pyruvate carboxylase activity in the brain
Báo cáo khoa học: Catalytic mechanism of the primary human prostaglandin F2asynthase, aldo-keto reductase 1B1 – prostaglandin D2 synthase activity in the absence of NADP(H) pptx
... core in this family [3–6] To identify the catalytic residues involved in the PGDS and PGFS activity catalyzed by AKR1B1, we introduced site-directed mutagenesis into the tetrad, generating the ... was incubated with various concentrations of PGH2 in the presence of 0.5 mM NADPH for PGFS activity or in the absence of NADPH or NADP+ for PGDS activity For PGDS activity, the enzymes were incubated ... (PNBR) activity at pH 7.0 by the wild-type and mutants (D) Typical fluorescence quenching curves of wild-type AKR1B1 and its mutants The binding of NADP+ to these proteins was determined by measuring...
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Báo cáo khoa học: Protein engineering of pyruvate carboxylase Investigation on the function of acetyl-CoA and the quaternary structure doc
... between the active site of the BC domain and the biotin moiety of the BCCP domain Based on these arguments, it is tempting to propose the following hypothesis: in the absence of acetyl-CoA, the active ... presence of free D-biotin as intact PC, suggesting that its three-dimensional structure remains intact even in the absence of other domains The enzymic activity of PC-(BC) in the presence of various ... mutation of the second amino acid residue, arising from the introduction of an NcoI site in the start codon region, to glutamate from the original lysine, was conrmed Likewise, the amino acid sequence...
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Báo cáo khoa học: Identification of preferred substrate sequences for transglutaminase 1 – development of a novel peptide that can efficiently detect cross-linking enzyme activity in the skin pot
... of the reactivity of the K5 peptide with casein in the presence of TGases The time-dependent incorporation of biotinylated peptides (pepK5, pepK5QN and pepT26) into casein was examined in the ... 2, and 5) are expressed in keratinocytes [13–18], and are involved in cross-linking of the structural proteins to form the CE at distinct intracellular sites [8,18] In the current model of TGase ... pepK5QN was not incorporated into casein, also acting as glutamine-donor substrate, in the presence of either TGase or TGase This result indicates that the lysine residue in the sequence of K5...
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2009 Investment Company Fact Book 49th edition - A Review of Trends and Activity in the Investment Company Industry pptx
... toward institutional investors attracted $525 billion in new cash during 2008 Increased economic uncertainty during the year and ongoing turmoil in the money markets encouraged these investors to increase ... effect on funds invested in foreign stocks U.S stock and bond funds holding international assets decreased further from the strengthening of the U.S dollar and the resulting decrease in the dollar ... effects of the crisis in 2008 include the failures of Lehman Brothers Holdings Inc., Washington Mutual, Inc., and a range of other financial institutions; the government-orchestrated rescues of The Bear...
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Báo cáo khoa học: Protective effects of endomorphins, endogenous opioid peptides in the brain, on human low density lipoprotein oxidation pdf
... investigating the antioxidant activity of melatonin in lipid model systems [20] and also in LDL [21,22] In addition, it has been reported that the brain monoamines and their metabolites can inhibit ... the control the inhibition period the rate of the absorbance increase became faster, which is close to the original rate of propagation, demonstrating the exhaustion of the antioxidant The kinetic ... found in much higher amounts in the human brain [27] The two peptides differ in one amino acid: EM1 (Tyr-Pro-Trp-Phe-NH2) and EM2 (Tyr-Pro-Phe-PheNH2) The major effect of the endomorphins is their...
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2011 Investment Company Fact Book - A Review of Trends and Activity in the Investment Company Industry doc
... funds dominated fund investing following the passage of the Investment Company Act of 1940 But successive bear markets in stocks in the 1970s along with rising interest rates drew investors into ... on the structure of the mutual fund industry, industry trends, and the broader financial markets Collins, who joined ICI in 2000, is responsible for conducting and overseeing research on the ... stocks However, gains in U.S stock and bond funds that held international assets were moderated by the strengthening of the U.S dollar and the resulting decrease in the dollar value of their foreign...
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Báo cáo khoa học: An enzymatic mechanism for generating the precursor of endogenous 13-cis retinoic acid in the brain docx
... showed that the RPE65 mRNA was predominantly expressed in the eye and at lower levels in the brain By contrast, the 13cIMH mRNA was detected at high levels in the brain and at low levels in the eye ... RPE65 is predominantly expressed in the eye and, to a lesser extent, in the brain Detection of RPE65 in the brain was not unexpected because a phototransduction system exists in the brain of lower ... Calretinin immunoreactivity in the brain of the zebrafish, Danio rerio: distribution and comparison with some neuropeptides and neurotransmitter-synthesizing enzymes II Midbrain, hindbrain, and...
