binding sites being less accessible to the target protein, leading to a decrease in target protein binding ... exposure in the mutants compared with the wild-type protein indicates that the structure of the N-terminal domain is maintained, at least in the vicinity of the tryptophan residues The increase in...
- 14
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Báo cáo khoa học: Phosphorylation of the Saccharomyces cerevisiae Grx4p glutaredoxin by the Bud32p kinase unveils a novel signaling pathway involving Sch9p, a yeast member of the Akt / PKB subfamily pot
... highlight for the first time Bud32p as a substrate of Sch9p and probably one of the effectors of this crucial protein kinase Interestingly, this pathway is unrelated to the known functions of the Bud32p-associated ... amplification product was cloned in the pYeDP-1 ⁄ 8.2 vector at the BamHI ⁄ KpnI sites [31] In this construct, the expression of the cloned gene is under the control of the CYC1–GAL1-10 promoter, allowing ... embedded in a highly acidic stretch of the protein [4] This sequence is situated in the linker region between the thioredoxin-like and the glutaredoxin domains of Grx4p [10], and its modification would...
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Báo cáo khoa học: The use of recombinant protein and RNA interference approaches to study the reproductive functions of a gonad-stimulating hormone from the shrimp Metapenaeus ensis ppt
... provide information on the initial mechanism of hormone action In other words, the in vitro results indicate that MeMIH-B may act directly on the hepatopancreas and ovary to increase the rate of vitellogenin ... assay for molt inhibition [4] Except for the role of CHH in the increase of glycemia, the use of recombinant protein to study molt-inhibiting function and gonad maturation remains a challenge ... been reported, and the inhibitory function on molting has been demonstrated convincingly Most biological assays of the gonad inhibition of this neuropeptide rely on its ability to inhibit ovary...
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Báo cáo khoa học: Variants of b2-microglobulin cleaved at lysine-58 retain the main conformational features of the native protein but are more conformationally heterogeneous and unstable at physiological temperature potx
... exists in the conformational equilibrium of the cleaved b2m variants This conformer is a monomeric intermediate (I2) occurring on the b2m-refolding pathway These findings are consistent with the existence, ... molecule is involved in dialysis-related amyloidosis (DRA) [1,2] This condition, somehow induced by long-standing dialysis or renal insufficiency, is characterized by fibrillation and precipitation of ... fact, distinct differences in the conformation of the variants are confined to the cleavage site region (the D–E loop) with additional involvement of the adjacent residues of strands D and E and the...
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Báo cáo khoa học: The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p ppt
... polypeptide involved in the insertion of mitochondrially encoded proteins into the IMM, but it also mediates the assembly of nuclear-encoded proteins into this submitochondrial fraction [9] The import of ... degradation of Psd1p resulting in partial protection of its enzymatic activity Thus, specific components of the mitochondrial biosynthetic machinery indirectly affect phospholipid homeostasis in this ... were inspected Labeling of aminoglycerophospholipids in vivo Labeling of aminoglycerophospholipids in vivo was determined by following the incorporation of [3H]serine into PtdSer, PtdEtn and PtdCho...
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Báo cáo hóa học: "Synthesis of SnS nanocrystals by the solvothermal decomposition of a single source precursor" pdf
... dependent on the nature of the stabilizing agents used in addition to the thermal conditions of the preparation Isotropic and anisotropic growth of SnS NCs is achieved by use different capping molecules ... properties and functions Techniques for improving the monodispersity and refining the optical characteristics are the subject of ongoing investigations Acknowledgments This work was supported by the Vanderbilt ... dropping the solution of NCs onto a silicon substrate HRTEM analysis was done using a Philips CM20 TEM operating at 200 kV The samples for TEM investigation were prepared by dropping a solution of...
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Báo cáo hóa học: " Synthesis of SnS nanocrystals by the solvothermal decomposition of a single source precursor" ppt
... dependent on the nature of the stabilizing agents used in addition to the thermal conditions of the preparation Isotropic and anisotropic growth of SnS NCs is achieved by use different capping molecules ... properties and functions Techniques for improving the monodispersity and refining the optical characteristics are the subject of ongoing investigations Acknowledgments This work was supported by the Vanderbilt ... dropping the solution of NCs onto a silicon substrate HRTEM analysis was done using a Philips CM20 TEM operating at 200 kV The samples for TEM investigation were prepared by dropping a solution of...
- 5
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Báo cáo y học: "Diabetic ketoacidosis complicated by the use of ecstasy: a case report" ppsx
... abuse and often ignore warnings about the danger of using such drugs means there is an increased risk of death among this age group [10] This risk should, therefore, be addressed in all medical interviews ... adolescents Conclusion The use of ecstasy may trigger diabetic ketoacidosis in patients with a preexisting metabolic disorder This is demonstrated in the present case and other cases described in the ... the published literature The strenuous exertion often associated with the use of this drug may compound the problem Often patients not wish to discontinue ecstasy use, despite their being made...
