... in series contributed to rening diagnostic prob-ability. It is important to point out that, to date, diagnosis of celiacdisease is still based on observation of histological abnormalities; ... Patients with positive anti-tTG serology were referred to the gastroen-terology clinic to continue investigation of celiac disease. Data were stored in Epi-Info version 6.0. Seropositivity was ... malnutrition and systemic diseases(2). Celiac disease is characterized by permanent gluten in-tolerance in people who are genetically susceptible. Gluten provokes an inammatory reaction that damages...
... Greco L. Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disor-ders in Celiac Disease. Gastroenterology 1999; ... 2001; 24: 27-32.8. Not T, Tommasini A, Tonini G, et al. Undiagnosed coeliac disease and risk of autoimmune disorders in subjects withType I diabetes mellitus. Diabetologia 2001; 44: 151-5.9. ... al. German Wor-king Group for Pediatric Diabetology. Anthropometry, me-tabolic control, and thyroid autoimmunity in type 1 diabe-tes with celiac disease: a multicenter survey. J Pediatr2004;...
... L. (1999) Duration ofexposure to gluten and risk for autoimmune disorders inpatients with celiac disease. SIGEP Study Group forAutoimmune Disorders in Celiac Disease. Gastroenterology 117,297–303.24. ... transglutaminase:apoptosis versus autoimmunity. Immunol. Today 20, 130–134.Ó FEBS 2002 Epitope mapping of anti-tTG Igs (Eur. J. Biochem. 269) 5181CD patients and shown to recognize two distinct epitopes,epitope ... This is identical to the region recognizedby anti-transglutaminase Igs found in the serum of celiac disease patients.Keywords: autoimmunity; celiac disease; transglutaminase;epitope mapping; phage...
... the toxic precursor [68].Evidence has been obtained in studies on Alzheimer’s disease that fibrils are not the most neurotoxic form of Ab[6]. The peptide also assembles into soluble proto-fibrils ... andsmaller oligomers. The proto-fibril of Ab was shown byAFM to be a slightly curved, of 4–11 nm diameter and< 200 nm long [56]. Isolated protofibrils were found to betoxic, causing oxidative ... strongtendency to aggregate in vitro. An interesting observationwas made that PrPC(the normal, cellular protein) binds to survival factors and that the PrPC to PrPSctransitionmight result in apoptotic...
... clinical picture (% of symptoms) of childhood celiacdisease in the Netherlands 1993 to 2000 (*P Ͻ 0.05).TABLE 2. Some diseases associated with childhood celiac disease (CD) Disease Frequencyof CD ... study.Practice Points● Celiacdisease is a common, but frequently unrec-ognized disease. Consequently, celiacdisease isseverely underdiagnosed.● The health burden of celiacdisease is considerable.Two ... theautoantigen of celiac disease. Nat Med 1997;3:797-801.94. Dieterich W, Laag E, Schöpper H, Volta U, Ferguson A,Gillett H, et al. Autoantibodies to tissue transglutaminase aspredictors of celiac...
... particular attention to handwashing.END OF DIARRHEAL DISEASES-6-CROUPINCUBATION & SYMPTOMSIncubation: Variable, depending upon causative agent.Symptoms: Acute respiratory infection which ... attention to handwashing.GIARDIASISINCUBATION & SYMPTOMSInfectious Agent: Giardia lambliaIncubation: 5-25 days or longer; median 7-10 days.Symptoms: It is common not to have symptoms. However, ... attention to handwashing.SHIGELLOSISINCUBATION & SYMPTOMSInfectious Agent: genus ShigellaIncubation: 12-96 hours (usually 1-3 days), and up to one week for S.dysenteriae 1.Symptoms: Characterized...
... transcriptional regulator Foxp3. These cells have been shown to possess immunosuppressive proper-ties towards various immune cell subsets and their defects are thought to contribute to many autoimmune disor-ders. ... translated to applica-tions for human autoimmune diseases by using IL-2 as a therapeutic agent to restore Treg cell fitness, numbersand functions.IntroductionPeripheral immune tolerance requires ... to the maintenance of peripheral tolerance,and their defect leads to organ-specific autoimmune dis-orders such as T1 D.The non-obese diabetic (NOD) mice are a prototypicmodel of human autoimmunity...
... and loss to follow up at one year, the relationship of advanced KS disease to mortality, and the incomplete access to che-motherapy for those with advanced disease. Contribut-ing factors likely ... advanced disease and high rates of mortality andloss to follow up. Risk factors for mortality included advanced Kaposi’s sarcoma disease and lack of chemotherapyuse. Contributing factors to the ... n(%).Follow-up time from time of AIDS-KS diagnosis to survival outcome (death,loss -to- follow up, or censor).IRIS, immune reconstitutioninflammatory syndrome. Denominator n = 137 forpatients on cART only.**...