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Báo cáo khoa học: Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates potx
... present in brain, but not in PBL (Fig 3A, lanes and 3) To examine whether the CbD4 variants were expressed in different parts of the brain as well as in fetal brain, PCR was carried out using the ... together, these results suggest that CbD4 variants are not expressed in human PBL Next, we searched for these splice variants in the brain of other species Rhesus monkey brain and mouse brain ... gene The novel Cb variants were designated CbD4 They were identified in NT2-N cells, human and Rhesus monkey brain, but not in human PBL or mouse brain, suggesting that skipping of exon in the...
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Báo cáo khoa học: acids in the brain: D-serine in neurotransmission and neurodegeneration ppt
... almost completely in these regions [34,35] In contrast with d-serine, glycine immunoreactivity is higher in the caudal areas of the brain, where the density of NMDARs is lower [36] The inverse localizations ... in brain slices or in vivo are still lacking The levels of l-serine relative to serine racemase expression will also in uence the distribution of d-serine l-Serine can be synthesized from either ... immunohistochemistry in neurons of the nervous system (Fig 3), including the cerebral cortex [25,39], some nuclei of the hindbrain [38,39,66] and in ganglion cells of the retina [67] Fig D-Serine localizes...
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Báo cáo khoa học: D-Amino acids in the brain: the biochemistry of brain serine racemase potx
... Residues involved in the binding to the PLP moiety are shown in blue, whereas those involved in protein–protein interaction are shown in green The first four amino acids of the barley serine racemase ... PDZ domaincontaining protein was found to interact with serine racemase, also requiring the C-terminal binding motif [30] Protein interacting with C kinase (PICK1) contains one PDZ domain that ... other GRIP-interacting protein that also binds to PDZ6 might disrupt the serine racemase–GRIP interaction, hence diminishing the activity of the former In a similar yeast two-hybrid screen using...
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martin - the organisation of conceptual knowledge in the brain (psychology press, 2003)
... form 20 THE ORGANISATION OF CONCEPTUAL KNOWLEDGE IN THE BRAIN INTRODUCTION A central issue in the cognitive brain sciences is the organisation of conceptual knowledge in the human brain The neuropsychological ... primarily in the terms used by the authors themselves A major emphasis has been on whether the results support one or another theory of the organisation of conceptual knowledge in the brain In this ... KNOWLEDGE IN THE BRAIN ANALYSIS OF THE DATABASE The database for a critical review Beginning with the first informative study in the literature (Warrington & Shallice, 1984), we have evaluated all the...
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scientific american - 1995 11 - guardian cells in the brain
... a start, they focused on neurons whose cell bodies were located in the brain but whose axons terminated at muscles outside the brain They injected a toxin into a site near the ends of the axons ... recognized in the 1800s Initially, biologists mistakenly thought of the glia as a single unit that served only as the uninteresting putty between neurons in the brain and spinal cord But by the 1920s ... belching up gas now and thenor whether they result from the sound bouncing back and forth along the path between the source and the receiving instrument Schlindwein and her co-workers point out...
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báo cáo hóa học: " Tumor necrosis factor-mediated inhibition of interleukin-18 in the brain: a clinical and experimental study in head-injured patients and in a murine model of closed head injury." pot
... pro-inflammatory mediators, depending on the kinetic of their expression and posttraumatic regulation in the injured brain [3,12,13] However, the TNF-dependent regulation of IL18 in the injured brain ... alpha in brain injury Cytokine Growth Factor Rev 1999, 10:119-130 Lenzlinger PM, Morganti-Kossmann MC, Laurer HL, McIntosh TK: The duality of the inflammatory response to traumatic brain injury ... levels in brains of normal WT mice, compared to normal untreated mice, which were in a similar range as in the brain- injured groups (53.6 ± 9.6 ng/ml, Fig 1) These data imply that a minor penetrating...
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Báo cáo y học: "Markers of B-lymphocyte activation are elevated in patients with early rheumatoid arthritis and correlated with disease activity in the ESPOIR cohort" pdf
... on the early pathogenic role of B lymphocytes in RA and suggests that targeting these cells might be a useful therapeutic strategy in early RA Competing interests The authors declare that they ... observed in patients with UA, including BAFF levels that were higher than in healthy donors, elevated IgG in 55% of the patients, and elevated levels of immunoglobulin FLCs in 22% (compared with 0% in ... of IgM, as in our patients with early RA [8] Our second important finding was the absence of an association between the BAFF gene polymorphism and either RA or any of the baseline clinical, immunological,...
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Báo cáo y học: "Regional characterization of energy metabolism in the brain of normal and MPTP-intoxicated mice using new markers of glucose and phosphate transport" doc
... PiT1-binding immunoadhesin generated by fusing the aminoterminal residues of the GALV (SEATO strain) Env, comprising the signal peptide, the RBD and the proline-rich region, to the rFc tag, herein, ... abundance in the striatum, the thalamus and the brainstem [24] In mice, only blood vessels were found to be immunostained using an antibody raised against the C-terminal part of the protein [25,26] ... of the inorganic phosphate transporters in the brain In conclusion, our data suggest that these new metabolic markers can be used to improve our understanding of the metabolism in the brain, ...
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Báo cáo y học: "Enhanced glutamate, IP3 and cAMP activity in the cerebral cortex of Unilateral 6-hydroxydopamine induced Parkinson’s rats: Effect of 5-HT, GABA and bone marrow cell supplementation" ppsx
... of the Receptor-Binding Data Linear Regression Analysis for Scatchard Plots The data were analysed [25] The specific binding was determined by subtracting non-specific binding from the total The ... 367:95-122 Glowinski J, Iversen LL: Regional studies of catecholamines in the rat brain: The disposition of [3H] norepinephrine, [3H] dopamine and [3H] dopa in various regions of the brain J Neurochem ... was infused into the right Substantia nigra Pars compacta (SNpc) at a flow rate of 0.2 μl/min After stopping the infusion of the toxin, the probe was kept in the same position for a further for...
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Báo cáo y học: "Development of daily rhythmicity in heart rate and locomotor activity in the human fetus" ppt
... The electrographic findings of the intrauterine fetus were correlated with evaluations by Apgar scale as well as with the data regarding the course of postnatal period The time of the recordings ... Hoppenbrowers [14] directed their investigations mainly toward the study of fetal heart rate changes during the mother's sleep Our findings agree with Hellbrugge's [13] results indicating the occurrence of ... both the mother and the fetus It is possible to suggest that the process involved in the intrauterine development of the fetus requires the availability of a relatively persistent homeostasis; the...
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Báo cáo khoa học: "Localization of deformed wing virus (DWV) in the brains of the honeybee, Apis mellifera Linnaeus" potx
... concentrations in the optic and antennal neuropils in the bee brain and in mushroom bodies We can therefore conclude that the virus is present in the brain regions that process the bees' sensory ... that the virus is actively replicating in these areas of infected bee brains The lighter staining with the sense probe is expected since picorna-like viruses produce only 10% as much of the antigenomic ... hybridized to the sense probe (Figure 1C) The detection of the antigenome by the sense probe, while lighter staining, confirms replication of the virus in this region of the brain The viral genome...
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Báo cáo y học: "Effects of redox cycling compounds on DT diaphorase activity in the liver of rainbow trout (Oncorhynchus mykiss)" doc
... http://www.comparative-hepatology.com/content/4/1/4 doubled the DTD activity in rainbow trout liver cytosol, whereas no increase in DTD activity was observed in the other fish species receiving the same treatment, including the brown trout ... mechanism involving the AHR) and have electrophilic metabolites that induce DTD activity (via the ARE) [18] Therefore, the results obtained in this study imply that rainbow trout DTD activity can be induced ... mechanism involving the AHR, as in mammals It is not yet known whether the promoter region of the rainbow trout DTD gene contains functional XRE or ARE Thus, it is not clear whether the observed induction...
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Tìm thêm: xác định các mục tiêu của chương trình xác định các nguyên tắc biên soạn tiến hành xây dựng chương trình đào tạo dành cho đối tượng không chuyên ngữ tại việt nam điều tra với đối tượng sinh viên học tiếng nhật không chuyên ngữ1 khảo sát thực tế giảng dạy tiếng nhật không chuyên ngữ tại việt nam khảo sát các chương trình đào tạo theo những bộ giáo trình tiêu biểu nội dung cụ thể cho từng kĩ năng ở từng cấp độ mở máy động cơ lồng sóc các đặc tính của động cơ điện không đồng bộ đặc tuyến hiệu suất h fi p2 đặc tuyến mômen quay m fi p2 đặc tuyến tốc độ rôto n fi p2 đặc tuyến dòng điện stato i1 fi p2 động cơ điện không đồng bộ một pha sự cần thiết phải đầu tư xây dựng nhà máy thông tin liên lạc và các dịch vụ phần 3 giới thiệu nguyên liệu từ bảng 3 1 ta thấy ngoài hai thành phần chủ yếu và chiếm tỷ lệ cao nhất là tinh bột và cacbonhydrat trong hạt gạo tẻ còn chứa đường cellulose hemicellulose chỉ tiêu chất lượng theo chất lượng phẩm chất sản phẩm khô từ gạo của bộ y tế năm 2008 chỉ tiêu chất lượng 9 tr 25