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Báo cáo y học: "Diabetic ketoacidosis complicated by the use of ecstasy: a case report." docx
... abuse and often ignore warnings about the danger of using such drugs means there is an increased risk of death among this age group [10] This risk should, therefore, be addressed in all medical interviews ... adolescents Conclusion The use of ecstasy may trigger diabetic ketoacidosis in patients with a preexisting metabolic disorder This is demonstrated in the present case and other cases described in the ... the published literature The strenuous exertion often associated with the use of this drug may compound the problem Often patients not wish to discontinue ecstasy use, despite their being made...
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Báo cáo y học: "Inhibition of NFκB by the natural product Withaferin A in cellular models of Cystic Fibrosis inflammation" pps
... http://www.journal-inflammation.com/content/6/1/15 Figure inhibition by WFA Quantification of p65 translocation upon PAF stimulation and Quantification of p65 translocation upon PAF stimulation and inhibition ... following selection in Hygromycin-containing media and tested for NFκB-mediated induction of luciferase reporter activity using recombinant TNF-α and filtrates of a clinically isolated mucoid strain ... fluorescence in nuclei of KKLEB cells as demonstrated in the bottom row fashion by ~70% in the KKLEB cells Inflammation in CF is regulated largely by activation of NFκB and transcription of pro-inflammatory...
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A study on the structure of the speech “ I have a dream” by Martin Luther King A systemic functional grammar analysis
... That is the reason why I have developed a great attention to Functional Grammar (or FG for short) The further I am absorbed in this linguistic aspect, the stronger my notion of its applications in ... the study There are four main chapters in this minor thesis Chapter I: Introduction , gives an overview of the rationale, aims, scope, methodology and design of the study Chapter II: Theoretical ... language teaching and learning becomes Hence, I decided to conduct a study on the structure and meaning of the speech “I have a dream” by Martin Luther King - a systemic functional grammar analysis...
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Tài liệu Protein Data Bank Contents Guide: Atomic Coordinate Entry Format Description Version 3.20 Document Published by the wwPDB ppt
... replaced replaced replaced this this this this this this this this this one one one one one one one one one Details * It is PDB policy that only the principal investigator and/ or the primary author who ... This is not repeated on continued lines 24 - 27 IDCode modId ID code of this entry This is not repeated on continuation lines 32 Integer modType An integer identifying the type of modification ... types Each record type consists of one or more lines Each record type is further divided into fields Each record type is detailed in this document The description of each record type includes the...
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Tài liệu Báo cáo khoa học: Mitochondrial chaperone tumour necrosis factor receptor-associated protein 1 protects cardiomyocytes from hypoxic injury by regulating mitochondrial permeability transition pore opening docx
... apoptosis and maintaining mitochondrial homeostasis and function Silencing TRAP1 enhances cytochrome c release from the mitochondria and apoptosis induced by b-hydroxyisovalerylshikonin and VP16 ... up-regulation of TRAP1 expression suppressed arsenite-induced apoptosis in lung epithelium cells [13] Apoptogenic inducers, such as the protein- tyrosine kinase inhibitor b-hydroxyisovalerylshikonin or the ... is found in the N-terminus of the protein, is for mitochondria matrix An analysis of the cDNA sequences reveals that TRAP1 is identical to heart shock protein (HSP) 75, which is a member of the...
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Tài liệu Báo cáo khoa học: Regulators of G-protein signalling are modulated by bacterial lipopeptides and lipopolysaccharide pptx
... Stimulation of TLR leads to activation of a series of signalling proteins, and to the expression of pro- and in ammatory cytokines There is evidence that the heteromeric guanine nucleotidebinding ... activation of TLR by different ligands However, little is known about the involvement of RGS2 proteins in the context of in ammation Under all RGS proteins, RGS2 contains a unique function, because ... no in uence on RGS1 modulation after stimulation with LPS and FSL-1 Involvement of TRIF in the upregulation of RGS1 and RGS2 mRNA The findings obtained from activation of TLR3 by stimulation with...
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Tìm thêm: hệ việt nam nhật bản và sức hấp dẫn của tiếng nhật tại việt nam xác định các nguyên tắc biên soạn khảo sát các chuẩn giảng dạy tiếng nhật từ góc độ lí thuyết và thực tiễn khảo sát chương trình đào tạo của các đơn vị đào tạo tại nhật bản khảo sát chương trình đào tạo gắn với các giáo trình cụ thể xác định thời lượng học về mặt lí thuyết và thực tế điều tra đối với đối tượng giảng viên và đối tượng quản lí khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu xác định mức độ đáp ứng về văn hoá và chuyên môn trong ct phát huy những thành tựu công nghệ mới nhất được áp dụng vào công tác dạy và học ngoại ngữ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose